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[Thromboinflammation in ischemic stroke: towards new therapeutic opportunities?] 缺血性卒中的血栓炎症：新的治疗机会？］
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025251
Laurine Bedoucha, Sandrine Delbosc, Jérémy Neel, Jean-Philippe Desilles, Mikaël Mazighi, Benoît Ho-Tin-Noé

Ischemic stroke results from the occlusion of an intracranial artery and requires rapid arterial recanalization to restore cerebral reperfusion. Arterial recanalization treatments, intravenous thrombolysis and mechanical thrombectomy, have improved prognosis, but their accessibility is restricted and their effectiveness in achieving cerebral reperfusion and ensuring good outcome remains limited. Recent studies have identified thromboinflammation as a key factor in resistance to these treatments, particularly by limiting the effectiveness of intravenous thrombolysis in achieving arterial recanalization, but also by preventing arterial recanalization from resulting in cerebral reperfusion. In this review, we present how thromboinflammation contributes to resistance to arterial recanalization treatments and discuss the opportunities offered by treatments targeting its mechanisms to optimize patient management and prognosis.

缺血性脑卒中是由颅内动脉闭塞引起的，需要快速动脉再通以恢复大脑再灌注。动脉再通治疗、静脉溶栓和机械取栓均可改善预后，但其可及性有限，在实现脑再灌注和确保良好预后方面的有效性仍然有限。最近的研究已经确定血栓炎症是抵抗这些治疗的关键因素，特别是通过限制静脉溶栓实现动脉再通的有效性，而且还通过阻止动脉再通导致脑再灌注。在这篇综述中，我们介绍了血栓炎症如何对动脉再通治疗产生抵抗，并讨论了针对其机制的治疗提供的机会，以优化患者管理和预后。
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引用次数: 0
[Malaria: Could NETosis, neutrophils' defense mechanism involved in severe cases of the disease, be a new therapeutic target?] 疟疾：NETosis（中性粒细胞在重症病例中的防御机制）能否成为新的治疗靶点？］
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025208
Lenka Kociánová, Salomé Larribau, Norma Veltz
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引用次数: 0
[ADAM10 and ADAM17 proteases: new players in the controlled release of extracellular vesicles]. [ADAM10和ADAM17蛋白酶：细胞外囊泡控制释放的新参与者]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025245
Chloé Bizingre, Flavien Picard, Aurélie Alleaume-Butaux, Mathéa Pietri, Anne Baudry, Benoit Schneider
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引用次数: 0
[Unintegrated HIV-1 escapes cGAS sensing through chromatin compaction]. [未整合的HIV-1通过染色质压缩逃脱cGAS传感]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025248
Cyprien Jahan, Monsef Benkirane, Suzie Thenin-Houssier
{"title":"[Unintegrated HIV-1 escapes cGAS sensing through chromatin compaction].","authors":"Cyprien Jahan, Monsef Benkirane, Suzie Thenin-Houssier","doi":"10.1051/medsci/2025248","DOIUrl":"https://doi.org/10.1051/medsci/2025248","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 1","pages":"33-36"},"PeriodicalIF":0.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[médecine/sciences: 40 years old and an evolving story]. [msamuine /sciences: 40年的历史和不断发展的故事]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2026001
Anna Salvetti
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引用次数: 0
[TL1A, an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation]. [TL1A，一种与IL-33合作引发过敏性气道炎症的上皮报警蛋白]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025200
Ilies Mimouni, Soufiane Delloul
{"title":"[TL1A, an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation].","authors":"Ilies Mimouni, Soufiane Delloul","doi":"10.1051/medsci/2025200","DOIUrl":"https://doi.org/10.1051/medsci/2025200","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 1","pages":"108"},"PeriodicalIF":0.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Testicular telocyte: a player in the regulation of spermatogenesis?] 睾丸远端细胞：调节精子发生的参与者？］
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025250
Bleuenn Bregaint, Dominique Mahé, Nathalie Dejucq-Rainsford, Célia Ravel

The telocyte, a cell long neglected, is now being investigated in several organs. These cells have a unique morphology with a shape that varies according to the number of telopods -the long cell extensions ranging from two to five per cell. This morphology suggests specific functions, some of which remain to be confirmed. The presence of telocytes in the testis suggests their involvement in regulating endocrine and exocrine functions specific to this organ. This article summarizes the current knowledge about this unique cell and its potential roles in the testis.

远端细胞是一种长期被忽视的细胞，现在正在几个器官中进行研究。这些细胞具有独特的形态，其形状根据端足类动物的数量而变化——每个细胞的细胞长度从2到5不等。这种形态暗示了特定的功能，其中一些功能仍有待证实。睾丸中存在的远端细胞表明它们参与调节该器官特有的内分泌和外分泌功能。本文综述了目前关于这种独特细胞及其在睾丸中的潜在作用的知识。
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引用次数: 0
[IL-23 stabilizes an effector Treg cell program in the tumor microenvironment]. [IL-23稳定肿瘤微环境中的效应Treg细胞程序]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025207
Nawel Chekrit, Nicolas Martel
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引用次数: 0
[Growth factor-triggered de-sialylation controls breast cancer invasion]. [生长因子触发的去唾液化控制乳腺癌的侵袭]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025249
Ewan MacDonald, Charlotte Nugues, Ludger Johannes
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引用次数: 0
[An intestinal microbiotal bacteria involved in the hepatic encephalopathy of patients with cirrhosis]. [一种与肝硬化肝性脑病有关的肠道微生物]。
IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1051/medsci/2025243
Hélène Gilgenkrantz
{"title":"[An intestinal microbiotal bacteria involved in the hepatic encephalopathy of patients with cirrhosis].","authors":"Hélène Gilgenkrantz","doi":"10.1051/medsci/2025243","DOIUrl":"https://doi.org/10.1051/medsci/2025243","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 1","pages":"19-21"},"PeriodicalIF":0.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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