Materia Socio-Medica最新文献

Bckground: Aerobic vaginitis is an imbalance of the vaginal flora and the main characteristic is an abnormal vaginal flora that contains aerobic and intestinal pathogens with varying degrees of vaginal inflammation. The frequency of AV varies from 12% to 23.7% in symptomatic women who are not pregnant and 4 to 8% during pregnancy and has an increased risk for sexually transmitted diseases (STI). The causative agents of AV are: Enterococcus faecalis (E. faecalis), Esherichia coli, group B streptococcus and Staphylococcus aureus.

Objective: The aim of this review was to present the most important features of aerobic vaginitis regarding description of this frequent clinical problems within population in Bosnia and Herzegovina and also worlfwide.

Methods: Author analized aerobic vaginitis based on scientific literature by searching published papers in important indexed databases.

Results and discussion: The most frequently isolated AV pathogen is E. faecalis in about 31%. New works indicate the presence of the HPV 16 gene and genome in E. faecalis in the biopsied material of cervical cancer, as well as the ability that HPV 16 genes can be translated and transcribed in these bacteria, and that the HPV gene can form viral particles in these bacteria leads to certain connection that can be a risk factor in the progression of cervical lesions to cancer. A decrease in the number of lactobacilli in the vaginal secretion reduces the defense ability and changes the pH value of the vaginal environment, which favors the development of bacterial inflammation. AV positive for E. faecalis leads to a change in the pH value of the vaginal environment above 5, and the increased pH value of the vaginal environment in HPV positive women can be an association for cervical intraepithelial lesion (CIN). A dominant pathogen in AV such as E. faecalis can reduce the protective effect of lactobacilli by causing inflammation, as well as an increase in IL-6, IL-8 and TNF, increasing the risk of HPV 16 infection resulting in CIN and cervical cancer. In cervical cancer research, the presence of genes and genomes (except E1) of human papillomavirus (HPV) type 16 was found in bacteria such as: E. faecalis and Staphylococcus aureus from cervical cancer biopsies. Intensive treatment of AV could be a very important factor in preventing the onset of precancerous lesions and cervical cancer. The recommended treatment of AV includes a combination of therapy such as: antibacterial (antiseptic and antibiotic), hormonal, non-steroidal anti-inflammatory and/or probiotics, which can be prescribed in the form of local or systemic therapy.

Conclusion: There is no generally accepted clinical strategy for the treatment of AV caused by E. faecalis. Most authors suggest that therapy be based on microscopic or microbiological findings using a topical antibiotic for the infectious agent, a

Background: Acute gastroenteritis remains an extremely common problem among the general population. In Western countries, an average person will probably face one or two episodes of gastrointestinal infections every year.

Objective: The aim of this study was to compare the efficacy of nifuroxazide and probiotic preparation containing lactic acid bacteria in the treatment of acute diarrheal syndrome.

Methods: The study was prospective, comparative study. Patients who suffered from acute infective diarrhoea for ≤72 hours and had ≥3 unformed stools per day, with no administration of antibiotics during 10 days before enrolment were divided into two groups: nifuroxazide group and the lactic acid probiotic group. All patients received therapies four times a day for three days. Data was collected at the baseline visit (before the initiation of the treatment) and two follow-up examinations on the third and seventh day from the treatment start.

Results: The study included 61 patients, 36 in nifuroxazide group and 25 in probiotic group. Nifuroxazide group compared to probiotic group showed faster improvement of patients' condition with lower number of stools three and seven days after therapy start (p=0.001 and p<0.001 respectively) and faster stool consistency normalization. On the seventh day from therapy start medium mushy stool consistency was observed in the majority of patients in nifuroxazide group (n=31, 86%) and only in small number of patients in probiotic group (n=5, 20%). Patients were feeling better and there was a trend of reporting better therapy efficacy in nifuroxazide group. Subjective assessment of therapy tolerability was also better in nifuroxazide group. Compliance to therapy and recommended dietary regime was similar between groups and there were no significant differences between groups regarding age, gender, elevated body temperature, abdominal pain, cramps, nausea and vomiting.

Conclusion: Although probiotics are sometimes used in the treatment of acute diarrheal syndrome, nifuroxazide has better efficacy and greater patients' satisfaction. Nifuroxazide can be recommended as the first choice empirical treatment in adult patients with the acute diarrheal syndrome.

Background: The COVID-19 pandemic has generated significant symptoms of stress, anxiety, and depression among health care workers, which can negatively affect the health and well-being of individuals. Although the WHO stressed the importance of nurturing mental health in the context of the COVID-19 pandemic, a more significant response focused on this area was still lacking in most countries.

Objective: The aim of the study was to examine the differences in the levels of depression, anxiety, and stress in healthcare professionals in relation to exposure to contact with COVID-19 positive patients, as well as to examine the differences and correlation of sociodemographic characteristics of health workers in the experience of symptoms of depression, anxiety and stress.

Methods: The research included 266 respondents, and it used a socio-demographic questionnaire and the DASS-21 scale. Mann-Whitney U tests, Kruskal-Wallis test and Spearman correlation coefficient were used in data processing.

Results: The prevalence of high to extremely high symptoms of depression was reported in 45.49% of employees, anxiety 63.91% and stress 23.22%. Those who have been in continuous contact with COVID-19 positive patients, or 27.07%, report experiencing high or extremely high symptoms of depression, 36.60%, high to extremely high symptoms of anxiety, and 22.18% high to extremely high symptoms of stress.

Discussion: The degree of self-care and family care, education level, and work experience were found to be a statistically significant factor in experiencing symptoms of depression, anxiety, and stress. Workers who were more in contact with COVID19 patients reported a higher degree of symptom on the DASS-21 scale. Those employees with more work experience had previously encountered similar situations of uncertainty and pressure, had better developed defense mechanisms, and showed less pronounced symptoms. A higher level of education often implies a higher degree of involvement in active treatment around each patient, which results in more responsibility and pressure in a given situation.

Conclusion: High levels of stress, anxiety and depression in healthcare workers can lead to repercussions in their work with patients. Therefore, the mental health of health workers should be put in focus, as a very important part of the public health problem during the COVID19 pandemic.

Background: Vitamin D is involved in numerous reactions in the human body, as well as in the regulation of about 3% of the human genome. Research shows that insufficient concentration of vitamin D in the blood is found in 40-50% of the population. The total intake of vitamin D through food is very low, only 20% of the total daily needs. This paper shows importance of vitamin D supplementation in different periods of woman's life.

Objective: To estimate average plasma levels of vitamin D3 in all researched group and establish which group should be supplemented with vitamin D3.

Methods: The study included 182 women, divided in appropriate groups according to age, who came regularly for annual gynecological check-ups. Total concentration of 25 (OH) vitamin D in plasma was determined by a competitive immunochemical test.

Results: The average value of vitamin D3 plasma level in patients aged 18 to 45 was 24,409 ng/ml, in the patients aged 46 to 55 years was 27,519 ng/ml and in the patients aged 56 and over 31,960 ng/ml. The results obtained indicate a vitamin D shortage in the first two groups of patients and an adequate vitamin D3 levels in third group of patients. Vitamin D supplementation is required in patients aged 18 to 55 years.

Conclusion: Vitamin D shortage is present in two groups of patients. Because of complex role that this vitamin plays in numerous reactions in human body adequate supplementation is necessary.

Background: Human papillomaviruses (HPV) are one of the most prevalent causes of cervical, anal, and oral cancer, and it is believed that nearly all sexually active males and females have been infected with HPV at some point in their lives.

Objective: The purpose of this study is to highlight epidemiological characteristics of the age and genotypical incidence of HPV infection among females in Canton Sarajevo during a 10-year period.

Methods: This cross-sectional study was conducted in the period between January 2012 and December 2021 at the medical institutions "Zavod za Ginekologiju, Perinatologiju i Neplodnost "Mehmedbašić" among females who were admitted for a routine gynaecological exam in Canton Sarajevo in Bosnia and Herzegovina.

Results: In total, 1517 patients who reported typical sexarche at 18.35±1.92, having one 721 (47.5%) sexual partner, regular use of contraceptive methods 820 (54.5%) with male condom 513 (62.6%) being the dominant choice of contraception and having gynacological hereditary oncological positive history 141 (9.3%), were included in the study from which 653 (43.05%) patients had positive HPV test and 864 (56.95%) had negative HPV results. HPV positive patients, 386 (59.1%) were infected either with one type of virus only, while 267 (40.9%) patients were infected with multiple virus strains where we have identified 166 virus strain combinations. Analysis showed that the patients infected by only one virus strain were one of next specific HPV viruses: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68. HPV-16 was the predominately strain 16 (22.5%) identified among all the patients. Mean age of HPV positive patients was 33.38±7.85, ranging from 18 to 61 years.

Conclusion: This study highlights the significance of the most frequent HPV high-risk strains (HPV-16, -18, -31.-33,-45,-52, and -58) among the Bosnia and Herzegovina population as one of the most common cancer-causing strains worldwide.

The decision of the citation database to include or not include a journal is not subject to the control of another entity, or the professional public, and there are no internationally established ethical standards that the citation database would have to apply. As a consequence of the absence of control, the already mentioned offensive reviews and arbitrary interpretation of the criteria for journal inclusion appear. Given that a journal's entry into the citation database is a condition for its long-term survival, people who make decisions in the citation databases gain the power to shut down or revive certain journals based on personal preferences. Any power that is not controlled is eventually abused. Therefore, our proposal is to urgently establish the principles of ethical behavior of citation databases at the global level and find ways to ensure compliance with such principles.

Background: COVID-19 patients with DM have increased mortality and severity of the disease. Although telemedicine helps to minimize the impact of COVID-19 on the DM standard of care, it is increasingly evident that COVID-19 has a significant impact on DM standards of care, especially in areas where telemedicine is not available.

Objective: The study aimed to assess the impact of COVID-19 on patients with diabetes standard of care in the Jazan region, Saudi Arabia.

Methods: A cross-sectional study using an online pretested questionnaire targeted adult diabetic patients living in the Jazan region between December 2021 to March 2022. The participants were selected through a random sampling method. They completed self-administered questionnaires that included demographic variables.

Results: A total of 258 study subjects participated in this study. In comparison to DM standards of care before and during COVID-19, there was no clinically significant difference in medication compliance, blood glucose checking, or experiencing blood glucose extrusion. However, with the spread of the corona pandemic and the closure of clinics, the percentage of those who have difficulty controlling blood sugar levels has increased to 22%, despite the availability of telemedicine.

Conclusion: DM standards of care have not been affected and were not statistically significant, which could be explained by the rapid adoption of telemedicine during the lockdown. However, as corona spread participants had difficulty controlling blood sugar levels. This indicates that governmental multidisciplinary work limits the COVID-19 impact; however, further work is still needed to ensure that DM care is not compromised.

Background: Community psychiatric treatment (CPT) is a novelty in the primary health care system for the people with mental health problems. The service operates according to the Flexible Assertive Community Treatment (FACT) model. FACT is a rehabilitation-oriented clinical case management model based on the ACT model (Assertive Community Treatment).

Objective: This study aimed to assess how involvement in a community psychiatry program affects the quality of life of program participants.

Methods: Between December 2020 and March 2021 we conducted a qualitative study. To obtain information, semi-structured interviews with twelve patients treated in the Community Psychiatric Treatment program were conducted. All restriction regarding COVID pandemic were considered at the research. Content analysis of the text was used for data analysis, which means that we interpreted the analysed text and determine the meaning of individual parts of the text.

Results: Twelve persons participated in the interviews, six of which were women (50%) and six men (50%). All the participants were of Slovenian nationality. They were from 28 to 80 years old, with a mean age of 47 years. We identified twelve categories and four themes: treatment problems, principles of operating of CPT program, satisfaction with inclusion in the CPT and improvement of quality of life through inclusion in the program.

Conclusion: Quality of life is essential for every individual, as well as for people with mental health problems. In our study we have proved that the Community psychiatric programs could significantly impact the quality of life of people with mental health problems.

Background: Dealing with critical issues in the intrapartum period requires comprehensive knowledge and a full understanding of the basic principles and skills involved, as complications during labor and birth occur unexpectedly..

Objective: The aim of this study was to evaluate the knowledge of critical issues in the intrapartum period among undergraduate final year midwifery students.

Methods: This is a descriptive observational cross-sectional study conducted between February-July 2017. Final year undergraduate midwifery students were recruited from one institution and four public hospitals. The research instrument was a questionnaire designed by the research team. Statistical significance was set at p<0.05 and analyses were performed using the IBM SPSS Statistics version 22.

Results: The final study sample consisted of 100 participants. The 36.0% of the students had started their final year internship, with a mean duration of 4.3 months. Only 2% of the participants had obtained a bachelor degree from another department, 76% had attended general high school, 17% had pre-graduate work experience and 48.0% had attended a seminar on critical issues in the intrapartum period. Participants' final scores ranged from 5% to 90%, with mean value being 49.7% (SD=16.5%). The knowledge score was found to be significantly higher in midwifery students who had started the internship. However, it was not significantly correlated with other educational characteristics. Finally, no significant correlation was observed between knowledge score and age (r= -0.15, p=0.138) or knowledge score and months of internship (r=0.27, p=0.114).

Conclusion: In the core midwifery curriculum, the design and integration of didactic and clinical courses focusing on emergency management in midwifery practice is considered of paramount importance. However, teachers should provide midwifery students with guidance on independent learning ability and implement effective strategies to enhance students' self-study skills.

Background: Temporary Contracting and Visiting Doctors' Program was initiated by the Saudi Ministry of Health to address issues of sustainable supply of healthcare professionals in the whole country and in remote areas in particular.

Objective: This study aimed to describe the experience of the Saudi Temporary Contracting and Visiting Doctors' Program, the undertaken reform steps and the program outputs.

Methods: We conducted a case study and reviewed documents of the Temporary Contracting and Visiting Doctors' Program to obtain data about the program's development and steps of reform. We also extracted data about the number of different types of temporary contracts, the program budget and the healthcare professionals registered on the "VISITORs" platform.

Results: Scope of the Temporary Contracting and Visiting Doctors' Program had widened from contracting physicians from outside Saudi Arabia to include healthcare professionals from inside the country. The program's reform efforts included: formation of a governing central committee, development of guidelines, adoption of decentralized implementation system and modified budget release system, development of electronic staff bank and e-recruitment system and the introduction of virtual healthcare under the scope of the program. During the program evolution the number of temporary contracts has increased steadily, specifically the more efficient part-time contract variety, the contracts with physicians with rare sub-specialties, and contracts with Saudi healthcare professionals.

Conclusion: Reform undertaken in the Saudi Temporary Contracting and Visiting Doctors' Program ensures needs-based recruitment, efficient use of resources, and supply of staff of verified quality.