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MODELLING OF HILLSLOPE STORAGE UNDER TEMPORALLY VARIED RAINFALL RECHARGE 降雨补给随时间变化的山坡蓄水模型
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-03-02 DOI: 10.1051/mmnp/2023009
P. Hsieh, Tzu-Ting Huang
Water storage inside hillslopes is a crucial issue of environment and water resources. This study separately built a numerical model and an analytical model employing a hillslope-storage equation to simulate the water storage in a sloping aquifer response to recharge. The variable width of hillslope was hypothetically represented by an exponential function to categorize the hillslope into three types: uniform, convergent, and divergent. An integral transform technique was introduced to derive the analytical solution whereas a finite difference method was employed for the numerical modelling. As a result, under the same scenario a gap existed between the two solutions to distinct forms of the water storage equation, and the gap decreases with a falling recharge rate for convergent hillslopes. Moreover, all outflows gradually approached one value based on different hillslopes under the same accumulative recharge amount for six typical rainfall recharge patterns. Particularly, while the recharge stops, the outflow decreases and then mildly rises for a long time for convergent hillslope because of the slow water release near the upstream boundary where the storage water is relatively abundant due to the widest width.
山坡内的蓄水是一个至关重要的环境和水资源问题。本研究分别建立了一个数值模型和一个分析模型,采用山坡蓄水方程来模拟斜坡含水层的蓄水对补给的响应。假设山坡的可变宽度由指数函数表示,将山坡分为三种类型:均匀型、收敛型和发散型。引入积分变换技术来导出解析解,而采用有限差分方法进行数值建模。因此,在相同的情况下,不同形式的蓄水方程的两个解之间存在差距,并且随着收敛山坡的补给率下降,差距减小。此外,对于六种典型的降雨补给模式,在相同的累积补给量下,基于不同的山坡,所有外流逐渐接近一个值。特别是,当补给停止时,收敛山坡的流出量减少,然后在很长一段时间内缓慢上升,因为上游边界附近的水释放缓慢,而上游边界由于宽度最宽而蓄水相对丰富。
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引用次数: 1
How do cell crowding and starvation affect avascular tumor growth of the EMT6/Ro tumor? 细胞拥挤和饥饿如何影响EMT6/Ro肿瘤的无血管肿瘤生长?
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-02-16 DOI: 10.1051/mmnp/2023007
Bjarke Spangsberg Bak, Morten Andersen, J. Ottesen, Jesper Schmidt Hansen
Here we re-examine experimental in vitro data for the EMT6/Ro tumor volume and viable rim thickness. This shows that the growth speed is constant in time, and independent of nutrient concentration at large concentrations, but that the viable rim thickness increases in this high concentration regime. We then present a simple mechanistic reaction-diffusion equation that includes crowding and starvation effects, and show that the model qualitatively captures the experimental observations. Moreover, the model predicts that the cancer cell concentration is characterised by a wave pulse (soliton), and the pulse shape is explored through zero’th order perturbation analysis corresponding to large wave speeds. It is shown that this zero’th order term is dominant for the experimental condition, further indicating that the non-linear reaction governs the pulse characteristic shape. Finally, at low nutrient concentrations we find that the front is a pulled-front, that is, the growth speed is determined by the cell multiplication at the wave front edge in accordance with earlier modelling approaches.
在这里,我们重新检查了EMT6/Ro肿瘤体积和活缘厚度的体外实验数据。这表明,生长速度在时间上是恒定的,并且在高浓度时不受营养物质浓度的影响,但在高浓度条件下,活菌边缘厚度增加。然后,我们提出了一个简单的机械反应-扩散方程,其中包括拥挤和饥饿效应,并表明该模型定性地捕获了实验观察结果。此外,该模型预测癌细胞浓度以波脉冲(孤子)为特征,并通过对应于大波速度的零阶微扰分析来探索脉冲形状。结果表明,该零阶项在实验条件下占主导地位,进一步表明非线性反应决定了脉冲特征形状。最后,在低营养物质浓度时,我们发现锋面是拉前的,即生长速度由波锋面边缘的细胞增殖决定,与早期的建模方法一致。
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引用次数: 0
Traveling solutions for a multi-anticipative car-following traffic model 多预期车辆跟随交通模型的出行解决方案
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-02-12 DOI: 10.1051/mmnp/2023006
Nader El Khatib, Amine Ghorbel, Agatha Joumaa, Mamdouh Zaydan
In this paper, we consider a steady state multi-anticipative traffic model and we provide necessarily and sufficient conditions for the existence of traveling solutions. In our work, the word "traveling" means that the distance between two consecutive vehicles travels continuously between two different states. As application to our result, we show that taking a strictly concave optimal velocity, we can construct a traveling solution such that the distance between two vehicles decreases. The existence, uniqueness and the study of the asymptotic behavior of such solutions is done at the level of the Hamilton-Jacobi equation.
本文考虑了一个稳态多预期交通模型,给出了出行解存在的充要条件。在我们的工作中,“行驶”一词意味着两辆连续车辆之间的距离在两种不同的状态之间连续行驶。作为对结果的应用,我们证明了取一个严格凹的最优速度,我们可以构造一个行驶解,使两辆车之间的距离减小。这些解的存在性、唯一性和渐近性的研究是在Hamilton-Jacobi方程的水平上进行的。
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引用次数: 0
Mathematical Modelling of the Effects of Statins on the Growth of Necrotic Core in Atherosclerotic Plaque 他汀类药物对动脉粥样硬化斑块坏死核心生长影响的数学模型
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-02-09 DOI: 10.1051/mmnp/2023005
Weirui Lei, Ji-wen Hu, Yaxian Xie, Can Liu, Xuekun Chen
A large necrotic core increases the risk of atherosclerotic plaque instability. Statins can delay the growth of necrotic core in plaques, but the kinetic mechanism of statins in slowing down the necrotic core has not yet been addressed in detail. In this paper, a mathematical model is governed by a system of advection-diffusion-reaction equations coupling of the porous nature of vessel wall is established and applied to illustrate the plaque growth with lipid-rich necrotic core (LRNC) with and without statins using finite element method. We study the influence of LRNC plaque growth for different drug concentrations at different time intervals. The results showed that the drug use at different time points has a significant impact on the treatment efficacy. Compared with  short-term, low-dose treatment, early statin treatment with high dose showed more pronounced effects on reducing the low-density lipoprotein (LDL) cholesterol, decreasing the volume of necrotic core, changing the characteristics of plaques, and improving the plaque stability. The model is validated by comparing with the clinical data, and may be used to predict the progression of LRNC plaque and the effects of statin therapy.
大的坏死核心会增加动脉粥样硬化斑块不稳定的风险。他汀类药物可以延缓斑块中坏死核心的生长,但他汀类药物减缓坏死核心的动力学机制尚未得到详细研究。本文建立了一个由平流-扩散反应方程组控制的数学模型,将血管壁多孔性耦合起来,并用有限元方法描述了含有和不含有他汀类药物的富脂坏死核(LRNC)斑块的生长。我们研究了不同药物浓度、不同时间间隔对LRNC斑块生长的影响。结果表明,不同时间点的用药对治疗效果有显著影响。与短期、低剂量治疗相比,早期他汀类药物高剂量治疗在降低低密度脂蛋白胆固醇、减少坏死核心体积、改变斑块特征、提高斑块稳定性方面表现出更显著的效果。该模型通过与临床数据的比较进行了验证,可用于预测LRNC斑块的进展和他汀类药物治疗的效果。
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引用次数: 1
Threshold Behavior of an Age-structured Tumor Immune Model 年龄结构肿瘤免疫模型的阈值行为
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-30 DOI: 10.1051/mmnp/2023001
Zhong Luo, Zijian Liu, Yuanshun Tan, Jin Yang, Huanhuan Qiu
In this paper, we present and analyze an age-structured tumor immune model. Based on the fact that tumor cells of different ages tend to exhibit different physiological behaviors, we consider the age structure of tumor cells, age-based proliferation function and age-dependent death function in the model. The threshold $mathfrak{R}_{0}$ for the existence of tumor-free steady state is derived. It is found that if $mathfrak{R}_{0}<1$, the tumor-free steady state is not only locally stable but also globally stable. Moreover, numerical simulation shows that the threshold $mathfrak{R}_{0}$ may be regarded as an index to reflect the ability of ``tumor immune surveillance", ie, the smaller the $mathfrak{R}_{0}$, the better the ability of tumor immune surveillance. If $mathfrak{R}_{0}>1$, it is proved that the tumor steady state is existent  and uniformly persistent. The local stability of the tumor steady state is investigated under some further conditions besides $mathfrak{R}_{0}>1$. In the end, we estimate the system parameters, verify the theoretical results and analyze some system  parameters' sensitivities.
在本文中,我们提出并分析了一个年龄结构的肿瘤免疫模型。基于不同年龄的肿瘤细胞往往表现出不同的生理行为,我们在模型中考虑了肿瘤细胞的年龄结构、年龄基础的增殖功能和年龄依赖的死亡功能。导出了无肿瘤稳态存在的阈值$mathfrak{R}_{0}$。发现,如果$mathfrak{R}_{0}1$,则证明了肿瘤稳态是存在且一致持久的。在$mathfrak{R}_{0}>1$以外的其他条件下,研究了肿瘤稳态的局部稳定性。最后对系统参数进行了估计,验证了理论结果,并对部分系统参数的灵敏度进行了分析。
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引用次数: 0
The effect of connecting sites in the environment of a harvested population 收获种群环境中连接位点的影响
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-23 DOI: 10.1051/mmnp/2023004
R. Bravo de la Parra, J. Poggiale, P. Auger
This work presents a model of a harvested population in a multisite environment. Locally it has the shape of the Gordon-Schaefer model. This model gives rise, placing us in the case of a fishery, to an equilibrium of the stock and the fishing effort and, therefore, of the yield that is obtained per unit of time. Considering that the management of the fishery can act on the fishing costs, the yield is optimized as a function of the cost.The objective of the work is to compare the maximum obtained yield in two extreme cases: unconnected sites and connected sites with rapid movements of both the stock and the fishing effort. The analysis of the model, first in an environment with two sites and later with any number of them, makes it possible to establish the conditions for one of the two cases to be more favorable from the point of view of the yield. In this way, it is proposed towards which of the two compared cases management should be directed.
这项工作提出了一个多站点环境中收获种群的模型。在局部上,它具有Gordon-Scheefer模型的形状。在渔业的情况下,这个模型使种群和捕捞努力达到平衡,从而使单位时间的产量达到平衡。考虑到渔业管理可以影响捕捞成本,产量作为成本的函数进行了优化。这项工作的目的是比较两种极端情况下获得的最大产量:未连接的地点和种群和捕鱼努力快速移动的连接地点。该模型的分析,首先是在有两个位点的环境中,然后是在有任意数量位点的环境下,可以从产量的角度建立两种情况中的一种更有利的条件。通过这种方式,提出了两个比较案例的管理应指向哪一个。
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引用次数: 0
FORECAST ANALYSIS AND SLIDING MODE CONTROL ON A STOCHASTICEPIDEMIC MODEL WITH ALERTNESS AND VACCINATION 具有警戒性和疫苗接种的随机流行病模型的预测分析与滑模控制
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-18 DOI: 10.1051/mmnp/2023003
Yue Zhang, Xiju Wu
In this paper, a stochastic SEIR epidemic model is studied with alertness and vaccination. The goal is to stabilize the infectious disease system quickly. The dynamic behavior of the model is analyzed and an integral sliding mode controller with distributed compensation is designed. By using Lyapunov function method, the sufficient conditions for the existence and uniqueness of global positive solutions and the existence of ergodic stationary distributions are obtained. The stochastic center manifold and stochastic average method are used to simplify the system into a one-dimensional Markov diffusion process. The stochastic stability and Hopf bifurcation are analyzed using singular boundary theory. An integral sliding mode controller with non-parallel distributed compensation is designed by linear matrix inequality (LMI) method, which realizes the stability of system and prevents the outbreak of epidemic disease. The correction of theoretical analysis and the effectiveness of controller are validated using numerical simulation performed in MATLAB/Simulink.
本文研究了一个具有警戒性和疫苗接种的随机SEIR流行病模型。目标是迅速稳定传染病系统。分析了模型的动态特性,设计了具有分布式补偿的积分滑模控制器。利用李雅普诺夫函数方法,得到了全局正解存在唯一性和遍历平稳分布存在的充分条件。利用随机中心流形和随机平均方法将系统简化为一维马尔可夫扩散过程。利用奇异边界理论分析了系统的随机稳定性和Hopf分岔。采用线性矩阵不等式(LMI)方法设计了一种具有非并行分布补偿的积分滑模控制器,实现了系统的稳定性,防止了流行病的爆发。在MATLAB/Simulink中进行数值仿真,验证了理论分析的正确性和控制器的有效性。
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引用次数: 0
A phenotype-structured model for the tumour-immune response 肿瘤免疫反应的表型结构模型
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-13 DOI: 10.1051/mmnp/2023025
Zineb Kaid, Camille Pouchol, Jean Clairambault Ljll, Mamba
This paper presents a mathematical model for tumour-immune response interactions in the perspective of immunotherapy by immune checkpoint inhibitors ICIs). The model is of the nonlocal integro-differential Lotka-Volterra type, in which heterogeneity of the cell populations is taken into account by structuring variables that are continuous internal traits (aka phenotypes) present in each individual cell. These represent a lumped ``aggressiveness'', i.e., for tumour cells, malignancy understood as the ability to thrive in a viable state under attack by immune cells or drugs - which we propose to identify as a potential of de-differentiation -, and for immune cells, ability to kill tumour cells, in other words anti-tumour efficacy. We analyse the asymptotic behaviour of the model in the absence of treatment. By means of two theorems, we characterise the limits of the integro-differential system under an a priori convergence hypothesis. We illustrate our results with a few numerical simulations, which show that our model reproduces the three Es of immunoediting: elimination, equilibrium, and escape. Finally, we exemplify the possible impact of ICIs on these three Es.
本文从免疫检查点抑制剂免疫治疗的角度提出了肿瘤-免疫反应相互作用的数学模型。该模型是非局部积分-微分Lotka-Volterra型,其中细胞群体的异质性通过结构变量来考虑,这些变量是每个细胞中存在的连续内部特征(又名表型)。这些代表了一种集中的“侵略性”,即,对于肿瘤细胞来说,恶性被理解为在免疫细胞或药物攻击下以存活状态茁壮成长的能力——我们建议将其确定为去分化的潜力——对于免疫细胞来说,杀死肿瘤细胞的能力,换句话说,抗肿瘤功效。我们分析了在没有处理的情况下模型的渐近行为。在先验收敛假设下,利用两个定理刻画了积分-微分系统的极限。我们用一些数值模拟来说明我们的结果,这表明我们的模型再现了免疫编辑的三个e:消除、平衡和逃逸。最后,我们举例说明了ici对这三个e可能产生的影响。
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引用次数: 1
Decay in full von Kármán beam with temperature and microtemperatures effects 具有温度和微温度效应的全von Kármán光束的衰变
IF 2.2 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-11 DOI: 10.1051/mmnp/2023002
M. Aouadi, Souad Guerine
In this article we derive the equations that constitute the mathematical model of the full vonK'{a}rm'{a}n beam with  temperature and microtemperatures effects. The nonlinear governing equations are derived by using Hamilton principle in the framework of Euler–Bernoulli beam theory.   Under quite general assumptions on nonlinear damping function acting on the transversal component and based on nonlinear semigroups and the theoryof monotone operators, we establish existence and uniqueness of weak and strong solutions to the derivedproblem.  Then using the  multiplier method, we show that solutions decay exponentially.Finally we consider the case  of zero thermal conductivity and we show that the dissipation given only by the microtemperatures is strong enough to produce  exponential stability.
本文推导了具有温度和微温度效应的全vonK'{a} m'{a}n光束的数学模型。在欧拉-伯努利梁理论的框架下,利用Hamilton原理推导了非线性控制方程。在非线性阻尼函数作用于横向分量的相当一般的假设下,基于非线性半群和单调算子理论,我们建立了所导出问题的弱解和强解的存在唯一性。然后利用乘数法,我们证明了解呈指数衰减。最后,我们考虑了导热系数为零的情况,并证明了仅由微温度给出的耗散足以产生指数稳定性。
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引用次数: 2
Mathematical modelling and optimal control of production losses caused by Miridae Miridae生产损失的数学建模及优化控制
4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Pub Date : 2023-01-01 DOI: 10.1051/mmnp/2023030
M. S. Djoukwe Tapi, Samuel Bowong TSAKOU, A. Nana Yakam, R. Tagne Wafo
Cocoa mirid, Sahlbergella singulars , is the major pest of cocoa ( Theobroma cacao ) responsible of several damage in plots in West Africa and particularly in Cameroon. Occasional damage accounts for 30 40% of pod losses. However, when miridae affect the foliage, gradual wilting occurs and eventually, tree death. A few studies have focused on describing the time evolution of Miridae in the plot in Cameroon, yet numerous questions remain. The aim of this paper is to estimate and control the losses of production caused by the bites of miridea. To do this, we will formulate and study a mathematical model for the dynamics of pods that takes into account the feeding and egg-laying of adults miridae on pods. We present the theoretical analysis of the model. More precisely, we compute equilibria and derive a threshold parameter that determines the presence or not of miridae in the plot. Throughout numerical simulations, we found that miridae can cause approximately 39.21% of production losses (which represents approximatively USD 1276.8 revenue losses) when initially, one has 1200 plants in the plot. After, we aim to increase cocoa production through optimal control. Optimal control consists in reducing density the number of nymphs and adults miridae in the plot. We studied the controlled model and we found that losses with control shrink to 20.58% which corresponds to USD670.32 income revenue.
可可螟,即单一萨尔伯格菌,是可可(可可树)的主要害虫,在西非,特别是在喀麦隆造成了几起破坏。偶尔的伤害占豆荚损失的30 - 40%。然而,当mirridae影响树叶时,逐渐发生枯萎,最终导致树木死亡。一些研究集中于描述喀麦隆情节中Miridae的时间演变,但仍存在许多问题。本文的目的是为了估计和控制因蠓叮咬造成的生产损失。为了做到这一点,我们将制定和研究一个数学模型的豆荚动力学,考虑到成虫在豆荚上的摄食和产卵。对该模型进行了理论分析。更准确地说,我们计算平衡并推导出一个阈值参数,该参数决定了图中是否存在miridae。通过数值模拟,我们发现,当最初在地块中有1200个植物时,miridae可以造成大约39.21%的生产损失(相当于大约1276.8美元的收入损失)。之后,我们的目标是通过最优控制来提高可可产量。最优控制包括降低田中若虫和成虫的密度和数量。我们研究了控制模型,我们发现控制下的损失缩小到20.58%,对应于670.32美元的收入收入。
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引用次数: 0
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Mathematical Modelling of Natural Phenomena
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