Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-67-75
T. Prokofyeva, O. Bashkina, O. S. Polunina, I. V. Sevostyanova, E. L. Gritsenko
Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes of myocardial infarction against the background of chronic obstructive pulmonary disease. Materials and methods: 325 patients with myocardial infarction were examined: 195 patients with infarction against the background of chronic obstructive pulmonary disease and 130 patients without chronic obstructive pulmonary disease. We studied markers of endogenous intoxication: molecules of average mass, hematological indexes of intoxication, blood gas composition, apoptosis, protein peroxidation, lipid and antioxidant protection, inflammation and renal function. Statistical processing of the data was performed using SPSS 26.0 software package. Results: A two-stage cluster analysis formed four clusters, which were labeled as «polymarker-retentive», «necrotic-inflammatory», «hypoxic-inflammatory», and a cluster with no endogenous intoxication syndrome. Among patients with myocardial infarction against the background of chronic obstructive pulmonary disease, the hypoxic-inflammatory phenotype prevailed — in 53.3 % of patients. Necrotic-inflammatory phenotype was noted in 8.2 % of patients, hypoxic-inflammatory — in 36.9% of patients, phenotype with the absence of endogenous intoxication syndrome — in 1.5 % of patients. Recurrent myocardial infarction, stroke and mortality constituted the combined endpoint. The highest incidence of the combined endpoint was observed in the polymarker-retentive infarct phenotype — in 37 (55.2 %) patients. Conclusion: Vascular life-threatening and fatal events (recurrent myocardial infarction, stroke, death from cardiac causes) during 12-month follow-up are most typical for the polymarker-retentive phenotype. The clinical features of this phenotype were the frequent presence of Q-shaped MI, transmural myocardial damage, and the presence of complications in the acute period. COPD in these patients was characterized by a long course, high smoker's index, mostly 3rd degree bronchoobstruction, and frequent exacerbations. The results of this study allow for a personalized approach to the assessment of the annual prognosis in patients with acute myocardial infarction against COPD.
{"title":"Clinical and biochemical phenotypes in cardiorespiratory comorbidity","authors":"T. Prokofyeva, O. Bashkina, O. S. Polunina, I. V. Sevostyanova, E. L. Gritsenko","doi":"10.21886/2219-8075-2023-14-2-67-75","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-67-75","url":null,"abstract":" Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes of myocardial infarction against the background of chronic obstructive pulmonary disease. Materials and methods: 325 patients with myocardial infarction were examined: 195 patients with infarction against the background of chronic obstructive pulmonary disease and 130 patients without chronic obstructive pulmonary disease. We studied markers of endogenous intoxication: molecules of average mass, hematological indexes of intoxication, blood gas composition, apoptosis, protein peroxidation, lipid and antioxidant protection, inflammation and renal function. Statistical processing of the data was performed using SPSS 26.0 software package. Results: A two-stage cluster analysis formed four clusters, which were labeled as «polymarker-retentive», «necrotic-inflammatory», «hypoxic-inflammatory», and a cluster with no endogenous intoxication syndrome. Among patients with myocardial infarction against the background of chronic obstructive pulmonary disease, the hypoxic-inflammatory phenotype prevailed — in 53.3 % of patients. Necrotic-inflammatory phenotype was noted in 8.2 % of patients, hypoxic-inflammatory — in 36.9% of patients, phenotype with the absence of endogenous intoxication syndrome — in 1.5 % of patients. Recurrent myocardial infarction, stroke and mortality constituted the combined endpoint. The highest incidence of the combined endpoint was observed in the polymarker-retentive infarct phenotype — in 37 (55.2 %) patients. Conclusion: Vascular life-threatening and fatal events (recurrent myocardial infarction, stroke, death from cardiac causes) during 12-month follow-up are most typical for the polymarker-retentive phenotype. The clinical features of this phenotype were the frequent presence of Q-shaped MI, transmural myocardial damage, and the presence of complications in the acute period. COPD in these patients was characterized by a long course, high smoker's index, mostly 3rd degree bronchoobstruction, and frequent exacerbations. The results of this study allow for a personalized approach to the assessment of the annual prognosis in patients with acute myocardial infarction against COPD.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73991187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-106-115
E. Kontorovich, Z. I. Berezina, Y. Gorblyansky, O. Ponamareva
The article presents an overview of foreign and domestic studies on the prevalence and structure of mental disorders in the world and among the working population, the problems of preserving the mental health of workers, the prevention of its violations. The role of psychosocial production factors in the development of stress and stress-induced mental health disorders of workers is shown. Examples of mental disorders in employees of various types of professional activity are given. The features of mental health disorders in medical workers during the pandemic of a new coronavirus infection are described. Modern integrated approaches to providing support to employees with mental illnesses in the workplace are considered. The issues of psychosocial risk management as an effective measure of primary prevention of mental disorders in employees are highlighted.
{"title":"Mental health disorders in workers","authors":"E. Kontorovich, Z. I. Berezina, Y. Gorblyansky, O. Ponamareva","doi":"10.21886/2219-8075-2023-14-2-106-115","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-106-115","url":null,"abstract":" The article presents an overview of foreign and domestic studies on the prevalence and structure of mental disorders in the world and among the working population, the problems of preserving the mental health of workers, the prevention of its violations. The role of psychosocial production factors in the development of stress and stress-induced mental health disorders of workers is shown. Examples of mental disorders in employees of various types of professional activity are given. The features of mental health disorders in medical workers during the pandemic of a new coronavirus infection are described. Modern integrated approaches to providing support to employees with mental illnesses in the workplace are considered. The issues of psychosocial risk management as an effective measure of primary prevention of mental disorders in employees are highlighted.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"9 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81035999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-76-83
E. Besedina, A. S. Badyan, S. G. Piskunova, E. V. Dudnikova, V. Kovalenko, A. M. Inkin
With the emergence of the SARS-CoV-2 virus in December 2019, all countries around the world have implemented various strategies to prevent its spread and intensively search for effective treatments. Initially, severe cases of the disease were considered only in adults, but later information appeared on the severe course of the disease in children and adolescents. This condition, which occurs as part of the transferred COVID-19, is called multisystem inflammatory syndrome (MIS) or Kawasaki-like syndrome. The available data indicate that MVS is the result of an innate and adaptive immune response characterized by a cytokine storm and a delayed immunological response to SARS-CoV-2. Epidemiological, clinical, and immunological differences classify MVS as a distinct syndrome from Kawasaki disease (БК), including age range, and geographic and ethnic distribution of patients. It should be noted that new data from patients with MVS point to unique characteristics of the immunological response, as well as clinical similarities with other inflammatory syndromes, which can serve as a guide in the search for molecular mechanisms involved in MVS. This review presents an analysis of studies on this topic: features of pathogenesis, diagnosis, treatment methods, as well as further directions for studying the problem. The search for mechanisms for the development of MVS in children continues, and, in turn, medical alertness, timely diagnosis and treatment make it possible to achieve the best possible result for such patients.
{"title":"Multisystem inflammatory syndrome (MIS) or Kawasaki-like syndrome associated with COVID-19","authors":"E. Besedina, A. S. Badyan, S. G. Piskunova, E. V. Dudnikova, V. Kovalenko, A. M. Inkin","doi":"10.21886/2219-8075-2023-14-2-76-83","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-76-83","url":null,"abstract":" With the emergence of the SARS-CoV-2 virus in December 2019, all countries around the world have implemented various strategies to prevent its spread and intensively search for effective treatments. Initially, severe cases of the disease were considered only in adults, but later information appeared on the severe course of the disease in children and adolescents. This condition, which occurs as part of the transferred COVID-19, is called multisystem inflammatory syndrome (MIS) or Kawasaki-like syndrome. The available data indicate that MVS is the result of an innate and adaptive immune response characterized by a cytokine storm and a delayed immunological response to SARS-CoV-2. Epidemiological, clinical, and immunological differences classify MVS as a distinct syndrome from Kawasaki disease (БК), including age range, and geographic and ethnic distribution of patients. It should be noted that new data from patients with MVS point to unique characteristics of the immunological response, as well as clinical similarities with other inflammatory syndromes, which can serve as a guide in the search for molecular mechanisms involved in MVS. This review presents an analysis of studies on this topic: features of pathogenesis, diagnosis, treatment methods, as well as further directions for studying the problem. The search for mechanisms for the development of MVS in children continues, and, in turn, medical alertness, timely diagnosis and treatment make it possible to achieve the best possible result for such patients.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82702744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-36-43
E. I. Kravtsova, I. N. Lukoshkina, L. B. Miroshnichenko, Y. V. Nicogda, I. I. Kravtsov
Objective: to identify the presence of chronic endometritis in patients with adenomyosis and its cumulative role in the formation of reproductive losses. Materials and methods: 101 women of reproductive age with grade II adenomyosis and habitual miscarriage were examined. The comparison group (group 2) consisted of 49 patients with grade II adenomyosis without a history of early reproductive losses. The control group (group 3) consisted of 50 healthy patients. In order to diagnose chronic endometritis, a comprehensive immunohistochemical study of the expression of specific immunological markers of chronic endometritis (natural killer CD56, B cells (CD20), plasma cells (CD138) and activated lymphocytes (HLA-DR) with antibodies and the determination of CD68 macrophages was carried out. Polymerase chain reaction in the “real-time” mode (PCR) was used to determine the types and amount of endometrial microbiota. Statistical data processing was carried out in the environment of the STATISTICA package. Results: despite the absence of pathogenic and conditionally pathogenic microflora, according to the results of microbiological examination from the vagina and cervical canal of all examined patients, statistically significant differences in the detection frequencies of various microbiota taxa of crops from the uterine cavity were obtained. Patients with reproductive losses on the background of adenomyosis had microbiological and immunohistochemical signs of chronic endometritis of moderate and mild severity. The presence of chronic endometritis combined with adenomyosis contributes to the occurrence of pronounced endothelial dysfunctions, eventually leading to a violation of reproductive function in patients with a combination of HE and adenomyosis. Conclusion: The similar symptoms of adenomyosis and CE, a reliable association of adenomyosis with CE in patients with habitual miscarriage requires the inclusion of immunohistochemical and microbiological examination of the endometrium in the volume of pre-gravidar examination, even if there are negative results of microbiological examination of the environment of the cervical canal.
{"title":"The role of chronic endometritis in the aspect of habitual miscarriage in patients with adenomyosis","authors":"E. I. Kravtsova, I. N. Lukoshkina, L. B. Miroshnichenko, Y. V. Nicogda, I. I. Kravtsov","doi":"10.21886/2219-8075-2023-14-2-36-43","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-36-43","url":null,"abstract":" Objective: to identify the presence of chronic endometritis in patients with adenomyosis and its cumulative role in the formation of reproductive losses. Materials and methods: 101 women of reproductive age with grade II adenomyosis and habitual miscarriage were examined. The comparison group (group 2) consisted of 49 patients with grade II adenomyosis without a history of early reproductive losses. The control group (group 3) consisted of 50 healthy patients. In order to diagnose chronic endometritis, a comprehensive immunohistochemical study of the expression of specific immunological markers of chronic endometritis (natural killer CD56, B cells (CD20), plasma cells (CD138) and activated lymphocytes (HLA-DR) with antibodies and the determination of CD68 macrophages was carried out. Polymerase chain reaction in the “real-time” mode (PCR) was used to determine the types and amount of endometrial microbiota. Statistical data processing was carried out in the environment of the STATISTICA package. Results: despite the absence of pathogenic and conditionally pathogenic microflora, according to the results of microbiological examination from the vagina and cervical canal of all examined patients, statistically significant differences in the detection frequencies of various microbiota taxa of crops from the uterine cavity were obtained. Patients with reproductive losses on the background of adenomyosis had microbiological and immunohistochemical signs of chronic endometritis of moderate and mild severity. The presence of chronic endometritis combined with adenomyosis contributes to the occurrence of pronounced endothelial dysfunctions, eventually leading to a violation of reproductive function in patients with a combination of HE and adenomyosis. Conclusion: The similar symptoms of adenomyosis and CE, a reliable association of adenomyosis with CE in patients with habitual miscarriage requires the inclusion of immunohistochemical and microbiological examination of the endometrium in the volume of pre-gravidar examination, even if there are negative results of microbiological examination of the environment of the cervical canal.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"105 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91547759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-52-55
O. A. Bobyk
Objective: to assess the impact of various wartime stresses on the condition of patients with mental illnesses, followed by the development of preventive measures. Materials and methods: a questionnaire and a survey of 510 patients with mental and behavioral disorders were conducted on voluntary terms. Then the subjects were divided into 2 groups: 1 group — those who were in the zone of direct combat operations; 2 group — those who were in safer zones. The calculation of the proportion of persons depending on the appropriate answers to questions, a comparison of the levels of anxiety and anxiety in connection with the military situation in patients of groups 1 and 2, as well as an analysis of the corresponding 510 outpatient charts studied in order to assess the impact of wartime stress on the nature of the course of mental illness. Results: the negative impact of wartime stress on the course of mental disorders was established in the form of a worsening of the clinical picture of diseases, an increase in the number of exacerbations and resistance to therapy. Conclusion: according to the results of the study, preventive measures are recommended.
{"title":"The problem of the influence of wartime stress on the condition of patients with mental and behavioral disorders","authors":"O. A. Bobyk","doi":"10.21886/2219-8075-2023-14-2-52-55","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-52-55","url":null,"abstract":" Objective: to assess the impact of various wartime stresses on the condition of patients with mental illnesses, followed by the development of preventive measures. Materials and methods: a questionnaire and a survey of 510 patients with mental and behavioral disorders were conducted on voluntary terms. Then the subjects were divided into 2 groups: 1 group — those who were in the zone of direct combat operations; 2 group — those who were in safer zones. The calculation of the proportion of persons depending on the appropriate answers to questions, a comparison of the levels of anxiety and anxiety in connection with the military situation in patients of groups 1 and 2, as well as an analysis of the corresponding 510 outpatient charts studied in order to assess the impact of wartime stress on the nature of the course of mental illness. Results: the negative impact of wartime stress on the course of mental disorders was established in the form of a worsening of the clinical picture of diseases, an increase in the number of exacerbations and resistance to therapy. Conclusion: according to the results of the study, preventive measures are recommended.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84282795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-116-120
L. Sizyakina, I. Andreeva, M. Kharitonova
Objective: B-2 lymphocytes characteristic of patients with CVID in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2. Materials and methods: 10 people with CVID diagnosis were included in the study among a cohort of patients with primary immunodeficiency under the supervision of the Research Institute and the Department of Clinical Immunology and allergology of Rostov State Medical University. For the immunoprophylaxis of COVID-19, a recombinant peptide vaccine was used, which was administered intramuscularly at a dose of 0.5 ml twice with an interval of 21 days. The parameters of the immune system were evaluated before vaccination, then 21 days after the first and second doses and 72 days after the first injection. Phenotypic characteristic of peripheral blood B cells was performed by cytofluoriometry flow method. Results: before vaccination, the number of memory B cells with a phenotypic option of switched and unswitched to antibody synthesis at the patients with CVID was lower than the control parameters of practically healthy donors. 21 days after the administration of the first dose, an increase in un-switched and switched memory B cells, plasma blasts, and a decrease in the proportion of B-regulatory lymphocytes were noted in relation to the initial values. 21 days after the second injection, an increase in the total pool of B-2 lymphocytes, naive B cells, switched memory B cells, plasma blasts were revealed. A month later, this tendency continued. Conclusion: in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2 in patients with CVID, a transformation of the subpopulation composition of B lymphocytes was revealed, as well as in the form of an increase in the number of memory B2 lymphocytes.
{"title":"Features of the functioning of B-2 lymphocytes in patients with common variable immune deficiency in post-vaccination immunity to SARS-CoV-2","authors":"L. Sizyakina, I. Andreeva, M. Kharitonova","doi":"10.21886/2219-8075-2023-14-2-116-120","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-116-120","url":null,"abstract":" Objective: B-2 lymphocytes characteristic of patients with CVID in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2. Materials and methods: 10 people with CVID diagnosis were included in the study among a cohort of patients with primary immunodeficiency under the supervision of the Research Institute and the Department of Clinical Immunology and allergology of Rostov State Medical University. For the immunoprophylaxis of COVID-19, a recombinant peptide vaccine was used, which was administered intramuscularly at a dose of 0.5 ml twice with an interval of 21 days. The parameters of the immune system were evaluated before vaccination, then 21 days after the first and second doses and 72 days after the first injection. Phenotypic characteristic of peripheral blood B cells was performed by cytofluoriometry flow method. Results: before vaccination, the number of memory B cells with a phenotypic option of switched and unswitched to antibody synthesis at the patients with CVID was lower than the control parameters of practically healthy donors. 21 days after the administration of the first dose, an increase in un-switched and switched memory B cells, plasma blasts, and a decrease in the proportion of B-regulatory lymphocytes were noted in relation to the initial values. 21 days after the second injection, an increase in the total pool of B-2 lymphocytes, naive B cells, switched memory B cells, plasma blasts were revealed. A month later, this tendency continued. Conclusion: in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2 in patients with CVID, a transformation of the subpopulation composition of B lymphocytes was revealed, as well as in the form of an increase in the number of memory B2 lymphocytes.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72764168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-26-35
T. L. Botasheva, O. I. Deriglazova, E. Lebedenko, E. Zheleznyakova, O. Zavodnov, V. Y. Zheltetskaya, A. A. Ulkina
Objective: to identify the diabetogenic type of the lateral behavioral profile of asymmetries, which reveals the highest incidence of GDM and obstetric complications in overweight pregnant women and, on its basis, to study the features of the somnological status in women with diabetogenic lateral constitution at the preconception period. Materials and methods: the study used special testing (Annette test, sleep quality questionnaire, sleep apnea/hypopnea syndrome questionnaire, sleepiness scale (Epworth)), polysomnographic study. Results: based on the results of a questionnaire survey and a polysomnographic study, somnological disorders were identified, expressed in a decrease in the efficiency and quality of sleep, fatigue, perceptible drowsiness in wakefulness, breathing disorders during sleep and other sleep disorders, which contributes to an increased risk of gestational diabetes mellitus mainly in women with an ambidextral lateral phenotype. Conclusion: the identified sleep disorders in overweight women in the pregravid period are, on the one hand, the result of hormonal changes against the background of already existing metabolic and vegetative abnormalities in overweight women planning pregnancy, on the other hand, they act as a “trigger” functional disorders both during the manifestation of GDM and during the formation of obstetric complications due to increasing hypoxemia in the maternal body against the background of the “obstructive sleep apnea” syndrome, which contributes to the development of fetal distress.
{"title":"The role of morphofunctional complexes and somnological signs of the pathogenesis of gestational diabetes mellitus in overweight women","authors":"T. L. Botasheva, O. I. Deriglazova, E. Lebedenko, E. Zheleznyakova, O. Zavodnov, V. Y. Zheltetskaya, A. A. Ulkina","doi":"10.21886/2219-8075-2023-14-2-26-35","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-26-35","url":null,"abstract":" Objective: to identify the diabetogenic type of the lateral behavioral profile of asymmetries, which reveals the highest incidence of GDM and obstetric complications in overweight pregnant women and, on its basis, to study the features of the somnological status in women with diabetogenic lateral constitution at the preconception period. Materials and methods: the study used special testing (Annette test, sleep quality questionnaire, sleep apnea/hypopnea syndrome questionnaire, sleepiness scale (Epworth)), polysomnographic study. Results: based on the results of a questionnaire survey and a polysomnographic study, somnological disorders were identified, expressed in a decrease in the efficiency and quality of sleep, fatigue, perceptible drowsiness in wakefulness, breathing disorders during sleep and other sleep disorders, which contributes to an increased risk of gestational diabetes mellitus mainly in women with an ambidextral lateral phenotype. Conclusion: the identified sleep disorders in overweight women in the pregravid period are, on the one hand, the result of hormonal changes against the background of already existing metabolic and vegetative abnormalities in overweight women planning pregnancy, on the other hand, they act as a “trigger” functional disorders both during the manifestation of GDM and during the formation of obstetric complications due to increasing hypoxemia in the maternal body against the background of the “obstructive sleep apnea” syndrome, which contributes to the development of fetal distress.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87442716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-56-60
I. I. Samrkhanova, R. F. Kadyrov, I. S. Efremov, A. E. Abdrakhmanova, A. Asadullin
Objective: to compare the severity of the relationship between mental state and insomnia of medical students working and not working as nurses. Materials and methods: research methods — sociological, psychometric, statistical. The study was conducted at the Bashkir State Medical University (BSMU) from February to April 2022. Data collection was carried out using Google Forms. Study group №1 — 172 students working as nurses. The proportion of males is 41 % (70/172), females — 59 % (102/172). The average age was 21-23 years. Study group № 1 — 66 non-working students. Among the studied 16.7 % (11/66) men, 83.3 % (55/66) women. The average age is 21-23 years. SCL-90-R (Symptom Check List-90-Revised), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI) were used as methods. Statistical processing was carried out using Microsoft Excel, STATISTICA 10, Spearman correlation coefficient, U — Mann-whitney test. Results: the degree of manifestation of insomnia in the study group № 1 and № 2 positively correlates with both all SCL-90-R scales and second-order indices. when comparing the studied groups, it was found that the mental state of non-working students is more unstable, the quality of sleep is worse. Conclusions: the relationship between the mental state and insomniac disorders in medical students, both working as nurses and not working, has been established. we assume that students who do not work as nurses have low adaptive abilities, as a result of which their mental state is accompanied by more pronounced insomniac disorders.
{"title":"Comparative assessment of the relationship between mental health and insomnia of medical students, working and non-working as nurses","authors":"I. I. Samrkhanova, R. F. Kadyrov, I. S. Efremov, A. E. Abdrakhmanova, A. Asadullin","doi":"10.21886/2219-8075-2023-14-2-56-60","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-56-60","url":null,"abstract":" Objective: to compare the severity of the relationship between mental state and insomnia of medical students working and not working as nurses. Materials and methods: research methods — sociological, psychometric, statistical. The study was conducted at the Bashkir State Medical University (BSMU) from February to April 2022. Data collection was carried out using Google Forms. Study group №1 — 172 students working as nurses. The proportion of males is 41 % (70/172), females — 59 % (102/172). The average age was 21-23 years. Study group № 1 — 66 non-working students. Among the studied 16.7 % (11/66) men, 83.3 % (55/66) women. The average age is 21-23 years. SCL-90-R (Symptom Check List-90-Revised), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI) were used as methods. Statistical processing was carried out using Microsoft Excel, STATISTICA 10, Spearman correlation coefficient, U — Mann-whitney test. Results: the degree of manifestation of insomnia in the study group № 1 and № 2 positively correlates with both all SCL-90-R scales and second-order indices. when comparing the studied groups, it was found that the mental state of non-working students is more unstable, the quality of sleep is worse. Conclusions: the relationship between the mental state and insomniac disorders in medical students, both working as nurses and not working, has been established. we assume that students who do not work as nurses have low adaptive abilities, as a result of which their mental state is accompanied by more pronounced insomniac disorders.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75495680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-61-66
A. O. Tolokonin
Currently, there is a significant prevalence of psychosomatic disorders: from 15 to 50% in the general population, 21-33 % in outpatient and 28-53% in inpatient somatic institutions. However, taking into account the variety of clinical manifestations of psychosomatic disorders and patients' seeking help not only from psychiatrists, but also from doctors of other specialties and representatives of nontraditional medicine, in reality these indicators are significantly higher. Untimely detection of the psychosomatic factor in the development of somatic disease often leads to the appointment of unreasonable and expensive treatment, including invasive interventions. The main cause of psychosomatic disorders is stress, prolonged exposure to which on the body leads to functional changes in the organs and their gradual destruction. Due to the high relevance of the problem of verification of psychosomatic disorders, the aim of this study was to develop an integrated approach to the diagnosis of psychosomatic diseases based on the analysis of existing concepts and notions; to achieve this goal, a literature review was conducted using Scopus, PubMed, Cochrane Library and CyberLeninka electronic libraries using keywords "psychosomatic disorder", "psychosomatics", "psychosomatic medicine". The concept of psychosomatic scenario of the disease (certificate of deposit No. 2207787) is suggested, based on combining the knowledge of classical western, Eastern medicine and psychotherapy, which allows the doctor to analyze, realize the psychosomatic scenario of the disease and see, what psychoemotional conflicts of the person himself and/or inherited from parents and ancestors, as well as distorted ideas about his present and future, was launched by the mechanism of adaptation to these distortions in the physical body in the form of a disease.
{"title":"Models of pathogenesis of psychosomatic disorders and the concept of psychosomatic scenario","authors":"A. O. Tolokonin","doi":"10.21886/2219-8075-2023-14-2-61-66","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-61-66","url":null,"abstract":" Currently, there is a significant prevalence of psychosomatic disorders: from 15 to 50% in the general population, 21-33 % in outpatient and 28-53% in inpatient somatic institutions. However, taking into account the variety of clinical manifestations of psychosomatic disorders and patients' seeking help not only from psychiatrists, but also from doctors of other specialties and representatives of nontraditional medicine, in reality these indicators are significantly higher. Untimely detection of the psychosomatic factor in the development of somatic disease often leads to the appointment of unreasonable and expensive treatment, including invasive interventions. The main cause of psychosomatic disorders is stress, prolonged exposure to which on the body leads to functional changes in the organs and their gradual destruction. Due to the high relevance of the problem of verification of psychosomatic disorders, the aim of this study was to develop an integrated approach to the diagnosis of psychosomatic diseases based on the analysis of existing concepts and notions; to achieve this goal, a literature review was conducted using Scopus, PubMed, Cochrane Library and CyberLeninka electronic libraries using keywords \"psychosomatic disorder\", \"psychosomatics\", \"psychosomatic medicine\". The concept of psychosomatic scenario of the disease (certificate of deposit No. 2207787) is suggested, based on combining the knowledge of classical western, Eastern medicine and psychotherapy, which allows the doctor to analyze, realize the psychosomatic scenario of the disease and see, what psychoemotional conflicts of the person himself and/or inherited from parents and ancestors, as well as distorted ideas about his present and future, was launched by the mechanism of adaptation to these distortions in the physical body in the form of a disease.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78575027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.21886/2219-8075-2023-14-2-90-96
M. M. Alimurzaeva, S. M. Izudinova, A. Dzhafarova, R. Khalilov
Objective: to study the effects of a new coronovirus infection on a number of standard biochemical blood parameters in patients of different ages. Materials and methods: 514 patients of 3 age groups (group 1st — 25–35 years old, group 2nd — 36–50 years old and group 3rd — over 51 years old) with a diagnosis of community-acquired pneumonia caused by COVID-19 infection were studied. All biochemical parameters of the blood of patients were determined using an Indiko biochemical analyzer. Results: the study of nitrogen metabolism indicators showed that in patients of all age groups, the content of total protein and urea does not undergo significant changes, however, there is an increase in the concentration of creatinine and uric acid, which is most pronounced in patients of the group 3rd. The study of the activities of AST, ALT in the blood of patients showed a significant increase in all age categories, more significant in persons of the groups 2nd and 3rd. At the same time, the activity of α-amylase, the concentration of bilirubin increase with age, and the levels of iron decrease, reaching pathological values. The content of the inflammation marker — CRP shows the most pronounced dependence on the age of patients: in patients of the group 1st, it increases by 6.9 times, in the 2nd group — by 12.3 times, in patients over 51 years old — by 17.25 once. Conclusion: with an increase in the age of patients, the deviations of many biochemical parameters from the control levels corresponding to each group become more pronounced and reach values that deviate significantly from the reference.
{"title":"Age aspects of the effects of the new coronavirus infection (COVID 19) on certain biochemical blood parameters","authors":"M. M. Alimurzaeva, S. M. Izudinova, A. Dzhafarova, R. Khalilov","doi":"10.21886/2219-8075-2023-14-2-90-96","DOIUrl":"https://doi.org/10.21886/2219-8075-2023-14-2-90-96","url":null,"abstract":" Objective: to study the effects of a new coronovirus infection on a number of standard biochemical blood parameters in patients of different ages. Materials and methods: 514 patients of 3 age groups (group 1st — 25–35 years old, group 2nd — 36–50 years old and group 3rd — over 51 years old) with a diagnosis of community-acquired pneumonia caused by COVID-19 infection were studied. All biochemical parameters of the blood of patients were determined using an Indiko biochemical analyzer. Results: the study of nitrogen metabolism indicators showed that in patients of all age groups, the content of total protein and urea does not undergo significant changes, however, there is an increase in the concentration of creatinine and uric acid, which is most pronounced in patients of the group 3rd. The study of the activities of AST, ALT in the blood of patients showed a significant increase in all age categories, more significant in persons of the groups 2nd and 3rd. At the same time, the activity of α-amylase, the concentration of bilirubin increase with age, and the levels of iron decrease, reaching pathological values. The content of the inflammation marker — CRP shows the most pronounced dependence on the age of patients: in patients of the group 1st, it increases by 6.9 times, in the 2nd group — by 12.3 times, in patients over 51 years old — by 17.25 once. Conclusion: with an increase in the age of patients, the deviations of many biochemical parameters from the control levels corresponding to each group become more pronounced and reach values that deviate significantly from the reference.","PeriodicalId":18314,"journal":{"name":"Medical Herald of the South of Russia","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84482327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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