{"title":"[Paleopathological analysis of prenatal and postnatal vitamin D deficiency using teeth as tool].","authors":"Ysabel-Marion Delbos, Marie-Amélie Deminière, Sarah Girard, Léa Zaragoza, Caroline Costedoat, Émeline Verna","doi":"10.1051/medsci/2024199","DOIUrl":"https://doi.org/10.1051/medsci/2024199","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"90-92"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-01-31DOI: 10.1051/medsci/2024187
Benjamin Davido, Djillali Annane
{"title":"[Correction of eosinopenia during respiratory infections is a predictor of oxygen weaning].","authors":"Benjamin Davido, Djillali Annane","doi":"10.1051/medsci/2024187","DOIUrl":"https://doi.org/10.1051/medsci/2024187","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"9-12"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-20DOI: 10.1051/medsci/2024194
Vincent Colot
{"title":"[Promises and excesses of the \"epigenetic era\"].","authors":"Vincent Colot","doi":"10.1051/medsci/2024194","DOIUrl":"https://doi.org/10.1051/medsci/2024194","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"881-882"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Protein arginine methyltransferase PRMT2 is involved in the control of inflammation in acute myeloid leukemia].","authors":"Camille Sauter, Jean-Noël Bastie, Laurent Delva, Romain Aucagne","doi":"10.1051/medsci/2024168","DOIUrl":"https://doi.org/10.1051/medsci/2024168","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"979-982"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-20DOI: 10.1051/medsci/2024182
Hedvika Martin, Michel Wassef
Cellular differentiation and homeostasis rely on complex mechanisms to control gene expression, enabling the different cell lineages of an organism to establish and then "memorize" different epigenetic states. The processes that control gene expression are centered on chromatin, a complex of DNA, histone proteins and RNA, whose structure is finely regulated. Targeted epigenomic engineering tools make it possible to interfere with and study these processes, revealing the logic of epigenetic memory mechanisms. This article reviews the main classes of targeted epigenome modification tools and illustrates how they can be used to better understand and modify the epigenome of cells, paving the way for potentially revolutionary therapeutic prospects.
{"title":"[Targeted epigenome engineering].","authors":"Hedvika Martin, Michel Wassef","doi":"10.1051/medsci/2024182","DOIUrl":"https://doi.org/10.1051/medsci/2024182","url":null,"abstract":"<p><p>Cellular differentiation and homeostasis rely on complex mechanisms to control gene expression, enabling the different cell lineages of an organism to establish and then \"memorize\" different epigenetic states. The processes that control gene expression are centered on chromatin, a complex of DNA, histone proteins and RNA, whose structure is finely regulated. Targeted epigenomic engineering tools make it possible to interfere with and study these processes, revealing the logic of epigenetic memory mechanisms. This article reviews the main classes of targeted epigenome modification tools and illustrates how they can be used to better understand and modify the epigenome of cells, paving the way for potentially revolutionary therapeutic prospects.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"955-962"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-20DOI: 10.1051/medsci/2024177
Clara Roidor, Karim Chebli, Maud Borensztein
The memory of cellular identity is crucial for the correct development of an individual and is maintained throughout life by the epigenome. Chromatin marks, such as DNA methylation and histone modifications, ensure the stability of gene expression programmes over time and through cell division. Loss of these marks can lead to severe pathologies, including cancer and developmental syndromes. However, reprogramming of cellular identity is also a natural phenomenon that occurs early in mammalian development, particularly in the germ line, which enables the production of mature and functional gametes. The germ line transmits genetic and epigenetic information to the next generation, contributing to the survival of the species. Primordial germ cells (PGCs) undergo extensive chromatin remodelling, including global DNA demethylation and erasure of the parental imprints. This review introduces the concept of epigenetic reprogramming, its discovery and key steps, as well as the transcriptional and chromatin changes that accompany germ cell formation in mice. Finally, we discuss the epigenetic mechanisms of genomic imprinting, its discovery, regulation and relevance to human disease.
细胞身份的记忆对个体的正确发育至关重要，并在整个生命过程中由表观基因组来维持。染色质标记（如 DNA 甲基化和组蛋白修饰）可确保基因表达程序随着时间的推移和细胞分裂而保持稳定。这些标记的缺失会导致严重的病症，包括癌症和发育综合症。然而，细胞身份的重编程也是哺乳动物发育早期的一种自然现象，尤其是在生殖系中，因为生殖系能够产生成熟的功能性配子。生殖细胞将遗传和表观遗传信息传递给下一代，为物种的生存做出贡献。原始生殖细胞（PGCs）经历了广泛的染色质重塑，包括全局 DNA 去甲基化和抹去亲代印记。本综述介绍了表观遗传重编程的概念、发现和关键步骤，以及伴随小鼠生殖细胞形成的转录和染色质变化。最后，我们将讨论基因组印记的表观遗传机制、其发现、调控以及与人类疾病的相关性。
{"title":"[Epigenetic reprogramming, germline and genomic imprinting].","authors":"Clara Roidor, Karim Chebli, Maud Borensztein","doi":"10.1051/medsci/2024177","DOIUrl":"https://doi.org/10.1051/medsci/2024177","url":null,"abstract":"<p><p>The memory of cellular identity is crucial for the correct development of an individual and is maintained throughout life by the epigenome. Chromatin marks, such as DNA methylation and histone modifications, ensure the stability of gene expression programmes over time and through cell division. Loss of these marks can lead to severe pathologies, including cancer and developmental syndromes. However, reprogramming of cellular identity is also a natural phenomenon that occurs early in mammalian development, particularly in the germ line, which enables the production of mature and functional gametes. The germ line transmits genetic and epigenetic information to the next generation, contributing to the survival of the species. Primordial germ cells (PGCs) undergo extensive chromatin remodelling, including global DNA demethylation and erasure of the parental imprints. This review introduces the concept of epigenetic reprogramming, its discovery and key steps, as well as the transcriptional and chromatin changes that accompany germ cell formation in mice. Finally, we discuss the epigenetic mechanisms of genomic imprinting, its discovery, regulation and relevance to human disease.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 12","pages":"892-903"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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