G. Mierzwa, J. Budzyński, D. Kupczyk, B. Augustyńska
Introduction: Inflammatory bowel disease (IBD) is a group of diseases of unexplained aetiology, charac - terized by periods of remissions and exacerbations. Reactive oxygen species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in the occurrence of IBD. The aim of the present study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease. Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) from Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was the material for biochemical analysis: HT, GSH, GPX p , GPX RBC , GST, GR, SOD-1, MDA, NO 2/NO 3-and CP. Results: There were statistically significant differences in oxidative stress parameters observed between the study group and the control group, especially concerning HT, GSH, GPX RBC , GST, SOD-1, MDA and NO 2/NO 3. Discussion: The assumption that increased activity of antioxidative compounds may constitute a defence against the influence of oxidative stress may be true. Their decreased activity may participate in lowering an organism’s abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies into targeted preventive strategies are needed. Conclusions: Prooxidative factors play an essential role in the pathogenesis of IBD. Due to the still un - known etiopathology of IBD, research on imbalances between pro-oxidants and antioxidants should be continued in larger groups of patients.
{"title":"Biochemical markers of oxidative stress in patients with inflammatory bowel diseases","authors":"G. Mierzwa, J. Budzyński, D. Kupczyk, B. Augustyńska","doi":"10.5603/mrj.a2022.0044","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0044","url":null,"abstract":"Introduction: Inflammatory bowel disease (IBD) is a group of diseases of unexplained aetiology, charac - terized by periods of remissions and exacerbations. Reactive oxygen species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in the occurrence of IBD. The aim of the present study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease. Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) from Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was the material for biochemical analysis: HT, GSH, GPX p , GPX RBC , GST, GR, SOD-1, MDA, NO 2/NO 3-and CP. Results: There were statistically significant differences in oxidative stress parameters observed between the study group and the control group, especially concerning HT, GSH, GPX RBC , GST, SOD-1, MDA and NO 2/NO 3. Discussion: The assumption that increased activity of antioxidative compounds may constitute a defence against the influence of oxidative stress may be true. Their decreased activity may participate in lowering an organism’s abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies into targeted preventive strategies are needed. Conclusions: Prooxidative factors play an essential role in the pathogenesis of IBD. Due to the still un - known etiopathology of IBD, research on imbalances between pro-oxidants and antioxidants should be continued in larger groups of patients.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90714261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intranasal vaccines: a panacea to vaccine hesitancy?","authors":"M. J. Oladoye","doi":"10.5603/mrj.a2022.0043","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0043","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85045913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanna Cholerzyńska, Wiktoria Zasada, Patryk Konieczka, T. Kłosiewicz
{"title":"The impact of the COVID-19 pandemic on alcohol-related emergency department visits in a large European city","authors":"Hanna Cholerzyńska, Wiktoria Zasada, Patryk Konieczka, T. Kłosiewicz","doi":"10.5603/mrj.a2022.0042","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0042","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85432368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamila Stopińska, Adrianna Marzec, A. Olejek, Tomasz Niebudek
{"title":"Treatment of vulvar lichen sclerosus with a fractional CO2 laser — case report","authors":"Kamila Stopińska, Adrianna Marzec, A. Olejek, Tomasz Niebudek","doi":"10.5603/mrj.a2022.0041","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0041","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91264196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Dudziński, Marcin Glinka, T. Kubiak, Mariusz Feltynowski
Introduction: After each weather front with gales all over Poland, firemen have to perform a few hundred or so interventions. The life of persons covered by a specialistic treatment — home mechanical ventilation HMV — depends upon stable supplies of electricity. In case of breakdowns, indispensable aid is given by firemen who deliver generating sets available in Rescue and Firefighting Units (RFU). Aim of the study: Analysis and a statistical presentation of interventions of fire protection units to support the correct operation of home medical machines in case of temporary power failure. Material and methods: Data obtained from the Decision Support System of the State Fire Service (SFS DSS), made available to the authors by the Operational Planning Bureau at the Headquarters of the State Fire Service. In graphical presentations utilized were materials from the Head Office of Geodesy and Cartography, Law on Geodesy and Cartography, viz. Database for Topographic Objects, National Register of Borders. Medical data consistent with the purpose of the study were collected from the analysis of reports compiled by the person in charge of a rescue action of the State Fire Service, which is not the leading service in medical interventions. Results: In 2015–2021 were 1490 local hazards in which case it was necessary to support the operation — in most cases of ventilators for home use among people requiring ventilator-based therapy. The data show a constantly rising trend, the number of such actions increased by 64.29% — from 163 to 276 [mean (M) = 215.86, standard deviation (SD) = 66.35]. The average waiting time for undertaking inter - vention in these types of events was 910.68 seconds (15 min, 10 s). Conclusions: A significant element of rescue actions are volunteer fire brigade squads for being better deployed in rural areas, provided with generating sets; they can ensure faster an emergency electricity source. Persons in charge of a rescue action should draw up the medical part of a report more accurately (concerning the victim and the disease entity) while performing qualified first aid procedures.
{"title":"Participation of fire protection units in Poland in ensuring the continuous operation of ventilators for home use — a 7-year observation","authors":"Łukasz Dudziński, Marcin Glinka, T. Kubiak, Mariusz Feltynowski","doi":"10.5603/mrj.a2022.0038","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0038","url":null,"abstract":"Introduction: After each weather front with gales all over Poland, firemen have to perform a few hundred or so interventions. The life of persons covered by a specialistic treatment — home mechanical ventilation HMV — depends upon stable supplies of electricity. In case of breakdowns, indispensable aid is given by firemen who deliver generating sets available in Rescue and Firefighting Units (RFU). Aim of the study: Analysis and a statistical presentation of interventions of fire protection units to support the correct operation of home medical machines in case of temporary power failure. Material and methods: Data obtained from the Decision Support System of the State Fire Service (SFS DSS), made available to the authors by the Operational Planning Bureau at the Headquarters of the State Fire Service. In graphical presentations utilized were materials from the Head Office of Geodesy and Cartography, Law on Geodesy and Cartography, viz. Database for Topographic Objects, National Register of Borders. Medical data consistent with the purpose of the study were collected from the analysis of reports compiled by the person in charge of a rescue action of the State Fire Service, which is not the leading service in medical interventions. Results: In 2015–2021 were 1490 local hazards in which case it was necessary to support the operation — in most cases of ventilators for home use among people requiring ventilator-based therapy. The data show a constantly rising trend, the number of such actions increased by 64.29% — from 163 to 276 [mean (M) = 215.86, standard deviation (SD) = 66.35]. The average waiting time for undertaking inter - vention in these types of events was 910.68 seconds (15 min, 10 s). Conclusions: A significant element of rescue actions are volunteer fire brigade squads for being better deployed in rural areas, provided with generating sets; they can ensure faster an emergency electricity source. Persons in charge of a rescue action should draw up the medical part of a report more accurately (concerning the victim and the disease entity) while performing qualified first aid procedures.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89759730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The clinical relevance assessment of ROSIER scale in emergency care","authors":"Dawid Woszczyk, T. Kłosiewicz","doi":"10.5603/mrj.a2022.0040","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0040","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77753624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Michalski, M. Kasprzak, A. Kosobucka-Ozdoba, Łukasz Pietrzykowski, Magadalena Kieszkowska, A. Bączkowska, A. Kubica
{"title":"The impact of knowledge on the functioning of patients with coronary artery disease","authors":"P. Michalski, M. Kasprzak, A. Kosobucka-Ozdoba, Łukasz Pietrzykowski, Magadalena Kieszkowska, A. Bączkowska, A. Kubica","doi":"10.5603/mrj.a2022.0039","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0039","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81160598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Robotycka, Sylwia Mielcarska, Miriam Dawidowicz, A. Kula, Błażej Ochman, Tomasz Niebudek, Bogumiła Strzałkowska, D. Waniczek, E. Świętochowska
{"title":"Evaluation of the associations between GDF-15, OPG, and IL-15 levels in CRC: preliminary results","authors":"Julia Robotycka, Sylwia Mielcarska, Miriam Dawidowicz, A. Kula, Błażej Ochman, Tomasz Niebudek, Bogumiła Strzałkowska, D. Waniczek, E. Świętochowska","doi":"10.5603/mrj.a2022.0037","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0037","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85333502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilona Skitek-Adamczak, Natalia Ciepluch, T. Kłosiewicz
{"title":"The level of knowledge of healthcare professionals about child restraint systems","authors":"Ilona Skitek-Adamczak, Natalia Ciepluch, T. Kłosiewicz","doi":"10.5603/mrj.a2022.0036","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0036","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88472271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. The COVID-19 pandemic has undoubtedly put a heavy burden on the efficacy of health care system. Recently, Paciorek et al. [1] have reported the impact of the COVID-19 pandemic on the functioning of emergency medical service (EMS). They observed a decrease in the number of emergency medical team interventions during the first year of the COVID-19 pandemic, with the lowest number recorded in the spring of 2020 when the incidence of infections was relatively low. Similar observations were reported by Nadolny et al. [2]. A considerable prolongation of the EMS response time was found in 2020 in comparison with the two-year pre-pandemic period, with the longest delay in the autumn, which corresponded to the peak of the second wave of COVID-19 infections in Poland [1]. These interesting observations complement the image of EMS functioning during the pandemic time [3–7]. Reduction in the rate of hospitalizations for acute heart failure was even more pronounced at the beginning of the pandemic in Poland during the first public lockdown from March to May 2020 [8]. It was suggested that the reluctance to seek professional medical assistance reflected the fear of in-hospital acquisition of COVID-19 [9]. Grandstrom et al. [10] showed that the COVID-19 pandemic discouraged patients from seeking medical care when presenting with an AMI. The emotion of fear reported by patients was related to the external threat to one’s own health, due to COVID-19, rather than fear of symptoms related to an AMI. The media reports, describing the healthcare system as ineffective and overloaded, additionally enhanced the feeling of insecurity and may have had a detrimental influence on the delay to medical care acquisition [10]. Considering these data, it seems advisable to undertake wide-ranging educational initiatives aimed at emphasizing the risks related to the lack of professional medical assistance in life-threatening situations [11–13]. Moreover, long-term studies on the impact of medical system efficacy and patient COVID-19-related behaviors on clinical outcome should provide a better understanding of the extent of “collateral damage” resulting from the pandemic.
本文在Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0)许可下开放获取，允许下载文章并与他人分享，只要他们注明作者和出版商，但不得以任何方式更改或用于商业用途。COVID-19大流行无疑给卫生保健系统的效率带来了沉重负担。最近，Paciorek等[1]报道了COVID-19大流行对应急医疗服务(EMS)运作的影响。他们观察到，在2019冠状病毒病大流行的第一年，紧急医疗队干预的数量有所减少，在感染发生率相对较低的2020年春季，紧急医疗队干预的数量最低。Nadolny等人也报道了类似的观察结果[2]。与大流行前的两年相比，EMS在2020年的响应时间大幅延长，其中秋季延迟时间最长，与波兰第二波COVID-19感染高峰期相对应[1]。这些有趣的观察结果补充了EMS在大流行期间的运作情况[3-7]。在2020年3月至5月波兰第一次公共封锁期间，因急性心力衰竭住院的比率下降更为明显[8]。有人认为，不愿寻求专业医疗援助反映了对院内感染的恐惧[9]。Grandstrom等人[10]表明，COVID-19大流行使出现AMI的患者不愿就医。患者报告的恐惧情绪与COVID-19对自身健康的外部威胁有关，而不是对AMI相关症状的恐惧。媒体报道将医疗保健系统描述为无效和超载，这进一步增强了不安全感，并可能对延迟获得医疗服务产生不利影响[10]。考虑到这些数据，似乎明智的做法是开展广泛的教育活动，旨在强调在危及生命的情况下缺乏专业医疗援助的风险[11-13]。此外，对医疗系统效能和患者covid -19相关行为对临床结果的影响进行长期研究，应有助于更好地了解大流行造成的“附带损害”的程度。
{"title":"The fear of COVID — a factor affecting the functioning of emergency medical service","authors":"R. Gajda","doi":"10.5603/mrj.a2022.0035","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0035","url":null,"abstract":"This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. The COVID-19 pandemic has undoubtedly put a heavy burden on the efficacy of health care system. Recently, Paciorek et al. [1] have reported the impact of the COVID-19 pandemic on the functioning of emergency medical service (EMS). They observed a decrease in the number of emergency medical team interventions during the first year of the COVID-19 pandemic, with the lowest number recorded in the spring of 2020 when the incidence of infections was relatively low. Similar observations were reported by Nadolny et al. [2]. A considerable prolongation of the EMS response time was found in 2020 in comparison with the two-year pre-pandemic period, with the longest delay in the autumn, which corresponded to the peak of the second wave of COVID-19 infections in Poland [1]. These interesting observations complement the image of EMS functioning during the pandemic time [3–7]. Reduction in the rate of hospitalizations for acute heart failure was even more pronounced at the beginning of the pandemic in Poland during the first public lockdown from March to May 2020 [8]. It was suggested that the reluctance to seek professional medical assistance reflected the fear of in-hospital acquisition of COVID-19 [9]. Grandstrom et al. [10] showed that the COVID-19 pandemic discouraged patients from seeking medical care when presenting with an AMI. The emotion of fear reported by patients was related to the external threat to one’s own health, due to COVID-19, rather than fear of symptoms related to an AMI. The media reports, describing the healthcare system as ineffective and overloaded, additionally enhanced the feeling of insecurity and may have had a detrimental influence on the delay to medical care acquisition [10]. Considering these data, it seems advisable to undertake wide-ranging educational initiatives aimed at emphasizing the risks related to the lack of professional medical assistance in life-threatening situations [11–13]. Moreover, long-term studies on the impact of medical system efficacy and patient COVID-19-related behaviors on clinical outcome should provide a better understanding of the extent of “collateral damage” resulting from the pandemic.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":" 1029","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91409350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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