Pub Date : 2023-10-04DOI: 10.36472/msd.v10i10.1044
Çağdaş Erdoğan, İbrahim Ethem Güven, Batuhan Başpınar, Zeki Mesut Yalın Kılıç
Objective: Irritable bowel syndrome (IBS) is a chronic, functional disorder of the gastrointestinal tract. Recent investigations have highlighted the potential involvement of inflammation, although the etiology of IBS remains unknown. This study aims to assess the connection between IBS and Monocyte/High-Density Lipoprotein (HDL) ratio (MHR), a new inflammatory marker. Material and Method: The study was conducted in the outpatient gastroenterology unit of a tertiary center between March-2021 and March-2022. Patients with IBS, according to the Rome IV criteria were examined retrospectively. Age- and sex-matched healthy controls were used to compute MHR and compare the results. Results: A total of 255 participants, 155 diagnosed with IBS and 100 in the control group, were included. The median (min-max) monocyte counts (cells/mm³) in the IBS and control groups were 380.0 (310.0-460.0) and 332.0 (232.0-449.3), respectively (p = 0.008). The median(min-max) HDL levels(mg/dl) in IBS and control groups were 45.0(36.0-55.0) and 49.0(43.0-57.0), respectively(p=0.001). The median MHR was higher in the IBS group (9.5) compared to healthy controls (6.73, p<0.001). Logistic regression analysis revealed MHR as an independent predictor of the presence of IBS (OR: 1.406, 95% CI: [insert confidence interval]). The cut-off value for MHR to detect IBS with 62.6% sensitivity and 63.0% specificity was 7.57, and ROC analysis revealed an AUROC value of 0.646 (95% CI: 0.577-0.715, p<0.001). Discussion: The study's primary findings were that IBS patients had significantly lower levels of HDL cholesterol and significantly higher levels of monocyte counts when compared to the control group. Consequently, monocyte/HDL ratios (MHR) were statistically substantially greater in IBS patients than in the control group. Furthermore, when the cut-off value was set at 7.6, MHR was found to be an independent predictor for IBS, with 62.6% sensitivity and 63.0% specificity. Conclusion: MHR can be a simple, inexpensive, and effective tool to demonstrate the inflammatory state in patients with IBS.
{"title":"Monocyte/High-Density Lipoprotein Ratio as an Inflammatory Marker in Patients with Irritable Bowel Syndrome","authors":"Çağdaş Erdoğan, İbrahim Ethem Güven, Batuhan Başpınar, Zeki Mesut Yalın Kılıç","doi":"10.36472/msd.v10i10.1044","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1044","url":null,"abstract":"Objective: Irritable bowel syndrome (IBS) is a chronic, functional disorder of the gastrointestinal tract. Recent investigations have highlighted the potential involvement of inflammation, although the etiology of IBS remains unknown. This study aims to assess the connection between IBS and Monocyte/High-Density Lipoprotein (HDL) ratio (MHR), a new inflammatory marker. Material and Method: The study was conducted in the outpatient gastroenterology unit of a tertiary center between March-2021 and March-2022. Patients with IBS, according to the Rome IV criteria were examined retrospectively. Age- and sex-matched healthy controls were used to compute MHR and compare the results. Results: A total of 255 participants, 155 diagnosed with IBS and 100 in the control group, were included. The median (min-max) monocyte counts (cells/mm³) in the IBS and control groups were 380.0 (310.0-460.0) and 332.0 (232.0-449.3), respectively (p = 0.008). The median(min-max) HDL levels(mg/dl) in IBS and control groups were 45.0(36.0-55.0) and 49.0(43.0-57.0), respectively(p=0.001). The median MHR was higher in the IBS group (9.5) compared to healthy controls (6.73, p<0.001). Logistic regression analysis revealed MHR as an independent predictor of the presence of IBS (OR: 1.406, 95% CI: [insert confidence interval]). The cut-off value for MHR to detect IBS with 62.6% sensitivity and 63.0% specificity was 7.57, and ROC analysis revealed an AUROC value of 0.646 (95% CI: 0.577-0.715, p<0.001). Discussion: The study's primary findings were that IBS patients had significantly lower levels of HDL cholesterol and significantly higher levels of monocyte counts when compared to the control group. Consequently, monocyte/HDL ratios (MHR) were statistically substantially greater in IBS patients than in the control group. Furthermore, when the cut-off value was set at 7.6, MHR was found to be an independent predictor for IBS, with 62.6% sensitivity and 63.0% specificity. Conclusion: MHR can be a simple, inexpensive, and effective tool to demonstrate the inflammatory state in patients with IBS.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135549283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.36472/msd.v10i10.1037
Seerwan Hamadameen Sulaiman, Halit Demir
Objective: Langerhans cell histiocytosis (LCH) stands as the most common histiocytic disorder. It is categorized into single-system single site, single-system multi-site, and multisystem types, with or without involvement of risk organs. Clinical presentation exhibits considerable variability, contingent upon the affected organ systems. Given its rarity, diverse locations, and varying severity, there are currently no established treatment guidelines for LCH. Case Presentation: We documented the case of a 5-month-old male diagnosed with Langerhans cell histiocytosis (LCH), presenting with high-risk multisystem organ involvement and concurrent unifocal bone involvement. Bone marrow aspiration revealed infiltration by multinucleated giant cells within the marrow. Skin biopsy demonstrated Langerhans cell proliferation with epidermotrophism and the characteristic reniform nucleus resembling a coffee bean. The patient was treated following the histiocytosis protocol, which included daily oral prednisone and 6-mercaptopurine, in addition to weekly intravenous vinblastine and methotrexate administered every two weeks. Unfortunately, the patient displayed limited response during the initial phase of treatment and, tragically, passed away during the eighth week of therapy. Conclusion: Langerhans cell histiocytosis (LCH) is a rare disease characterized by variable disease presentations and is associated with significant morbidity and mortality. Timely recognition of clinical manifestations and risk factors, coupled with appropriate treatment, is crucial to reduce mortality and long-term complications associated with the condition.
{"title":"A rare case of high risk multisystem Langerhans Cell Histiocytosis in infant","authors":"Seerwan Hamadameen Sulaiman, Halit Demir","doi":"10.36472/msd.v10i10.1037","DOIUrl":"https://doi.org/10.36472/msd.v10i10.1037","url":null,"abstract":"Objective: Langerhans cell histiocytosis (LCH) stands as the most common histiocytic disorder. It is categorized into single-system single site, single-system multi-site, and multisystem types, with or without involvement of risk organs. Clinical presentation exhibits considerable variability, contingent upon the affected organ systems. Given its rarity, diverse locations, and varying severity, there are currently no established treatment guidelines for LCH. Case Presentation: We documented the case of a 5-month-old male diagnosed with Langerhans cell histiocytosis (LCH), presenting with high-risk multisystem organ involvement and concurrent unifocal bone involvement. Bone marrow aspiration revealed infiltration by multinucleated giant cells within the marrow. Skin biopsy demonstrated Langerhans cell proliferation with epidermotrophism and the characteristic reniform nucleus resembling a coffee bean. The patient was treated following the histiocytosis protocol, which included daily oral prednisone and 6-mercaptopurine, in addition to weekly intravenous vinblastine and methotrexate administered every two weeks. Unfortunately, the patient displayed limited response during the initial phase of treatment and, tragically, passed away during the eighth week of therapy. Conclusion: Langerhans cell histiocytosis (LCH) is a rare disease characterized by variable disease presentations and is associated with significant morbidity and mortality. Timely recognition of clinical manifestations and risk factors, coupled with appropriate treatment, is crucial to reduce mortality and long-term complications associated with the condition.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135689485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
None Audrey, Kadek Ayu Yani Lastariana, Anak Agung Ngurah Ketut Putra Widnyana, Ketut Ariawati
Objective: Langerhans cell histiocytosis (LCH) stands as the most common histiocytic disorder. It is categorized into single-system single site, single-system multi-site, and multisystem types, with or without involvement of risk organs. Clinical presentation exhibits considerable variability, contingent upon the affected organ systems. Given its rarity, diverse locations, and varying severity, there are currently no established treatment guidelines for LCH. Case Presentation: We documented the case of a 5-month-old male diagnosed with Langerhans cell histiocytosis (LCH), presenting with high-risk multisystem organ involvement and concurrent unifocal bone involvement. Bone marrow aspiration revealed infiltration by multinucleated giant cells within the marrow. Skin biopsy demonstrated Langerhans cell proliferation with epidermotrophism and the characteristic reniform nucleus resembling a coffee bean. The patient was treated following the histiocytosis protocol, which included daily oral prednisone and 6-mercaptopurine, in addition to weekly intravenous vinblastine and methotrexate administered every two weeks. Unfortunately, the patient displayed limited response during the initial phase of treatment and, tragically, passed away during the eighth week of therapy. Conclusion: Langerhans cell histiocytosis (LCH) is a rare disease characterized by variable disease presentations and is associated with significant morbidity and mortality. Timely recognition of clinical manifestations and risk factors, coupled with appropriate treatment, is crucial to reduce mortality and long-term complications associated with the condition.
{"title":"A rare case of high risk multisystem Langerhans Cell Histiocytosis in infant","authors":"None Audrey, Kadek Ayu Yani Lastariana, Anak Agung Ngurah Ketut Putra Widnyana, Ketut Ariawati","doi":"10.36472/msd.v10i9.1040","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1040","url":null,"abstract":"Objective: Langerhans cell histiocytosis (LCH) stands as the most common histiocytic disorder. It is categorized into single-system single site, single-system multi-site, and multisystem types, with or without involvement of risk organs. Clinical presentation exhibits considerable variability, contingent upon the affected organ systems. Given its rarity, diverse locations, and varying severity, there are currently no established treatment guidelines for LCH. Case Presentation: We documented the case of a 5-month-old male diagnosed with Langerhans cell histiocytosis (LCH), presenting with high-risk multisystem organ involvement and concurrent unifocal bone involvement. Bone marrow aspiration revealed infiltration by multinucleated giant cells within the marrow. Skin biopsy demonstrated Langerhans cell proliferation with epidermotrophism and the characteristic reniform nucleus resembling a coffee bean. The patient was treated following the histiocytosis protocol, which included daily oral prednisone and 6-mercaptopurine, in addition to weekly intravenous vinblastine and methotrexate administered every two weeks. Unfortunately, the patient displayed limited response during the initial phase of treatment and, tragically, passed away during the eighth week of therapy. Conclusion: Langerhans cell histiocytosis (LCH) is a rare disease characterized by variable disease presentations and is associated with significant morbidity and mortality. Timely recognition of clinical manifestations and risk factors, coupled with appropriate treatment, is crucial to reduce mortality and long-term complications associated with the condition.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to examine the demographic and epidemiological characteristics of forensic cases arriving at the emergency department of a tertiary-care hospital in Turkey. The objectives include profiling the demographics of the cases, documenting the types of injuries, understanding the circumstances surrounding these incidents, and identifying any potential seasonal or temporal trends. Material and Methods: We conducted a retrospective cross-sectional study, utilizing data from 9,427 forensic cases that were presented to the emergency department from January 1 to December 31, 2008. Data were extracted from the hospital's electronic medical records after obtaining the necessary ethical approvals. The inclusion criteria encompassed all age groups for trauma-related cases, while medical forensic cases were limited to subjects aged 16 and above. Cases with incomplete data were excluded from the analysis. The cases were categorized into nine subgroups based on the type of incident, following the classification system of the International Classification of Diseases, 10th Revision (ICD-10). Results: Forensic cases accounted for 3.107% of all emergency department admissions. The majority of these cases were males (68.83%), and they were primarily associated with trauma (86.80%). A significant gender disparity was observed in the types of cases, with males being more prevalent in traumatic cases, while females were more commonly seen in non-traumatic cases. Seasonal patterns revealed a higher incidence of forensic cases during the summer months. Interestingly, there was an uptick in female suicide attempts during the summer, whereas male suicide attempts saw an increase during the winter. Conclusion: This study provides valuable insights into the demographic and seasonal distribution of forensic cases in emergency settings. The findings underscore the importance of implementing targeted preventive measures and specialized healthcare protocols, especially in light of the high occurrence of trauma-related cases and seasonal trends. Future research endeavors should delve deeper into understanding the sociocultural and behavioral factors that contribute to these observed patterns.
{"title":"Demographic Evaluation of Forensic Cases Presented to the Emergency Medicine Clinic of a Tertiary Care Hospital","authors":"Feruza Turan Sönmez, Umut Yücel Çavuş","doi":"10.36472/msd.v10i9.1046","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1046","url":null,"abstract":"Objective: This study aims to examine the demographic and epidemiological characteristics of forensic cases arriving at the emergency department of a tertiary-care hospital in Turkey. The objectives include profiling the demographics of the cases, documenting the types of injuries, understanding the circumstances surrounding these incidents, and identifying any potential seasonal or temporal trends. Material and Methods: We conducted a retrospective cross-sectional study, utilizing data from 9,427 forensic cases that were presented to the emergency department from January 1 to December 31, 2008. Data were extracted from the hospital's electronic medical records after obtaining the necessary ethical approvals. The inclusion criteria encompassed all age groups for trauma-related cases, while medical forensic cases were limited to subjects aged 16 and above. Cases with incomplete data were excluded from the analysis. The cases were categorized into nine subgroups based on the type of incident, following the classification system of the International Classification of Diseases, 10th Revision (ICD-10). Results: Forensic cases accounted for 3.107% of all emergency department admissions. The majority of these cases were males (68.83%), and they were primarily associated with trauma (86.80%). A significant gender disparity was observed in the types of cases, with males being more prevalent in traumatic cases, while females were more commonly seen in non-traumatic cases. Seasonal patterns revealed a higher incidence of forensic cases during the summer months. Interestingly, there was an uptick in female suicide attempts during the summer, whereas male suicide attempts saw an increase during the winter. Conclusion: This study provides valuable insights into the demographic and seasonal distribution of forensic cases in emergency settings. The findings underscore the importance of implementing targeted preventive measures and specialized healthcare protocols, especially in light of the high occurrence of trauma-related cases and seasonal trends. Future research endeavors should delve deeper into understanding the sociocultural and behavioral factors that contribute to these observed patterns.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to investigate the effect of hematologic parameters including International Normalized Ratio (INR), platelet (Plt), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), leukocyte, neutrophil, lymphocyte, C-Reactive Protein (CRP) on the outcomes of surgical treatment of acute subdural hematoma.
Material and Methods: The file data of 31 cases who were operated on with the diagnosis of Acute Subdural Hematoma (ASDH) at the Private Ankara Güven Hospital Neurosurgery Clinic between 01.01.2019 and 31.12.2021 were examined retrospectively. The ages, genders, history of anticoagulant/antiaggregant use, INR, platelet, hemoglobin, hematocrit, leukocyte, and CRP values of patients were recorded, and their relationships with re-bleeding, number of surgeries performed, and mortality were evaluated statistically.
Results: The study was conducted with a total of 31 cases (35.5% (n=11) female and 64.5% (n=20) male). The average age of the cases was 72 (45-93). A single surgery was performed in 23 cases (74.2%), 8 patients (25.8%) were operated on again because of re-bleeding, and 9 of the cases (29%) died following the surgery. Among the 9 patients who died, 5 (55.5%) underwent single surgery and 4 (44.5%) underwent more than one surgery. The number of cases not using pre-operative anticoagulants/antiaggregants was 10 (32.3%), 9 (29%) patients were using anticoagulants, 7 patients (22.6%) were using single antiaggregant, and 5 patients (16.1%) were using dual antiaggregants. It was detected as statistically significant that the preoperative INR, leukocyte, and neutrophil counts of the patients who underwent multiple surgeries were detected to be higher than those of ASDH patients who underwent single surgery.
Conclusion: Although pre-operative INR, leukocyte, and neutrophil elevation are not associated with mortality, these parameters can be associated with the requirement for re-surgery because of re-bleeding.
Key words: re-bleeding, subdural hematoma, mortality, leukocyte, neutrophil
{"title":"The effects of hematological parameters and anticoagulant/antiaggregant use on surgical outcomes in acute subdural hematoma","authors":"Tuba Bulduk, Havva Nur Karaaslan","doi":"10.36472/msd.v10i9.1043","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1043","url":null,"abstract":"Objective: This study aims to investigate the effect of hematologic parameters including International Normalized Ratio (INR), platelet (Plt), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), leukocyte, neutrophil, lymphocyte, C-Reactive Protein (CRP) on the outcomes of surgical treatment of acute subdural hematoma.
 Material and Methods: The file data of 31 cases who were operated on with the diagnosis of Acute Subdural Hematoma (ASDH) at the Private Ankara Güven Hospital Neurosurgery Clinic between 01.01.2019 and 31.12.2021 were examined retrospectively. The ages, genders, history of anticoagulant/antiaggregant use, INR, platelet, hemoglobin, hematocrit, leukocyte, and CRP values of patients were recorded, and their relationships with re-bleeding, number of surgeries performed, and mortality were evaluated statistically.
 Results: The study was conducted with a total of 31 cases (35.5% (n=11) female and 64.5% (n=20) male). The average age of the cases was 72 (45-93). A single surgery was performed in 23 cases (74.2%), 8 patients (25.8%) were operated on again because of re-bleeding, and 9 of the cases (29%) died following the surgery. Among the 9 patients who died, 5 (55.5%) underwent single surgery and 4 (44.5%) underwent more than one surgery. The number of cases not using pre-operative anticoagulants/antiaggregants was 10 (32.3%), 9 (29%) patients were using anticoagulants, 7 patients (22.6%) were using single antiaggregant, and 5 patients (16.1%) were using dual antiaggregants. It was detected as statistically significant that the preoperative INR, leukocyte, and neutrophil counts of the patients who underwent multiple surgeries were detected to be higher than those of ASDH patients who underwent single surgery.
 Conclusion: Although pre-operative INR, leukocyte, and neutrophil elevation are not associated with mortality, these parameters can be associated with the requirement for re-surgery because of re-bleeding.
 Key words: re-bleeding, subdural hematoma, mortality, leukocyte, neutrophil","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Leptin, a 16 kDa hormone encoded by the obese (Ob) gene, is known for its role in regulating food intake, body composition, and energy expenditure. Leptin receptor expression has been demonstrated in several tissues, including the small intestine. Weight gain may occur in humans after menopause or in animals following ovariectomy. Estrogen affects leptin and leptin receptor expressions. In this study, we aimed to contribute to the etiology of obesity by investigating the effects of E2 on leptin receptors in the small intestines of ovariectomized rats as a model of postmenopausal conditions. Materials and Methods: Bilateral ovariectomy was performed on 6-month-old Sprague-Dawley female rats. Ovariectomized rats (Ovx) were injected with 0.2 ml of sesame oil/rat/day or E2 (25 µg/rat/day) and euthanized at the 18th, 90th, or 162nd hours. Duodenum, jejunum, and ileum samples were fixed and embedded in paraffin using standard methods. The expression of leptin receptors were detected in the small intestine through immunohistochemistry. Results: Leptin receptor expression was found in the villi and crypt epithelium of the small intestine and in Brunner’s gland of the duodenum. E2 administration increased the leptin receptor expressions on the epithelium of villi and crypt in the duodenum and jejunum at the 90th hour (p<0.05); ileum at the 18th hour (p<0.05); and also on the epithelium of villi in the duodenum at the 162nd hour (p<0.05). Conclusion: Our results indicate that E2 may upregulate the expression of leptin receptors in the small intestine, where glucose and other nutrients are absorbed after food intake and digestion, depending on the timing.
{"title":"The Effect of Estrogen Hormone on Leptin Receptor in Small Intestine of Ovariectomized Rats","authors":"Özlem Özden Akkaya, Korhan Altunbaş","doi":"10.36472/msd.v10i9.1010","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1010","url":null,"abstract":"Objective: Leptin, a 16 kDa hormone encoded by the obese (Ob) gene, is known for its role in regulating food intake, body composition, and energy expenditure. Leptin receptor expression has been demonstrated in several tissues, including the small intestine. Weight gain may occur in humans after menopause or in animals following ovariectomy. Estrogen affects leptin and leptin receptor expressions. In this study, we aimed to contribute to the etiology of obesity by investigating the effects of E2 on leptin receptors in the small intestines of ovariectomized rats as a model of postmenopausal conditions. Materials and Methods: Bilateral ovariectomy was performed on 6-month-old Sprague-Dawley female rats. Ovariectomized rats (Ovx) were injected with 0.2 ml of sesame oil/rat/day or E2 (25 µg/rat/day) and euthanized at the 18th, 90th, or 162nd hours. Duodenum, jejunum, and ileum samples were fixed and embedded in paraffin using standard methods. The expression of leptin receptors were detected in the small intestine through immunohistochemistry. Results: Leptin receptor expression was found in the villi and crypt epithelium of the small intestine and in Brunner’s gland of the duodenum. E2 administration increased the leptin receptor expressions on the epithelium of villi and crypt in the duodenum and jejunum at the 90th hour (p<0.05); ileum at the 18th hour (p<0.05); and also on the epithelium of villi in the duodenum at the 162nd hour (p<0.05). Conclusion: Our results indicate that E2 may upregulate the expression of leptin receptors in the small intestine, where glucose and other nutrients are absorbed after food intake and digestion, depending on the timing.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sule Karabulut Gul, Mehmet Alper Kaya, Cem Ata Turkyilmaz, Cihan Dural, Irem Yuksel, Omar Alomari, Raghad Al-Shomali, Huseyin Tepetam, Hakan Levent Gul
Objective: This study aims to investigate the impact of B12 vitamin and folate deficiency on depression levels in breast cancer patients. Material and Methods: A total of 99 breast cancer patients were included in the study, and sociodemographic data, treatment information, and lifestyle factors were recorded. Depression levels were evaluated using the Beck Depression Inventory, and B12 and folate levels were measured through laboratory tests. Statistical analyses were performed using the SPSS software, and the Mann-Whitney U test was used. Results: Patients who smoked and used alcohol had significantly higher depression scores (p=0.009 and p=0.028, respectively). Additionally, patients with low B12 vitamin levels had significantly higher depression scores (p=0.036). Similarly, patients with folate deficiency also had higher depression scores (p=0.015). Conclusion: This study demonstrates that B12 and folate deficiency can increase depression levels in breast cancer patients. Correcting B12 and folate levels in the management of depression may help improve the quality of life and positively influence the treatment process. Regular monitoring of B12 and folate levels and providing necessary treatment and support are essential in clinical practice.
{"title":"The Impact of B12 Vitamin and Folate Deficiency on Depression Levels in Breast Cancer Patients","authors":"Sule Karabulut Gul, Mehmet Alper Kaya, Cem Ata Turkyilmaz, Cihan Dural, Irem Yuksel, Omar Alomari, Raghad Al-Shomali, Huseyin Tepetam, Hakan Levent Gul","doi":"10.36472/msd.v10i9.1042","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1042","url":null,"abstract":"Objective: This study aims to investigate the impact of B12 vitamin and folate deficiency on depression levels in breast cancer patients. Material and Methods: A total of 99 breast cancer patients were included in the study, and sociodemographic data, treatment information, and lifestyle factors were recorded. Depression levels were evaluated using the Beck Depression Inventory, and B12 and folate levels were measured through laboratory tests. Statistical analyses were performed using the SPSS software, and the Mann-Whitney U test was used. Results: Patients who smoked and used alcohol had significantly higher depression scores (p=0.009 and p=0.028, respectively). Additionally, patients with low B12 vitamin levels had significantly higher depression scores (p=0.036). Similarly, patients with folate deficiency also had higher depression scores (p=0.015). Conclusion: This study demonstrates that B12 and folate deficiency can increase depression levels in breast cancer patients. Correcting B12 and folate levels in the management of depression may help improve the quality of life and positively influence the treatment process. Regular monitoring of B12 and folate levels and providing necessary treatment and support are essential in clinical practice.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136014841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this research, we aimed to evaluate the success of the minimally invasive surgical method performed with intraoperative gamma-probe despite early wash-out in solitary primary parathyroid lesions and to contribute to the literature on this subject. Methods: This retrospective study included 48 adult patients diagnosed with hyperparathyroidism, with an average parathormone value of 105 pg/mL (range: 82-127 pg/mL). Radionuclide imaging was conducted using Tc-99m sestamibi and Tc-99m-pertechnetate. Minimally invasive surgery with an intraoperative gamma probe was planned for patients with primary parathyroid lesions and surgical indications. At the conclusion of the operation, count equalization was observed in all four quadrants. Results: Minimally invasive surgery was performed on 42 patients with the assistance of an intraoperative gamma probe. In 6 patients, the procedure was extended to conduct a four-gland exploration due to early wash-out. Each patient had one pathological lesion removed, all of which were histopathologically confirmed as parathyroid adenomas. Among the 6 patients with extended surgeries, 4 experienced early wash-out, and all 6 had been diagnosed with multinodular goiter. Conclusion: In cases with primary hyperparathyroidism, it is aimed to remove the pathological lesion with minimally invasive surgery and leave the glands that continue their normal function in place. Preoperative localization methods help the surgeon in this regard, but pathologies in the surrounding tissue can reduce the success of minimally invasive surgery.
{"title":"Determination of Lesion Localization with Intraoperative Gamma Probe in the Presence of a Primary Parathyroid Lesion with Early Wash-Out in Radionuclide","authors":"Sule Ceylan","doi":"10.36472/msd.v10i9.1031","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1031","url":null,"abstract":"Objective: In this research, we aimed to evaluate the success of the minimally invasive surgical method performed with intraoperative gamma-probe despite early wash-out in solitary primary parathyroid lesions and to contribute to the literature on this subject. Methods: This retrospective study included 48 adult patients diagnosed with hyperparathyroidism, with an average parathormone value of 105 pg/mL (range: 82-127 pg/mL). Radionuclide imaging was conducted using Tc-99m sestamibi and Tc-99m-pertechnetate. Minimally invasive surgery with an intraoperative gamma probe was planned for patients with primary parathyroid lesions and surgical indications. At the conclusion of the operation, count equalization was observed in all four quadrants. Results: Minimally invasive surgery was performed on 42 patients with the assistance of an intraoperative gamma probe. In 6 patients, the procedure was extended to conduct a four-gland exploration due to early wash-out. Each patient had one pathological lesion removed, all of which were histopathologically confirmed as parathyroid adenomas. Among the 6 patients with extended surgeries, 4 experienced early wash-out, and all 6 had been diagnosed with multinodular goiter. Conclusion: In cases with primary hyperparathyroidism, it is aimed to remove the pathological lesion with minimally invasive surgery and leave the glands that continue their normal function in place. Preoperative localization methods help the surgeon in this regard, but pathologies in the surrounding tissue can reduce the success of minimally invasive surgery.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134913757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Our study aims to evaluate the depression and burnout states (according to their sociodemographic characteristic) of Turkish Oncology Physicians (both medical and radiation oncologists) who follow up and treat oncology patients. Materials and methods: Actively working radiation oncology practitioners (n:267)who completed the questionnaire voluntarily were included to the study. A 13-item personal information form was prepared to determine the participants' sociodemographic characteristics. Data were transferred to the IBM SPSS Statistics 23 program using the Maslach Burnout Inventory (MBI), Beck Depression Inventory (BDE). Results: A statistically significant relationship (with both positive and high levels) was found between the beck depression scale score and the emotional exhaustion subscale while a statistically significant association (with bothpositive and middle levels) was found between the Beck depression scale score and the depersonalization subscale, and a statistically significant relationship (with both positive and low levels) was found between the beck depression scale score and the personal success subscale (p<0,05). Conclusion: In our study, depression status and burnout presence were detected in the doctors working in the field of oncology. It is important to take precautions before entering depression and before burnout begins. As a result, the quality of life for physicians will improve, leading to enhanced diagnoses and treatments for cancer patients, as well as fostering positive relationships with both patients and their families
{"title":"Exploring Burnout and Depression Among Oncology Physicians: Impacts and Preventive Measures","authors":"Hüseyin Tepetam","doi":"10.36472/msd.v10i9.1034","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1034","url":null,"abstract":"Objective: Our study aims to evaluate the depression and burnout states (according to their sociodemographic characteristic) of Turkish Oncology Physicians (both medical and radiation oncologists) who follow up and treat oncology patients.\u0000Materials and methods: Actively working radiation oncology practitioners (n:267)who completed the questionnaire voluntarily were included to the study. A 13-item personal information form was prepared to determine the participants' sociodemographic characteristics. Data were transferred to the IBM SPSS Statistics 23 program using the Maslach Burnout Inventory (MBI), Beck Depression Inventory (BDE).\u0000Results: A statistically significant relationship (with both positive and high levels) was found between the beck depression scale score and the emotional exhaustion subscale while a statistically significant association (with bothpositive and middle levels) was found between the Beck depression scale score and the depersonalization subscale, and a statistically significant relationship (with both positive and low levels) was found between the beck depression scale score and the personal success subscale (p<0,05).\u0000Conclusion: In our study, depression status and burnout presence were detected in the doctors working in the field of oncology. It is important to take precautions before entering depression and before burnout begins. As a result, the quality of life for physicians will improve, leading to enhanced diagnoses and treatments for cancer patients, as well as fostering positive relationships with both patients and their families","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84977550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The cementing technique employed in total knee arthroplasty (TKA) significantly influences the penetration of cement into the bone, ultimately affecting the stability of the joint. This study aimed to assess the impact of tourniquet usage on tibial cement penetration, operative time, bleeding, and functional outcomes following TKA. Materials and Methods: A retrospective evaluation was conducted on 103 patients who had undergone TKA and had a minimum follow-up period of 2 years. The patients were categorized into three groups: Group 1 utilized a tourniquet throughout the entire surgery, Group 2 released the tourniquet immediately after prosthesis implantation, just before cement hardening, and Group 3 did not employ a tourniquet at any stage of the procedure. Tibial cement penetration was assessed via X-ray examination, following the Knee Society Scoring System criteria. Operative time, bleeding levels, and Lysholm and Oxford scores were compared among the groups. Statistical analysis was performed using SPSS version 22.0 software. Results: In Group 1, bone penetration of cement was significantly higher than in both Group 2 and Group 3, except for zone 1 in the anterior-posterior (AP) view (p < 0.017). Group 3 exhibited significantly less bleeding compared to the other groups (p < 0.017). There was no significant difference in terms of bleeding between Group 1 and Group 2. The operation time was significantly shorter in Group 1 compared to the other groups (p < 0.017). The mean cement penetration depth across all groups was measured at 2.44 ± 0.27 mm. Bleeding volume and operation time did not have a significant effect on mean cement penetration (p > 0.05). Additionally, there were no significant differences observed between the groups in terms of the Lysholm and Oxford functional test results (p > 0.017). Conclusions: The use of a tourniquet was found to increase cement penetration and reduce operation time; however, it did not have a significant impact on reducing bleeding. Based on our findings, we recommend considering a shorter tourniquet time and implementing effective bleeding control measures to mitigate potential complications associated with tourniquet usage.
{"title":"Total Knee Arthroplasty: The Impact of Tourniquet Usage on Cement Penetration, Operation Time, and Bleeding Control","authors":"Gökhan Peker, İbrahim Altun","doi":"10.36472/msd.v10i9.1035","DOIUrl":"https://doi.org/10.36472/msd.v10i9.1035","url":null,"abstract":"Objective: The cementing technique employed in total knee arthroplasty (TKA) significantly influences the penetration of cement into the bone, ultimately affecting the stability of the joint. This study aimed to assess the impact of tourniquet usage on tibial cement penetration, operative time, bleeding, and functional outcomes following TKA. Materials and Methods: A retrospective evaluation was conducted on 103 patients who had undergone TKA and had a minimum follow-up period of 2 years. The patients were categorized into three groups: Group 1 utilized a tourniquet throughout the entire surgery, Group 2 released the tourniquet immediately after prosthesis implantation, just before cement hardening, and Group 3 did not employ a tourniquet at any stage of the procedure. Tibial cement penetration was assessed via X-ray examination, following the Knee Society Scoring System criteria. Operative time, bleeding levels, and Lysholm and Oxford scores were compared among the groups. Statistical analysis was performed using SPSS version 22.0 software. Results: In Group 1, bone penetration of cement was significantly higher than in both Group 2 and Group 3, except for zone 1 in the anterior-posterior (AP) view (p < 0.017). Group 3 exhibited significantly less bleeding compared to the other groups (p < 0.017). There was no significant difference in terms of bleeding between Group 1 and Group 2. The operation time was significantly shorter in Group 1 compared to the other groups (p < 0.017). The mean cement penetration depth across all groups was measured at 2.44 ± 0.27 mm. Bleeding volume and operation time did not have a significant effect on mean cement penetration (p > 0.05). Additionally, there were no significant differences observed between the groups in terms of the Lysholm and Oxford functional test results (p > 0.017). Conclusions: The use of a tourniquet was found to increase cement penetration and reduce operation time; however, it did not have a significant impact on reducing bleeding. Based on our findings, we recommend considering a shorter tourniquet time and implementing effective bleeding control measures to mitigate potential complications associated with tourniquet usage.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135254284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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