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2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)最新文献

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Direct PET reconstruction of regional binding potentials 区域结合电位的直接PET重建
P. Gravel, J. Soucy, A. Reader
This work evaluates a maximum likelihood parameter estimation method for regions-of-interest (ML-ROI) when incorporated in a direct 4D PET image reconstruction framework including the simplified reference tissue model with the basis function method (SRTM-BFM) tracer kinetic model. The ML-ROI algorithm has been evaluated for the usual task of estimating the radioactivity concentration for ROI spatial-bases compared to voxels. We therefore extend the application of this method to include the direct estimation of binding potential (BP) values on simulated 2D+time data sets (with use of [11C]raclopride time-activity curves (TACs) from real data). The performance of the proposed method is evaluated by comparing BP estimates with those obtained from a conventional post reconstruction approach, as well as the original ML-ROI method. It is shown that the use of ROIs as spatial basis functions leads to much lower %RMSE for BP regional estimates (%RMSE reduced by a factor of 2 or more), and furthermore using direct BP estimation in conjunction with ROI spatial basis functions reduces the still further. However, the major improvement is from the use of ROI spatial basis functions, rather than the use of direct kinetic parameter estimation. On the other hand, the considerable time gained (2 orders of magnitude) makes it a potential candidate for routine application.
本研究评估了一种兴趣区域(ML-ROI)的最大似然参数估计方法,该方法与直接4D PET图像重建框架相结合,包括简化的参考组织模型和基函数法(SRTM-BFM)示踪动力学模型。与体素相比,ML-ROI算法通常用于估计ROI空间基的放射性浓度。因此,我们扩展了该方法的应用,包括在模拟2D+时间数据集上直接估计结合电位(BP)值(使用[11C]raclopride时间-活性曲线(TACs)从真实数据)。通过将BP估计与传统的后重建方法以及原始的ML-ROI方法获得的BP估计进行比较,评估了所提出方法的性能。结果表明,使用ROI作为空间基函数导致BP区域估计的%RMSE低得多(%RMSE降低了2倍或更多),并且使用直接BP估计与ROI空间基函数相结合进一步降低了。然而,主要的改进来自ROI空间基函数的使用,而不是使用直接的动力学参数估计。另一方面,获得的可观时间(2个数量级)使其成为常规应用的潜在候选。
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引用次数: 0
Hydrogen beam extraction of penning ion source for compact neutron generator 紧凑型中子发生器penning离子源的氢束提取
C. Lee, D. Chang, B. Oh, J. Son, Yong-Kyun Kim
Penning ion source was made for applying a compact neutron generator. Electrical and vacuum system was assembled to test the ion source. As a preliminary test, a hydrogen gas using a mass flow system was inserted to produce plasma into the ion source and the plasma was produced and the hydrogen ion beams were extracted successfully. Operation conditions such as anode voltage, pressure change, and extraction voltage were changed to extract a higher current of the hydrogen ion beams and the highest current was achieved to be 0.9 mA at 0.0021 mbar (40 sccm) and 7.5 kV anode biased voltage. Some details on the operation conditions of the penning ion source were discussed.
彭宁离子源是为应用于小型中子发生器而研制的。安装了电气和真空系统,对离子源进行了测试。作为初步试验,利用质量流系统将氢气注入离子源产生等离子体,成功地产生了等离子体并提取了氢离子束。通过改变阳极电压、压力变化和提取电压等操作条件,提取出更大的氢离子束电流,在0.0021 mbar (40 sccm)和7.5 kV阳极偏置电压下,获得了0.9 mA的最大电流。对离子源的运行条件进行了详细的讨论。
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引用次数: 0
A portable fast-neutron imager with 6Li-containing scintillators 携带6li闪烁体的便携式快中子成像仪
Toru Matsumura, T. Shinkawa
Li-containing scintillators arranged in cage-shaped are proposed as a fast-neutron imager for nuclear security. Counting rate difference among the scintillators enables us to reconstruct the direction of neutron source by the aid of an iterative-Bayesian unfolding method. Simulation studies show that the proposed imager has angular resolution of 10 degrees and even identifies multiple source directions. The simulation can reproduce experimental results with a prototype detector. This indicates that the idea of the fast neutron imager is feasible.
提出了笼形含锂闪烁体作为核安全快中子成像仪。闪烁体之间的计数速率差异使我们能够借助迭代-贝叶斯展开法重建中子源的方向。仿真研究表明,该成像仪具有10度角分辨率,并能识别多个源方向。该仿真可以再现探测器样机的实验结果。这表明快中子成像仪的思想是可行的。
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引用次数: 0
Optimization of pinhole aperture size of a combined MPH/fanbeam SPECT system for I-123 DAT imaging 用于I-123数据成像的MPH/扇束SPECT系统的针孔孔径尺寸优化
A. Könik, J. M. Mukherjee, Soumyanil Banerjee, J. De Beenhouwer, G. Zubal, M. King
We proposed an inexpensive method to improve the performance of the conventional dual-camera SPECT systems for I-123 dopamine transporter (DAT) imaging for Parkinson Disease. In this method, one of the collimators is replaced with a specifically designed multi-pinhole (MPH) collimator, thus performing combined MPH/Fanbeam acquisition. The MPH consists of 9 pinholes focusing to the central brain and covering a cylindrical field of view (diameter: 12cm and height: 8cm), which includes the striatum. We present here our Monte Carlo simulation work investigating the optimal aperture size for the striatal binding ratio (SBR) and caudate/putamen ratio (C/P). Projections of the XCAT brain phantom were obtained for a range of aperture sizes (radius:1–5 mm, with increments of 1mm). Multiple noise realizations were simulated for each aperture size at realistic count levels. Reconstructions from MPH, Fanbeam and combined MPH/Fanbeam systems were obtained for various numbers of iterations. For SBR and C/P calculations activities within the striatum were estimated for a range of region of interests. Normalized root mean square errors (NRMSE) of the SBR and C/P measurements were obtained for the Fanbeam and combined MPH/Fanbeam reconstructions at different iterations and VOIs, using custom made and clinically employed quantitative analysis software. Our preliminary results suggest that an aperture radius of 2-3 mm for the MPH component yields both visually and quantitatively better estimations for the MPH/Fanbeam reconstructions.
我们提出了一种廉价的方法来提高传统双摄像头SPECT系统用于帕金森病I-123多巴胺转运体(DAT)成像的性能。在该方法中,将其中一个准直器替换为专门设计的多针孔(MPH)准直器,从而实现MPH/Fanbeam联合采集。MPH由9个针孔组成,聚焦于大脑中央,覆盖一个圆柱形视野(直径12厘米,高度8厘米),其中包括纹状体。本文通过蒙特卡罗模拟研究了纹状体结合比(SBR)和尾状核/壳核比(C/P)的最佳孔径大小。在不同孔径范围内(半径:1-5 mm,增量为1mm)获得XCAT脑影的投影。在实际计数水平下,模拟了每种孔径大小的多种噪声实现。对不同迭代次数的MPH、Fanbeam和MPH/Fanbeam组合系统进行了重构。对于SBR和C/P计算,纹状体内的活动对一系列感兴趣的区域进行了估计。使用定制的和临床使用的定量分析软件,获得了不同迭代和VOIs下Fanbeam和联合MPH/Fanbeam重建的SBR和C/P测量的归一化均方根误差(NRMSE)。我们的初步结果表明,MPH组件的孔径半径为2-3 mm,可以在视觉上和定量上更好地估计MPH/Fanbeam重建。
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引用次数: 4
Development and deployment of a fully parameterized fast Monte Carlo simulation in LHCb 在LHCb中开发和部署一个全参数化的快速蒙特卡罗模拟
B. Siddi
Faster alternatives to a full, GEANT4-based simulation are being pursued within LHCb experiment. In this context the integration of the Delphes toolkit in the LHCb simulation framework is intended to provide a fully parameterized option. Delphes is a modular software designed to perform fast simulations by propagating stable particles using a parametric approach and providing reconstructed physical objects as output. It includes propagation inside a magnetic field and parameterized response for tracking and muon systems as well as calorimetric response. Particle energies are computed by smearing the initial visible particles momenta according to detector resolution in a highly-customizable way. Delphes was initially designed for general-purpose experiments such as ATLAS and CMS where is already used. The present contribution illustrates the different aspect of the integration of the Delphes toolkit in Gauss, the LHCb simulation framework. Technically the particle transport performed by GEANT4 and subsequent mimicking of detector response and reconstruction has been replaced with a parametric response of the various detector elements. The implementation required extension to Delphes itself to constrain the particle transport inside the spectrometer acceptance, in order to match the LHCb dipole magnetic field. The configuration of various parameterizations of resolution and efficiency (charged particle tracking, mis-identification rate of particle identification algorithms, calorimeter, trigger response) is also a major aspect of the work to provide a fully functional simulation system. The output of the resulting fast simulation is formatted in such a way that can be used in the LHCb physics analysis framework. The status of the integration of Delphes is given.
在LHCb实验中,人们正在寻求更快的替代方案,以替代基于geant4的完整模拟。在这种情况下,Delphes工具包在LHCb仿真框架中的集成旨在提供一个完全参数化的选项。Delphes是一款模块化软件,旨在通过使用参数方法传播稳定粒子并提供重建的物理对象作为输出来执行快速模拟。它包括磁场内的传播,跟踪和μ子系统的参数化响应以及量热响应。粒子能量的计算是通过涂抹初始可见粒子动量根据探测器的分辨率在一个高度可定制的方式。Delphes最初是为通用实验设计的,如ATLAS和CMS,这些实验已经在使用。目前的贡献说明了Delphes工具包在高斯(LHCb模拟框架)中的集成的不同方面。从技术上讲,由GEANT4执行的粒子输运以及随后对探测器响应的模拟和重建已被各种探测器元件的参数响应所取代。实现需要扩展到Delphes本身来约束谱仪内部的粒子输运,以匹配LHCb偶极子磁场。配置分辨率和效率的各种参数化(带电粒子跟踪、粒子识别算法的错误识别率、量热计、触发响应)也是提供功能齐全的仿真系统的一个主要方面。生成的快速模拟的输出格式可以在LHCb物理分析框架中使用。给出了德尔菲斯积分的现状。
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引用次数: 0
Lithium foil gas-filled neutron detector using microstrip electrodes 采用微带电极的锂箔充气中子探测器
Nathaniel S. Edwards, B. Montag, L. C. Henson, S. Bellinger, R. Fronk, M. Reichenberger, D. Mcgregor
Microstrip electrodes have been fabricated and combined with one and five suspended 6Li foils positioned within a pressurized, gas-filled chamber to create a suspended foil microstrip neutron detector. This new detector offers a mechanically and electrically robust alternative to multi-wire proportional counters. Incident neutrons are converted into charged-particle reaction products that ionize the backfill gas. Charge carriers produced from the ionization of the backfill gas drift toward their respectively-charged electrodes due to the influence of the electric field formed from the potential difference between the drift electrode and the microstrip electrode anode and cathode strips. Gas multiplication occurs as electrons approach the surface of the microstrip electrode resulting in an increase in signal amplitude. Suspended foil microstrip neutron detectors containing one and five suspended 6Li foils were simulated using MCNP6 and compared to experimental results. The measured count rates from a moderated 26-ng 252Cf source positioned 18 cm from microstrip neutron detectors equipped with one and five suspended 6Li foils were 3.25 ± 0.04 and 10.62 ± 0.14 counts per second, respectively. The intrinsic thermal neutron detection efficiency of each detector was 4.02 ± 0.04% and 14.58 ± 0.11% for one and five suspended 6Li foils, respectively.
微带电极已经被制造出来,并与放置在一个加压的、充满气体的腔室中的一个和五个悬浮6Li箔相结合,以创建一个悬浮箔微带中子探测器。这种新的检测器提供了一种机械和电气健壮的多线比例计数器替代方案。入射中子转化为带电粒子反应产物,使回填气体电离。由于漂移电极与微带电极阳极和阴极带之间的电位差形成的电场的影响,由回填气体电离产生的载流子向各自的带电电极漂移。当电子接近微带电极表面导致信号幅度增加时,气体倍增发生。采用MCNP6模拟了含有1个和5个悬浮6Li箔的悬浮箔微带中子探测器,并对实验结果进行了比较。在距离1个和5个悬浮6Li箔的微带中子探测器18 cm处的慢化26-ng 252Cf源测得的计数率分别为3.25±0.04和10.62±0.14次/秒。每个探测器对1个和5个悬浮6Li箔的本态热中子探测效率分别为4.02±0.04%和14.58±0.11%。
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引用次数: 2
Empirical noise power spectrum based on the image subtraction in radiography imaging 基于图像减法的放射成像经验噪声功率谱
Dong Sik Kim, Eunae Lee
In order to measure the noise power spectrum (NPS) of a radiography detector from acquired images without any object, a subtraction-based algorithm, in which the input image is subtracted from another image acquired at the same exposure condition, is usually used to alleviate the fixed pattern noise influence. However, depending on variations in the x-ray tube and the readout circuits in the detector, the acquired images show nonuniform statistics and thus selecting an appropriate image pair from a given image set is important for a stable measurement of NPS. In order to select a good image pair for measuring an accurate normalized NPS (NNPS), a measurement method is proposed based on selecting an image pair from comparing the signal-to-noise ratios, which are obtained from the subtracted image. For the comparison, a commutative relationship as a sufficient condition for the accurate NNPS is considered. For a given image pair, the proposed method can provide a degree of accuracy of the empirical NNPS. For real x-ray images acquired from an indirect radiography detector, the proposed method is tested and shows stable measuring results for a set of images.
为了从采集的无目标图像中测量射线照相检测器的噪声功率谱(NPS),通常采用一种基于减法的算法,该算法将在相同曝光条件下采集的另一图像减去输入图像,以减轻固定模式噪声的影响。然而,根据x射线管和探测器读出电路的变化,所获得的图像显示出不均匀的统计量,因此从给定的图像集中选择合适的图像对对于稳定测量NPS很重要。为了选择合适的图像对进行精确的归一化NPS (NNPS)测量,提出了一种基于比较相减图像的信噪比来选择图像对的测量方法。为了进行比较,考虑了交换关系作为精确NNPS的充分条件。对于给定的图像对,该方法可以提供一定程度的经验NNPS精度。对于从间接射线照相探测器获取的真实x射线图像,对该方法进行了测试,并对一组图像显示出稳定的测量结果。
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引用次数: 1
A novel electronics for large scale SiPM array readout and advanced PET applications 用于大规模SiPM阵列读出和先进PET应用的新型电子器件
Zhixiang Zhao, Qiu Huang, T. Sui, Jianfeng Xu, Q. Peng
The Silicon photomultiplier (SiPM) becomes a choice of photon sensors for advanced radiation detector development. However, reading out large-scale SiPM arrays is still a fundamental technical obstacle. We present a new method (named π-PET electronics) to address this issue. Very different from conventional front-end electronics design, the key innovation of the new electronics is to include almost all functions of front-end readout electronics inside a low-cost FPGA. That not only simplifies the analog components and reduce the cost (with only one linear amplifier) but also provides powerful and flexible signal processes to enable applying different algorithms to both enhance the performance and add new real-time dark current measurement and calibration features.
硅光电倍增管(SiPM)成为发展先进辐射探测器的光子传感器的一种选择。然而,读取大规模SiPM阵列仍然是一个基本的技术障碍。我们提出了一种新的方法(π-PET电子学)来解决这个问题。与传统的前端电子设计不同,新电子设计的关键创新在于将前端读出电子的几乎所有功能都包含在低成本的FPGA中。这不仅简化了模拟元件并降低了成本(仅使用一个线性放大器),而且还提供了强大而灵活的信号处理,从而能够应用不同的算法来提高性能并添加新的实时暗电流测量和校准功能。
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引用次数: 0
Does energy non-linearity affect noise estimates from Monte Carlo simulations of X-ray imaging detectors? 能量非线性是否影响从蒙特卡罗模拟x射线成像探测器的噪声估计?
A. Badano
Publicly available Monte Carlo simulation packages for light transport in scintillator-based x-ray imaging detectors utilize a linear yield model. However, scintillators are known to be non-linear in the lower end of the energy range. Is this assumption reasonable for x-ray imaging simulations? We modified a freely available Monte Carlo package for modeling x-ray scintillators (MANTIS) to compare a linear versus a nonlinear optical yield model. We report simulations in the diagnostic x-ray energy range for a CsI:Tl. To determine the effect of the light yield model on imaging performance, we calculated the distribution of signal outputs characterized by the information or Swank factor. We find that the choice of yield model plays a significant role in the outcome statistics increasing the intensity of lower energy peaks favored by the non-linear model. This observation is confirmed by the results for the Swank factor with larger values for the non-linear models for an increase with respect to the linear model results of 42 and 26% for a high-resolution and a high-light-output model respectively. Our findings indicate that the assumption of linear light yield in Monte Carlo simulations of imaging detectors might introduce a significant bias in the estimates of noise as expressed by the Swank factor. More research is needed to implement realistic nonlinear yield models, to calculate the effect on realistic simulations including x-ray spectra of interest, and to experimentally validate these models.
在基于闪烁体的x射线成像探测器中,可公开获得的光传输蒙特卡罗模拟包利用线性产率模型。然而,已知闪烁体在能量范围的低端是非线性的。这个假设对x射线成像模拟合理吗?我们修改了一个免费的蒙特卡罗软件包,用于模拟x射线闪烁体(MANTIS),以比较线性和非线性光学产率模型。我们报告了CsI:Tl诊断x射线能量范围的模拟。为了确定光产率模型对成像性能的影响,我们计算了以信息或Swank因子为特征的信号输出的分布。我们发现,产量模型的选择在结果统计中起着显著的作用,增加了非线性模型所青睐的低能量峰的强度。结果证实了这一观察结果,非线性模型的Swank因子值较大,相对于线性模型的结果,高分辨率和高光输出模型的Swank因子分别增加了42%和26%。我们的研究结果表明,在成像探测器的蒙特卡罗模拟中,线性光产率的假设可能会在由Swank因子表示的噪声估计中引入显著的偏差。需要更多的研究来实现现实的非线性屈服模型,计算包括感兴趣的x射线光谱在内的现实模拟的影响,并通过实验验证这些模型。
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引用次数: 0
Neutron spallation to enhance muon scattering tomography 中子散裂增强介子散射层析成像
C. Grove, C. Eldridge, J. Burns, C. Steer, G. Chapman, A. Lohstroh
This work presents data obtained from an investigation into muon stimulated neutron emission in combination with the technique of muon scattering tomography. Initial measurements in lead of the neutron emission measured a half-life of 56.9 ± 6.63 ns which is three standard deviations lower than expected, with the error primarily attributed to prompt X-ray emission. A hypothetical detector, based on a muon scattering tomography prototype at AWE was used to examine the data expected from an integrated system. A lifetime 81 ± 3 ns was obtained here. Alongside this a portable muon trigger detector has been developed which aims to be implemented in a deployable muon scattering tomography system. The portable detector successfully measures muons to an accuracy of 20%.
本文介绍了结合介子散射层析成像技术对介子受激中子发射的研究所得的数据。铅中中子发射的初始测量结果为56.9±6.63 ns,比预期低3个标准差,误差主要归因于x射线的提示发射。一个假设的探测器,基于AWE的介子散射层析成像原型,用于检查集成系统的预期数据。寿命为81±3 ns。除此之外,还开发了一种便携式μ子触发检测器,其目的是在可部署的μ子散射层析成像系统中实现。便携式探测器成功地以20%的精度测量μ子。
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引用次数: 0
期刊
2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)
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