Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1093
Mehmet Esad Güven, Aslihan Usumez
Objective: Screw loosening in implant-supported crowns is a common issue, leading to potential mechanical and biological complications. This study aimed to evaluate the combined influence of cyclic loading, abutment angulation, and implant diameter on screw torque loss in dental implants. Material and Methods: A total of 80 bone-level implants, divided into standard and narrow diameters, underwent cyclic loading protocols. These implants were paired with straight and 15-degree angled abutments. The study assessed the reverse torque values (RTV) before and after loading, with a primary focus on the effects of cyclic loading, abutment angulation, and implant diameter on screw torque loss. Results: Cyclic loading protocols and screw diameter significantly influenced screw torque loss. Standard diameter implants exhibited higher RTV compared to narrow diameter implants. . While the role of abutment angulation was less definitive, narrow diameter implants with angled placements showed a pronounced decrease in RTV. The study also highlighted that even with optimal preload values, a percentage of the initial preload is lost, potentially leading to screw loosening Conclusion: Cyclic loading and screw diameter are pivotal determinants of screw torque loss in dental implants. The study underscores the need for careful consideration of implant diameter and abutment angulation, especially in narrow diameter implants with angled abutments, to ensure optimal implant stability.
{"title":"Effect of Dynamic Cycles and Abutment Angle on The Screw Stability of Standard and Narrow Implants: An In vitro Study","authors":"Mehmet Esad Güven, Aslihan Usumez","doi":"10.36472/msd.v10i10.1093","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1093","url":null,"abstract":"Objective: Screw loosening in implant-supported crowns is a common issue, leading to potential mechanical and biological complications. This study aimed to evaluate the combined influence of cyclic loading, abutment angulation, and implant diameter on screw torque loss in dental implants. Material and Methods: A total of 80 bone-level implants, divided into standard and narrow diameters, underwent cyclic loading protocols. These implants were paired with straight and 15-degree angled abutments. The study assessed the reverse torque values (RTV) before and after loading, with a primary focus on the effects of cyclic loading, abutment angulation, and implant diameter on screw torque loss. Results: Cyclic loading protocols and screw diameter significantly influenced screw torque loss. Standard diameter implants exhibited higher RTV compared to narrow diameter implants. . While the role of abutment angulation was less definitive, narrow diameter implants with angled placements showed a pronounced decrease in RTV. The study also highlighted that even with optimal preload values, a percentage of the initial preload is lost, potentially leading to screw loosening Conclusion: Cyclic loading and screw diameter are pivotal determinants of screw torque loss in dental implants. The study underscores the need for careful consideration of implant diameter and abutment angulation, especially in narrow diameter implants with angled abutments, to ensure optimal implant stability.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136105772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1092
Ali Osman Başer, Pelin Ilhan, Havva Sert, Mine Adas, Mustafa Taner Yıldırmak
Objective: The research was conducted to identify the factors influencing social adaptation to the disease in the COVID-19 pandemic. Material and Methods: The cross-sectional study was carried out prospectively in a pandemic hospital in Istanbul between 10 May 2020 and 30 May 2020 after obtaining the permission of the Ministry of Health COVID-19 Scientific Research Evaluation Commission, institutional permission and ethics committee permission, with 100 patients who accepted to participate in the study who received inpatient treatment due to COVID-19. A patient information form, which includes demographic information, and the Psychosocial Self-Adjustment to Illness Scale were administered to the patients. Results: The mean age of patients participating in the study was 45.74±17.27 years, 49% were female, 63% were married, 25% had completed primary school, and 41% were not working. The mean psychosocial adjustment score of individuals with COVID-19 was 39.27±19.53. Conclusion: COVID-19 patients were observed to have a moderate psychosocial adjustment to the disease. Gender, marital status, education level, the presence of chronic diseases, and age were identified as factors influencing psychosocial adjustment.
{"title":"What are the Factors Affecting Psychosocial Adaptation to the Disease in the COVID-19 Pandemic?","authors":"Ali Osman Başer, Pelin Ilhan, Havva Sert, Mine Adas, Mustafa Taner Yıldırmak","doi":"10.36472/msd.v10i10.1092","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1092","url":null,"abstract":"Objective: The research was conducted to identify the factors influencing social adaptation to the disease in the COVID-19 pandemic. Material and Methods: The cross-sectional study was carried out prospectively in a pandemic hospital in Istanbul between 10 May 2020 and 30 May 2020 after obtaining the permission of the Ministry of Health COVID-19 Scientific Research Evaluation Commission, institutional permission and ethics committee permission, with 100 patients who accepted to participate in the study who received inpatient treatment due to COVID-19. A patient information form, which includes demographic information, and the Psychosocial Self-Adjustment to Illness Scale were administered to the patients. Results: The mean age of patients participating in the study was 45.74±17.27 years, 49% were female, 63% were married, 25% had completed primary school, and 41% were not working. The mean psychosocial adjustment score of individuals with COVID-19 was 39.27±19.53. Conclusion: COVID-19 patients were observed to have a moderate psychosocial adjustment to the disease. Gender, marital status, education level, the presence of chronic diseases, and age were identified as factors influencing psychosocial adjustment.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"101 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: We aim to identify appendiceal neuroendocrine tumors (NETs) seen after acute appendicitis and investigate their incidence in patients with laparoscopic or open appendectomy surgery. Here we have shaped the characteristic features of the tumor according to the 2010 classification rating of The World Health Organization (WHO) (surgical margin, invasion, grading, TNM stages) and also explored the disease-free survival in these patients. Material and Methods: This is the medical record of the patient with 7266 appendectomy retrospectively evaluated, and with these examples in histopathological analysis, a total of 43 patients were diagnosed with appendicitis NETs and included in the study. Age, gender, prediction of the surgical team during the operation, location of the tumor, WHO grade, depth of invasion, positive surgical margin, tumor size, TNM stage, and postoperative survival of these patients were analyzed retrospectively. Results: In this study, the incidence of appendiceal (NETs) was found to be 0.59% among 7,266 patients. Out of the 42 patients with appendiceal NETs, 27 were female and 16 were male. The mean age of the patients was 33.65 years (range: 11–78). The diagnosis was aided by clinical examination, ultrasound, and abdominal computerized tomography (CT) imaging. Most patients were initially diagnosed with appendicitis, and surgical interventions, including laparoscopic and conventional appendectomy, were performed. The pathological analysis confirmed appendicitis with NETs, classified according to the WHO 2010 recommendation. The majority of patients had well-differentiated NETs (G1 or G2). Surgical resection achieved negative radial margins, and no pathological signs were detected during follow-up colonoscopies. At a median follow-up of 70.2 months, all patients remained disease-free and alive. Conclusion: Appendiceal neuroendocrine tumors are rare but distinct entities that require a multidisciplinary approach for diagnosis and management. Surgical resection is the primary treatment, with systemic therapies reserved for advanced cases. The prognosis is generally favorable, with better outcomes seen in well-differentiated tumors. Long-term follow-up is crucial. Further research is needed to improve understanding and optimize treatment strategies for these tumors.
{"title":"Neuroendocrine Tumor of The Appendix: Retrospective 7266 analysis of Appendectomy Patients in a single center","authors":"Merve Tokoçin, Serhat Meriç, Haşim Furkan Güllü, Nihat Buğdaycı, Kamil Özdoğan, Onur Tokoçin, Osman Bilgin Gülçüçek","doi":"10.36472/msd.v10i10.1088","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1088","url":null,"abstract":"Objective: We aim to identify appendiceal neuroendocrine tumors (NETs) seen after acute appendicitis and investigate their incidence in patients with laparoscopic or open appendectomy surgery. Here we have shaped the characteristic features of the tumor according to the 2010 classification rating of The World Health Organization (WHO) (surgical margin, invasion, grading, TNM stages) and also explored the disease-free survival in these patients. Material and Methods: This is the medical record of the patient with 7266 appendectomy retrospectively evaluated, and with these examples in histopathological analysis, a total of 43 patients were diagnosed with appendicitis NETs and included in the study. Age, gender, prediction of the surgical team during the operation, location of the tumor, WHO grade, depth of invasion, positive surgical margin, tumor size, TNM stage, and postoperative survival of these patients were analyzed retrospectively. Results: In this study, the incidence of appendiceal (NETs) was found to be 0.59% among 7,266 patients. Out of the 42 patients with appendiceal NETs, 27 were female and 16 were male. The mean age of the patients was 33.65 years (range: 11–78). The diagnosis was aided by clinical examination, ultrasound, and abdominal computerized tomography (CT) imaging. Most patients were initially diagnosed with appendicitis, and surgical interventions, including laparoscopic and conventional appendectomy, were performed. The pathological analysis confirmed appendicitis with NETs, classified according to the WHO 2010 recommendation. The majority of patients had well-differentiated NETs (G1 or G2). Surgical resection achieved negative radial margins, and no pathological signs were detected during follow-up colonoscopies. At a median follow-up of 70.2 months, all patients remained disease-free and alive. Conclusion: Appendiceal neuroendocrine tumors are rare but distinct entities that require a multidisciplinary approach for diagnosis and management. Surgical resection is the primary treatment, with systemic therapies reserved for advanced cases. The prognosis is generally favorable, with better outcomes seen in well-differentiated tumors. Long-term follow-up is crucial. Further research is needed to improve understanding and optimize treatment strategies for these tumors.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"101 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1063
Kudret Selki, Mehmet Cihat Demir
Objective: Venous thromboembolism (VTE), which encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE), represents a significant source of morbidity and mortality in individuals with malignancies. Thromboprophylaxis is commonly employed in the management of most cancer patients, with the most common side effect being bleeding. It is not uncommon for patients to experience a recurrence of VTE during their treatment, highlighting a notable gap in the available evidence on this issue. Case: A 67-year-old male patient, actively undergoing chemotherapy for lung adenocarcinoma and initiated on low molecular weight heparin (LMWH) due to the development of PE, presented to the emergency department with DVT as a consequence of irregular use of anticoagulant injections. The patient, after being re-administered heparin, subsequently presented with intracranial hemorrhage on the 5th day post-discharge, ultimately leading to a fatal outcome. Conclusion: Both cancer patients and the elderly are at a heightened risk of experiencing VTE recurrence. The initiation of anticoagulation treatment elevates the risk of bleeding, particularly within the first ten days. Despite the frequent presentation of VTE recurrence in cancer patients at emergency departments, it remains underreported.
{"title":"Venous thromboembolism recurrence and intracranial hemorrhage in the cancer patient: A fatal course","authors":"Kudret Selki, Mehmet Cihat Demir","doi":"10.36472/msd.v10i10.1063","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1063","url":null,"abstract":"Objective: Venous thromboembolism (VTE), which encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE), represents a significant source of morbidity and mortality in individuals with malignancies. Thromboprophylaxis is commonly employed in the management of most cancer patients, with the most common side effect being bleeding. It is not uncommon for patients to experience a recurrence of VTE during their treatment, highlighting a notable gap in the available evidence on this issue. Case: A 67-year-old male patient, actively undergoing chemotherapy for lung adenocarcinoma and initiated on low molecular weight heparin (LMWH) due to the development of PE, presented to the emergency department with DVT as a consequence of irregular use of anticoagulant injections. The patient, after being re-administered heparin, subsequently presented with intracranial hemorrhage on the 5th day post-discharge, ultimately leading to a fatal outcome. Conclusion: Both cancer patients and the elderly are at a heightened risk of experiencing VTE recurrence. The initiation of anticoagulation treatment elevates the risk of bleeding, particularly within the first ten days. Despite the frequent presentation of VTE recurrence in cancer patients at emergency departments, it remains underreported.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"131 S2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1087
Merve Nalbant, Gamze Akbaş, Yunus Özcan
Objective: Panniculitis, an inflammatory disorder primarily affecting subcutaneous adipose tissue, is frequently associated with inflammatory rheumatic diseases. Panniculitis is an uncommon cutaneous manifestation of Sjögren's syndrome (SS), an autoimmune disease primarily known for causing dry eyes and mouth. Case: We report the case of a 56-year-old female initially diagnosed with rheumatoid arthritis, who later met the 2016 ACR-EULAR criteria for primary Sjögren’s syndrome. Following several treatments, she developed nodular lesions in the interscapular area, which were later diagnosed as septal panniculitis associated with SS. Panniculitis can sometimes precede the formal diagnosis of systemic diseases, such as SS. Therefore, it is essential to consider conditions like Sjögren syndrome in the differential diagnosis of unexplained panniculitis. Conclusion: This case underscores the potential link between Sjögren's syndrome and panniculitis. Panniculitis may manifest before the formal diagnosis of Sjögren's syndrome. It is imperative to include connective tissue diseases, including not only the more common lupus erythematosus and dermatomyositis but also Sjögren's syndrome, in the differential diagnosis when confronted with unexplained cases of panniculitis
{"title":"Panniculitis; A Rare Cutaneous Mafestation of Sjögren’s Syndrome","authors":"Merve Nalbant, Gamze Akbaş, Yunus Özcan","doi":"10.36472/msd.v10i10.1087","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1087","url":null,"abstract":"Objective: Panniculitis, an inflammatory disorder primarily affecting subcutaneous adipose tissue, is frequently associated with inflammatory rheumatic diseases. Panniculitis is an uncommon cutaneous manifestation of Sjögren's syndrome (SS), an autoimmune disease primarily known for causing dry eyes and mouth. Case: We report the case of a 56-year-old female initially diagnosed with rheumatoid arthritis, who later met the 2016 ACR-EULAR criteria for primary Sjögren’s syndrome. Following several treatments, she developed nodular lesions in the interscapular area, which were later diagnosed as septal panniculitis associated with SS. Panniculitis can sometimes precede the formal diagnosis of systemic diseases, such as SS. Therefore, it is essential to consider conditions like Sjögren syndrome in the differential diagnosis of unexplained panniculitis. Conclusion: This case underscores the potential link between Sjögren's syndrome and panniculitis. Panniculitis may manifest before the formal diagnosis of Sjögren's syndrome. It is imperative to include connective tissue diseases, including not only the more common lupus erythematosus and dermatomyositis but also Sjögren's syndrome, in the differential diagnosis when confronted with unexplained cases of panniculitis","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1086
Ceyda Hayretdağ
Objective: This study aims to provide a comprehensive overview of deaths related to central and peripheral nervous system (CNS and PNS, respectively) disorders in Turkey over a 5-year period. The objective is to identify patterns in mortality rates, investigate regional prevalence, and analyze demographic factors contributing to fatal outcomes. Additionally, we aim to critique existing data collection methodologies. Materials and Methods: Utilizing cross-sectional analysis, data were obtained from the Turkish Statistical Institute (TUIK). Mortality rates were calculated using population estimates from the TUIK, with age- and sex-specific rates, and age-standardized rates (ASRs) derived from the world standard population. Causes of death were classified according to the World Health Organization's International Classification of Diseases, Tenth Revision (ICD-10). Results: The data revealed distinct patterns in mortality rates for CNS and PNS disorders from 2018 to 2022, with significant variations between male and female populations. A prominent upward trend in deaths attributed to CNS and PNS diseases was observed after 2018, despite a decline in the population growth rate. The highest mortality rates were particularly notable in 2020 and 2021. Conclusion: This study identified a significant increase in deaths related to CNS and PNS disorders amid the backdrop of the COVID-19 pandemic. A potential correlation between COVID-19 and the prevalence of neurological disorders has been suggested. With potential underdiagnosis due to the absence of routine post-mortem diagnostic autopsies, this study underscores the need for improved diagnostic capabilities and medical practices.
{"title":"Mortality Attributed to Central and Peripheral Nervous System Disorders: A Five-years Comprehensive Review from Turkey","authors":"Ceyda Hayretdağ","doi":"10.36472/msd.v10i10.1086","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1086","url":null,"abstract":"Objective: This study aims to provide a comprehensive overview of deaths related to central and peripheral nervous system (CNS and PNS, respectively) disorders in Turkey over a 5-year period. The objective is to identify patterns in mortality rates, investigate regional prevalence, and analyze demographic factors contributing to fatal outcomes. Additionally, we aim to critique existing data collection methodologies. Materials and Methods: Utilizing cross-sectional analysis, data were obtained from the Turkish Statistical Institute (TUIK). Mortality rates were calculated using population estimates from the TUIK, with age- and sex-specific rates, and age-standardized rates (ASRs) derived from the world standard population. Causes of death were classified according to the World Health Organization's International Classification of Diseases, Tenth Revision (ICD-10). Results: The data revealed distinct patterns in mortality rates for CNS and PNS disorders from 2018 to 2022, with significant variations between male and female populations. A prominent upward trend in deaths attributed to CNS and PNS diseases was observed after 2018, despite a decline in the population growth rate. The highest mortality rates were particularly notable in 2020 and 2021. Conclusion: This study identified a significant increase in deaths related to CNS and PNS disorders amid the backdrop of the COVID-19 pandemic. A potential correlation between COVID-19 and the prevalence of neurological disorders has been suggested. With potential underdiagnosis due to the absence of routine post-mortem diagnostic autopsies, this study underscores the need for improved diagnostic capabilities and medical practices.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1060
Fatih İşleyen, Dilek Ulubaş Işık, Ayşen Sumru Kavurt, Arslan Bayram, Ahmet Yağmur Baş, Nihal Demirel
Introduction: Neonatal Bartter Syndrome (NBS) is an extremely rare congenital chronic renal tubular transport disorder characterized by preterm birth, polyhydramnios, polyuria, salt wasting, and severe dehydration. Congenital Cutis Laxa (CCL) is a rare disease characterized by loss of skin flexibility and laxity, and atypical facial appearance.
Case Presentation: A 1290-gram female baby at 30+6 weeks of gestation was hospitalized due to premature birth and respiratory distress. During physical examination, an atypical facial appearance, wrinkles on the forehead, skin laxity, and philtrum were visible as well as a small chin and arachnodactyly in the fingers and toes. The patient displayed metabolic alkalosis in her blood gases. The patient, with an atypical face and current findings submitted her exome for genetic diagnosis. Genetic analysis revealed the presence of homozygous NM_001184832.2:c.2485+5G>A (rs749269268) in SLC12A1, and NBS Type 1 was diagnosed. A novel heterozygous NM_000501.4:c.352G>T, p.Val118Phe (rs781922544) variant was detected in ELN, and CCL syndrome with autosomal dominant inheritance was diagnosed.
Conclusions: The rare co-occurrence of NBS and CCL syndrome in our patient was seen as a mere coincidence. Since this is the first reported case in the literature, it was deemed appropriate to present this case.
{"title":"Coexistence of Neonatal Bartter Syndrome and Congenital Cutis Laxa, in which a new mutation in SLC12A1 was identified","authors":"Fatih İşleyen, Dilek Ulubaş Işık, Ayşen Sumru Kavurt, Arslan Bayram, Ahmet Yağmur Baş, Nihal Demirel","doi":"10.36472/msd.v10i10.1060","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1060","url":null,"abstract":"Introduction: Neonatal Bartter Syndrome (NBS) is an extremely rare congenital chronic renal tubular transport disorder characterized by preterm birth, polyhydramnios, polyuria, salt wasting, and severe dehydration. Congenital Cutis Laxa (CCL) is a rare disease characterized by loss of skin flexibility and laxity, and atypical facial appearance.
 Case Presentation: A 1290-gram female baby at 30+6 weeks of gestation was hospitalized due to premature birth and respiratory distress. During physical examination, an atypical facial appearance, wrinkles on the forehead, skin laxity, and philtrum were visible as well as a small chin and arachnodactyly in the fingers and toes. The patient displayed metabolic alkalosis in her blood gases. The patient, with an atypical face and current findings submitted her exome for genetic diagnosis. Genetic analysis revealed the presence of homozygous NM_001184832.2:c.2485+5G>A (rs749269268) in SLC12A1, and NBS Type 1 was diagnosed. A novel heterozygous NM_000501.4:c.352G>T, p.Val118Phe (rs781922544) variant was detected in ELN, and CCL syndrome with autosomal dominant inheritance was diagnosed.
 Conclusions: The rare co-occurrence of NBS and CCL syndrome in our patient was seen as a mere coincidence. Since this is the first reported case in the literature, it was deemed appropriate to present this case.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"30 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.36472/msd.v10i10.1084
Gizem Akyurt, Sibel Dogan
Objective: Healthcare professionals are susceptible to experiencing cynicism and burnout syndrome. This study aimed to assess the cynicism and burnout syndrome levels among hospital nurses. Material and Methods: The study employed a descriptive design and involved the administration of standardized scales and a questionnaire to voluntary participants, who were nurses at a designated tertiary hospital. The questionnaire, conducted through face-to-face interviews, aimed to collect socio-demographic information, address specific concerns relevant to nurses, and comprehensively evaluate their levels of cynicism and Burnout, thereby capturing crucial socio-demographic details. Results: A total of 327 nurses participated in the study. Findings indicated that 58.1% of the nurses had willingly chosen their profession, 48.6% expressed satisfaction with their profession, and 22.3% believed their profession was valued. The study revealed a positive correlation between sub-dimensions of the burnout scale, sub-dimensions of the organizational cynicism scale, total organizational cynicism scale scores, and general cynicism scale scores (p < 0.05). Conclusion: These results indicate that nurses are at risk of experiencing cynicism and burnout syndrome. It is, therefore, crucial to identify risk factors and implement preventive measures early on to minimize the risk. Recommendations include enhancing the working environment and conditions for healthcare professionals, particularly nurses, adjusting working hours, and providing psychological counselling services for employees.
{"title":"Assessment of Cynicism and Burnout Syndrome Among Nurses; A Descriptive Study","authors":"Gizem Akyurt, Sibel Dogan","doi":"10.36472/msd.v10i10.1084","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1084","url":null,"abstract":"Objective: Healthcare professionals are susceptible to experiencing cynicism and burnout syndrome. This study aimed to assess the cynicism and burnout syndrome levels among hospital nurses. Material and Methods: The study employed a descriptive design and involved the administration of standardized scales and a questionnaire to voluntary participants, who were nurses at a designated tertiary hospital. The questionnaire, conducted through face-to-face interviews, aimed to collect socio-demographic information, address specific concerns relevant to nurses, and comprehensively evaluate their levels of cynicism and Burnout, thereby capturing crucial socio-demographic details. Results: A total of 327 nurses participated in the study. Findings indicated that 58.1% of the nurses had willingly chosen their profession, 48.6% expressed satisfaction with their profession, and 22.3% believed their profession was valued. The study revealed a positive correlation between sub-dimensions of the burnout scale, sub-dimensions of the organizational cynicism scale, total organizational cynicism scale scores, and general cynicism scale scores (p < 0.05). Conclusion: These results indicate that nurses are at risk of experiencing cynicism and burnout syndrome. It is, therefore, crucial to identify risk factors and implement preventive measures early on to minimize the risk. Recommendations include enhancing the working environment and conditions for healthcare professionals, particularly nurses, adjusting working hours, and providing psychological counselling services for employees.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-26DOI: 10.36472/msd.v10i10.1082
Uğur Burak Şimşek, Mehmet Fatih Özdağ
Objective: Microembolic signals (MES) are markers that can be detected by Transcranial Doppler Ultrasonography (TCD) and are risk factors for stroke. The aim of our study is to explore the relationship between the number of MES and the extent of carotid stenosis as well as plaque morphology. Our goal is to provide a fresh perspective on the treatment of carotid stenosis. Materials and Methods: A total of 95 patients, who were admitted to the emergency department of Sultan 2.Abdülhamid Han Training and Research Hospital and were hospitalized with a diagnosis of stroke, were enrolled in the study. Patients with high-risk cardiac diseases were excluded from the study. Detailed medical histories, risk factors, and current medical treatments of the patients were documented, and microemboli detection was conducted using Transcranial Doppler (TCD). The number of microemboli in TCD was obtained by averaging the results of 2 consecutive half-hour follow-ups in a region. Carotid stenosis rates of the patients were determined by computed tomography angiography (CTA) according to the North American Symptomatic Endarterectomy Trial (NASCET) classification, and the plaque morphology was determined according to the Gray-Weale scale of carotid ultrasonography. Patients were categorized into symptomatic and asymptomatic carotid stenosis groups, and the number of microembolic signals (MES) was compared between these groups. Result: MES numbers of 95 patients with symptomatic carotid stenosis; while MES was not detected in 47.4% (n=45); 35.8% (n=34) had 1-2 MES, 8.4% (n=8) had 3-4 MES and 8.4% (n=8) 5 or more MES were detected. The relationship between the MES obtained and carotid stenosis was statistically significant (p<0.001). According to the type of plaque; while there is no MES in 68.2% (n=15) of Type-4 symptomatic stenosis, this rate is only 15% (n=3) in Type-1 stenosis. In addition, 20% (n=4) of Type-1 symptomatic stenosis had MES between 3-4 and 30% (n=6) of 5 or more MES. According to these results, the relationship between plaque type and the presence of MES is statistically significant. (p<0.001) Similar results were obtained in asymptomatic carotid stenosis. Conclusion: TCD is an easy-to-apply, non-invasive imaging technique, and MES detectable by TCD are risk factors for stroke. The relationship between MES and carotid stenosis rate and plaque type heterogeneity is statistically significant.
{"title":"The Relationship of Carotid Artery Plaque and Stenosis with Microemboli","authors":"Uğur Burak Şimşek, Mehmet Fatih Özdağ","doi":"10.36472/msd.v10i10.1082","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1082","url":null,"abstract":"Objective: Microembolic signals (MES) are markers that can be detected by Transcranial Doppler Ultrasonography (TCD) and are risk factors for stroke. The aim of our study is to explore the relationship between the number of MES and the extent of carotid stenosis as well as plaque morphology. Our goal is to provide a fresh perspective on the treatment of carotid stenosis. Materials and Methods: A total of 95 patients, who were admitted to the emergency department of Sultan 2.Abdülhamid Han Training and Research Hospital and were hospitalized with a diagnosis of stroke, were enrolled in the study. Patients with high-risk cardiac diseases were excluded from the study. Detailed medical histories, risk factors, and current medical treatments of the patients were documented, and microemboli detection was conducted using Transcranial Doppler (TCD). The number of microemboli in TCD was obtained by averaging the results of 2 consecutive half-hour follow-ups in a region. Carotid stenosis rates of the patients were determined by computed tomography angiography (CTA) according to the North American Symptomatic Endarterectomy Trial (NASCET) classification, and the plaque morphology was determined according to the Gray-Weale scale of carotid ultrasonography. Patients were categorized into symptomatic and asymptomatic carotid stenosis groups, and the number of microembolic signals (MES) was compared between these groups. Result: MES numbers of 95 patients with symptomatic carotid stenosis; while MES was not detected in 47.4% (n=45); 35.8% (n=34) had 1-2 MES, 8.4% (n=8) had 3-4 MES and 8.4% (n=8) 5 or more MES were detected. The relationship between the MES obtained and carotid stenosis was statistically significant (p<0.001). According to the type of plaque; while there is no MES in 68.2% (n=15) of Type-4 symptomatic stenosis, this rate is only 15% (n=3) in Type-1 stenosis. In addition, 20% (n=4) of Type-1 symptomatic stenosis had MES between 3-4 and 30% (n=6) of 5 or more MES. According to these results, the relationship between plaque type and the presence of MES is statistically significant. (p<0.001) Similar results were obtained in asymptomatic carotid stenosis. Conclusion: TCD is an easy-to-apply, non-invasive imaging technique, and MES detectable by TCD are risk factors for stroke. The relationship between MES and carotid stenosis rate and plaque type heterogeneity is statistically significant.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136376948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-26DOI: 10.36472/msd.v10i10.1079
Hemra Nur Özaşık, Merve Abaklı İnci
Objective: All root canal preparation techniques can potentially result in debris protruding apically, leading to postoperative pain. This study aimed to assess the effects of different file systems on postoperative pain in root canal treatments performed on primary molar teeth. Material and Methods: The study included 100 patients aged 5-8 years. NiTi K-type hand files (NTK), rotary file systems ProTaper Next (PTN), AF Baby (AFB), EndoArt Niti Pedo Gold (EAN), and reciprocal file system WaveOne Gold (WOG) were employed in the canal treatment of mandibular primary molars. Postoperative pain was assessed using the Visual Analog Scale (VAS) at the 6th, 12th, 18th, 24th, 48th, 72nd hour, and 1st week following treatment, and the collected data were evaluated statistically. Results: When considering time as a factor, the postoperative pain values among the groups were compared using the Kruskal-Wallis H test, and no statistically significant differences were observed (p = 0.007). In numerical terms, the group using NTK, EAN, AFB, and PTN exhibited the highest average postoperative pain, while the group using WOG, a reciprocal system, had the lowest pain. Conclusion: In conclusion, the choice of file used impacts postoperative pain. There was no statistically significant difference in time-independent postoperative pain values between rotary files designed for primary teeth and those intended for permanent teeth. However, using files specifically designed for primary teeth is recommended, considering factors such as working comfort and suitability for working length.
目的:所有的根管预备技术都可能导致根管碎片向根尖突出，导致术后疼痛。本研究旨在评估不同文件系统对初级磨牙根管治疗术后疼痛的影响。材料与方法:研究纳入100例5-8岁的患者。采用NiTi k型手锉(NTK)、ProTaper Next (PTN)、AF Baby (AFB)、EndoArt NiTi Pedo Gold (EAN)、WaveOne Gold (WOG)等旋转锉系统进行下颌初级磨牙的根管治疗。分别于治疗后第6、12、18、24、48、72小时和第1周采用视觉模拟评分法(VAS)评估患者术后疼痛，并对收集到的数据进行统计学评价。结果:在考虑时间因素的情况下，采用Kruskal-Wallis H检验比较各组术后疼痛值，差异无统计学意义(p = 0.007)。在数值上，使用NTK、EAN、AFB和PTN的组表现出最高的平均术后疼痛，而使用WOG(一种互惠系统)的组疼痛最低。结论:手术刀的选择对术后疼痛有一定影响。专为乳牙设计的旋转锉和专为恒牙设计的旋转锉在与时间无关的术后疼痛值上无统计学差异。然而，考虑到工作舒适度和工作长度的适宜性等因素，建议使用专为乳牙设计的锉。
{"title":"The effect of various file systems on postoperative pain in primary Tooth Root Canal treatments: A randomized controlled clinical trial","authors":"Hemra Nur Özaşık, Merve Abaklı İnci","doi":"10.36472/msd.v10i10.1079","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1079","url":null,"abstract":"Objective: All root canal preparation techniques can potentially result in debris protruding apically, leading to postoperative pain. This study aimed to assess the effects of different file systems on postoperative pain in root canal treatments performed on primary molar teeth. Material and Methods: The study included 100 patients aged 5-8 years. NiTi K-type hand files (NTK), rotary file systems ProTaper Next (PTN), AF Baby (AFB), EndoArt Niti Pedo Gold (EAN), and reciprocal file system WaveOne Gold (WOG) were employed in the canal treatment of mandibular primary molars. Postoperative pain was assessed using the Visual Analog Scale (VAS) at the 6th, 12th, 18th, 24th, 48th, 72nd hour, and 1st week following treatment, and the collected data were evaluated statistically. Results: When considering time as a factor, the postoperative pain values among the groups were compared using the Kruskal-Wallis H test, and no statistically significant differences were observed (p = 0.007). In numerical terms, the group using NTK, EAN, AFB, and PTN exhibited the highest average postoperative pain, while the group using WOG, a reciprocal system, had the lowest pain. Conclusion: In conclusion, the choice of file used impacts postoperative pain. There was no statistically significant difference in time-independent postoperative pain values between rotary files designed for primary teeth and those intended for permanent teeth. However, using files specifically designed for primary teeth is recommended, considering factors such as working comfort and suitability for working length.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"10 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134907016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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