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Ultrasound-Guided Bilateral Modified-Thoracoabdominal Nerve Block Through a Perichondral Approach in a Patient Undergoing Bilateral Laparoscopic Inguinal Hernia Repair: A Case Report. 接受双侧腹腔镜腹股沟疝修补术的患者通过软骨周围入路接受超声引导的双侧改良胸腹神经阻滞:病例报告。
IF 1.5 Q3 ANESTHESIOLOGY Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S482038
Jassim Rauf, Mohammad Mohsin A M Haji

Background: Modified thoracoabdominal nerve block through the perichondrial approach (M TAPA), described by Tulgar et al in 2019, is a relatively new block. The block is relatively superficial and easy to perform. It has been successfully used in various laparoscopic surgeries and has been shown to reduce the perioperative opioid requirements.

Case presentation: We report the case of a 41-year-old male with ASA grade 2, who was scheduled to undergo laparoscopic unilateral inguinal hernia repair. The patient had General Anaesthesia with bilateral M TAPA using 30 mL of 0.25% levobupivacaine on each side before the incision. Intraoperatively, the surgeon decided that the patient would require bilateral inguinal hernia repair. The patient received 100 µg fentanyl at induction, and intravenous paracetamol and ketorolac intraoperatively. The surgery was uneventful, and the patient was transferred to a post anaesthesia care unit. In the postoperative period, the patient did not require opioids and received only two doses each of paracetamol and ketorolac. The patient was discharged the following day, without any further sequelae.

Conclusion: When administered bilaterally, MTAPA can provide adequate analgesia and has opioid-sparing effects in both the intra and postoperative periods.

背景:由 Tulgar 等人于 2019 年描述的经软骨周入路的改良胸腹神经阻滞(M TAPA)是一种相对较新的阻滞方法。该阻滞相对表浅,易于操作。它已成功用于各种腹腔镜手术,并被证明可减少围手术期的阿片类药物需求:我们报告的病例是一名 41 岁男性,ASA 2 级,计划接受腹腔镜单侧腹股沟疝修补术。患者在切口前接受了双侧 M TAPA 全身麻醉,每侧使用 30 毫升 0.25% 左布比卡因。术中,外科医生决定患者需要进行双侧腹股沟疝修补术。患者在诱导时接受了 100 µg 芬太尼,术中静脉注射了扑热息痛和酮咯酸。手术很顺利,病人被转移到麻醉后护理病房。术后,患者无需使用阿片类药物,只需服用扑热息痛和酮咯酸各两剂。病人第二天就出院了,没有留下任何后遗症:结论:双侧给药时,MTAPA 可以提供充分的镇痛,并且在术中和术后都有阿片类药物的节省作用。
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引用次数: 0
Foot Drop Following a Popliteal Sciatic Nerve Block with Ropivacaine, A Case Report and Literature Review. 罗哌卡因腘坐骨神经阻滞术后足下垂,病例报告和文献综述。
IF 1.5 Q3 ANESTHESIOLOGY Pub Date : 2024-07-11 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S470574
Andreas Clipet-Jensen, Hans Fjeldsøe-Nielsen, Peter Roy Kirkegaard

Although peripheral nerve blocks are deemed very safe, a significant number of patients for whom this anesthetic technique may be particularly appealing to apply may present with preexisting peripheral neuropathies, putting them at risk for further nerve damage. We present a case with a 74-year-old male with several risk factors for peripheral neuropathy who developed a foot drop following a popliteal sciatic nerve block with ropivacaine. We suggest that the vasoconstrictive properties of ropivacaine may have contributed to a preexisting neuronal ischemia, thus further damaging an already compromised nerve.

尽管外周神经阻滞被认为是非常安全的,但有相当多的患者在应用这种麻醉技术时可能特别有吸引力,他们可能已经存在外周神经病变,从而面临进一步神经损伤的风险。我们介绍了一例 74 岁男性患者的病例,他有多种周围神经病变的危险因素,在使用罗哌卡因进行腘坐骨神经阻滞后出现了足下垂。我们认为罗哌卡因的血管收缩特性可能导致了原有的神经元缺血,从而进一步损伤了已经受损的神经。
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引用次数: 0
Comparison of Spinal Morphine and Transversus Abdominis Plane Block on Opioid Requirements After Caesarean Section: An Observational Study. 脊髓吗啡与腹横肌平面阻滞对剖腹产后阿片类药物需求的影响比较:一项观察性研究。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-06-12 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S459530
Suwarman, Osmond Muftilov Pison, Mohammad Fikry Maulana, Prapanca Nugraha

Objective: Acute postoperative pain is one of the major clinical problems that occurs in patients undergoing cesarean section with a prevalence of 89.8%. Postoperative pain causes discomfort and various complications for the mother. In addition, postoperative pain that is not handled properly can increase the risk of becoming chronic pain by 2.5 times. One of the methods recommended in the Enhanced Recovery After Caesarean Section (ERACS) protocol to prevent acute postoperative pain is the use of intrathecal long-acting opioids, with intrathecal morphine as the gold standard and Transversus Abdominis Plane (TAP) block. This study aims to assess the comparison of opioid needs as analgesic rescue between the administration of 0.1mg spinal morphine and TAP block with bupivacaine 0.2% 10mg in patients undergoing cesarean section.

Methods: This study is an observational study in a single Tertiary Hospital in West Java - Indonesia. Patients were given patient-controlled anesthesia (PCA) with fentanyl as analgesic rescue. Statistical analysis of the numerical data used the unpaired t-test and Chi-Square test for categorical data.

Results: In the group that was given spinal morphine, the duration of additional opioids was longer (p < 0.05), and the total dose of additional opioids was less than the TAP block group (p < 0.05).

Conclusion: The spinal morphine requires fewer additional opioids than the TAP block.

目的:急性术后疼痛是剖腹产患者的主要临床问题之一,发生率高达 89.8%。术后疼痛会给产妇带来不适和各种并发症。此外,术后疼痛如果处理不当,变成慢性疼痛的风险会增加 2.5 倍。增强剖腹产术后恢复(ERACS)方案中推荐的预防术后急性疼痛的方法之一是使用鞘内长效阿片类药物,其中鞘内吗啡是金标准,另外还有腹横肌平面(TAP)阻滞。本研究旨在评估剖宫产手术患者在使用 0.1 毫克脊髓吗啡和使用 0.2% 10 毫克布比卡因进行 TAP 阻滞时阿片类药物镇痛需求的比较:本研究是在印度尼西亚西爪哇的一家三级甲等医院进行的观察性研究。患者接受患者自控麻醉(PCA),并使用芬太尼镇痛。数字数据的统计分析采用非配对 t 检验,分类数据采用 Chi-Square 检验:结果:与 TAP 阻滞组相比,给予脊髓吗啡组的额外阿片类药物持续时间更长(P < 0.05),额外阿片类药物的总剂量更少(P < 0.05):结论:与TAP阻滞相比,脊髓吗啡所需的额外阿片类药物更少。
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引用次数: 0
Current Status and Global Trend of Rebound Pain After Regional Anesthesia: A Bibliometric Analysis. 区域麻醉后反跳痛的现状和全球趋势:文献计量分析。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-05-09 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S455347
Rui Zhou, Wencai Jiang, Qingyuan Miao, Xinyang Li, Lize Xiong

Purpose: Rebound pain after regional anesthesia, a common phenomenon when the analgesic effect wears off, has been recognized in the last a few years. The aim of this study is to analyze the status and tendency of this area in a macroscopic perspective.

Methods: Bibliometric analysis is the primary methodology of this study. Literature retrieval was conducted in Web of Science (WoS) Core Collection. WoS, Excel, VOSviewer and CiteSpace were employed to do the analyses and visualization. Parameters were analyzed, such as publications, citations, journals, and keywords, etc.

Results: In total, 70 articles in the past 10 years were identified eligible. Most articles (14 pieces) were published in 2021, followed by 2022 and 2023 with 13 articles. Researchers come from 134 institutions and 20 countries. Huang Jung-Taek, Hallym College, and USA are the most productive author, institution and country, respectively. The articles were mainly published on the top journals of anesthesiology, orthopedics and surgery. The topic of these articles is primarily about the clinical issues of rebound pain. Peripheral nerve block, brachial plexus block and femoral nerve block are the activist keywords in the area, while perioperative management, fracture surgery and outcome may become hotpots in the next years.

Conclusion: Our results show that the study of rebound pain after regional anesthesia starts relatively late and is in upward tendency, future studies can focus on the perioperative management and outcomes of fracture patients, and the definition and mechanism of rebound pain after regional anesthesia.

目的:区域麻醉后的反跳痛是镇痛效果消失后的一种常见现象,在过去几年中已得到认可。本研究旨在从宏观角度分析这一领域的现状和趋势:文献计量分析是本研究的主要方法。文献检索在科学网(WoS)核心库中进行。采用 WoS、Excel、VOSviewer 和 CiteSpace 进行分析和可视化。分析的参数包括出版物、引文、期刊和关键词等:结果:在过去 10 年中,共有 70 篇文章符合条件。大多数文章(14 篇)发表于 2021 年,其次是 2022 年和 2023 年,共 13 篇。研究人员来自 134 个机构和 20 个国家。黄政泽、Hallym 学院和美国分别是发表文章最多的作者、机构和国家。这些文章主要发表在麻醉学、骨科和外科的顶级期刊上。这些文章的主题主要是反跳痛的临床问题。外周神经阻滞、臂丛神经阻滞和股神经阻滞是该领域的活跃关键词,而围术期管理、骨折手术和疗效可能成为未来几年的热点:我们的研究结果表明,区域麻醉后反跳痛的研究起步相对较晚,且呈上升趋势,未来的研究可重点关注骨折患者的围手术期管理和预后,以及区域麻醉后反跳痛的定义和机制。
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引用次数: 0
Knowledge, Attitudes and Practices Regarding Use of Local Anaesthetics Among Non-Anaesthesia Healthcare Professionals at Mulago National Referral Hospital. 穆拉戈国家转诊医院非麻醉专业医护人员对局部麻醉剂使用的认识、态度和实践。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-03-08 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S428661
Intisar Ahmed Abdi, John Mark Kasumba, Agnes Wabule, Mary T Nabukenya, Joseph Kayongo, Bernadette Kyoheirwe, Abdirizak Abdullahi Sheikdon, Kamaludin D Osman

Introduction: Local anaesthetics (LA) are commonly used in dental and surgical emergency wards by both anaesthesia professionals and non-anaesthesia professionals. Anecdotal evidence shows that non-anaesthesia health-care professionals do not monitor vital signs during the use of local anaesthesia, and there are no standard hospital guidelines on the use of LA and management of LA toxicity by non-anaesthesia professionals.

Purpose: This study sought to assess the knowledge, attitudes and practices regarding local anaesthetic use among non-anaesthesia health-care professionals at Mulago National Referral Hospital.

Patients and methods: This was a cross-sectional study that utilized a quantitative research approach. The sample size of the study was 43 non-anaesthesia healthcare professionals from the casualty and surgical outpatient wards and Mulago dental ward. Data was collected using a questionnaire and analyzed using STATA 15.

Results: Overall, 66.67% of the Specialist, 76.47% of the senior house officers, 100% of medical officers, and 80% of the clinical orthopedic house officers had unsatisfactory levels of knowledge in Mulago casualty and surgical outpatient wards. 20% of the specialist and 16.67% of the senior house officers had unsatisfactory levels of knowledge in Mulago dental ward. 87.5% of the non-anaesthesia health-care professionals do not give a test dose on a routine basis in Mulago casualty and surgical outpatient wards. A total of 63.64% of the non-anaesthesia healthcare professionals in Mulago dental ward do not sterilize the site of injection.

Conclusion: Non-anaesthesia health-care professionals had unsatisfactory levels of knowledge, somewhat good practices, and negative attitudes toward LA use.

简介:局部麻醉剂(LA)通常被麻醉专业人员和非麻醉专业人员用于牙科和外科急诊病房。轶事证据显示,非麻醉专业医护人员在使用局麻药期间不会对生命体征进行监测,而且医院也没有关于非麻醉专业人员使用局麻药和处理局麻药中毒的标准指南:这是一项采用定量研究方法的横断面研究。研究样本量为43名非麻醉专业医护人员,分别来自伤科、外科门诊病房和穆拉戈牙科病房。研究采用问卷调查的方式收集数据,并使用 STATA 15 进行分析:总体而言,在 Mulago 伤科和外科门诊病房,66.67% 的专科医生、76.47% 的高级住院医师、100% 的医务人员和 80% 的临床骨科住院医师的知识水平不尽人意。20% 的专科医师和 16.67% 的高级内科医师对 Mulago 牙科病房的知识水平不满意。在穆拉戈急诊室和外科门诊病房,87.5%的非麻醉专业医护人员没有进行常规剂量测试。穆拉戈牙科病房共有63.64%的非麻醉医护人员没有对注射部位进行消毒:结论:非麻醉医护人员对LA使用的知识水平、良好实践和消极态度均不令人满意。
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引用次数: 0
Combined Supra-Inguinal Fascia Iliaca, Sciatic Nerve, and Posterior Femoral Cutaneous Nerve Blocks in Austere Settings for Hemodynamically Unstable Patients with Vascular Injuries from Weapon Wounds: A Case Series. 在严酷环境下对因武器伤导致血管损伤、血流动力学不稳定的患者进行髂上肌筋膜、坐骨神经和股后皮神经联合阻滞:病例系列。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-03-02 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S452367
Majaliwa Shabani, Seydina Alioune Beye, Abdoulaye Traore, Xavier Raingeval, Daouda Coulibaly, Sophie Crespo

Purpose: The management of unstable patients with weapon-wounded lower limb vascular injuries presents significant anesthetic challenges. Regional anesthesia blocks, which combine lumbar and sacral plexus blocks, or their respective branches, minimize systemic effects and are deemed appropriate for high-risk patients requiring lower limb surgery. This case series aims to share our preliminary experiences with a combined anesthetic technique-sciatic nerve (SN), posterior femoral cutaneous nerve (PFCN), and supra-inguinal fascia iliaca (SIFI) blocks -in patients sustaining weapon wounds and undergoing lower limb vascular injury repair in austere environments.

Patients and methods: Seven patients with lower limb vascular injuries resulting from weapons who required surgery at district hospitals supported by the International Committee of the Red Cross were included in this study. Included patients underwent surgery for vascular repair and debridement using a combined nerve block technique involving the SN, PFCN, and SIFI blocks between May and December 2023. The blocks were administered using a 1:1 mixture of 1% lidocaine and 0.5% levobupivacaine.

Results: The combined block technique for the Sciatic Nerve (SN), Posterior Femoral Cutaneous Nerve (PFCN), and the Supra-Inguinal Fascia Iliaca (SIFI) were performed without complications in all patients. Three of the patients received light sedation prior to the initiation of the block procedure. All surgeries were completed successfully without the need for additional analgesics or conversion to general anesthesia.

Conclusion: The combined block technique for the Sciatic Nerve (SN), Posterior Femoral Cutaneous Nerve (PFCN), and the Supra-Inguinal Fascia Iliaca (SIFI) appears to be a safe anesthetic option for unstable or high-risk patients requiring lower limb surgery. Further research with a larger cohort is necessary to validate our findings and to potentially standardize this approach.

目的:治疗被武器击伤的下肢血管损伤的不稳定患者是一项重大的麻醉挑战。结合腰椎和骶神经丛阻滞或其各自分支的区域麻醉阻滞可将全身影响降至最低,被认为适合需要进行下肢手术的高风险患者。本系列病例旨在分享我们在恶劣环境下对遭受武器伤害并接受下肢血管损伤修复的患者采用联合麻醉技术--坐骨神经(SN)、股后皮神经(PFCN)和髂腹股沟上筋膜(SIFI)阻滞的初步经验:本研究纳入了七名因武器造成下肢血管损伤并需要在红十字国际委员会支持的地区医院进行手术的患者。在 2023 年 5 月至 12 月期间,这些患者接受了血管修复和清创手术,手术中使用了联合神经阻滞技术,包括 SN、PFCN 和 SIFI 阻滞。阻滞使用 1:1 的 1%利多卡因和 0.5% 左旋布比卡因混合物:结果:所有患者均接受了坐骨神经(SN)、股后皮神经(PFCN)和髂上筋膜(SIFI)联合阻滞技术,无并发症发生。其中三名患者在开始阻滞手术前接受了轻度镇静。所有手术均顺利完成,无需额外使用镇痛剂或转为全身麻醉:结论:坐骨神经(SN)、股后皮神经(PFCN)和髂上筋膜(SIFI)联合阻滞技术似乎是需要进行下肢手术的不稳定或高风险患者的安全麻醉选择。为了验证我们的研究结果并有可能将这种方法标准化,有必要对更大的群体进行进一步研究。
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引用次数: 0
Successful Use of Ultrasound Guided Quadratus Lumborum Block Without General Anesthesia for Open Appendectomy in a Patient with Heart Failure with Reduced Ejection Fraction- A Case Report and Literature Review. 超声引导下腰椎四头肌阻滞在无全身麻醉情况下成功用于射血分数降低型心力衰竭患者的开腹阑尾切除术--病例报告和文献综述。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S438176
Muhammad Jaffar Khan, Yasir Eltayeb, Arunabha Karmakar, Rohma Malik, Tarig Elsafi

Background: Patients diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF) are at high risk of perioperative cardiovascular complications. While it is important to focus on optimizing their cardiac function, it is also crucial to address and optimize any other modifiable risk factors that could potentially impact postoperative outcome. This also includes careful consideration of anesthetic techniques to suit the patient and facilitate the surgery. However, there is a scarcity of evidence regarding the safety of specific anesthetic approaches for heart failure patients.

Case presentation: We describe the case of an adult patient in mid-50s, with a history of ischemic dilated cardiomyopathy with reduced Ejection Fraction (about 25%) who presented with acute gangrenous appendicitis and was scheduled for an open appendectomy. It was deemed to be a high-risk patient for general and spinal anesthesia. With the guidance of a multidisciplinary team, surgery was successfully performed using a quadratus lumborum block with standard monitoring. The patient was comfortable and hemodynamically stable throughout the procedure. The postoperative course was uneventful.

Conclusion: Quadratus Lumborum Block for open appendectomy can be a beneficial alternative anesthesia technique in high-risk patients that significantly lowers perioperative cardiovascular risk, maintains hemodynamics, enhances satisfaction, and shortens hospital stay.

背景:被诊断为射血分数降低性心力衰竭(HFrEF)的患者围手术期心血管并发症风险很高。重点优化其心脏功能固然重要,但解决和优化可能影响术后效果的任何其他可改变的风险因素也至关重要。这还包括仔细考虑麻醉技术,以适合患者并促进手术。然而,有关心衰患者特定麻醉方法安全性的证据却很少:我们描述了一例 50 多岁的成年患者的病例,该患者有缺血性扩张型心肌病史,射血分数降低(约 25%),因急性坏疽性阑尾炎而被安排进行开腹阑尾切除术。该患者被认为是全身麻醉和脊髓麻醉的高风险患者。在多学科团队的指导下,手术在标准监测下通过腰椎四头肌阻滞成功实施。在整个手术过程中,患者感觉舒适,血流动力学稳定。术后恢复顺利:腰椎四头肌阻滞用于开放式阑尾切除术是一种有益的替代麻醉技术,适用于高风险患者,可显著降低围术期心血管风险、维持血流动力学、提高满意度并缩短住院时间。
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引用次数: 0
A Novel Ultrasound-Guided "Three in One" Approach Plus Interfascial Plane Blocks for the Treatment of Cervicogenic Headache. 治疗颈源性头痛的新型超声引导 "三合一 "疗法加筋膜间平面阻滞术
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2024-02-01 eCollection Date: 2024-01-01 DOI: 10.2147/LRA.S446667
Danxu Ma, Abulaihaiti Maimaitimin, Yun Wang

Objective: Cervicogenic headache (CEH) is a condition resulting from upper cervical spine dysfunction and associated structural and soft tissue abnormalities, significantly impacting patients' quality of life. To acquire better therapeutic results, we presented a novel ultrasound-guided "three in one" approach plus interfascial plane (IFP) blocks for the treatment of CEH. This approach allows for the modulation of C2 dorsal root ganglion (DRG), third occipital nerve (TON), and C3 medial branch with one-point puncture. Additionally, it allows for IFP blocks between the upper neck and occipital muscles within the same scanning plane.

Patients and methods: We evaluated patients diagnosed with CEH from July 2021 to December 2022 in our pain clinic. We included those who did not respond to conservative treatment and single occipital nerve block, therefore received nerve block or pulsed radiofrequency (PRF) using the "Three in One" approach plus IFP blocks. The accuracy of the ultrasound-guided C2 DRG puncture procedures was confirmed through fluoroscopy with C-arm and the sensory testing of PRF. The therapeutic effect of these interventions was assessed using the numerical rating scale (NRS) scores during telephone follow-ups at 1, 3, and 6 months.

Results: Utilizing the "Three in One" approach, a total of 5 patients diagnosed with CEH underwent nerve block plus IFP blocks, while 2 patients underwent PRF plus IFP blocks. Employing ultrasound-guided C2 DRG puncture procedures, the needle tip's correct placement was confirmed through both fluoroscopy and sensory testing of PRF. Notably, none of the cases experienced any complications associated with the approach. Subsequent follow-up assessments revealed an improvement in the NRS scores for CEH in all patients.

Conclusion: The ultrasound-guided "Three in One" approach plus IFP blocks may be a potential effective method for the treatment of CEH.

目的:颈源性头痛(CEH颈源性头痛(CEH)是一种由上颈椎功能障碍及相关结构和软组织异常引起的疾病,严重影响患者的生活质量。为了获得更好的治疗效果,我们提出了一种新颖的超声引导 "三合一 "方法加筋膜间平面(IFP)阻滞治疗颈源性头痛。这种方法可通过单点穿刺调节 C2 背根神经节 (DRG)、第三枕神经 (TON) 和 C3 内侧支。此外,它还能在同一扫描平面内对上颈部和枕部肌肉进行 IFP 阻滞:我们对 2021 年 7 月至 2022 年 12 月期间在疼痛诊所确诊为 CEH 的患者进行了评估。我们评估了 2021 年 7 月至 2022 年 12 月期间在我院疼痛门诊确诊为 CEH 的患者,其中包括对保守治疗和单一枕神经阻滞治疗无效的患者,因此他们接受了神经阻滞或脉冲射频(PRF)治疗,采用 "三合一 "方法加 IFP 阻滞治疗。超声引导下的 C2 DRG 穿刺程序的准确性通过 C 臂透视和 PRF 的感觉测试得到了证实。在 1 个月、3 个月和 6 个月的电话随访中,使用数字评分量表(NRS)评分评估了这些干预措施的治疗效果:利用 "三合一 "方法,共有 5 名确诊为 CEH 的患者接受了神经阻滞加 IFP 阻滞治疗,2 名患者接受了 PRF 加 IFP 阻滞治疗。采用超声引导的 C2 DRG 穿刺程序,通过透视和 PRF 的感觉测试确认针尖的正确位置。值得注意的是,所有病例均未出现与该方法相关的并发症。随后的随访评估显示,所有患者的 CEH NRS 评分均有改善:结论:超声引导下的 "三合一 "方法加 IFP 阻滞可能是治疗 CEH 的一种有效方法。
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引用次数: 0
Analgesic Effects of Different Local Infiltration Anesthesia Techniques Combined with Femoral Nerve Block in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Clinical Trial 不同局部浸润麻醉技术联合股神经阻滞对全膝关节置换术患者的镇痛效果:随机对照临床试验
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2023-12-01 DOI: 10.2147/lra.s436767
Yong-Kang Gui, Rui-Fei Xiao, Ya-Ru Luo, Yang Liu, Xin Da, Sizhu Zhu, De-Wen Shi, Xu-Dong Hu, Guang-Hong Xu
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引用次数: 0
The Impact of Missing Postoperative Longitudinal Pain Data on Study Results Investigating Analgesia from Transversus Abdominis Plane Block on Postoperative Day One Following Abdominal Surgery: A Single-Center Retrospective Chart Review. 术后纵向疼痛数据缺失对腹部手术后第一天腹横肌平面阻滞镇痛研究结果的影响:单中心回顾性病历审查。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2023-11-30 eCollection Date: 2023-01-01 DOI: 10.2147/LRA.S439429
James Harvey Jones

Background: The aims of this study are to analyze the association between the number of recorded pain scores and baseline pain following surgery, analgesia technique, and patient demographics, as well as the substitution of missing data with the results from mean substitution, last observation carried forward, regression imputation, multiple imputation, and mixed models.

Methods: This retrospective chart review was approved by the Institutional Review Board (IRB). The following data were collected: patient demographics (age, gender, body mass index (BMI), race, and ethnicity); surgery type and date; analgesia with or without transversus abdominis plane (TAP) block; as well as the time, date, and value for all postoperative pain scores on the first postoperative day (POD). The following null hypotheses were tested: (1) the number of pain recordings will be independent of TAP block analgesia, baseline pain on POD 1, and patient demographics; and (2) there will be no significant differences in pain scores with and without TAP block analgesia following complete case analysis, mean substitution, last observation carried forward, regression imputation, multiple imputation, and mixed models.

Results: This study analyzed 486 patients including 2562 recorded pain scores. An increase in age by one year is, on average, associated with a 0.04 (95% confidence interval (CI) -0.060 to -0.025) decrease in the number of pain scores recorded (p < 0.001). Black race is associated with 0.763 less pain scores, on average (95% CI -1.49 to -0.039) and this value is statistically significant (p = 0.039). All datasets with substituted values for missing data yield lower pain scores for patients who did not receive TAP block. Significant differences in recorded pain scores are only noted for scores recorded between 0400 and 0759 and 1600-1959 in mixed models.

Conclusion: Discrepancies in pain score recordings among patients are associated with age and black race. When these discrepancies are addressed with statistical methods, clinically significant differences are appreciated.

研究背景本研究的目的是分析记录的疼痛评分次数与术后基线疼痛、镇痛技术和患者人口统计学特征之间的关联,以及用平均替代、最后观察结转、回归归因、多重归因和混合模型的结果替代缺失数据:这项回顾性病历审查已获得机构审查委员会(IRB)批准。收集的数据包括:患者人口统计学特征(年龄、性别、体重指数 (BMI)、种族和民族);手术类型和日期;使用或不使用腹横肌平面 (TAP) 阻滞镇痛;以及术后第一天 (POD) 所有术后疼痛评分的时间、日期和数值。对以下零假设进行了检验:(1) 疼痛记录的数量与 TAP 阻滞镇痛、POD 1 的基线疼痛和患者人口统计学特征无关;(2) 经过完整病例分析、平均值替代、最后观察结果结转、回归归因、多重归因和混合模型分析后,采用 TAP 阻滞镇痛和未采用 TAP 阻滞镇痛的疼痛评分无显著差异:本研究分析了 486 名患者,包括 2562 份疼痛评分记录。年龄每增加一岁,记录的疼痛评分数量平均会减少 0.04(95% 置信区间 (CI) -0.060 至 -0.025)(p < 0.001)。黑种人的疼痛评分平均减少 0.763 分(95% CI -1.49 至 -0.039),且该值具有统计学意义(p = 0.039)。所有用替代值替代缺失数据的数据集都显示,未接受 TAP 阻滞的患者疼痛评分较低。在混合模型中,只有在 4:00 至 0759 和 16:00 至 1959 之间记录的疼痛评分存在显著差异:结论:患者疼痛评分记录的差异与年龄和黑人种族有关。结论:患者疼痛评分记录的差异与年龄和黑人种族有关。当使用统计方法处理这些差异时,就会发现有临床意义的差异。
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Local and Regional Anesthesia
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