{"title":"New method of treating type 1 diabetes — closed-loop system","authors":"Karolina Matuszewska, Adrian Bystroń","doi":"10.5603/mrj.97386","DOIUrl":"https://doi.org/10.5603/mrj.97386","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135209021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bindu Abraham, Philip Idaewor, Ali Salih, Wayne Chicken, Mohamed Elamass, Jessica English, Vanessa Kendle, Denise Bonner, Christiana Aryee, Helen Merron, Elin Edwards, Noreen Rasheed, Abdalla Saad Abdalla Al-Zawi
Breast cancer is known to be the most common malignancy in women worldwide, the spectrum of the histological type varies from common types as invasive ductal carcinoma, of no special type to a rare variety as apocrine breast carcinoma. This study reports a case of apocrine carcinoma in a 60-year-old female patient, exploring the diagnosis strategies and management of this case.
{"title":"Breast apocrine carcinoma: a case report and review of literature","authors":"Bindu Abraham, Philip Idaewor, Ali Salih, Wayne Chicken, Mohamed Elamass, Jessica English, Vanessa Kendle, Denise Bonner, Christiana Aryee, Helen Merron, Elin Edwards, Noreen Rasheed, Abdalla Saad Abdalla Al-Zawi","doi":"10.5603/mrj.96297","DOIUrl":"https://doi.org/10.5603/mrj.96297","url":null,"abstract":"Breast cancer is known to be the most common malignancy in women worldwide, the spectrum of the histological type varies from common types as invasive ductal carcinoma, of no special type to a rare variety as apocrine breast carcinoma. This study reports a case of apocrine carcinoma in a 60-year-old female patient, exploring the diagnosis strategies and management of this case.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134912658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Kubica, A. Kubica, Z. Grąbczewska, Paweł Stróżecki, Piotr Adamski, A. Brymora, Rafał Donderski, T. Fabiszak, M. Flisiński, Robert Gajda, Beata Januszko-Giergielewicz, Przemysław Magielski, P. Michalski, M. Kasprzak, A. Kosobucka-Ozdoba, E. Laskowska, G. Casu, E. Navarese, Piotr Niezgoda, M. Ostrowska, Łukasz Pietrzykowski, Grzegorz Skonieczny, B. Sulikowska, Łukasz Szarpak, P. Szymański, Julia M Umińska, Paweł Zalewski
Complex metabolic disorders associated with obesity and diabetes pose a serious therapeutic challenge. The DEMETER-SIRIO 11 study is a phase III, multicenter, randomized, open-label, investigator-initiated clinical trial with a 6-month follow-up aimed at performing a comparative evaluation of the effect of two empagliflozin doses (10 mg vs. 20 mg) on selected metabolic parameters in patients with metabolic syndrome. The primary hypothesis of the study is that a higher dose of empagliflozin will result in a significant reduction of BMI and HbA1c in patients with obesity and MS receiving empagliflozin 20 mg as compared to 10 mg. Sample size and power calculation were based on a superiority assumption for the primary efficacy endpoint (the difference in decrease of body weight by > 1.5 kg and HbA1c by > 0.4%) for the higher vs. standard dose arm at 6-months of follow-up. Therefore, a sample size of 79 patients per arm is required to provide 80% power to detect a higher decrease in BMI, and 85 patients per arm is required to provide 80% power to detect a higher decrease in HbA1c in the 20 mg versus 10 mg arm with a type I error rate of 0.05. Summing up, enrollment of a total of 200 patients (100 in each arm) is planned to compensate for the potential drop-out rate from the study of up to 15%. Prespecified subanalyses will be performed according to: 1
与肥胖和糖尿病相关的复杂代谢紊乱构成了严重的治疗挑战。DEMETER-SIRIO 11研究是一项III期、多中心、随机、开放标签、研究者发起的临床试验，为期6个月的随访，旨在对两种剂量的恩格列净(10mg vs 20mg)对代谢综合征患者选定代谢参数的影响进行比较评估。本研究的主要假设是高剂量的恩帕列净将导致肥胖和MS患者接受恩帕列净20mg比10mg的BMI和HbA1c显著降低。在6个月的随访中，样本量和功率计算基于高剂量组与标准剂量组的主要疗效终点的优势假设(体重减少> 1.5 kg和糖化血红蛋白减少> 0.4%的差异)。因此，每组79例患者的样本量需要提供80%的功率来检测更高的BMI下降，每组85例患者需要提供80%的功率来检测20 mg组比10 mg组的HbA1c下降更高，I型错误率为0.05。总而言之，计划共入组200例患者(每组100例)，以弥补高达15%的研究潜在退出率。预先指定的子分析将按照:1
{"title":"Efficacy of double vs. standard empagliflozin dose for METabolic syndromE tReatment (DEMETER — SIRIO 11) study. Rationale and protocol of the study","authors":"J. Kubica, A. Kubica, Z. Grąbczewska, Paweł Stróżecki, Piotr Adamski, A. Brymora, Rafał Donderski, T. Fabiszak, M. Flisiński, Robert Gajda, Beata Januszko-Giergielewicz, Przemysław Magielski, P. Michalski, M. Kasprzak, A. Kosobucka-Ozdoba, E. Laskowska, G. Casu, E. Navarese, Piotr Niezgoda, M. Ostrowska, Łukasz Pietrzykowski, Grzegorz Skonieczny, B. Sulikowska, Łukasz Szarpak, P. Szymański, Julia M Umińska, Paweł Zalewski","doi":"10.5603/mrj.97187","DOIUrl":"https://doi.org/10.5603/mrj.97187","url":null,"abstract":"Complex metabolic disorders associated with obesity and diabetes pose a serious therapeutic challenge. The DEMETER-SIRIO 11 study is a phase III, multicenter, randomized, open-label, investigator-initiated clinical trial with a 6-month follow-up aimed at performing a comparative evaluation of the effect of two empagliflozin doses (10 mg vs. 20 mg) on selected metabolic parameters in patients with metabolic syndrome. The primary hypothesis of the study is that a higher dose of empagliflozin will result in a significant reduction of BMI and HbA1c in patients with obesity and MS receiving empagliflozin 20 mg as compared to 10 mg. Sample size and power calculation were based on a superiority assumption for the primary efficacy endpoint (the difference in decrease of body weight by > 1.5 kg and HbA1c by > 0.4%) for the higher vs. standard dose arm at 6-months of follow-up. Therefore, a sample size of 79 patients per arm is required to provide 80% power to detect a higher decrease in BMI, and 85 patients per arm is required to provide 80% power to detect a higher decrease in HbA1c in the 20 mg versus 10 mg arm with a type I error rate of 0.05. Summing up, enrollment of a total of 200 patients (100 in each arm) is planned to compensate for the potential drop-out rate from the study of up to 15%. Prespecified subanalyses will be performed according to: 1","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75033323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliwia Abramczyk, Sylwia Stawieraj, Agnieszka Mlicka, Wioletta Zielińska, Paweł Niewiadomski, Marta Hałas-Wiśniewska, M. Izdebska
Introduction : Breast cancer is one of the most common cancers in women. Current recommendations for combination therapy in patients with breast cancer are still being developed and new therapies with greater success are sought. A relatively new approach is the administration of cytostatics in combination with vitamins. Hence, the study aimed to clarify whether the combination of calcifediol [25(OH)D3] with doxorubicin affects the response of the MCF-7 breast cancer cell line to the cytostatic. Material and methods : In the MCF-7 cell line, the authors assessed cytotoxicity using the MTT assay, analysed the cell cycle and cell death mechanism using flow cytometry, and examined the structure of the cytoskeleton and cell morphology. Results : The results showed that doxorubicin in combination with calcifediol in a 1:1 ratio showed a synergistic effect resulting in a dose-dependent decrease in cell survival. Further studies have shown that this is due to the pro-apoptotic and necrotic effects of the combination of these compounds. There were also changes in the organization of the cytoskeleton and cell morphology. In addition, features of entosis were noted in MCF-7 cells. Conclusion : The synergistic effect of doxorubicin and calcifediol significantly reduced the viability of MCF-7 breast cancer cells. Inducing the desired effect by lowering the cytostatic dose is of great clinical importance, taking into account the cardiotoxicity of doxorubicin. Another very interesting aspect is the entosis process induced in the present research, which may have a dual nature.
{"title":"Effect of combined action of doxorubicin and calcifediol on MCF-7 breast cancer cells","authors":"Oliwia Abramczyk, Sylwia Stawieraj, Agnieszka Mlicka, Wioletta Zielińska, Paweł Niewiadomski, Marta Hałas-Wiśniewska, M. Izdebska","doi":"10.5603/mrj.96387","DOIUrl":"https://doi.org/10.5603/mrj.96387","url":null,"abstract":"Introduction : Breast cancer is one of the most common cancers in women. Current recommendations for combination therapy in patients with breast cancer are still being developed and new therapies with greater success are sought. A relatively new approach is the administration of cytostatics in combination with vitamins. Hence, the study aimed to clarify whether the combination of calcifediol [25(OH)D3] with doxorubicin affects the response of the MCF-7 breast cancer cell line to the cytostatic. Material and methods : In the MCF-7 cell line, the authors assessed cytotoxicity using the MTT assay, analysed the cell cycle and cell death mechanism using flow cytometry, and examined the structure of the cytoskeleton and cell morphology. Results : The results showed that doxorubicin in combination with calcifediol in a 1:1 ratio showed a synergistic effect resulting in a dose-dependent decrease in cell survival. Further studies have shown that this is due to the pro-apoptotic and necrotic effects of the combination of these compounds. There were also changes in the organization of the cytoskeleton and cell morphology. In addition, features of entosis were noted in MCF-7 cells. Conclusion : The synergistic effect of doxorubicin and calcifediol significantly reduced the viability of MCF-7 breast cancer cells. Inducing the desired effect by lowering the cytostatic dose is of great clinical importance, taking into account the cardiotoxicity of doxorubicin. Another very interesting aspect is the entosis process induced in the present research, which may have a dual nature.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83906511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sulikowski, Agnieszka Orłowska-Szafrańska, J. Pawlus, Jarosław Lichota, K. Ciechanowski, M. Marchelek-Myśliwiec, A. Brodkiewicz, K. Safranow, L. Domański, A. Pawlik
{"title":"Expression of KIM-1, VEGF and bFGF in the transplanted kidney as predictive factors of kidney allograft function","authors":"T. Sulikowski, Agnieszka Orłowska-Szafrańska, J. Pawlus, Jarosław Lichota, K. Ciechanowski, M. Marchelek-Myśliwiec, A. Brodkiewicz, K. Safranow, L. Domański, A. Pawlik","doi":"10.5603/mrj.95927","DOIUrl":"https://doi.org/10.5603/mrj.95927","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77024709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of the systemic immune-inflammation index to predict the severity of pneumonia in the emergency department","authors":"Fatma Tortum, E. Tekin, Emine Ozdal","doi":"10.5603/mrj.96312","DOIUrl":"https://doi.org/10.5603/mrj.96312","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84290960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martyna Wyszyńska-Gołaszewska, Mateusz Łukaszyk, W. Naumnik
{"title":"High-flow oxygen therapy — its application in COVID-19-related respiratory failure and beyond","authors":"Martyna Wyszyńska-Gołaszewska, Mateusz Łukaszyk, W. Naumnik","doi":"10.5603/mrj.a2023.0037","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0037","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88101317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interpersonal communication between medical rescue service employees and patients as perceived by patients","authors":"Justyna M. Graniczna, Anna Burak","doi":"10.5603/mrj.a2023.0036","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0036","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81566037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kałużna, K. Kałużny, M. Pyskir, Agata Staniewska, M. Hagner-Derengowska, J. Budzyński
{"title":"The effect of kinesiotherapy supported by visual biofeedback on a stabilometric platform on health-related quality of life among patients with non-specific low back pain. A randomized, open-label study with a 6-month follow-up","authors":"A. Kałużna, K. Kałużny, M. Pyskir, Agata Staniewska, M. Hagner-Derengowska, J. Budzyński","doi":"10.5603/mrj.a2023.0035","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0035","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91308179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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