B. Buchroithner, G. Hannesschläger, E. Leiss-Holzinger, A. Prylepa, B. Heise
This paper illustrates specific features and use of optical coherence tomography (OCT) in the raster-scanning and in comparison in the full field version of this imaging technique. Cases for nondestructive testing are discussed alongside other application schemes. In particular monitoring time-dependent processes and probing of birefringent specimens are considered here. In the context of polymer testing birefringence mapping may often provide information about internal strain and stress states. Recent results obtained with conventional raster-scanning OCT systems, with (dual and single-shot) full field OCT configurations, and with polarization-sensitive versions of (full field) OCT are presented here.
{"title":"(Full field) optical coherence tomography and applications","authors":"B. Buchroithner, G. Hannesschläger, E. Leiss-Holzinger, A. Prylepa, B. Heise","doi":"10.1117/12.2292176","DOIUrl":"https://doi.org/10.1117/12.2292176","url":null,"abstract":"This paper illustrates specific features and use of optical coherence tomography (OCT) in the raster-scanning and in comparison in the full field version of this imaging technique. Cases for nondestructive testing are discussed alongside other application schemes. In particular monitoring time-dependent processes and probing of birefringent specimens are considered here. In the context of polymer testing birefringence mapping may often provide information about internal strain and stress states. Recent results obtained with conventional raster-scanning OCT systems, with (dual and single-shot) full field OCT configurations, and with polarization-sensitive versions of (full field) OCT are presented here.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126747581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Meadway, Seyed Hamid Hosseiny Darbrazi, R. Cernat, G. Dobre, A. Podoleanu, R. Rosen
A detection method based on 7 spectral windows at the photodetection stage in an optical coherence tomography system was tested. We investigated its utility in two directions: spectroscopic optical coherence tomography and signal to noise ratio improvement. A diffraction grating was used in the photodetection unit to diffract light over a 16 photodetector array. Currently, this array has been configured to deliver 7 channels only by binning two adjacent photodetectors. The improvement of the signal to noise ratio has been investigated. Preliminary results of spectroscopy analysis which will be shown are B-scan OCT imaging of paint layers. The ultimate aim of the project is to perform spectroscopic analysis of the retina.
{"title":"Multi-channel time domain spectroscopic optical coherence tomography system","authors":"A. Meadway, Seyed Hamid Hosseiny Darbrazi, R. Cernat, G. Dobre, A. Podoleanu, R. Rosen","doi":"10.1117/12.816608","DOIUrl":"https://doi.org/10.1117/12.816608","url":null,"abstract":"A detection method based on 7 spectral windows at the photodetection stage in an optical coherence tomography system was tested. We investigated its utility in two directions: spectroscopic optical coherence tomography and signal to noise ratio improvement. A diffraction grating was used in the photodetection unit to diffract light over a 16 photodetector array. Currently, this array has been configured to deliver 7 channels only by binning two adjacent photodetectors. The improvement of the signal to noise ratio has been investigated. Preliminary results of spectroscopy analysis which will be shown are B-scan OCT imaging of paint layers. The ultimate aim of the project is to perform spectroscopic analysis of the retina.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"7139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131022090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Trifanov, M. Berendt, J. Salcedo, A. Podoleanu, A. L. Lobo Ribeiro
Recent developments on broadband optical sources emitting at 1050 nm wavelength for medical applications, in particular optical coherence tomography (OCT), have revealed enhanced depth penetration into the choroid, reduced scattering losses and improved image performances in eyes with turbid media, when compared to the most commercial used semiconductor optical source technology at 820 nm. In this paper, we present our study of fibre optic broadband sources (BBS) at 1 micron region, based on the amplified spontaneous emission (ASE) from rare-earth doped silica fibres for the integration into OCT systems. The target specifications for this type of sources are: 1050 nm central emission wavelength, with spectral width of ~70 nm, tens of miliwatts of output power and smoothly shaped output spectra. Several combinations of rare-earth doped optical fibres integrated into different fibre optic configurations have been tested. Optical bandwidth optimization and spectral shaping using different fibre optic techniques are presented and their autocorrelation function compared.
{"title":"Development of fibre optic broadband sources at 1 μm region for optical coherence tomography","authors":"I. Trifanov, M. Berendt, J. Salcedo, A. Podoleanu, A. L. Lobo Ribeiro","doi":"10.1117/12.815347","DOIUrl":"https://doi.org/10.1117/12.815347","url":null,"abstract":"Recent developments on broadband optical sources emitting at 1050 nm wavelength for medical applications, in particular optical coherence tomography (OCT), have revealed enhanced depth penetration into the choroid, reduced scattering losses and improved image performances in eyes with turbid media, when compared to the most commercial used semiconductor optical source technology at 820 nm. In this paper, we present our study of fibre optic broadband sources (BBS) at 1 micron region, based on the amplified spontaneous emission (ASE) from rare-earth doped silica fibres for the integration into OCT systems. The target specifications for this type of sources are: 1050 nm central emission wavelength, with spectral width of ~70 nm, tens of miliwatts of output power and smoothly shaped output spectra. Several combinations of rare-earth doped optical fibres integrated into different fibre optic configurations have been tested. Optical bandwidth optimization and spectral shaping using different fibre optic techniques are presented and their autocorrelation function compared.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126632084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tuohy, A. Bradu, F. Harms, N. Château, A. Podoleanu
The capabilities of a novel deformable mirror and wave-front sensor combination to correct aberrations in microscopy are analyzed. The deformable mirror, (Mirao52-D, Imagine Eyes) is incorporated with a Shack-Hartmann sensor (HASO, Imagine Optic) within a complex imaging system able to produce simultaneous en-face Optical Coherence Tomography and Laser Scanning Confocal Microscopy images as well as B-scan OCT images. A large angle imaging along one of the scanning directions is demonstrated using the AO loop to correct for the interface optics aberration. The image is split into three panels, and each panel is imaged using its own set of corrections. The three images are subsequently collaged into a final image and preliminary promising results are presented.
{"title":"Adaptive optics loop for en-face optical coherence tomography and laser scanning confocal microscopy","authors":"S. Tuohy, A. Bradu, F. Harms, N. Château, A. Podoleanu","doi":"10.1117/12.817814","DOIUrl":"https://doi.org/10.1117/12.817814","url":null,"abstract":"The capabilities of a novel deformable mirror and wave-front sensor combination to correct aberrations in microscopy are analyzed. The deformable mirror, (Mirao52-D, Imagine Eyes) is incorporated with a Shack-Hartmann sensor (HASO, Imagine Optic) within a complex imaging system able to produce simultaneous en-face Optical Coherence Tomography and Laser Scanning Confocal Microscopy images as well as B-scan OCT images. A large angle imaging along one of the scanning directions is demonstrated using the AO loop to correct for the interface optics aberration. The image is split into three panels, and each panel is imaged using its own set of corrections. The three images are subsequently collaged into a final image and preliminary promising results are presented.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131827666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have assembled a swept source optical coherence tomography (OCT) system for use in Art & Archaeological Conservation. The system is illuminated by an in-house swept source with a central wavelength of 1300 nm. This system includes dedicated optics to allow for angular averaging for speckle noise reduction. We demonstrate that the averaging produces significant improvements in speckle SNR in art and archaeological type objects and allows easier identification of features. We further demonstrate that there is practically no loss of axial resolution.
{"title":"A swept source OCT at 1300 nm with angular compounding for art and archaeological conservation","authors":"M. Hughes, D. Jackson, A. Podoleanu","doi":"10.1117/12.816222","DOIUrl":"https://doi.org/10.1117/12.816222","url":null,"abstract":"We have assembled a swept source optical coherence tomography (OCT) system for use in Art & Archaeological Conservation. The system is illuminated by an in-house swept source with a central wavelength of 1300 nm. This system includes dedicated optics to allow for angular averaging for speckle noise reduction. We demonstrate that the averaging produces significant improvements in speckle SNR in art and archaeological type objects and allows easier identification of features. We further demonstrate that there is practically no loss of axial resolution.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130724752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. McLaughlin, L. Scolaro, B. R. Klyen, S. Hamza, P. Robbins, C. Saunders, D. Sampson
Assessment of lymph node involvement is a key prognostic marker in early breast cancer. This paper demonstrates the ability of optical coherence tomography (OCT) to characterise the micro-architecture of healthy, non-cancerous lymph nodes. OCT is shown to differentiate stroma, cortex and adipose tissue. Characteristic patterns are also identified for germinal centres and blood vessels within the node. Results are correlated against a histopathological gold standard.
{"title":"Can normal lymph node architecture be characterised by optical coherence tomography?","authors":"R. McLaughlin, L. Scolaro, B. R. Klyen, S. Hamza, P. Robbins, C. Saunders, D. Sampson","doi":"10.1117/12.815182","DOIUrl":"https://doi.org/10.1117/12.815182","url":null,"abstract":"Assessment of lymph node involvement is a key prognostic marker in early breast cancer. This paper demonstrates the ability of optical coherence tomography (OCT) to characterise the micro-architecture of healthy, non-cancerous lymph nodes. OCT is shown to differentiate stroma, cortex and adipose tissue. Characteristic patterns are also identified for germinal centres and blood vessels within the node. Results are correlated against a histopathological gold standard.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121464096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Leitner, Andreas Henkel, C. Sönnichsen, C. Rosa, A. Podoleanu
A new variety of nanoparticles showing unique and characteristic optical properties, appeals for its use as contrast agents in medical imaging. Gold nanospheres, nanorods and nanoshells with a silica core are new forms of promising contrast agents which can be tuned to specific absorption or scattering characteristics within the near-infrared (NIR) spectrum ranging from 650 - 1300 nm. They have the ability to be used for both image enhancement and as photosensitive markers due to their well designable scattering and absorption properties. Furthermore, their strong optical absorption permits treatment of malignant cells by photoablation processes, induced when heating them with a matched light source. Differential absorption optical coherence tomography (DA-OCT) allows for the detection and depth resolved concentration measurement of such markers. So far, reports on DA-OCT systems used A-scan based imaging systems to assess depth resolved information about the absorption properties and the concentration of a chemical compound. Enface OCT (B(T) or C(T) scan based) images allow for better depth localization and a depth resolved concentration measurement of the compound under investigation. For this aim, we evaluate the suitability of a multiscan time-domain OCT set-up, compatible with different light sources providing different wavelengths and bandwidths in the NIR, to perform differential absorption OCT measurements, using gold nanorods as the contrast agent.
{"title":"En-Face differential absorption optical coherence tomography with gold nanorods as the contrast agent","authors":"M. Leitner, Andreas Henkel, C. Sönnichsen, C. Rosa, A. Podoleanu","doi":"10.1117/12.814624","DOIUrl":"https://doi.org/10.1117/12.814624","url":null,"abstract":"A new variety of nanoparticles showing unique and characteristic optical properties, appeals for its use as contrast agents in medical imaging. Gold nanospheres, nanorods and nanoshells with a silica core are new forms of promising contrast agents which can be tuned to specific absorption or scattering characteristics within the near-infrared (NIR) spectrum ranging from 650 - 1300 nm. They have the ability to be used for both image enhancement and as photosensitive markers due to their well designable scattering and absorption properties. Furthermore, their strong optical absorption permits treatment of malignant cells by photoablation processes, induced when heating them with a matched light source. Differential absorption optical coherence tomography (DA-OCT) allows for the detection and depth resolved concentration measurement of such markers. So far, reports on DA-OCT systems used A-scan based imaging systems to assess depth resolved information about the absorption properties and the concentration of a chemical compound. Enface OCT (B(T) or C(T) scan based) images allow for better depth localization and a depth resolved concentration measurement of the compound under investigation. For this aim, we evaluate the suitability of a multiscan time-domain OCT set-up, compatible with different light sources providing different wavelengths and bandwidths in the NIR, to perform differential absorption OCT measurements, using gold nanorods as the contrast agent.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129291497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haida Liang, B. Perić, M. Hughes, A. Podoleanu, M. Spring, S. Roehrs
There has been a long tradition of applying biomedical imaging techniques to the examination of historical artefacts, owing to similar demands for non-invasive methods in both fields. Optical Coherence Tomography (OCT) is no exception. We review the achievements on OCT applications to art conservation and archaeology since the publication of the first papers in 2004. Historical artefacts include a much broader range of materials than biological tissues, hence presenting a greater and somewhat different challenge to the field of OCT. New results will be presented to illustrate the various applications of OCT including both qualitative and quantitative analysis.
{"title":"Optical Coherence Tomography in archaeological and conservation science - a new emerging field","authors":"Haida Liang, B. Perić, M. Hughes, A. Podoleanu, M. Spring, S. Roehrs","doi":"10.1117/12.819499","DOIUrl":"https://doi.org/10.1117/12.819499","url":null,"abstract":"There has been a long tradition of applying biomedical imaging techniques to the examination of historical artefacts, owing to similar demands for non-invasive methods in both fields. Optical Coherence Tomography (OCT) is no exception. We review the achievements on OCT applications to art conservation and archaeology since the publication of the first papers in 2004. Historical artefacts include a much broader range of materials than biological tissues, hence presenting a greater and somewhat different challenge to the field of OCT. New results will be presented to illustrate the various applications of OCT including both qualitative and quantitative analysis.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125609330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Krstajić, J. Jacobs, M. Bonesi, L. Smith, P. Deshpande, S. Macneil, R. Smallwood, S. Matcher
We present results of OCT and polarization-OCT applied to various ex vivo tissue samples and discuss related issues of image contrast, comparing in vivo and ex vivo preparations. Time-domain and frequency-domain OCT at 835nm and 1300nm have been applied to ex vivo skin and rabbit cornea. We can distinguish rabbit cornea epithelium for up to a month after excision. However, the skin loses all contrast upon excision and despite numerous experiments we cannot distinguish epidermis, which is clearly visible in vivo. Using a time-domain system, birefringence is clearly visible for decalcified tissue but can also be detected more weakly on fully mineralised tissue. Analysis suggests that demineralization increases the birefringence value.
{"title":"Ex vivo and in vivo OCT image contrast","authors":"N. Krstajić, J. Jacobs, M. Bonesi, L. Smith, P. Deshpande, S. Macneil, R. Smallwood, S. Matcher","doi":"10.1117/12.819495","DOIUrl":"https://doi.org/10.1117/12.819495","url":null,"abstract":"We present results of OCT and polarization-OCT applied to various ex vivo tissue samples and discuss related issues of image contrast, comparing in vivo and ex vivo preparations. Time-domain and frequency-domain OCT at 835nm and 1300nm have been applied to ex vivo skin and rabbit cornea. We can distinguish rabbit cornea epithelium for up to a month after excision. However, the skin loses all contrast upon excision and despite numerous experiments we cannot distinguish epidermis, which is clearly visible in vivo. Using a time-domain system, birefringence is clearly visible for decalcified tissue but can also be detected more weakly on fully mineralised tissue. Analysis suggests that demineralization increases the birefringence value.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134353582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Adie, S. Alexandrov, J. Armstrong, B. Kennedy, D. Sampson
Optical elastography is aimed at using the visco-elastic properties of soft tissue as a contrast mechanism, and could be particularly suitable for high-resolution differentiation of tumour from surrounding normal tissue. We present a new approach to measure the effect of an applied stimulus in the kilohertz frequency range that is based on optical coherence tomography. We describe the approach and present the first in vivo optical coherence elastography measurements in human skin at audio excitation frequencies.
{"title":"A first demonstration of audio-frequency optical coherence elastography of tissue","authors":"S. Adie, S. Alexandrov, J. Armstrong, B. Kennedy, D. Sampson","doi":"10.1117/12.816210","DOIUrl":"https://doi.org/10.1117/12.816210","url":null,"abstract":"Optical elastography is aimed at using the visco-elastic properties of soft tissue as a contrast mechanism, and could be particularly suitable for high-resolution differentiation of tumour from surrounding normal tissue. We present a new approach to measure the effect of an applied stimulus in the kilohertz frequency range that is based on optical coherence tomography. We describe the approach and present the first in vivo optical coherence elastography measurements in human skin at audio excitation frequencies.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"23 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133425781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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