Pub Date : 2023-05-26DOI: 10.21886/2219-8075-2023-14-2-44-51
I. Fatkullin, Y. V. Orlov, F. Fatkullin
The presented review summarizes current data on the tactics of accompanying patients with uterine myoma at various stages of their reproductive potential realization: the stage of pregravid preparation, the stage of pregnancy management, the moment of delivery and the postpartum period. Based on the analysis of domestic and foreign special scientific and practical literature, various methods of childbirth are proposed, from more preferable delivery through the natural birth canal, to the necessary caesarean section, performed strictly according to indications. Data are presented on the options for elective and emergency myomectomy during pregnancy, during operative delivery and in the postpartum period. Based on the results of systematization of the information received, the authors raise the question of the need for further research in the field of developing methods for optimal management of patients during pregnancy and childbirth complicated by uterine myoma, due to the relevance of the problems discussed.
{"title":"Modern approaches to the management of pregnancy in uterine myoma","authors":"I. Fatkullin, Y. V. Orlov, F. Fatkullin","doi":"10.21886/2219-8075-2023-14-2-44-51","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-44-51","url":null,"abstract":" The presented review summarizes current data on the tactics of accompanying patients with uterine myoma at various stages of their reproductive potential realization: the stage of pregravid preparation, the stage of pregnancy management, the moment of delivery and the postpartum period. Based on the analysis of domestic and foreign special scientific and practical literature, various methods of childbirth are proposed, from more preferable delivery through the natural birth canal, to the necessary caesarean section, performed strictly according to indications. Data are presented on the options for elective and emergency myomectomy during pregnancy, during operative delivery and in the postpartum period. Based on the results of systematization of the information received, the authors raise the question of the need for further research in the field of developing methods for optimal management of patients during pregnancy and childbirth complicated by uterine myoma, due to the relevance of the problems discussed.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85912145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-101-111
Y. Gorblyansky, E. R. Ramazanova, E. Kontorovich, O. Ponamareva
The article describes the current issues in occupational medicine and the ways to resolve them in the context of the spread of a new coronavirus infection COVID-19. The risks of COVID-19 infection in medical and non-medical workers are considered. Modern approaches to establishment of COVID-19 causal relationship with occupation and medical examinations in patients with COVID-19 are presented. The main provisions of the National concept of healthcare-associated infections relevant in the context of COVID-19 pandemic are presented. Problems in public health care related to restructuring of work of medical organizations in conditions of COVID-19 spread are shown. Attention is paid to mental health disorders in medical workers providing medical care to patients with COVID-19. The prospects of development and implementation of measures for prevention of COVID-19, its complications and adverse outcomes taking into account complex assessment of working environment and professional health of workers are considered from the position of occupational medicine.
{"title":"Challenges for occupational medicine during the pandemic of a new coronavirus infectious disease (COVID-19)","authors":"Y. Gorblyansky, E. R. Ramazanova, E. Kontorovich, O. Ponamareva","doi":"10.21886/2219-8075-2023-14-1-101-111","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-101-111","url":null,"abstract":"The article describes the current issues in occupational medicine and the ways to resolve them in the context of the spread of a new coronavirus infection COVID-19. The risks of COVID-19 infection in medical and non-medical workers are considered. Modern approaches to establishment of COVID-19 causal relationship with occupation and medical examinations in patients with COVID-19 are presented. The main provisions of the National concept of healthcare-associated infections relevant in the context of COVID-19 pandemic are presented. Problems in public health care related to restructuring of work of medical organizations in conditions of COVID-19 spread are shown. Attention is paid to mental health disorders in medical workers providing medical care to patients with COVID-19. The prospects of development and implementation of measures for prevention of COVID-19, its complications and adverse outcomes taking into account complex assessment of working environment and professional health of workers are considered from the position of occupational medicine.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73576525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-119-124
A. Lutsenko, L. Saroyants
Leprosy is a chronic infectious disease caused by M. leprae with a primary lesion of the skin and peripheral nervous system. Currently, clinicians using bacterioscopic studies of scarification and skin biopsy mainly diagnose leprosy. However, the development and application of new diagnostic criteria, especially those associated with damage to nerve fibers, remains an urgent task of modern leprology. This review considers the important role of neurotrophic factor (nerve growth factor, NGF) in the pathogenesis of nervous system damage in leprosy and establishes the relationship between NGF levels and forms of the disease. The review includes data from foreign and domestic articles; the search was carried out using the “Scopus”, “PubMed”, “Web of Science”, “elIBRARY” databases.
麻风病是一种由麻风分枝杆菌引起的慢性传染病，原发损害皮肤和周围神经系统。目前，临床医生主要使用细菌学检查和皮肤活检来诊断麻风病。然而，制定和应用新的诊断标准，特别是与神经纤维损伤有关的诊断标准，仍然是现代麻风学的一项紧迫任务。本文综述了神经营养因子(神经生长因子，NGF)在麻风病神经系统损伤发病机制中的重要作用，并建立了NGF水平与麻风病形式之间的关系。综述数据来自国内外文献;使用“Scopus”、“PubMed”、“Web of Science”、“elIBRARY”等数据库进行搜索。
{"title":"The role of nerve growth factor (NGF) in the pathogenesis of leprosy","authors":"A. Lutsenko, L. Saroyants","doi":"10.21886/2219-8075-2023-14-1-119-124","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-119-124","url":null,"abstract":"Leprosy is a chronic infectious disease caused by M. leprae with a primary lesion of the skin and peripheral nervous system. Currently, clinicians using bacterioscopic studies of scarification and skin biopsy mainly diagnose leprosy. However, the development and application of new diagnostic criteria, especially those associated with damage to nerve fibers, remains an urgent task of modern leprology. This review considers the important role of neurotrophic factor (nerve growth factor, NGF) in the pathogenesis of nervous system damage in leprosy and establishes the relationship between NGF levels and forms of the disease. The review includes data from foreign and domestic articles; the search was carried out using the “Scopus”, “PubMed”, “Web of Science”, “elIBRARY” databases.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77243525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-83-92
E. Kovalev, T. Tverdokhlebova, E. N. Simovanyan
Objective: the study of molecular epidemiological and clinical aspects of EVI in the Rostov region for the period 2006-2020. to improve the disease surveillance system. Research methods: epidemiological, virological, molecular biological (PCR, sequencing, phylogenetic analysis), microbiological, statistical. Materials and methods: the analysis of medical records of 139 patients with EVI was carried out. Samples of biomaterial (feces, throat swab) from 17293 people, samples from environmental objects (2710 samples), strains of enteroviruses (EV) in the amount of 142 specimens were studied. Results: in the Rostov region until 2013. sporadic incidence of EVI prevailed with registration from 1 to 38 cases per year. June 2013 there was a sharp increase in the incidence of EVI with the formation of local foci in organized groups, associated with the circulation of a new genotype — EV 71 type of subgenotype C4 of “Chinese” origin (622 patients with EVI were registered, one death). The clinical features of the disease were determined: acute onset with manifestations of intoxication, foot and mouth disease-like syndromes, followed by the development of CNS pathology in 37.4% of patients. According to the results of sequencing of biomaterial samples from patients and virus carriers for the period 2006-2020. EVs of 22 types were detected. Conclusions: EVs are subject to intense genetic variability, due to which new genovariants pathogenic for humans may appear. The change in EV genotypes, which dominated the circulation among the population of the Rostov region, determined the rise in the incidence of EVI in 2013. A significant diversity of non-polio EV genotypes was revealed, while the structure of EV genovariants changed in different years.
{"title":"Molecular epidemiological and clinical aspects of enterovirus infection in the south of Russia","authors":"E. Kovalev, T. Tverdokhlebova, E. N. Simovanyan","doi":"10.21886/2219-8075-2023-14-1-83-92","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-83-92","url":null,"abstract":"Objective: the study of molecular epidemiological and clinical aspects of EVI in the Rostov region for the period 2006-2020. to improve the disease surveillance system. Research methods: epidemiological, virological, molecular biological (PCR, sequencing, phylogenetic analysis), microbiological, statistical. Materials and methods: the analysis of medical records of 139 patients with EVI was carried out. Samples of biomaterial (feces, throat swab) from 17293 people, samples from environmental objects (2710 samples), strains of enteroviruses (EV) in the amount of 142 specimens were studied. Results: in the Rostov region until 2013. sporadic incidence of EVI prevailed with registration from 1 to 38 cases per year. June 2013 there was a sharp increase in the incidence of EVI with the formation of local foci in organized groups, associated with the circulation of a new genotype — EV 71 type of subgenotype C4 of “Chinese” origin (622 patients with EVI were registered, one death). The clinical features of the disease were determined: acute onset with manifestations of intoxication, foot and mouth disease-like syndromes, followed by the development of CNS pathology in 37.4% of patients. According to the results of sequencing of biomaterial samples from patients and virus carriers for the period 2006-2020. EVs of 22 types were detected. Conclusions: EVs are subject to intense genetic variability, due to which new genovariants pathogenic for humans may appear. The change in EV genotypes, which dominated the circulation among the population of the Rostov region, determined the rise in the incidence of EVI in 2013. A significant diversity of non-polio EV genotypes was revealed, while the structure of EV genovariants changed in different years.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"226 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75087391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-24-30
A. E. Shklyaev, D. Kazarin, O. A. Grigoreva
Objective: to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods: 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results: in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion: patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.
{"title":"Balneotherapy of epigastric pain syndrome: the meaning of motilin in the implementation of the therapeutic effect","authors":"A. E. Shklyaev, D. Kazarin, O. A. Grigoreva","doi":"10.21886/2219-8075-2023-14-1-24-30","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-24-30","url":null,"abstract":"Objective: to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods: 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results: in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion: patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"47 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83185734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-31-37
N. Volkova, A. Volkov
Very few works are devoted to the problem of medical semiotics, meanwhile, modern medical science, having received new research methods, expanding knowledge about diseases and the human body, continuously introduces new concepts, terms, indicators. Their integration into the general context of medical semiotics is an important problem. A significant difficulty is the large volume of symptoms, syndromes currently accumulated in medicine. This article is devoted to the transformation of empirical medical semiotics into analytical one. The authors, relying on the apparatus of theoretical semiotics, proposed a new classification of symptoms and the concept of the meaning of symptoms. These approaches make it possible to make all the array of medical symptoms available for use by a doctor and to diagnose diseases based on a logically consistent and modeling human thinking algorithm. The article outlines a further program for the improvement and development of medical semiotics.
{"title":"On some issues of medical semiotics","authors":"N. Volkova, A. Volkov","doi":"10.21886/2219-8075-2023-14-1-31-37","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-31-37","url":null,"abstract":"Very few works are devoted to the problem of medical semiotics, meanwhile, modern medical science, having received new research methods, expanding knowledge about diseases and the human body, continuously introduces new concepts, terms, indicators. Their integration into the general context of medical semiotics is an important problem. A significant difficulty is the large volume of symptoms, syndromes currently accumulated in medicine. This article is devoted to the transformation of empirical medical semiotics into analytical one. The authors, relying on the apparatus of theoretical semiotics, proposed a new classification of symptoms and the concept of the meaning of symptoms. These approaches make it possible to make all the array of medical symptoms available for use by a doctor and to diagnose diseases based on a logically consistent and modeling human thinking algorithm. The article outlines a further program for the improvement and development of medical semiotics.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72825857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-125-134
I. F. Shlyk, L. Sizyakina, I. Evsegneeva, S. Shlyk, D. Besedina, I. V. Makarchuk
Objective: to assess changes in the immune status before and after coronary bypass surgery. Materials and methods: included 70 male patients with coronary atherosclerosis (group 1) and 30 volunteers (group 2) without signs of coronary artery disease comparable in age to group 1. Immunity parameters were studied before surgery, after 4–5, 9–10 and 28–30 days by the method of phenotyping of CD3+ populations; CD3+CD4+; CD3+CD8+; CD3+CD25+; CD3+CD45+; CD3+CD95+; CD4+CD25+; CD4+CD154+; CD19+, CD19+CD40+. The levels of Ig A, M, G were assessed by the method of radial immunodiffusion in the gel. Serum precipitation in polyethylene glycol was used to determine circulating immune complexes. Statistical analysis of the study results was performed using the Statistica 12.0 program (StatSoft, USA). Statistical significance was considered significant at p<0.05. Results: in patients of the IHD group, uncoupling of the processes of T-lymphocyte activation, their maturation and apoptosis was noted; suppression of immunoregulation and activation of intercellular cooperation. After CABG, in dynamics, these processes reflect the multidirectional changes. Conclusions: in patients with coronary atherosclerosis, there is a discoordination of the processes of T-lymphocyte activation, their maturation and apoptosis. Suppression of immunoregulation and activation of intercellular cooperation. In the dynamics after CABG, immunity parameters differ in different directions in different periods of observation and demonstrate different degrees of involvement of adaptive mechanisms of immune defense.
{"title":"Adaptive immune response in patients with atherosclerosis before and after coronary bypass surgery","authors":"I. F. Shlyk, L. Sizyakina, I. Evsegneeva, S. Shlyk, D. Besedina, I. V. Makarchuk","doi":"10.21886/2219-8075-2023-14-1-125-134","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-125-134","url":null,"abstract":"Objective: to assess changes in the immune status before and after coronary bypass surgery. Materials and methods: included 70 male patients with coronary atherosclerosis (group 1) and 30 volunteers (group 2) without signs of coronary artery disease comparable in age to group 1. Immunity parameters were studied before surgery, after 4–5, 9–10 and 28–30 days by the method of phenotyping of CD3+ populations; CD3+CD4+; CD3+CD8+; CD3+CD25+; CD3+CD45+; CD3+CD95+; CD4+CD25+; CD4+CD154+; CD19+, CD19+CD40+. The levels of Ig A, M, G were assessed by the method of radial immunodiffusion in the gel. Serum precipitation in polyethylene glycol was used to determine circulating immune complexes. Statistical analysis of the study results was performed using the Statistica 12.0 program (StatSoft, USA). Statistical significance was considered significant at p<0.05. Results: in patients of the IHD group, uncoupling of the processes of T-lymphocyte activation, their maturation and apoptosis was noted; suppression of immunoregulation and activation of intercellular cooperation. After CABG, in dynamics, these processes reflect the multidirectional changes. Conclusions: in patients with coronary atherosclerosis, there is a discoordination of the processes of T-lymphocyte activation, their maturation and apoptosis. Suppression of immunoregulation and activation of intercellular cooperation. In the dynamics after CABG, immunity parameters differ in different directions in different periods of observation and demonstrate different degrees of involvement of adaptive mechanisms of immune defense.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79527970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-93-100
D. Nikitin, S. K. Udovichenko, E. Putintseva, N. Borodai, A. Toporkov
Objective: to assess the quality and effectiveness of West Nile fever (WNF) causative agent’s monitoring in the Volgograd region and to develop a set of measures to its optimization. Materials and methods: data on the detection of WNV cases, results of serological and zooentomological monitoring in 2009–2021. A comprehensive methodological approach was applied, including statistical and epidemiological methods. Results: based on the assessment of WNF causative agent’s monitoring key aspects in the Volgograd region, it was shown that one of the priority problems is the insufficient and untimely detection of cases among the population. Among the urgent problems of serological monitoring are the lack of a clearly established frequency of serological examination in the population of the region’s administrative territories and the termination of one of the indicator population groups examination, regulated by the current regulatory and methodological documents. An assessment of the parameters of monitoring studies of the external environment indicates an insufficient territorial coverage and a decrease in the volume of studies, primarily in relation to the main carriers of the West Nile virus, which determines the overall low detection rate of West Nile virus markers. Conclusion: recommendations are proposed for optimizing monitoring, which will enhance the efficiency of WNF epidemiological surveillance and develop a scientifically based forecast of the development of the epidemiological situation.
{"title":"Optimization of scientifico-practical aspects of West Nile fever causative agent’s monitoring (by the example of the Volgograd region)","authors":"D. Nikitin, S. K. Udovichenko, E. Putintseva, N. Borodai, A. Toporkov","doi":"10.21886/2219-8075-2023-14-1-93-100","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-93-100","url":null,"abstract":"Objective: to assess the quality and effectiveness of West Nile fever (WNF) causative agent’s monitoring in the Volgograd region and to develop a set of measures to its optimization. Materials and methods: data on the detection of WNV cases, results of serological and zooentomological monitoring in 2009–2021. A comprehensive methodological approach was applied, including statistical and epidemiological methods. Results: based on the assessment of WNF causative agent’s monitoring key aspects in the Volgograd region, it was shown that one of the priority problems is the insufficient and untimely detection of cases among the population. Among the urgent problems of serological monitoring are the lack of a clearly established frequency of serological examination in the population of the region’s administrative territories and the termination of one of the indicator population groups examination, regulated by the current regulatory and methodological documents. An assessment of the parameters of monitoring studies of the external environment indicates an insufficient territorial coverage and a decrease in the volume of studies, primarily in relation to the main carriers of the West Nile virus, which determines the overall low detection rate of West Nile virus markers. Conclusion: recommendations are proposed for optimizing monitoring, which will enhance the efficiency of WNF epidemiological surveillance and develop a scientifically based forecast of the development of the epidemiological situation.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73351325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-13-23
E. Darin, O. Zaitseva
The article presents a review of the literature on the subject of non-suicidal self-injurious behavior (NSSI), the study of which attracts the attention of authors, both in the Russian Federation and around the world. Large meta-analyses of NSSP studies, proposed models, probable causes and mechanisms of occurrence, neurobiological factors, social factors, as well as the influence of modern means of communication and social networks are considered. Objective is to study, summarize and present data on the causes and risk factors of non-suicidal self-injurious behavior. Research method — articles in the “MEDLINE/PubMed”, “Scopus” databases in international medical journals were selected and analyzed. Articles were searched by keywords: “Self-Injurious Behavior”, “Non-Suicidal Self Injury”, “Deliberate Self-Harm”, “Self-Harm”, “Risk Factors”. Inclusion criteria: publication date from 2017 to 2022, clinical studies, meta-analyses and systematic reviews, randomized controlled trials, availability of the full text in the public domain or abstract. Exclusion criteria: abstracts; monographs, study guides; publication date until 2017, inconsistency with the research topic. A total of 94 publications were found. The review included 61 publications from 2017 to 2022 that corresponded to the topic and purpose of the study, and also added 19 sources older than 2017 that are significant for disclosing the subject of the study from references in the reference lists of the analyzed sources.
{"title":"Etiology and risk factors for non-suicidal self-injurious behavior","authors":"E. Darin, O. Zaitseva","doi":"10.21886/2219-8075-2023-14-1-13-23","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-1-13-23","url":null,"abstract":"The article presents a review of the literature on the subject of non-suicidal self-injurious behavior (NSSI), the study of which attracts the attention of authors, both in the Russian Federation and around the world. Large meta-analyses of NSSP studies, proposed models, probable causes and mechanisms of occurrence, neurobiological factors, social factors, as well as the influence of modern means of communication and social networks are considered. Objective is to study, summarize and present data on the causes and risk factors of non-suicidal self-injurious behavior. Research method — articles in the “MEDLINE/PubMed”, “Scopus” databases in international medical journals were selected and analyzed. Articles were searched by keywords: “Self-Injurious Behavior”, “Non-Suicidal Self Injury”, “Deliberate Self-Harm”, “Self-Harm”, “Risk Factors”. Inclusion criteria: publication date from 2017 to 2022, clinical studies, meta-analyses and systematic reviews, randomized controlled trials, availability of the full text in the public domain or abstract. Exclusion criteria: abstracts; monographs, study guides; publication date until 2017, inconsistency with the research topic. A total of 94 publications were found. The review included 61 publications from 2017 to 2022 that corresponded to the topic and purpose of the study, and also added 19 sources older than 2017 that are significant for disclosing the subject of the study from references in the reference lists of the analyzed sources.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88071336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.21886/2219-8075-2023-14-1-56-65
S. B. Berezhanskaya, A. Afonin, N. N. Vostrikh, K. I. Lazareva, I. Loginova, L. Kravchenko, A. V. Medoyan, L. I. Monat
A clinical case of a familial form of peroxisomal D-bifunctional protein (DBP) deficiency (OMIM 261515) with an unfavorable (fatal) outcome caused by a mutation in type 4 17ß-hydroxysteroid dehydrogenase (HSD17B4) with a nucleotide replacement of chr5:118788316G>A in the homozygous state is presented. (D-bifunctional protein deficiency or 17-beta-hydroxysteroid dehydrogenase IV deficiency). Bifunctional protein deficiency is an autosomal recessive birth defect of peroxisomal fatty acid oxidation. The total incidence of morbidity is one case per 50,000 newborns. Most peroxisomal disorders manifest in the early neonatal period with an extremely severe course and phenotypic features, which facilitates their diagnosis. This is the difference between them and diseases with a milder and prolonged course, which debuted at different age periods, often had no neonatal or infantile symptoms and were accompanied, in some cases, by satisfactory cognitive functions. The purpose of the report was to highlight the clinical manifestations, variants of the course and complexity of the diagnosis of peroxisomal disorders to a wide range of doctors of different specialization: in the field of perinatology, pediatrics, neurology, genetics, endocrinology.
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