Pub Date : 2023-12-10DOI: 10.36472/msd.v10i12.1106
Mehmet Gürkan Arıkan, Ebru Taştekin, E. Arda
Objective: Prostate cancer continues to pose a significant health challenge, with diverse prognoses influenced by preoperative and postoperative assessments. This study aims to elucidate the correlation between preoperative clinical indicators and postoperative histopathological outcomes to enhance prognostic models. The primary objective of this study is to investigate the predictive value of preoperative factors, such as age, Prostate-Specific Antigen (PSA) level, prostate volume (PV), and tumor volume (TV), on postoperative outcomes, specifically focusing on extracapsular invasion (ECI), seminal vesicle invasion (SVI), and positive surgical margins (PSM). Materials and Methods: We retrospectively analyzed the data of 63 patients with prostate cancer who underwent radical prostatectomy. Preoperative clinical data, including age, PSA level, PV, and TV, were collected. Postoperative histopathological data were gathered for ECI, SVI, and PSM. Statistical analyses, including correlation coefficients and median comparisons, were employed to identify significant predictors of postoperative outcomes. Results: The cohort had a mean age of 64.1 years, with PSA levels ranging from 3.65 to 112 ng/ml. Patients with ECI had a median PSA of 14.9 ng/ml, whereas those without had 8.2 ng/ml (p=0.001). Median PV and TV were significantly higher in patients with ECI (PV: 55 cc, TV: 8.07 cc) than in those without ECI (PV: 49 cc, TV: 4.25 cc, p=0.001). Similar significant differences were noted for SVI and PSM, with higher PSA, PV, and TV values in patients with these features (p≤0.042). Age did not significantly affect the outcomes. Conclusion: Preoperative PSA level, prostate volume, and tumor volume were significant predictors of adverse postoperative histopathological features in patients with prostate cancer. These findings highlight the need for a multifactorial approach in preoperative evaluation and advocate the development of enhanced predictive models for improved clinical decision-making and patient management.
目的：前列腺癌仍然是一项重大的健康挑战，其不同的预后受到术前和术后评估的影响。本研究旨在阐明术前临床指标与术后组织病理学结果之间的相关性，以改进预后模型。本研究的主要目的是探讨年龄、前列腺特异性抗原（PSA）水平、前列腺体积（PV）和肿瘤体积（TV）等术前因素对术后结果的预测价值，尤其关注囊外侵犯（ECI）、精囊侵犯（SVI）和手术切缘阳性（PSM）：我们对 63 名接受前列腺癌根治术的前列腺癌患者的数据进行了回顾性分析。收集了包括年龄、PSA 水平、PV 和 TV 在内的术前临床数据。术后组织病理学数据包括ECI、SVI和PSM。统计分析包括相关系数和中位数比较，以确定术后结果的重要预测因素：研究对象的平均年龄为64.1岁，PSA水平从3.65到112纳克/毫升不等。ECI患者的PSA中位数为14.9纳克/毫升，而非ECI患者的PSA中位数为8.2纳克/毫升（P=0.001）。ECI患者的中位PV和TV（PV：55cc，TV：8.07cc）明显高于非ECI患者（PV：49cc，TV：4.25cc，P=0.001）。SVI和PSM也存在类似的显著差异，具有这些特征的患者PSA、PV和TV值更高（P≤0.042）。年龄对结果没有明显影响：结论：术前 PSA 水平、前列腺体积和肿瘤体积是前列腺癌患者术后组织病理学不良特征的重要预测因素。这些发现强调了在进行术前评估时采用多因素方法的必要性，并提倡开发增强型预测模型，以改善临床决策和患者管理。
{"title":"Correlations Between Preoperative Indicators and Postoperative Histopathological Outcomes in Prostate Cancer Patients","authors":"Mehmet Gürkan Arıkan, Ebru Taştekin, E. Arda","doi":"10.36472/msd.v10i12.1106","DOIUrl":"https://doi.org/10.36472/msd.v10i12.1106","url":null,"abstract":"Objective: Prostate cancer continues to pose a significant health challenge, with diverse prognoses influenced by preoperative and postoperative assessments. This study aims to elucidate the correlation between preoperative clinical indicators and postoperative histopathological outcomes to enhance prognostic models. The primary objective of this study is to investigate the predictive value of preoperative factors, such as age, Prostate-Specific Antigen (PSA) level, prostate volume (PV), and tumor volume (TV), on postoperative outcomes, specifically focusing on extracapsular invasion (ECI), seminal vesicle invasion (SVI), and positive surgical margins (PSM).\u0000Materials and Methods: We retrospectively analyzed the data of 63 patients with prostate cancer who underwent radical prostatectomy. Preoperative clinical data, including age, PSA level, PV, and TV, were collected. Postoperative histopathological data were gathered for ECI, SVI, and PSM. Statistical analyses, including correlation coefficients and median comparisons, were employed to identify significant predictors of postoperative outcomes.\u0000Results: The cohort had a mean age of 64.1 years, with PSA levels ranging from 3.65 to 112 ng/ml. Patients with ECI had a median PSA of 14.9 ng/ml, whereas those without had 8.2 ng/ml (p=0.001). Median PV and TV were significantly higher in patients with ECI (PV: 55 cc, TV: 8.07 cc) than in those without ECI (PV: 49 cc, TV: 4.25 cc, p=0.001). Similar significant differences were noted for SVI and PSM, with higher PSA, PV, and TV values in patients with these features (p≤0.042). Age did not significantly affect the outcomes.\u0000Conclusion: Preoperative PSA level, prostate volume, and tumor volume were significant predictors of adverse postoperative histopathological features in patients with prostate cancer. These findings highlight the need for a multifactorial approach in preoperative evaluation and advocate the development of enhanced predictive models for improved clinical decision-making and patient management.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"52 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.36472/msd.v10i12.1098
Aydan Topal, Z. Öztekin
Objective: The incidence of epileptic seizures after a stroke falls within a range of 2.3-43%. Varying opinions exist in the literature concerning the association between thrombolytic therapy, endovascular interventions, and the development of epileptic seizures post-stroke. Material and Methods: Seizure rates were compared based on the treatment method (thrombolytic therapy, endovascular intervention, or conventional therapy) in patients experiencing acute ischemic stroke within a two-year period in the neurology and neurology intensive care unit. Patients were categorized into three groups: the first group received IV thrombolytic therapy, the second group underwent mechanical thrombectomy, and the third group received conventional therapy. The occurrence of epileptic seizures from hospitalization to discharge was compared. Results: IV thrombolytics were administered to 1.5% of patients, mechanical thrombectomy to 3.6%, and 94.9% received medical treatment. Epileptic seizures were observed in 0.9% of patients. No statistically significant relationship was found between the development of epileptic seizures and the treatment method for ischemic stroke. Furthermore, no statistically significant correlation was identified between the development of epileptic seizures and the modified Rankin score at discharge. Conclusion: Our findings align with existing studies. In conclusion, this retrospective study aimed to assess how the treatment method applied in acute ischemic stroke might influence the background of epileptic seizures.
{"title":"A Comparison of Post-Stroke Seizure Rates in Patients Receiving IV Thrombolytic, Mechanical Thrombectomy, and Conventional Treatment Following Acute Ischemic Stroke","authors":"Aydan Topal, Z. Öztekin","doi":"10.36472/msd.v10i12.1098","DOIUrl":"https://doi.org/10.36472/msd.v10i12.1098","url":null,"abstract":"Objective: The incidence of epileptic seizures after a stroke falls within a range of 2.3-43%. Varying opinions exist in the literature concerning the association between thrombolytic therapy, endovascular interventions, and the development of epileptic seizures post-stroke.\u0000Material and Methods: Seizure rates were compared based on the treatment method (thrombolytic therapy, endovascular intervention, or conventional therapy) in patients experiencing acute ischemic stroke within a two-year period in the neurology and neurology intensive care unit. Patients were categorized into three groups: the first group received IV thrombolytic therapy, the second group underwent mechanical thrombectomy, and the third group received conventional therapy. The occurrence of epileptic seizures from hospitalization to discharge was compared.\u0000Results: IV thrombolytics were administered to 1.5% of patients, mechanical thrombectomy to 3.6%, and 94.9% received medical treatment. Epileptic seizures were observed in 0.9% of patients. No statistically significant relationship was found between the development of epileptic seizures and the treatment method for ischemic stroke. Furthermore, no statistically significant correlation was identified between the development of epileptic seizures and the modified Rankin score at discharge.\u0000Conclusion: Our findings align with existing studies. In conclusion, this retrospective study aimed to assess how the treatment method applied in acute ischemic stroke might influence the background of epileptic seizures.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.36472/msd.v10i12.1097
Betül Özenç, O. Kurşun
Objective: Non-vitamin K antagonist oral anticoagulants (NOACs) have become widely utilized for various clinical indications, including non-valvular atrial fibrillation (NVAF), deep vein thrombosis (DVT), and apical thrombus. Despite their increasing popularity, limited comparative data exist on the clinical outcomes associated with different NOACs. This study aims to address this gap by directly comparing NOACs in terms of ischemic stroke, hemorrhagic stroke, and gastrointestinal bleeding. Materials and Methods: A retrospective search of the electronic database was conducted to identify patients using NOACs for NVAF, DVT, and apical thrombus. Clinical outcomes, including ischemic stroke, hemorrhagic stroke, and gastrointestinal bleeding, were directly compared among different NOACs. The chi-square test and Fisher's exact test were employed to assess the relative incidence of stroke and extracranial complications across four patient groups. Results: Among the 4,112 retrospectively analyzed patients, 55 were included in the study. Demographic and clinical profiles showed no significant differences among patients in the four different drug groups (p > 0.05). Ischemic stroke was observed in 90.9% of the patients, hemorrhagic stroke in 5.8%, and gastrointestinal bleeding in 3.3%. A statistically significant difference was identified between drug doses and the rate of ischemic stroke (p < 0.001). Conclusion: The findings of this retrospective study carry significant implications, especially considering the widespread global use of NOACs. The study revealed no discernible difference in the risk of ischemic stroke among patients using different NOACs. Notably, the risk of hemorrhagic stroke was dose-dependent in the dabigatran group, while rivaroxaban was associated with the highest risk of gastrointestinal bleeding. Given the elevated rate of thromboembolism in patients and the relatively short half-life of NOACs, the study concludes that further optimization of NOAC use is imperative.
{"title":"Comparison of Non-Vitamin K Antagonist Oral Anticoagulants on Ischemic Stroke and Bleeding","authors":"Betül Özenç, O. Kurşun","doi":"10.36472/msd.v10i12.1097","DOIUrl":"https://doi.org/10.36472/msd.v10i12.1097","url":null,"abstract":"Objective: Non-vitamin K antagonist oral anticoagulants (NOACs) have become widely utilized for various clinical indications, including non-valvular atrial fibrillation (NVAF), deep vein thrombosis (DVT), and apical thrombus. Despite their increasing popularity, limited comparative data exist on the clinical outcomes associated with different NOACs. This study aims to address this gap by directly comparing NOACs in terms of ischemic stroke, hemorrhagic stroke, and gastrointestinal bleeding.\u0000Materials and Methods: A retrospective search of the electronic database was conducted to identify patients using NOACs for NVAF, DVT, and apical thrombus. Clinical outcomes, including ischemic stroke, hemorrhagic stroke, and gastrointestinal bleeding, were directly compared among different NOACs. The chi-square test and Fisher's exact test were employed to assess the relative incidence of stroke and extracranial complications across four patient groups.\u0000Results: Among the 4,112 retrospectively analyzed patients, 55 were included in the study. Demographic and clinical profiles showed no significant differences among patients in the four different drug groups (p > 0.05). Ischemic stroke was observed in 90.9% of the patients, hemorrhagic stroke in 5.8%, and gastrointestinal bleeding in 3.3%. A statistically significant difference was identified between drug doses and the rate of ischemic stroke (p < 0.001).\u0000Conclusion: The findings of this retrospective study carry significant implications, especially considering the widespread global use of NOACs. The study revealed no discernible difference in the risk of ischemic stroke among patients using different NOACs. Notably, the risk of hemorrhagic stroke was dose-dependent in the dabigatran group, while rivaroxaban was associated with the highest risk of gastrointestinal bleeding. Given the elevated rate of thromboembolism in patients and the relatively short half-life of NOACs, the study concludes that further optimization of NOAC use is imperative.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"44 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.36472/msd.v10i12.1105
Burak Okumuş
Suicidal behavior is frequently observed in association with diagnosable psychiatric disorders. Psychiatry is the only branch of medicine that has a tradition of suicide prevention and defines suicidal ideation as a disorder criterion. Recently, there has been growing international interest in the increasing number of suicides among physicians. The reason for this is the increasing accumulation of data reporting completed suicides among physicians. As one of the most respected and sought-after professions, medicine carries with it stressors specific to professions that require high levels of responsibility and equipment. Physicians who have access to lethal means and the knowledge to use them effectively are the most important part of countries' health systems, and given the increased risk of suicide, it can be said that it has the potential to become a serious public health problem. Physician suicide must therefore go beyond the desire of psychiatrists to care for their colleagues. As a result, physicians may have attitudes that make it difficult to access psychiatry, and misconceptions and prejudices that can lead to stigma. These difficulties can be transformed into more acceptable norms. It may be appropriate to assess factors that increase risk in the workplace. Physicians may benefit from psychoeducational programmes that provide information about suicide. Crisis intervention aimed at early warning signs of psychiatric disorders can save lives. Medicine is influenced by biopsychosocial factors that can change. In this regard, regular periodic evaluations can be planned.
{"title":"The Silent Cry of Physicians: Suicide","authors":"Burak Okumuş","doi":"10.36472/msd.v10i12.1105","DOIUrl":"https://doi.org/10.36472/msd.v10i12.1105","url":null,"abstract":"Suicidal behavior is frequently observed in association with diagnosable psychiatric disorders. Psychiatry is the only branch of medicine that has a tradition of suicide prevention and defines suicidal ideation as a disorder criterion. Recently, there has been growing international interest in the increasing number of suicides among physicians. The reason for this is the increasing accumulation of data reporting completed suicides among physicians. As one of the most respected and sought-after professions, medicine carries with it stressors specific to professions that require high levels of responsibility and equipment. Physicians who have access to lethal means and the knowledge to use them effectively are the most important part of countries' health systems, and given the increased risk of suicide, it can be said that it has the potential to become a serious public health problem. Physician suicide must therefore go beyond the desire of psychiatrists to care for their colleagues. As a result, physicians may have attitudes that make it difficult to access psychiatry, and misconceptions and prejudices that can lead to stigma. These difficulties can be transformed into more acceptable norms. It may be appropriate to assess factors that increase risk in the workplace. Physicians may benefit from psychoeducational programmes that provide information about suicide. Crisis intervention aimed at early warning signs of psychiatric disorders can save lives. Medicine is influenced by biopsychosocial factors that can change. In this regard, regular periodic evaluations can be planned.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"3 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.36472/msd.v10i11.1090
M. Tokoçin, Serhat Meric, Kamil Özdoğan, T. Aktokmakyan, N. Buğdaycı, Haşim Furkan Güllü, Onur Tokoçin, H. Yiğitbaş
Objective: Appendectomy for appendicitis is one of the most common surgical procedures performed worldwide. The remnant of the appendix stump after the first appendectomy carries the risk of developing stump appendicitis. Stump appendicitis is a rare late complication of appendectomy; inflammation occurs in the remaining appendicular stump. Delayed diagnosis of this condition can cause serious complications. Stump appendicitis is indeed a recognized clinical picture, but is often overlooked when evaluating patients with right lower quadrant abdominal pain, especially those with a history of appendectomy. It remains a clinical challenge because of its often delayed diagnosis and effective treatment, and possible accompanying morbidity or mortality. Material and Methods: Materials and Methods: We retrospectively screened the patients who were hospitalized in our general surgery clinic and diagnosed with stump appendicitis in the hospital for 12 years. There were 11 patients between January 2011 and 2023 Results: The mean age of all 11 patients described was 55 years (range: 20 to 66). 72% of the patients were male (8/11 males and 3/11 females). 63% of the patients had their first operations open, and 36% of them were laparoscopic. The mean white blood cell count on presentation of all reported 11 cases was 11,996 cells/mm3 (range: 5930 to 18,740), the mean fever was 37.82°C (range: 36.8 to 38.6), and the mean CRP count on presentation of all cases was 36.7 (range: 0.4 to 142.91). The most commonly performed radiographic examination used to diagnose stump appendicitis is the abdominal computerized tomography (CT) scan. It was used in 100% (11 cases). Ultrasound was also used in 100% (11 cases). Conclusion: The appendicular base must be accessed prior to undertaking an appendectomy, irrespective of the chosen strategy or technique. It is noteworthy that, apart from open or laparoscopic appendectomy, antibiotic therapy should also be considered as part of the treatment regimen, as documented in the literature series.
{"title":"Stump Appendicitis: A Rare Late Complication of Appendectomy, a Retrospective Analysis of 9082 Appendectomy Cases","authors":"M. Tokoçin, Serhat Meric, Kamil Özdoğan, T. Aktokmakyan, N. Buğdaycı, Haşim Furkan Güllü, Onur Tokoçin, H. Yiğitbaş","doi":"10.36472/msd.v10i11.1090","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1090","url":null,"abstract":"Objective: Appendectomy for appendicitis is one of the most common surgical procedures performed worldwide. The remnant of the appendix stump after the first appendectomy carries the risk of developing stump appendicitis. Stump appendicitis is a rare late complication of appendectomy; inflammation occurs in the remaining appendicular stump. Delayed diagnosis of this condition can cause serious complications. Stump appendicitis is indeed a recognized clinical picture, but is often overlooked when evaluating patients with right lower quadrant abdominal pain, especially those with a history of appendectomy. It remains a clinical challenge because of its often delayed diagnosis and effective treatment, and possible accompanying morbidity or mortality. Material and Methods: Materials and Methods: We retrospectively screened the patients who were hospitalized in our general surgery clinic and diagnosed with stump appendicitis in the hospital for 12 years. There were 11 patients between January 2011 and 2023 Results: The mean age of all 11 patients described was 55 years (range: 20 to 66). 72% of the patients were male (8/11 males and 3/11 females). 63% of the patients had their first operations open, and 36% of them were laparoscopic. The mean white blood cell count on presentation of all reported 11 cases was 11,996 cells/mm3 (range: 5930 to 18,740), the mean fever was 37.82°C (range: 36.8 to 38.6), and the mean CRP count on presentation of all cases was 36.7 (range: 0.4 to 142.91). The most commonly performed radiographic examination used to diagnose stump appendicitis is the abdominal computerized tomography (CT) scan. It was used in 100% (11 cases). Ultrasound was also used in 100% (11 cases). Conclusion: The appendicular base must be accessed prior to undertaking an appendectomy, irrespective of the chosen strategy or technique. It is noteworthy that, apart from open or laparoscopic appendectomy, antibiotic therapy should also be considered as part of the treatment regimen, as documented in the literature series.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-24DOI: 10.36472/msd.v10i11.1100
Feruza Turan Sönmez, R. Eröz, Bilge Yurdakul
Objective: This study aimed to evaluate the prognostic significance of Argyrophilic Nucleolar Organizing Region (AgNOR) proteins in patients with acute myocardial infarction (AMI) and to determine their potential role in predicting the extent of myocardial damage. Materials and Methods: A case-control study was conducted with 20 AMI patients and 17 healthy controls. Peripheral blood samples were stained to assess AgNOR protein levels. The AgNOR parameters, such as the number of AgNORs and the total AgNOR area to total nuclear area (TAA/NA) ratio, were analyzed using ImageJ software. Statistical analyses were performed using SPSS to assess differences between groups and correlations with clinical markers. Results: The study revealed a significant increase in both the mean AgNOR number and TAA/NA ratio among AMI patients compared to controls (p < 0.01). These parameters also correlated with known cardiac damage markers such as Troponin I level. Sensitivity (100%) and specificity (100%) analysis indicated that these AgNOR parameters could effectively differentiate between AMI patients and healthy individuals. Conclusion: AgNOR proteins emerge as a promising and dependable biomarker for evaluating myocardial damage and predicting patient prognosis in cases of AMI. Their remarkable sensitivity and specificity in distinguishing AMI cases underscore their potential clinical utility. However, further studies with larger cohorts are imperative to validate these findings.
{"title":"Investigation of the AgNOR (Argyrophilic Nucleolar Organizing Region) Protein Levels in Patients with Coronary Artery Diseases","authors":"Feruza Turan Sönmez, R. Eröz, Bilge Yurdakul","doi":"10.36472/msd.v10i11.1100","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1100","url":null,"abstract":"Objective: This study aimed to evaluate the prognostic significance of Argyrophilic Nucleolar Organizing Region (AgNOR) proteins in patients with acute myocardial infarction (AMI) and to determine their potential role in predicting the extent of myocardial damage. Materials and Methods: A case-control study was conducted with 20 AMI patients and 17 healthy controls. Peripheral blood samples were stained to assess AgNOR protein levels. The AgNOR parameters, such as the number of AgNORs and the total AgNOR area to total nuclear area (TAA/NA) ratio, were analyzed using ImageJ software. Statistical analyses were performed using SPSS to assess differences between groups and correlations with clinical markers. Results: The study revealed a significant increase in both the mean AgNOR number and TAA/NA ratio among AMI patients compared to controls (p < 0.01). These parameters also correlated with known cardiac damage markers such as Troponin I level. Sensitivity (100%) and specificity (100%) analysis indicated that these AgNOR parameters could effectively differentiate between AMI patients and healthy individuals. Conclusion: AgNOR proteins emerge as a promising and dependable biomarker for evaluating myocardial damage and predicting patient prognosis in cases of AMI. Their remarkable sensitivity and specificity in distinguishing AMI cases underscore their potential clinical utility. However, further studies with larger cohorts are imperative to validate these findings.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"96 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139241955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-23DOI: 10.36472/msd.v10i11.1077
Ahmet Melih Şahin, Sinan Çetin, Ersin Kuloğlu, Ali Muhtaroğlu, A. Dülger
Objective: Dyspepsia, a common gastrointestinal disorder, is characterized by persistent or recurrent pain or discomfort centered in the upper abdomen. It often presents with symptoms such as bloating, belching, and nausea. Understanding the epidemiological variations in dyspepsia between EU and Turkish patients can provide valuable insights into potential factors influencing this condition's clinical and endoscopic profiles across different populations. This study aimed to retrospectively examine and compare haematological, biochemical, and endoscopic biopsy parameters among dyspeptic patients from European Union (EU) countries and domestic regions. Material and Methods: e conducted an analysis involving 149 dyspeptic patients, comprising 62 individuals from the European Union (EU) and 87 from Turkey. Data pertaining to hemogram, biochemical parameters, and endoscopic biopsy findings (with a focus on Helicobacter pylori colonization, intestinal metaplasia, and gastric atrophy) were systematically compared between the two groups.zz Results: The study revealed a significantly higher incidence of Helicobacter pylori colonization in the Turkish cohort compared to their EU counterparts. Moreover, variations in hematological and biochemical markers were observed, indicating potential regional and lifestyle differences that may influence dyspeptic symptoms. Conclusion: This study highlights significant epidemiological differences in dyspeptic presentations, particularly the higher prevalence of Helicobacter pylori colonisation in Turkish patients compared to those in the EU. These findings underscore the need for tailored clinical approaches considering regional health determinants in dyspeptic patients.
{"title":"Epidemiological Differences in Dyspepsia: A Comparative Analysis of Clinical and Endoscopic Parameters Between European Union and Turkish Patients","authors":"Ahmet Melih Şahin, Sinan Çetin, Ersin Kuloğlu, Ali Muhtaroğlu, A. Dülger","doi":"10.36472/msd.v10i11.1077","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1077","url":null,"abstract":"Objective: Dyspepsia, a common gastrointestinal disorder, is characterized by persistent or recurrent pain or discomfort centered in the upper abdomen. It often presents with symptoms such as bloating, belching, and nausea. Understanding the epidemiological variations in dyspepsia between EU and Turkish patients can provide valuable insights into potential factors influencing this condition's clinical and endoscopic profiles across different populations. This study aimed to retrospectively examine and compare haematological, biochemical, and endoscopic biopsy parameters among dyspeptic patients from European Union (EU) countries and domestic regions. Material and Methods: e conducted an analysis involving 149 dyspeptic patients, comprising 62 individuals from the European Union (EU) and 87 from Turkey. Data pertaining to hemogram, biochemical parameters, and endoscopic biopsy findings (with a focus on Helicobacter pylori colonization, intestinal metaplasia, and gastric atrophy) were systematically compared between the two groups.zz Results: The study revealed a significantly higher incidence of Helicobacter pylori colonization in the Turkish cohort compared to their EU counterparts. Moreover, variations in hematological and biochemical markers were observed, indicating potential regional and lifestyle differences that may influence dyspeptic symptoms. Conclusion: This study highlights significant epidemiological differences in dyspeptic presentations, particularly the higher prevalence of Helicobacter pylori colonisation in Turkish patients compared to those in the EU. These findings underscore the need for tailored clinical approaches considering regional health determinants in dyspeptic patients.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"20 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-23DOI: 10.36472/msd.v10i11.1095
Oya Güven, Fatma Nazlı Ünkazan
Objective: Pain is an essential symptom in emergency department admissions, but few studies have focused on its effect. This study aimed to determine the admission rates of patients with a pain diagnosis and to evaluate the rate of re-admissions to the emergency service within one month. Also, this patient group will determine the reasons for returning to the emergency department by examining the emergency service data of the only hospital in the city centre and the largest in the province. Material and Methods: In this study, patients who presented to the emergency department with a complaint of musculoskeletal pain between January 1 and December 31, 2021, and entered the R52, M25, M54, and M79 ICD codes (and their subgroups) as a diagnosis into the system were selected. Patients were classified as traumatic/non-traumatic (patients who requested extremity radiography or tomography were considered traumatic). The files were retrospectively scanned to determine the treatments administered to specific patients in the emergency department. It was investigated whether these patients subsequently sought treatment in the relevant branches, such as neurosurgery, orthopedics, or physical medicine and rehabilitation outpatient clinics, within one month. Furthermore, the patients' re-admission to the emergency service within one month were examined. Results: A total of 1742 patient files were included in the study. 50.8% of the patients were male, and the mean age was 41.9±17.3. It was determined that 1407 patients (80.8%) were treated in the emergency department, and the highest rate (61.2%) was intramuscular (IM) injection. The rate of going to the outpatient clinic was 17.6%, and the mean time of being examined was 2±5.4 days. It was observed that 30.4% of the patients were admitted to the emergency department again. The patients were divided into two groups according to whether they had a history of trauma or not. The ratio of male patients was higher in both groups (p>0.05), and the mean age of patients with trauma was lower (35±18.6). The rate of re-admission to the emergency department of the patients without trauma was significantly higher than the other group (p<0.05). The rate of being examined in the relevant polyclinic was higher in the group without trauma (17.8%). Conclusion: This study found a high admission rate to the emergency department for patients presenting with pain complaints. Furthermore, there was a notable high re-admission rate among patients without trauma following outpatient clinic examinations. It is evident that achieving effective pain control for these patients may require a significant amount of time. The recurrent emergency admissions may be attributed to persistent pain complaints
{"title":"Examination of re-admission and causes with pain patients in the emergency department","authors":"Oya Güven, Fatma Nazlı Ünkazan","doi":"10.36472/msd.v10i11.1095","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1095","url":null,"abstract":"Objective: Pain is an essential symptom in emergency department admissions, but few studies have focused on its effect. This study aimed to determine the admission rates of patients with a pain diagnosis and to evaluate the rate of re-admissions to the emergency service within one month. Also, this patient group will determine the reasons for returning to the emergency department by examining the emergency service data of the only hospital in the city centre and the largest in the province. Material and Methods: In this study, patients who presented to the emergency department with a complaint of musculoskeletal pain between January 1 and December 31, 2021, and entered the R52, M25, M54, and M79 ICD codes (and their subgroups) as a diagnosis into the system were selected. Patients were classified as traumatic/non-traumatic (patients who requested extremity radiography or tomography were considered traumatic). The files were retrospectively scanned to determine the treatments administered to specific patients in the emergency department. It was investigated whether these patients subsequently sought treatment in the relevant branches, such as neurosurgery, orthopedics, or physical medicine and rehabilitation outpatient clinics, within one month. Furthermore, the patients' re-admission to the emergency service within one month were examined. Results: A total of 1742 patient files were included in the study. 50.8% of the patients were male, and the mean age was 41.9±17.3. It was determined that 1407 patients (80.8%) were treated in the emergency department, and the highest rate (61.2%) was intramuscular (IM) injection. The rate of going to the outpatient clinic was 17.6%, and the mean time of being examined was 2±5.4 days. It was observed that 30.4% of the patients were admitted to the emergency department again. The patients were divided into two groups according to whether they had a history of trauma or not. The ratio of male patients was higher in both groups (p>0.05), and the mean age of patients with trauma was lower (35±18.6). The rate of re-admission to the emergency department of the patients without trauma was significantly higher than the other group (p<0.05). The rate of being examined in the relevant polyclinic was higher in the group without trauma (17.8%). Conclusion: This study found a high admission rate to the emergency department for patients presenting with pain complaints. Furthermore, there was a notable high re-admission rate among patients without trauma following outpatient clinic examinations. It is evident that achieving effective pain control for these patients may require a significant amount of time. The recurrent emergency admissions may be attributed to persistent pain complaints","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-21DOI: 10.36472/msd.v10i11.1099
Bilge Yurdakul
Objective: Vision impairment and eye diseases significantly affect quality of life and present a substantial public health challenge. According to the TUIK and the World Health Organization, a significant portion of the population suffers from preventable or unaddressed visual impairments. Understanding the prevalence, causes, and demographic distribution of these impairments can aid in formulating effective public health strategies. To analyze the prevalence, determinants, and demographic characteristics of individuals with vision impairment in Turkey, using data provided by TUIK. This proposal aims to utilize existing data to provide valuable insights into the public health issue of vision impairment in Turkey and to foster improved outcomes through targeted intervention strategies. Methods: Secure access to TUIK health survey data focusing on vision impairment in the population aged 0–65 years. We collected additional variables that may influence vision health, such as socioeconomic status, access to healthcare, educational level, and urban versus rural residence. We conducted a cross-sectional study using TUIK data from 2019 onwards, including demographic variables (age, sex, education, and income), and correlated them with the incidence and type of vision impairment. Results: Visual impairment affects approximately 1039000 individuals in Turkey, with a prevalence rate of 1.4%. There was a pronounced increase in visual impairment with age, peaking at 46.5% in those aged > 75 years. Females exhibited higher rates of impairment in most age groups. The most common causes of visual impairment include uncorrected refractive errors in children and young adults, glaucoma in adults aged 15-50, and age-related macular degeneration and diabetic retinopathy in those aged > 50 years. Conclusion: This study highlights a significant age and sex disparity in the prevalence of visual impairment in Turkey, necessitating age-specific and gender-responsive public health strategies. Prioritizing early screening, access to corrective measures, and managing age-related ocular diseases can address the increasing burden of visual impairment. Interventions should be tailored to mitigate risks and provide equitable healthcare access to improve visual health outcomes in the Turkish population.
{"title":"A Comprehensive Study on the Prevalence and Determinants of Vision Impairment in the Turkish Population","authors":"Bilge Yurdakul","doi":"10.36472/msd.v10i11.1099","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1099","url":null,"abstract":"Objective: Vision impairment and eye diseases significantly affect quality of life and present a substantial public health challenge. According to the TUIK and the World Health Organization, a significant portion of the population suffers from preventable or unaddressed visual impairments. Understanding the prevalence, causes, and demographic distribution of these impairments can aid in formulating effective public health strategies. To analyze the prevalence, determinants, and demographic characteristics of individuals with vision impairment in Turkey, using data provided by TUIK. This proposal aims to utilize existing data to provide valuable insights into the public health issue of vision impairment in Turkey and to foster improved outcomes through targeted intervention strategies. Methods: Secure access to TUIK health survey data focusing on vision impairment in the population aged 0–65 years. We collected additional variables that may influence vision health, such as socioeconomic status, access to healthcare, educational level, and urban versus rural residence. We conducted a cross-sectional study using TUIK data from 2019 onwards, including demographic variables (age, sex, education, and income), and correlated them with the incidence and type of vision impairment. Results: Visual impairment affects approximately 1039000 individuals in Turkey, with a prevalence rate of 1.4%. There was a pronounced increase in visual impairment with age, peaking at 46.5% in those aged > 75 years. Females exhibited higher rates of impairment in most age groups. The most common causes of visual impairment include uncorrected refractive errors in children and young adults, glaucoma in adults aged 15-50, and age-related macular degeneration and diabetic retinopathy in those aged > 50 years. Conclusion: This study highlights a significant age and sex disparity in the prevalence of visual impairment in Turkey, necessitating age-specific and gender-responsive public health strategies. Prioritizing early screening, access to corrective measures, and managing age-related ocular diseases can address the increasing burden of visual impairment. Interventions should be tailored to mitigate risks and provide equitable healthcare access to improve visual health outcomes in the Turkish population.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139254442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.36472/msd.v10i11.1094
Ceyda Hayretdağ
Objective: The rapidly changing demographics and lifestyles of the global population demand updated anthropometric data to ensure appropriate designs, interventions, and policies. Recognizing the lack of recent comprehensive anthropometric data on the Turkish adult population, the primary objective of this study was to present an authoritative perspective on the evolution of average heights and Body Mass Index (BMI) distributions in Turkey, focusing on the period between 2008 and 2022. Materials and Methods: Data for this research was sourced from the Türkiye Health Survey conducted by TurkStat. Our sample encapsulated diverse age groups over 15, covering all seven geographical regions of Turkey, ensuring nationwide representation. Comprehensive analyses were undertaken to segregate the data based on sex and age group, providing a nuanced insight into height variations and BMI distributions. Results: Our findings suggest that the overall average height for the entire Turkish population remained relatively consistent during the study period, with males averaging around 173 cm and females approximately 161 cm. Interestingly, the 15-24 age bracket registered a noticeable height increase, suggesting a potential growth trend in the younger generation. In terms of BMI, our research revealed a consistent distribution across all categories over the years. However, there was a slight decrease in underweight individuals, particularly among males, and an upward trend in the 'pre-obese' category, especially in the male demographic. The obese category experienced a minor increase from 2008 to 2016 but showed signs of stabilization in recent years. Conclusion: Given the dynamic nature of population health and growth patterns, this study underscores the significance of continuous anthropometric monitoring. Our findings offer a modern benchmark for various stakeholders – from health professionals to designers – to appropriately tailor their solutions and interventions for the Turkish populace. Furthermore, the subtle shifts in BMI categories over the years highlight potential focus areas for public health initiatives, emphasizing the importance of diet, lifestyle, and exercise in ensuring a healthy nation.
{"title":"Anatomy of a Nation: Exploring Weight, Height, and BMI Variations among Turkish Adults (2008-2022)","authors":"Ceyda Hayretdağ","doi":"10.36472/msd.v10i11.1094","DOIUrl":"https://doi.org/10.36472/msd.v10i11.1094","url":null,"abstract":"Objective: The rapidly changing demographics and lifestyles of the global population demand updated anthropometric data to ensure appropriate designs, interventions, and policies. Recognizing the lack of recent comprehensive anthropometric data on the Turkish adult population, the primary objective of this study was to present an authoritative perspective on the evolution of average heights and Body Mass Index (BMI) distributions in Turkey, focusing on the period between 2008 and 2022. Materials and Methods: Data for this research was sourced from the Türkiye Health Survey conducted by TurkStat. Our sample encapsulated diverse age groups over 15, covering all seven geographical regions of Turkey, ensuring nationwide representation. Comprehensive analyses were undertaken to segregate the data based on sex and age group, providing a nuanced insight into height variations and BMI distributions. Results: Our findings suggest that the overall average height for the entire Turkish population remained relatively consistent during the study period, with males averaging around 173 cm and females approximately 161 cm. Interestingly, the 15-24 age bracket registered a noticeable height increase, suggesting a potential growth trend in the younger generation. In terms of BMI, our research revealed a consistent distribution across all categories over the years. However, there was a slight decrease in underweight individuals, particularly among males, and an upward trend in the 'pre-obese' category, especially in the male demographic. The obese category experienced a minor increase from 2008 to 2016 but showed signs of stabilization in recent years. Conclusion: Given the dynamic nature of population health and growth patterns, this study underscores the significance of continuous anthropometric monitoring. Our findings offer a modern benchmark for various stakeholders – from health professionals to designers – to appropriately tailor their solutions and interventions for the Turkish populace. Furthermore, the subtle shifts in BMI categories over the years highlight potential focus areas for public health initiatives, emphasizing the importance of diet, lifestyle, and exercise in ensuring a healthy nation.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"58 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135217221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：