Medicina cutanea ibero-latino-americana最新文献

A potential therapeutic role of minoxidil in fibrotic or sclerotic conditions, such as keloids, has been suggested on the basis of its reported ability to inhibit the proliferation of human dermal fibroblasts. We have studied the effect of minoxidil on 3H-deoxythymidine uptake in cultures of human dermal fibroblasts derived from lesional and non-lesional skin from patients with keloids. The effect of the addition of fetal bovine serum, plasma and growth factors (insulin, EGF, PDGF, FGF and beta-TGF) to the medium has also been studied. Minoxidil, at concentrations ranging from 500 to 1,000 microM., caused an increase in DNA synthesis, which was proportional to the initial degree of fibroblast activation. Concentrations higher than 1,000 microM. caused a cytotoxic effect. Some reservations arise on the potential therapeutic use of minoxidil in conditions characterized by increased fibroblast proliferation, given the narrow margin between activation of DNA synthesis and cytotoxicity we have found in our experimental model.

This report describes three cases of eosinophilic cellulitis (Wells' syndrome) observed during six years. In the author's opinion this condition is not frequent, but neither exceptional. A revision of clinico-pathological, etiopathogenic and therapeutics aspects is carried out.

We present four new cases of tubular apocrine adenoma. Clinical histopathological and ultrastructural findings are discussed. The presence of carcinoembryonic antigen (CEA) has been studied in three cases of tubular apocrine adenoma. This antigen was found predominantly in the lumen of the ducts and in the apical portion of the luminal cells. This pattern is similar to the distribution described in normal sweat glands and in other adnexal tumors.

There is a 37 years old patient with a erythemato-nodular pathology on her lower limbs, which has relapsed during three years. The characteristics of the eosinophilic cellulitis are observed in the microscopic study. The clinical and laboratory attributes of this entity are discussed, according to the world medical literature.

We present a case of subungueal keratoacanthoma. The tumor recurred three months after extirpation and didn't resolve spontaneously. The patient need a new surgery a year later. We revised the literature and comment the clinical and histological features that define this distinct entity and differentiate it from common keratoacanthoma and subungueal squamous cell carcinoma.

We report a case of perforating granuloma annulare characterized by a scare number of lesions, that were located around breast areola. The patient was a young female without personal or family remarkable history.

We show the case of a six-years-old little girl with a herpes zoster which appeared while a varicella was resolving. We are discussing the diagnosis difficulties of this process.

A new case of fibrous hamartoma of infancy is described as a benign but persistent soft-tissue tumor that appears during the first 2 years of life, as a rare condition. The histopathological study shows the three characteristic elements: fibrous, uni-locular adipose tissue and mixoid mesenchymal tissue. The histogenesis of this peculiar tumor is discussed.

Twelve cases of chronic urticaria with histopathologic features of lecocitoclastic allergic angitis are studied. The type of cutaneous lesion, personal and familiar atopic history and the presence of autoimmune disease are described. Light microscopy, direct immunofluorescence, anti DNA, antinuclear, antithyroid, Ro, La, Rnp and Sm antibodies, total complement levels, C3 and C4, rheumatoid factor, latex, ASTO, cryoglobulines and complete workup were investigated, taking into account natural progression and response to therapy. Two different groups are defined: 1) normocomplementemic (5 patients) and 2) hypocomplementemic (7 patients). They were all women except one. The cutaneous lesions were indistinguishable in the two groups. Only in the second group there was an associated disease (systemic lupus erythematosus, Sjogren syndrome disease, lupus-Sjogren overlap, autoimmune thyroid disease). Urticaria had been present from the onset of the disease in 4 patients, and occurred later during its course in 8 others. Five patients had thyroid disease (Hashimoto thyroiditis or Graves disease), two of them being mother and daughter. Another patient had a family history of Grave's disease and urticaria. Anti DNA antibodies were found in 7 cases, and anti Ro + La + in 3 cases. Response to treatment was variable with spontaneous cycles of worsening and remissions. One of the patients found a relationship with certain foods. Histopathologic results are related in both clinical normocomplementemic and hypocomplementemic groups. No significant differences were found between the two groups, but Ro+ and La+ patients exhibit more intense cariorexis and neutrophilic infiltrates.

A case of Epithelioid Sarcoma in a 26 years old woman is reported. Clinical aspects of this entity are commented. Immunomarcation with monoclonal and policlonal antibodies was made, the findings were compared to those of the literature. Supervivence of the patient for 6 years without agressive surgery is remarked. Treatment was ruled out with recombinant alfa interferon for the last 3 years.