Objective: Despite organ donations, the need for organs is increasing daily, and efforts to increase organ donation continue without slowing down. Cadaver donation, necessary for medical education, is an issue waiting to be supported worldwide. In our study, a questionnaire was applied to measure the knowledge and attitudes of Turkish and international students toward organ and cadaver donation. Material and Methods: A total of 305 students, including 236 Turkish citizens and 68 international students, participated in the study. Students accessed the prepared questionnaires via a Google form. Results: It was determined that there was a statistical difference between Turkish and international students regarding their knowledge about organ donation compared to cadaver donation (Turkish students 78.8 % (n=186) yes, international students 57.,4 % (n=39) yes). In the social circles of Turkish and international students, organ donations were more common than cadaver donations, and a statistically significant difference was found for both groups (Turkish students 42.8 % (n=101) yes, international students 48.5 % (n=33) yes). The reasons for donating their bodies (Turkish students 48.3% (n=114) ''For use in organ transplantation'', international students 35.3 % (n=24) ''Because your body is useless after death and decays''), and organs (Turkish students 35.6 % (n=84), international students 32.4 % (n=22) ''For use in organ transplantation'') of Turkish and international students differed significantly. Conclusion: Based on the answers given by the students, it has been concluded that donations will increase when information is provided about the importance of organ and cadaver donation.
{"title":"Organ and Cadaver Donation; Student Opinions from Different Cultures.","authors":"Asrın Nalbant, M. B. Uzuner, Nuriye Kurbetli","doi":"10.36472/msd.v10i9.1011","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1011","url":null,"abstract":"Objective: Despite organ donations, the need for organs is increasing daily, and efforts to increase organ donation continue without slowing down. Cadaver donation, necessary for medical education, is an issue waiting to be supported worldwide. In our study, a questionnaire was applied to measure the knowledge and attitudes of Turkish and international students toward organ and cadaver donation.\u0000Material and Methods: A total of 305 students, including 236 Turkish citizens and 68 international students, participated in the study. Students accessed the prepared questionnaires via a Google form.\u0000Results: It was determined that there was a statistical difference between Turkish and international students regarding their knowledge about organ donation compared to cadaver donation (Turkish students 78.8 % (n=186) yes, international students 57.,4 % (n=39) yes). In the social circles of Turkish and international students, organ donations were more common than cadaver donations, and a statistically significant difference was found for both groups (Turkish students 42.8 % (n=101) yes, international students 48.5 % (n=33) yes). The reasons for donating their bodies (Turkish students 48.3% (n=114) ''For use in organ transplantation'', international students 35.3 % (n=24) ''Because your body is useless after death and decays''), and organs (Turkish students 35.6 % (n=84), international students 32.4 % (n=22) ''For use in organ transplantation'') of Turkish and international students differed significantly.\u0000Conclusion: Based on the answers given by the students, it has been concluded that donations will increase when information is provided about the importance of organ and cadaver donation.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72867228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Hypoxia-inducible factor (HIF) is a transcription factor that is effective in the ability of cells to sense and adapt to changes in oxygen levels. HIF1α gene is located in the 14q23.2 chromosome region and consists of 15 exons and 14 introns. It is a transcriptional regulator of metabolic processes such as angiogenesis and erythropoiesis and is required for immunological responses. Material and Methods: Our study examined the function of HIF1α and its relations with other genes and diseases using various bioinformatics database tools. GENEMANIA/GeneCard databases were used to detect the relationship of HIF gene with other genes, miRDB to show target miRNAs, STRING to detect protein-protein interaction, and GWAS databases to show its relationship with diseases. In addition, organs and tissues in which it is expressed were determined using the UniProt database. Results: The bioinformatic analysis yielded significant results, revealing that 189 miRNAs target HIF1α and exhibits close interactions with 10 genes, among which important genes like STAT3, MDM2, TP53, SMAD3, and VHL were identified. The most predominant pathway utilized by the HIF1α gene was determined to be the HIF-1 signaling pathway. A co-expression relationship was also established with proteins EPO, PLIN2, BNIP3, and the enzyme ENO1. Furthermore, it was ascertained that HIF1α exhibits the highest expression levels in the kidney and the perivenous region of the liver. Moreover, close associations have been established between HIF1α and diseases such as renal cell carcinoma and bladder cancer. Conclusion: Identifying the pathways associated with HIF1α, other genes, and epigenetic factors with the help of Bioinformatics Tools may enable experimental studies to be carried out with large cohorts and using a broad perspective. Thus, it may contribute to our understanding of how this gene affects diseases and anomalies and to accelerate the studies of targeted therapeutic treatment.
{"title":"Exploring the Interplay of Hypoxia-Inducible Factors: Unveiling Genetic Connections to Diseases Through Bioinformatics Analysis","authors":"Demet Kivanc Izgi, S. Oguz","doi":"10.36472/msd.v10i9.1030","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1030","url":null,"abstract":"Objective: Hypoxia-inducible factor (HIF) is a transcription factor that is effective in the ability of cells to sense and adapt to changes in oxygen levels. HIF1α gene is located in the 14q23.2 chromosome region and consists of 15 exons and 14 introns. It is a transcriptional regulator of metabolic processes such as angiogenesis and erythropoiesis and is required for immunological responses.\u0000Material and Methods: Our study examined the function of HIF1α and its relations with other genes and diseases using various bioinformatics database tools. GENEMANIA/GeneCard databases were used to detect the relationship of HIF gene with other genes, miRDB to show target miRNAs, STRING to detect protein-protein interaction, and GWAS databases to show its relationship with diseases. In addition, organs and tissues in which it is expressed were determined using the UniProt database.\u0000Results: The bioinformatic analysis yielded significant results, revealing that 189 miRNAs target HIF1α and exhibits close interactions with 10 genes, among which important genes like STAT3, MDM2, TP53, SMAD3, and VHL were identified. The most predominant pathway utilized by the HIF1α gene was determined to be the HIF-1 signaling pathway. A co-expression relationship was also established with proteins EPO, PLIN2, BNIP3, and the enzyme ENO1. Furthermore, it was ascertained that HIF1α exhibits the highest expression levels in the kidney and the perivenous region of the liver. Moreover, close associations have been established between HIF1α and diseases such as renal cell carcinoma and bladder cancer.\u0000Conclusion: Identifying the pathways associated with HIF1α, other genes, and epigenetic factors with the help of Bioinformatics Tools may enable experimental studies to be carried out with large cohorts and using a broad perspective. Thus, it may contribute to our understanding of how this gene affects diseases and anomalies and to accelerate the studies of targeted therapeutic treatment.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"172 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83375352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure employed to treat aortic valve disease in patients who are ineligible for open-heart surgery. Undergoing TAVR patients generally include the elderly and frail. Malnutrition is associated with high morbidity and mortality in patients with undergoing TAVR. The aim of this study was to investigate the prognostic value of the prognostic nutritional index (PNI) for two-year survival after TAVR. Material and Methods: A cohort of 213 consecutive patients with severe aortic stenosis who underwent transcatheter aortic valve replacement between March 2019 and July 2021. The study population was divided into two groups according to the cut-off PNI level in a receiver operator characteristic (ROC) curve analysis. The two-year follow-up results of the patients were recorded retrospectively. PNI was defined according to the following formula: PNI = (10 x serum albumin [g/dl]) + (0.005 x total lymphocyte counts [1000/mcL]). Results: Mean age of the patients was 76.15, and 93 (43.7%) of them were males. Patients with low PNI (group 1) were significantly older. The mean PNI of group 1 was 43.17 ± 4.04 and the mean PNI of group 2 was 54.23 ± 4.30. Mortality at two-year was 32.6% in low PNI group and 10.7% in high PNI group. Hypertension and PNI were independent predictors of mortality after TAVR. In ROC curve analysis, PNI at a cut off value of 48.325 predicted the mortality after TAVR with 63.5% sensitivity and 70.1% specificity. Kaplan-Meier curves for two-year mortality between low and high PNI groups showed worse outcomes in patients with low PNI. Conclusion: PNI is a practical and useful nutritional index that predicts two-year mortality after TAVR.
{"title":"The Prognostic Nutritional Index in prediction of two-year mortality in patients undergoing Transcatheter Aortic Valve Replacement","authors":"M. O. Ozilhan, S. K. Açıkgöz","doi":"10.36472/msd.v10i9.1029","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1029","url":null,"abstract":"Objective: Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure employed to treat aortic valve disease in patients who are ineligible for open-heart surgery. Undergoing TAVR patients generally include the elderly and frail. Malnutrition is associated with high morbidity and mortality in patients with undergoing TAVR. The aim of this study was to investigate the prognostic value of the prognostic nutritional index (PNI) for two-year survival after TAVR.\u0000Material and Methods: A cohort of 213 consecutive patients with severe aortic stenosis who underwent transcatheter aortic valve replacement between March 2019 and July 2021. The study population was divided into two groups according to the cut-off PNI level in a receiver operator characteristic (ROC) curve analysis. The two-year follow-up results of the patients were recorded retrospectively. PNI was defined according to the following formula: PNI = (10 x serum albumin [g/dl]) + (0.005 x total lymphocyte counts [1000/mcL]).\u0000Results: Mean age of the patients was 76.15, and 93 (43.7%) of them were males. Patients with low PNI (group 1) were significantly older. The mean PNI of group 1 was 43.17 ± 4.04 and the mean PNI of group 2 was 54.23 ± 4.30. Mortality at two-year was 32.6% in low PNI group and 10.7% in high PNI group. Hypertension and PNI were independent predictors of mortality after TAVR. In ROC curve analysis, PNI at a cut off value of 48.325 predicted the mortality after TAVR with 63.5% sensitivity and 70.1% specificity. Kaplan-Meier curves for two-year mortality between low and high PNI groups showed worse outcomes in patients with low PNI.\u0000Conclusion: PNI is a practical and useful nutritional index that predicts two-year mortality after TAVR.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"2675 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Korkmaz, Hatice Nur Turunç, Yıldırım Alpay Özarslan, Ümmühan İrem Yıldırım, Yusuf Büyükarmutçu, Serkan Dağlı, Barış Manavlı
Objective: The primary objective of this study was to measure medical students' knowledge, attitudes, and future professional intentions regarding HPV and its vaccines. This study aims to identify the factors that impact these variables within Turkey's distinctive sociocultural and healthcare landscapes. The insights derived from data analysis can be employed to guide focused educational interventions, aiming to enhance HPV vaccination rates and mitigate HPV-related health outcomes in Turkey. Material and Methods: Carried out between November and December 2022, this study employed a descriptive and comparative research design to evaluate HPV-related knowledge, attitudes, and intentions among 687 medical students enrolled in the Medical Faculty of Afyonkarahisar Health Sciences University. A comprehensive 20-question survey was administered, covering demographic details, HPV awareness, and attitudes towards vaccination, followed by statistical analysis. Results: The study population exhibited a mean age of 20.6 years and was predominantly female (60.1%). Overall, 91.6% of the participants were aware of HPV, primarily through their medical education (52.1%) and social media (42.3%). However, only 3.5% of the patients were vaccinated against HPV. Factors influencing vaccine uptake included having close contacts diagnosed with HPV or cervical cancer (p=0.001), gender (p=0.01 for females, p=0.02 for males), and prior HPV awareness (p=0.03). Significant misconceptions existed, notably regarding HPV's association with specific cancers and the vaccine's inclusion in the regular schedule. Conclusions: According to our study, medical students' attitudes and knowledge about HPV and HPV vaccination are critically important for future healthcare providers and policymakers. HPV-related cancers beyond cervical cancer are poorly understood, and vaccine counselling training is inadequate. Students who had been in close contact with HPV or cervical cancer exhibited a significantly higher likelihood of receiving the vaccine. It is crucial to formulate focused educational strategies that enhance HPV vaccine adherence and provide future medical professionals with the skills to educate patients effectively.
{"title":"Assessment of HPV Vaccine Knowledge Levels Among Medical Faculty Students: A Comprehensive Examination in the Turkish Context","authors":"D. Korkmaz, Hatice Nur Turunç, Yıldırım Alpay Özarslan, Ümmühan İrem Yıldırım, Yusuf Büyükarmutçu, Serkan Dağlı, Barış Manavlı","doi":"10.36472/msd.v10i9.1033","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1033","url":null,"abstract":"Objective: The primary objective of this study was to measure medical students' knowledge, attitudes, and future professional intentions regarding HPV and its vaccines. This study aims to identify the factors that impact these variables within Turkey's distinctive sociocultural and healthcare landscapes. The insights derived from data analysis can be employed to guide focused educational interventions, aiming to enhance HPV vaccination rates and mitigate HPV-related health outcomes in Turkey.\u0000Material and Methods: Carried out between November and December 2022, this study employed a descriptive and comparative research design to evaluate HPV-related knowledge, attitudes, and intentions among 687 medical students enrolled in the Medical Faculty of Afyonkarahisar Health Sciences University. A comprehensive 20-question survey was administered, covering demographic details, HPV awareness, and attitudes towards vaccination, followed by statistical analysis.\u0000Results: The study population exhibited a mean age of 20.6 years and was predominantly female (60.1%). Overall, 91.6% of the participants were aware of HPV, primarily through their medical education (52.1%) and social media (42.3%). However, only 3.5% of the patients were vaccinated against HPV. Factors influencing vaccine uptake included having close contacts diagnosed with HPV or cervical cancer (p=0.001), gender (p=0.01 for females, p=0.02 for males), and prior HPV awareness (p=0.03). Significant misconceptions existed, notably regarding HPV's association with specific cancers and the vaccine's inclusion in the regular schedule.\u0000Conclusions: According to our study, medical students' attitudes and knowledge about HPV and HPV vaccination are critically important for future healthcare providers and policymakers. HPV-related cancers beyond cervical cancer are poorly understood, and vaccine counselling training is inadequate. Students who had been in close contact with HPV or cervical cancer exhibited a significantly higher likelihood of receiving the vaccine. It is crucial to formulate focused educational strategies that enhance HPV vaccine adherence and provide future medical professionals with the skills to educate patients effectively.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81789047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Heavy metals threaten life by accumulating in the body via various sources as water,air and foods. Smoking is one of the important factors that causes this problem. Despite there is an abundant number of studies showing the detrimental effects of smoking on periodontal health, the mechanisms that cause these harmful effects is not clearly known yet. The main aim of our study is to discover whether heavy metal deposition on the tooth surface is related to the disease-causing potential of smoking. Materials and Method: Total of 80 individuals consist of 43 women and 37 men were included in this study. The participants were divided into 4 groups of 20 individuals each according to the results from clinical examination and anamnesis. Plaque index, gingival index, pocket depth, bleeding on probing and clinical attachment level were recorded clinically. The teeth indicated for extraction were collected. Cd, Pb, Ni, Cr and Fe depositions on teeth were measured by ICP-OES device. Kolmogorov-Smirnov, Student T, Mann Whitney U, One way ANOVA, Kruskal Wallis, Ki-Kare, Pearson, and Spearman tests were performed for the statistical analysis. Results: Smoking increases the accumulation of heavy metals such as Cd, Ni, Cr, and Pb. The Pb level was higher in both the smoking group and the periodontitis group, compared with the control group. Fe levels were found high in the non-smoking healthy group. Cr and Fe levels were found higher in women while Cd level was higher in men. Positive correlations were found between Pb and plaque index, gingival index, pocket depth and bleeding on probing; and also between Ni and plaque index. ( p=0.000, p=0.009, p=0.025, p=0.011, p=0.019) Conclusion: In conclusion, our study explored the connection between heavy metal deposition on tooth surfaces and the disease-causing potential of smoking. Smoking has been identified as a significant factor in the increased accumulation of heavy metals, including Cd, Ni, Cr, and Pb. The higher Pb levels seen in both the smoking and periodontitis groups, compared to the control group, suggest a potential link between Pb accumulation and periodontal health. Additionally, differences based on gender were observed, with women showing higher Cr and Fe levels, while Cd levels were more elevated in men. The positive correlations between Pb and various periodontal indices, along with the correlation between Ni and plaque index, shed light on the potential influence of heavy metal deposition on periodontal health. While our findings enhance our understanding of the interplay between smoking, heavy metal deposition, and oral health, further research is needed to fully comprehend the underlying mechanisms. Such insights could lead to interventions aimed at minimizing the adverse effects of heavy metal accumulation on oral health.
{"title":"Assessing the relationship between Tooth Heavy Metal Deposition and Periodontal Disease in Smokers and Non-Smokers","authors":"Meltem Başaran Acar, Meltem ZİHNİ KORKMAZ","doi":"10.36472/msd.v10i9.1028","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1028","url":null,"abstract":"Objective: Heavy metals threaten life by accumulating in the body via various sources as water,air and foods. Smoking is one of the important factors that causes this problem. Despite there is an abundant number of studies showing the detrimental effects of smoking on periodontal health, the mechanisms that cause these harmful effects is not clearly known yet. The main aim of our study is to discover whether heavy metal deposition on the tooth surface is related to the disease-causing potential of smoking.\u0000Materials and Method: Total of 80 individuals consist of 43 women and 37 men were included in this study. The participants were divided into 4 groups of 20 individuals each according to the results from clinical examination and anamnesis. Plaque index, gingival index, pocket depth, bleeding on probing and clinical attachment level were recorded clinically. The teeth indicated for extraction were collected. Cd, Pb, Ni, Cr and Fe depositions on teeth were measured by ICP-OES device. Kolmogorov-Smirnov, Student T, Mann Whitney U, One way ANOVA, Kruskal Wallis, Ki-Kare, Pearson, and Spearman tests were performed for the statistical analysis.\u0000Results: Smoking increases the accumulation of heavy metals such as Cd, Ni, Cr, and Pb. The Pb level was higher in both the smoking group and the periodontitis group, compared with the control group. Fe levels were found high in the non-smoking healthy group. Cr and Fe levels were found higher in women while Cd level was higher in men. Positive correlations were found between Pb and plaque index, gingival index, pocket depth and bleeding on probing; and also between Ni and plaque index. ( p=0.000, p=0.009, p=0.025, p=0.011, p=0.019)\u0000Conclusion: In conclusion, our study explored the connection between heavy metal deposition on tooth surfaces and the disease-causing potential of smoking. Smoking has been identified as a significant factor in the increased accumulation of heavy metals, including Cd, Ni, Cr, and Pb. The higher Pb levels seen in both the smoking and periodontitis groups, compared to the control group, suggest a potential link between Pb accumulation and periodontal health. Additionally, differences based on gender were observed, with women showing higher Cr and Fe levels, while Cd levels were more elevated in men. The positive correlations between Pb and various periodontal indices, along with the correlation between Ni and plaque index, shed light on the potential influence of heavy metal deposition on periodontal health. While our findings enhance our understanding of the interplay between smoking, heavy metal deposition, and oral health, further research is needed to fully comprehend the underlying mechanisms. Such insights could lead to interventions aimed at minimizing the adverse effects of heavy metal accumulation on oral health.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82141969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Our study aimed to investigate the levels of anti-Müllerian hormone (AMH) to determine ovarian reserve in women in intensive care units experiencing metabolic and physiological stress. Materials and Methods: For this purpose, 37 women were hospitalized in the intensive care unit (ICU) of Siirt Training and Research Hospital between November 2022 and February 2023. The same number of healthy control groups were included in the study. Patient selection was based on acute physiology and chronic health assessment (APACHI II) score and injury severity score (ISS).Anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) thyroid stimulating hormone (TSH), triiodothyronine (T3), tetraiodothyronine (T4), adrenocorticotropic hormone (ACTH), cortisol. , prolactin, C-reactive hormone (CRP) serum levels were examined Results: There was no significant difference in mean age between intensive care patients (29.3±8.3 , n=37) and control group (28.0±0.0, n=37) (p=0.349). A statistically significant difference was found between the AMH values between the patients hospitalized in the intensive care unit and the control group (p=0.012).AMH values were significantly lower in ICU patients. However, the T3 value was observed to be significantly lower in ICU patients compared to the control group (p < 0.0001). Additionally, prolactin, CRP, and cortisol values were found to be statistically significantly higher. Conclusion: This study revealed a significant decrease in anti-Müllerian hormone (AMH) levels among women experiencing metabolic and physiological stress in intensive care units. The lowered AMH levels suggest a potential impact on ovarian reserve in such conditions. Additionally, the observation of reduced T3 levels in ICU patients could indicate thyroid function alterations during times of stress. The elevated prolactin, CRP, and cortisol levels further underscore the physiological disruptions experienced by ICU patients. These findings emphasize the importance of considering hormonal and metabolic changes in critically ill women, particularly in relation to their ovarian health. Further research is warranted to elucidate the intricate mechanisms underlying these hormonal alterations and their potential long-term implications.
{"title":"The relationship between metabolic stress and Anti- Müllerian hormone (AMH) in women hospitalized in intensive care units","authors":"Ş. Aksin, Mehmet Yılmaz","doi":"10.36472/msd.v10i9.1032","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1032","url":null,"abstract":"Objective: Our study aimed to investigate the levels of anti-Müllerian hormone (AMH) to determine ovarian reserve in women in intensive care units experiencing metabolic and physiological stress.\u0000Materials and Methods: For this purpose, 37 women were hospitalized in the intensive care unit (ICU) of Siirt Training and Research Hospital between November 2022 and February 2023. The same number of healthy control groups were included in the study. Patient selection was based on acute physiology and chronic health assessment (APACHI II) score and injury severity score (ISS).Anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) thyroid stimulating hormone (TSH), triiodothyronine (T3), tetraiodothyronine (T4), adrenocorticotropic hormone (ACTH), cortisol. , prolactin, C-reactive hormone (CRP) serum levels were examined\u0000Results: There was no significant difference in mean age between intensive care patients (29.3±8.3 , n=37) and control group (28.0±0.0, n=37) (p=0.349). A statistically significant difference was found between the AMH values between the patients hospitalized in the intensive care unit and the control group (p=0.012).AMH values were significantly lower in ICU patients. However, the T3 value was observed to be significantly lower in ICU patients compared to the control group (p < 0.0001). Additionally, prolactin, CRP, and cortisol values were found to be statistically significantly higher.\u0000Conclusion: This study revealed a significant decrease in anti-Müllerian hormone (AMH) levels among women experiencing metabolic and physiological stress in intensive care units. The lowered AMH levels suggest a potential impact on ovarian reserve in such conditions. Additionally, the observation of reduced T3 levels in ICU patients could indicate thyroid function alterations during times of stress. The elevated prolactin, CRP, and cortisol levels further underscore the physiological disruptions experienced by ICU patients. These findings emphasize the importance of considering hormonal and metabolic changes in critically ill women, particularly in relation to their ovarian health. Further research is warranted to elucidate the intricate mechanisms underlying these hormonal alterations and their potential long-term implications.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76931450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kılıç, Melih Yüksel, Musa Şahin, A. Oto, S. Eraybar, V. Durak, Sümeyye Tuğba Sarkı Cander
Objective: Electric scooters are a new form of inner-city transportation, which is considered to be an accessible, affordable, and popular option within society. Aims: This study aimed to describe the demographic and clinical characteristics of individuals involved in electric scooter accidents and the factors associated with these incidents. Methods: We conducted a prospective observational study of individuals involved in electric scooter crashes presented to the emergency department of four hospitals in Bursa/Turkey. Those hospitals were divided into two groups as Impoverished Region (IR) and Wealthy Region (WR). Sixty-two individuals who sustained ESA and were admitted to the ED of the four hospitals involved in our study from the start date 11/08/2022 till the end date of 11/012/2022. Results: A total number of 62 patients (24 females, 38 males) sustained electric scooter related injuries. The most commonly seen injury patterns were abrasion (n=42, 67.7%), soft tissue injury (n=27, 43.5%), and bone fracture (n=11, 17.7%), respectively. The lower and upper limbs and head injuries were the most commonly seen injury sites. Injury of the head (p=0.000), injury of the lower extremity (p=0.0230), injury of the upper extremity (p=0.004), and injury of trunk (p=0.008), were significantly associated with multiple injuries. Loss of balance was the most frequent ESA cause (n=43, 69.4%) followed by a hit to a stable object (n=11, 17.7%) Conclusions: Our study revealed that electric scooter accidents occurred in the initial moments of driving in low-income regions of the city compared to the wealthy areas. Head/neck injuries are more likely to occur in children in those cases
{"title":"The Investigation of Electric Scooter Accident Cases Admitted to the Emergency Department: A Multicenter Study","authors":"S. Kılıç, Melih Yüksel, Musa Şahin, A. Oto, S. Eraybar, V. Durak, Sümeyye Tuğba Sarkı Cander","doi":"10.36472/msd.v10i8.1026","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1026","url":null,"abstract":"Objective: Electric scooters are a new form of inner-city transportation, which is considered to be an accessible, affordable, and popular option within society.\u0000Aims: This study aimed to describe the demographic and clinical characteristics of individuals involved in electric scooter accidents and the factors associated with these incidents.\u0000Methods: We conducted a prospective observational study of individuals involved in electric scooter crashes presented to the emergency department of four hospitals in Bursa/Turkey. Those hospitals were divided into two groups as Impoverished Region (IR) and Wealthy Region (WR). Sixty-two individuals who sustained ESA and were admitted to the ED of the four hospitals involved in our study from the start date 11/08/2022 till the end date of 11/012/2022.\u0000Results: A total number of 62 patients (24 females, 38 males) sustained electric scooter related injuries. The most commonly seen injury patterns were abrasion (n=42, 67.7%), soft tissue injury (n=27, 43.5%), and bone fracture (n=11, 17.7%), respectively. The lower and upper limbs and head injuries were the most commonly seen injury sites. Injury of the head (p=0.000), injury of the lower extremity (p=0.0230), injury of the upper extremity (p=0.004), and injury of trunk (p=0.008), were significantly associated with multiple injuries. Loss of balance was the most frequent ESA cause (n=43, 69.4%) followed by a hit to a stable object (n=11, 17.7%)\u0000Conclusions: Our study revealed that electric scooter accidents occurred in the initial moments of driving in low-income regions of the city compared to the wealthy areas. Head/neck injuries are more likely to occur in children in those cases","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78530669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to evaluate the perfusion in the affected brain lobes with radionuclide imaging in patients with dementia and to contribute to the literature by determining the relationship between the degree of dementia. Methods: In this retrospective study, 44 adult patients were included. The mean age of the patients was 73 (57-87). Twenty-three (52.3%) of these were female. All patients underwent mini-mental state test, neurological examinations and radionuclide brain perfusion imaging. The areas of interest of the frontal, parietal, temporal, and occipital lobes and the cerebellum were drawn, respectively, and the cerebellum ratios of the relevant lobes were compared. In this way, brain perfusion index values of lobes were obtained. Results: Brain perfusion in group 1 was higher than in other groups. Groups were also compared in pairs. There was no significant difference in perfusion values in the occipital lobe. There was a significant difference in perfusion between groups 1 and 2 in lobes other than the occipital lobe. This was also the case for Groups 1 and 3. When group 2 with early dementia symptoms, and group 3 with moderate dementia were compared, there was a significant difference between the perfusion values of only the right and left frontal lobes. Conclusion: Early diagnosis is very important in progressive dementia. Clinical tests are successfully applied to categorize patients. Evaluation of brain perfusion and metabolism with functional radionuclide imaging is significant in guiding the treatment and evaluating the success of the treatment.
{"title":"Evaluation of Brain Perfusion with Radionuclide Imaging in Dementia Patients","authors":"S. Ceylan","doi":"10.36472/msd.v10i8.1019","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1019","url":null,"abstract":"Objective: This study aims to evaluate the perfusion in the affected brain lobes with radionuclide imaging in patients with dementia and to contribute to the literature by determining the relationship between the degree of dementia.\u0000Methods: In this retrospective study, 44 adult patients were included. The mean age of the patients was 73 (57-87). Twenty-three (52.3%) of these were female. All patients underwent mini-mental state test, neurological examinations and radionuclide brain perfusion imaging. The areas of interest of the frontal, parietal, temporal, and occipital lobes and the cerebellum were drawn, respectively, and the cerebellum ratios of the relevant lobes were compared. In this way, brain perfusion index values of lobes were obtained.\u0000Results: Brain perfusion in group 1 was higher than in other groups. Groups were also compared in pairs. There was no significant difference in perfusion values in the occipital lobe. There was a significant difference in perfusion between groups 1 and 2 in lobes other than the occipital lobe. This was also the case for Groups 1 and 3. When group 2 with early dementia symptoms, and group 3 with moderate dementia were compared, there was a significant difference between the perfusion values of only the right and left frontal lobes.\u0000Conclusion: Early diagnosis is very important in progressive dementia. Clinical tests are successfully applied to categorize patients. Evaluation of brain perfusion and metabolism with functional radionuclide imaging is significant in guiding the treatment and evaluating the success of the treatment.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87368537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pelin Ilhan, Ali Sarıdaş, Seyma Trabzon, M. Olt, Havva Sert
Objective: Our aim was to compare emergency department visits among homeless patients before and during the COVID-19 pandemic. Material and Methods: We retrospectively examined data from homeless patients who visited a city hospital's emergency department in Istanbul between March 11, 2018, and March 10, 2022. The study included patients over 18 years old who were registered in the hospital's automation system as "homeless" or "living on the street," and who had sought social service support. Descriptive statistics, Student's t-test, Mann-Whitney U test, chi-squared test, Fisher's exact chi-squared test, Fisher-Freeman-Halton exact chi-squared test, and Yates continuity correction test were utilized for data analysis. Results: The study encompassed a total of 105 homeless patients, with 85 (81%) being male and aged between 18 and 88 years. The mean age was 44.54±16.25 years. Of the patients, 21.9% visited the emergency department before the pandemic, and 78.1% visited during the pandemic. Among homeless patients suspected of COVID-19, 20% who visited the emergency department tested positive for the polymerase chain reaction (PCR) test. Conclusion: Our findings indicate an increase in the number of homeless patients seeking care in the emergency department during the COVID-19 pandemic
{"title":"Has the COVID-19 Pandemic Affected Homeless Patients Visiting the Emergency Department?","authors":"Pelin Ilhan, Ali Sarıdaş, Seyma Trabzon, M. Olt, Havva Sert","doi":"10.36472/msd.v10i8.1003","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1003","url":null,"abstract":"Objective: Our aim was to compare emergency department visits among homeless patients before and during the COVID-19 pandemic.\u0000Material and Methods: We retrospectively examined data from homeless patients who visited a city hospital's emergency department in Istanbul between March 11, 2018, and March 10, 2022. The study included patients over 18 years old who were registered in the hospital's automation system as \"homeless\" or \"living on the street,\" and who had sought social service support. Descriptive statistics, Student's t-test, Mann-Whitney U test, chi-squared test, Fisher's exact chi-squared test, Fisher-Freeman-Halton exact chi-squared test, and Yates continuity correction test were utilized for data analysis.\u0000Results: The study encompassed a total of 105 homeless patients, with 85 (81%) being male and aged between 18 and 88 years. The mean age was 44.54±16.25 years. Of the patients, 21.9% visited the emergency department before the pandemic, and 78.1% visited during the pandemic. Among homeless patients suspected of COVID-19, 20% who visited the emergency department tested positive for the polymerase chain reaction (PCR) test.\u0000Conclusion: Our findings indicate an increase in the number of homeless patients seeking care in the emergency department during the COVID-19 pandemic","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77291473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this study, we aimed to determine whether hematologic parameters have an effect on the post-operative outcomes in patients operated for lumbar disc herniation. Material and Methods: The study was conducted in the retrospective cohort design in the Department of Neurosurgery of Ankara Güven Hospital and included patients who were hospitalized and treated with the diagnosis of Lumbar Disc Herniation (LDH) between 01.01.2019 and 31.12.2020. Patients' pre-operative hematologic parameters, which were routinely studied preoperatively, and Visual Analogue Scale (VAS) scoring records, which were routinely used to monitor pain levels, were retrospectively reviewed, and the outpatient clinic notes of the patients within 6 months post-operatively were evaluated. Results: Among 117 patients hospitalized with LDH over a 1-year period, 87 patients were included in the study. 30 LDH patients, owning factors that may affect wound healing and platelet function (active infection/diabetes mellitus, antiaggregants/anticoagulants) were excluded. When Hb was examined from the pre-operative hematological parameters, anemia was detected in 6 (7%) of 87 patients; however, it had no significant effects on VAS scores and surgical outcomes (p>0.05). Pre-operative Neutrophil-to-Lymphocyte Ratio (NLR) was elevated in 17 (20%) of the 87 patients, and the VAS score of these patients was found to be 1.5-fold higher than normal patients (p=0.031). Post-operative complications (infection, hemorrhage and cerebrospinal fluid fistula) were detected in 5 (6%) of the 87 patients who underwent surgery, and it was found that the pre-operative NLR values were high in these 5 patients. It was also found that high NLR increased the risk of post-operative complications 1.4-fold in patients (p=0.002). No results could be obtained regarding the platelet values because this parameter was within the normal range preoperatively in all patients. Conclusion: In the present study, the effects of hematological parameters on lumbar disc surgery were investigated, and it was concluded that elevated NLR values increased wound site infection among post-operative complications and VAS scores.
{"title":"Association of Hematologic Parameters with Post-operative Outcomes in Patients Undergoing Lumbar Disc Herniation Surgery","authors":"T. Bulduk, Yiğit Aksoğan","doi":"10.36472/msd.v10i8.1025","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1025","url":null,"abstract":"Objective: In this study, we aimed to determine whether hematologic parameters have an effect on the post-operative outcomes in patients operated for lumbar disc herniation.\u0000Material and Methods: The study was conducted in the retrospective cohort design in the Department of Neurosurgery of Ankara Güven Hospital and included patients who were hospitalized and treated with the diagnosis of Lumbar Disc Herniation (LDH) between 01.01.2019 and 31.12.2020. Patients' pre-operative hematologic parameters, which were routinely studied preoperatively, and Visual Analogue Scale (VAS) scoring records, which were routinely used to monitor pain levels, were retrospectively reviewed, and the outpatient clinic notes of the patients within 6 months post-operatively were evaluated.\u0000Results: Among 117 patients hospitalized with LDH over a 1-year period, 87 patients were included in the study. 30 LDH patients, owning factors that may affect wound healing and platelet function (active infection/diabetes mellitus, antiaggregants/anticoagulants) were excluded. When Hb was examined from the pre-operative hematological parameters, anemia was detected in 6 (7%) of 87 patients; however, it had no significant effects on VAS scores and surgical outcomes (p>0.05). Pre-operative Neutrophil-to-Lymphocyte Ratio (NLR) was elevated in 17 (20%) of the 87 patients, and the VAS score of these patients was found to be 1.5-fold higher than normal patients (p=0.031). Post-operative complications (infection, hemorrhage and cerebrospinal fluid fistula) were detected in 5 (6%) of the 87 patients who underwent surgery, and it was found that the pre-operative NLR values were high in these 5 patients. It was also found that high NLR increased the risk of post-operative complications 1.4-fold in patients (p=0.002). No results could be obtained regarding the platelet values because this parameter was within the normal range preoperatively in all patients.\u0000Conclusion: In the present study, the effects of hematological parameters on lumbar disc surgery were investigated, and it was concluded that elevated NLR values increased wound site infection among post-operative complications and VAS scores.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86765280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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