{"title":"Semaglutide as a chance for obesity treatment","authors":"U. Giordano, Jakub Kobiałka, Justyna Pilch","doi":"10.5603/mrj.a2023.0034","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0034","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91518098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrycja Pawłuszewicz, P. Gołaszewski, Paulina Głuszyńska, Zuzanna Razak Hady, J. Łukaszewicz, J. Ładny, K. Nadolny, H. Razak Hady
{"title":"What does the volume of stomach resected during Laparoscopic Sleeve Gastrectomy depend on and what impact does it have on postoperative results?","authors":"Patrycja Pawłuszewicz, P. Gołaszewski, Paulina Głuszyńska, Zuzanna Razak Hady, J. Łukaszewicz, J. Ładny, K. Nadolny, H. Razak Hady","doi":"10.5603/mrj.a2023.0033","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0033","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76935353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Chyrek-Tomaszewska, A. Popiołek, K. Linkowska, Mariusz Kozakiewicz, Adam Szelągowski, J. Budzyński, M. Bieliński
{"title":"Brain-derived neurotrophic factor serum concentration and BDNF Val66Met polymorphism in patients with peripheral artery disease: the importance of heart failure","authors":"Aleksandra Chyrek-Tomaszewska, A. Popiołek, K. Linkowska, Mariusz Kozakiewicz, Adam Szelągowski, J. Budzyński, M. Bieliński","doi":"10.5603/mrj.a2023.0032","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0032","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"3304 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86607529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Gałązka, Agnieszka Kwiatkowska, Kuba Bieńkowski, Albert Bielaska, A. Filip
{"title":"The impact of metformin on the development and course of anaplastic thyroid cancer in comparison to other histologic types of thyroid cancer","authors":"J. Gałązka, Agnieszka Kwiatkowska, Kuba Bieńkowski, Albert Bielaska, A. Filip","doi":"10.5603/mrj.a2023.0031","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0031","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88863100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agata Trafalska, Krzysztof Kotecki, Magdalena Kazimierska-Zając, A. Druszcz, M. Miś, Luba Ślósarz
{"title":"Short-term efficacy of botulinum neurotoxin for spastic cerebral palsy: A prospective and controlled study with parental feedback","authors":"Agata Trafalska, Krzysztof Kotecki, Magdalena Kazimierska-Zając, A. Druszcz, M. Miś, Luba Ślósarz","doi":"10.5603/mrj.a2023.0025","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0025","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73716083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of prognosis of intracerebral haemorrhage with respect to clinical, biochemical and radiological parameters: a study in a tertiary health care centre in Eastern India","authors":"Anasuyak Roy, Rishad Ahmed","doi":"10.5603/mrj.a2023.0030","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0030","url":null,"abstract":"viamedica","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76400752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil
Introduction: The research aimed to compare the characteristics and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) patients with coronary slow flow (CSF) vs. normal coronary flow (no CSF) in a 5-year follow-up. Material and methods: Between 2010–2015 were identified 111 patients as having final MINOCA diagno - sis and available calculated corrected TIMI frame count (cTFC). CSF was defined as cTFC greater than 27 frames per second in any of the three coronary arteries. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: The mean cTFC was 28.9 ± 6.1 frames per second (median: 28, IQR 24–33; min-max: 19–58). 62 (55.9%) patients had normal coronary flow, and 49 (44.1%) had CSF. Patients did not differ in sex (fe - males no CSF vs. CSF: 58% vs. 61%, p = 0.7) or age (63 ± 15 years vs. 63 ± 13 years, p = 0.8). Patients with CSF characterized higher rates of chronic kidney disease (0 vs. 8.2%, p = 0.035). No statistically significant difference was observed for any of the analysed points. MACE rates for no CSF vs. CSF were 9.6% vs. 14.3% (HR 0.80, 95% CI 0.28–2.96, p = 0.7), respectively. Conclusions: CSF was not associated with a higher risk of adverse events among MINOCA patients at five years.
前言:本研究旨在通过5年随访，比较非阻塞性冠状动脉(MINOCA)患者冠脉慢流(CSF)与正常冠脉流(无CSF)的心肌梗死的特点和结局。材料和方法:2010-2015年间，确定了111例最终MINOCA诊断的患者和可计算的校正TIMI帧计数(cTFC)。CSF被定义为在三条冠状动脉中任何一条的cTFC大于27帧/秒。主要终点是5年主要不良心血管事件发生率，定义为心源性死亡、心肌梗死或因心绞痛住院。结果:平均cTFC为28.9±6.1帧/秒(中位数:28,IQR 24-33;min-max: 19-58)。62例(55.9%)冠脉血流正常，49例(44.1%)有脑脊液。患者在性别(男性无脑脊液vs.脑脊液:58% vs. 61%， p = 0.7)和年龄(63±15岁vs. 63±13岁，p = 0.8)上没有差异。CSF患者的慢性肾脏疾病发生率较高(0比8.2%，p = 0.035)。在任何分析点上都没有观察到统计学上的显著差异。无脑脊液组和脑脊液组的MACE率分别为9.6%和14.3% (HR 0.80, 95% CI 0.28-2.96, p = 0.7)。结论:脑脊液与MINOCA患者5年不良事件的高风险无关。
{"title":"Coronary slow flow is not an adverse prognostic factor in MINOCA patients in the 5-year follow-up","authors":"P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil","doi":"10.5603/mrj.a2023.0024","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0024","url":null,"abstract":"Introduction: The research aimed to compare the characteristics and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) patients with coronary slow flow (CSF) vs. normal coronary flow (no CSF) in a 5-year follow-up. Material and methods: Between 2010–2015 were identified 111 patients as having final MINOCA diagno - sis and available calculated corrected TIMI frame count (cTFC). CSF was defined as cTFC greater than 27 frames per second in any of the three coronary arteries. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: The mean cTFC was 28.9 ± 6.1 frames per second (median: 28, IQR 24–33; min-max: 19–58). 62 (55.9%) patients had normal coronary flow, and 49 (44.1%) had CSF. Patients did not differ in sex (fe - males no CSF vs. CSF: 58% vs. 61%, p = 0.7) or age (63 ± 15 years vs. 63 ± 13 years, p = 0.8). Patients with CSF characterized higher rates of chronic kidney disease (0 vs. 8.2%, p = 0.035). No statistically significant difference was observed for any of the analysed points. MACE rates for no CSF vs. CSF were 9.6% vs. 14.3% (HR 0.80, 95% CI 0.28–2.96, p = 0.7), respectively. Conclusions: CSF was not associated with a higher risk of adverse events among MINOCA patients at five years.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82186409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil
Introduction: The authors analysed the potential of red blood cell and platelet indices such as red cell distribution width (RDW), mean corpuscular volume (MCV), and mean platelet volume (MPV) as predicting factors in myocardial infarction with non-obstructive coronary arteries (MINOCA) patients of 5-year outcomes. Material and methods: Between 2010–2015 were identified 112 patients who had final MINOCA diagnosis and available laboratory findings. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: Only RDW had a significant impact on long-term outcomes. 93 (83%) patients had RDW ≤ 14.5 (group 1), and 19 (17%) patients had RDW > 14.5 (group 2). The mean RDW value was 13.58 ± 1.11%. In group 1 and group 2, mean RDW values were 13.18 ± 0.55%, and 15.54 ± 1.06% (p < 0.001), respectively. Patients with abnormal RDW values (group 2) characterized lower value of left ventricular eject fraction (60 ± 8% vs. 53 ± 13%, p = 0.024), and higher NT-proBNP values (3,170 ± 5,285 pg/mL vs. 6,200 ± 4,223 pg/mL, p = 0.013) as well as troponin levels (501–2500 ng/mL: 31% vs. 53%, p = 0.02). A statistically significant difference was observed only for all-cause death. All-cause death rates for no RDW ≤ 14.5% vs. RDW > 14.5% were 2.2% vs. 21.1% (HR 5.09, 95% CI 1.03–25.2, p = 0.046), respectively. Conclusions: RDW was significantly associated with the increased risk of all-cause mortality in MINOCA patients at 5 years.
作者分析了红细胞和血小板指标，如红细胞分布宽度(RDW)、平均红细胞体积(MCV)和平均血小板体积(MPV)作为非阻塞性冠状动脉(MINOCA)心肌梗死患者5年预后预测因素的潜力。材料和方法:2010-2015年间，确定了112例最终MINOCA诊断和现有实验室结果的患者。主要终点是5年主要不良心血管事件发生率，定义为心源性死亡、心肌梗死或因心绞痛住院。结果:只有RDW对长期预后有显著影响。RDW≤14.5的患者93例(83%)(第1组)，RDW > 14.5的患者19例(17%)(第2组)，RDW平均值为13.58±1.11%。1组和2组的RDW平均值分别为13.18±0.55%和15.54±1.06% (p < 0.001)。RDW值异常的患者(2组)左心室射血分数较低(60±8% vs. 53±13%，p = 0.024)， NT-proBNP值较高(3170±5285 pg/mL vs. 6200±4,223 pg/mL, p = 0.013)，肌钙蛋白水平较高(501 ~ 2500 ng/mL: 31% vs. 53%， p = 0.02)。仅在全因死亡中观察到统计学上的显著差异。无RDW≤14.5%组和RDW > 14.5%组的全因死亡率分别为2.2%和21.1% (HR 5.09, 95% CI 1.03-25.2, p = 0.046)。结论:RDW与5年MINOCA患者全因死亡风险增加显著相关。
{"title":"The predictive value of complete blood count-derived indices for major adverse cardiovascular events in MINOCA patients at 5-year follow-up","authors":"P. Buller, Adam Kern, Maciej Tyczyński, Wojciech Rosiak, Wojciech Figatowski, R. Gil, J. Bil","doi":"10.5603/mrj.a2023.0023","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0023","url":null,"abstract":"Introduction: The authors analysed the potential of red blood cell and platelet indices such as red cell distribution width (RDW), mean corpuscular volume (MCV), and mean platelet volume (MPV) as predicting factors in myocardial infarction with non-obstructive coronary arteries (MINOCA) patients of 5-year outcomes. Material and methods: Between 2010–2015 were identified 112 patients who had final MINOCA diagnosis and available laboratory findings. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results: Only RDW had a significant impact on long-term outcomes. 93 (83%) patients had RDW ≤ 14.5 (group 1), and 19 (17%) patients had RDW > 14.5 (group 2). The mean RDW value was 13.58 ± 1.11%. In group 1 and group 2, mean RDW values were 13.18 ± 0.55%, and 15.54 ± 1.06% (p < 0.001), respectively. Patients with abnormal RDW values (group 2) characterized lower value of left ventricular eject fraction (60 ± 8% vs. 53 ± 13%, p = 0.024), and higher NT-proBNP values (3,170 ± 5,285 pg/mL vs. 6,200 ± 4,223 pg/mL, p = 0.013) as well as troponin levels (501–2500 ng/mL: 31% vs. 53%, p = 0.02). A statistically significant difference was observed only for all-cause death. All-cause death rates for no RDW ≤ 14.5% vs. RDW > 14.5% were 2.2% vs. 21.1% (HR 5.09, 95% CI 1.03–25.2, p = 0.046), respectively. Conclusions: RDW was significantly associated with the increased risk of all-cause mortality in MINOCA patients at 5 years.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"47 2-4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77904703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian Krych, Katarzyna Krzyżak, Tomasz Styn, Witold Bratkowski, Michał Jamrozik, M. Knapik, Małgorzata Jekiełek, T. Hrapkowicz
Von Willebrand disease (VWD), is the most common hereditary bleeding disorder (HBD) and affects ap - proximately 1–2% of the population. Type 1 accounts for 70–80% of all cases and involves partially reduced levels of functional VWF. It is usually manifested by mild to moderate mucocutaneous bleeding. A 63-year-old patient with multivessel coronary artery disease and diagnosed with Von Willebrand’s disease type 1 after a previous NSTEMI infarction (10 days earlier) was admitted to the cardiac surgery department for a planned CABG procedure. The coagulation factor values on admission to the ward were successively (VIII 15%; VWF: Ag 12%). Coronary angiography revealed MV CAD. The patient was consulted with the HEART Team. The decision was made to qualify the patient for CABG using the OPCAB technique. A detailed plan for securing the haemostasis was established. Haemate P 500/1200 and 1000/2400, a lyophilized concentrate of humans VIII and von Willebrand Factors, were secured. During surgery, LITA- LAD and Ao-RCA bridges were performed using Medtronic Starfish® Heart Positioners. In the post-operation period, no complications were noted. Plasma levels of VIII and VW factors were measured daily and antihemorrhagic prophylaxis was given accordingly to measured values. The patient was discharged on the eighth day after surgery in good condition, with the haematological recommendations. Currently, there are no guidelines for the management of patients with Von Willebrand’s disease undergoing cardiac surgery. Incorrectly conducted pharmacotherapy may result in an elevated level of VW factor and additional exposure to the occurrence of acute coronary syndromes and heart attacks.
血管性血友病(VWD)是最常见的遗传性出血性疾病(HBD)，大约影响1-2%的人口。1型占所有病例的70-80%，涉及部分功能性VWF水平降低。通常表现为轻度至中度皮肤粘膜出血。一名63岁的多支冠状动脉疾病患者，在先前的非stemi梗死(10天前)后被诊断为1型血管性血友病，住进心脏外科接受计划的CABG手术。入院时凝血因子值依次为(VIII 15%;VWF: Ag 12%)。冠状动脉造影显示为中枢性冠心病。病人接受了心脏科的会诊。决定采用OPCAB技术对患者进行冠脉搭桥。制定了详细的止血方案。血液p500 /1200和1000/2400，冻干浓缩人VIII和血管性血友病因子，是安全的。在手术期间，LITA- LAD和Ao-RCA桥使用美敦力海星®心脏定位器进行。术后无并发症发生。每日测定血浆VIII和VW因子水平，并根据测量值给予抗出血预防。患者术后第8天出院，血液学检查结果良好。目前，对于接受心脏手术的血管性血友病患者的管理尚无指南。不正确的药物治疗可能导致VW因子水平升高，增加急性冠状动脉综合征和心脏病发作的风险。
{"title":"Coronary artery bypass graft in a patient with Von Willebrand disease type 1","authors":"Sebastian Krych, Katarzyna Krzyżak, Tomasz Styn, Witold Bratkowski, Michał Jamrozik, M. Knapik, Małgorzata Jekiełek, T. Hrapkowicz","doi":"10.5603/mrj.a2023.0028","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0028","url":null,"abstract":"Von Willebrand disease (VWD), is the most common hereditary bleeding disorder (HBD) and affects ap - proximately 1–2% of the population. Type 1 accounts for 70–80% of all cases and involves partially reduced levels of functional VWF. It is usually manifested by mild to moderate mucocutaneous bleeding. A 63-year-old patient with multivessel coronary artery disease and diagnosed with Von Willebrand’s disease type 1 after a previous NSTEMI infarction (10 days earlier) was admitted to the cardiac surgery department for a planned CABG procedure. The coagulation factor values on admission to the ward were successively (VIII 15%; VWF: Ag 12%). Coronary angiography revealed MV CAD. The patient was consulted with the HEART Team. The decision was made to qualify the patient for CABG using the OPCAB technique. A detailed plan for securing the haemostasis was established. Haemate P 500/1200 and 1000/2400, a lyophilized concentrate of humans VIII and von Willebrand Factors, were secured. During surgery, LITA- LAD and Ao-RCA bridges were performed using Medtronic Starfish® Heart Positioners. In the post-operation period, no complications were noted. Plasma levels of VIII and VW factors were measured daily and antihemorrhagic prophylaxis was given accordingly to measured values. The patient was discharged on the eighth day after surgery in good condition, with the haematological recommendations. Currently, there are no guidelines for the management of patients with Von Willebrand’s disease undergoing cardiac surgery. Incorrectly conducted pharmacotherapy may result in an elevated level of VW factor and additional exposure to the occurrence of acute coronary syndromes and heart attacks.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75459263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. G. Ponomarova, T. Lisyana, Olga Ivanivna Matyashova, Svitlana Urijivna Krishchuk
Introduction: Tobacco use has a negative effect on the immune system and contributes to a decrease in the protective properties of a woman’s body, which leads to dysbiotic changes in the microbiota of the genital tract. Materials and methods: To assess the species and quantity composition of the microflora of the vagina in women, bacteriological studies were conducted. The research group consisted of women with inflamma - tory diseases of the genital tract who smoke (40 women) and 40 women who do not smoke. The control group consisted of 30 healthy women who did not smoke. Results: The obtained results indicate that the state of the microbiota of the genital organs in women who smoke is characterized by an increase in the spectrum of isolated microflora of enterobacteria and Gram-positive cocci, anaerobic bacteria, an increase in the level of viral infection and a significant decrease in the concentration of protective microflora. The microbiota of the genital tract of women who smoke is characterized by the formation of 2–3 component associations (in 45% of women) of infectious agents in various combinations. In non-smoking women, bacterial associations were found in 17.5% of cases. Conclusions: In women who smoke, there is a significant imbalance of protective and potentially patho - genic flora with active contamination of the genital tract with conditionally pathogenic microorganisms that form multicomponent associations of infectious agents. The obtained data indicate the need for constant monitoring of the causative agents of vaginal dysbiosis in women who smoke, as well as the need for further research to identify the impact of smoking cessation on the vaginal microbiome.
{"title":"The state of the microbiota of the genital tract in women who smoke","authors":"I. G. Ponomarova, T. Lisyana, Olga Ivanivna Matyashova, Svitlana Urijivna Krishchuk","doi":"10.5603/mrj.a2023.0027","DOIUrl":"https://doi.org/10.5603/mrj.a2023.0027","url":null,"abstract":"Introduction: Tobacco use has a negative effect on the immune system and contributes to a decrease in the protective properties of a woman’s body, which leads to dysbiotic changes in the microbiota of the genital tract. Materials and methods: To assess the species and quantity composition of the microflora of the vagina in women, bacteriological studies were conducted. The research group consisted of women with inflamma - tory diseases of the genital tract who smoke (40 women) and 40 women who do not smoke. The control group consisted of 30 healthy women who did not smoke. Results: The obtained results indicate that the state of the microbiota of the genital organs in women who smoke is characterized by an increase in the spectrum of isolated microflora of enterobacteria and Gram-positive cocci, anaerobic bacteria, an increase in the level of viral infection and a significant decrease in the concentration of protective microflora. The microbiota of the genital tract of women who smoke is characterized by the formation of 2–3 component associations (in 45% of women) of infectious agents in various combinations. In non-smoking women, bacterial associations were found in 17.5% of cases. Conclusions: In women who smoke, there is a significant imbalance of protective and potentially patho - genic flora with active contamination of the genital tract with conditionally pathogenic microorganisms that form multicomponent associations of infectious agents. The obtained data indicate the need for constant monitoring of the causative agents of vaginal dysbiosis in women who smoke, as well as the need for further research to identify the impact of smoking cessation on the vaginal microbiome.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85376195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：