Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.019
New phototherapeutic agents based on synthetic porphyrin- type tetrapyrroles and small-molecule-targeted tyrosine kinase inhibitor Erlotinib have been synthesized based on the scheme involving ‘click’ reaction between bis(4- azidophenyl)-containing zinc porphyrinate derivative and N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)- quinazoline. The final compound and its precursors were tested as potential photosensitizers for targeted photo- dynamic therapy (PDT), the conjugate having shown photoinduced cytotoxicity IC50 for NKE cells 0.86 ± 0.017 μm and for A431 cells 0.54 ± 0.011 μm.
{"title":"The ‘click’ synthesis of new cytotoxic conjugate based on meso-arylporphyrin and Erlotinib","authors":"","doi":"10.1016/j.mencom.2024.09.019","DOIUrl":"10.1016/j.mencom.2024.09.019","url":null,"abstract":"<div><div>New phototherapeutic agents based on synthetic porphyrin- type tetrapyrroles and small-molecule-targeted tyrosine kinase inhibitor Erlotinib have been synthesized based on the scheme involving ‘click’ reaction between bis(4- azidophenyl)-containing zinc porphyrinate derivative and <em>N</em>-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)- quinazoline. The final compound and its precursors were tested as potential photosensitizers for targeted photo- dynamic therapy (PDT), the conjugate having shown photoinduced cytotoxicity IC<sub>50</sub> for NKE cells 0.86 ± 0.017 μm and for A431 cells 0.54 ± 0.011 μm.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.004
This work introduces non-covalent hydrophilic coating of NaGd0.7Eu0.3F4 nanocrystals by polylysine (PL) and polyethyleneimine (PEI) for MRI and fluorescent imaging purposes. PL- and PEI-stabilized nanocrystals exhibit high colloidal stability, cell internalization, fluorescent contrasting of nuclei and cytoplasm, low cytotoxicity, and relaxivity (r1= 0.17 dm3 mmol–1 s–1 and r1 = 0.23 dm3 mmol–1 s–1).
{"title":"Dual contrasting ability of NaGd0.7Eu0.3F4 nanocrystals tuned by their hydrophilic coating mode","authors":"","doi":"10.1016/j.mencom.2024.09.004","DOIUrl":"10.1016/j.mencom.2024.09.004","url":null,"abstract":"<div><div>This work introduces non-covalent hydrophilic coating of NaGd<sub>0.7</sub>Eu<sub>0.3</sub>F<sub>4</sub> nanocrystals by polylysine (PL) and polyethyleneimine (PEI) for MRI and fluorescent imaging purposes. PL- and PEI-stabilized nanocrystals exhibit high colloidal stability, cell internalization, fluorescent contrasting of nuclei and cytoplasm, low cytotoxicity, and relaxivity (<em>r</em><sub>1</sub>= 0.17 dm<sup>3</sup> mmol<sup>–1</sup> s<sup>–1</sup> and <em>r</em><sub>1</sub> = 0.23 dm<sup>3</sup> mmol<sup>–1</sup> s<sup>–1</sup>).</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.016
A new approach to stabilization of the reduced state of nitroxides in solution is suggested. Thermodynamic stabilization of the strongly basic aminoxyl anions toward protonation and hydrogen bond formation with the solvent was achieved by intramolecular n → π* interactions. A new stable nitroxide radical bearing ortho-acyl group was synthesized to demonstrate this effect by means of cyclic voltammetry.
提出了一种稳定溶液中硝化物还原状态的新方法。通过分子内 n → π* 相互作用，强碱性氨基氧阴离子在质子化和与溶剂形成氢键方面实现了热力学稳定。为了证明这种效果，我们合成了一种带有正酰基的新的稳定的亚硝基自由基，并采用了循环伏安法。
{"title":"Competition between n → π* interactions and H-bonding: a way to stabilize aminoxyl anions and to improve electron transfer kinetics","authors":"","doi":"10.1016/j.mencom.2024.09.016","DOIUrl":"10.1016/j.mencom.2024.09.016","url":null,"abstract":"<div><div>A new approach to stabilization of the reduced state of nitroxides in solution is suggested. Thermodynamic stabilization of the strongly basic aminoxyl anions toward protonation and hydrogen bond formation with the solvent was achieved by intramolecular n → π* interactions. A new stable nitroxide radical bearing <em>ortho</em>-acyl group was synthesized to demonstrate this effect by means of cyclic voltammetry.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.020
New azidomethyl-substituted 7-azacoumarin-3-carbox- amides were converted into the corresponding 1,2,3-triazole hybrids by the copper-catalyzed click reaction with phenyl- acetylene. Cytotoxicity and antimicrobial activity were evaluated, and leading compounds were identified.
{"title":"New triazole-containing 7-azacoumarin-3-carboxamides: synthesis and biological properties","authors":"","doi":"10.1016/j.mencom.2024.09.020","DOIUrl":"10.1016/j.mencom.2024.09.020","url":null,"abstract":"<div><div>New azidomethyl-substituted 7-azacoumarin-3-carbox- amides were converted into the corresponding 1,2,3-triazole hybrids by the copper-catalyzed click reaction with phenyl- acetylene. Cytotoxicity and antimicrobial activity were evaluated, and leading compounds were identified.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.042
The citric acid modification produces an intermediate layer on the AB-17-8:C6H8O7 surface; the layer, on one hand, is firmly secured to the surface owing to the electrostatic coupling between the citrate anion and the positively charged trimethylammonium centers of the anion exchanger surface; on the other hand, it has carbonyl groups with a local negative electron density. The sorption of heavy metals cations occurs through coordination interactions via electrostatic mechanism with local centers of negative electron density, in particular, with the carbonylic oxygen atom.
{"title":"Control for selective sorption of heavy metals cations with anion exchanger AB-17-8 by modifying the surface with citrate groups","authors":"","doi":"10.1016/j.mencom.2024.09.042","DOIUrl":"10.1016/j.mencom.2024.09.042","url":null,"abstract":"<div><div>The citric acid modification produces an intermediate layer on the AB-17-8:C<sub>6</sub>H<sub>8</sub>O<sub>7</sub> surface; the layer, on one hand, is firmly secured to the surface owing to the electrostatic coupling between the citrate anion and the positively charged trimethylammonium centers of the anion exchanger surface; on the other hand, it has carbonyl groups with a local negative electron density. The sorption of heavy metals cations occurs through coordination interactions <em>via</em> electrostatic mechanism with local centers of negative electron density, in particular, with the carbonylic oxygen atom.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.001
Copolyfluorenes have drawn considerable attention owing to their remarkable optoelectronic characteristics, chemical and thermal stability, good film-forming properties, and thus present an active subject of cutting-edge research in the organic electroluminescence. This current systematic review examines and summarizes the latest research on copolyfluorene-based materials for light emitting layers of OLEDs over the past decades.
{"title":"Fluorene-based π-conjugated polymers for OLEDs: advances, opportunities, and challenges","authors":"","doi":"10.1016/j.mencom.2024.09.001","DOIUrl":"10.1016/j.mencom.2024.09.001","url":null,"abstract":"<div><div>Copolyfluorenes have drawn considerable attention owing to their remarkable optoelectronic characteristics, chemical and thermal stability, good film-forming properties, and thus present an active subject of cutting-edge research in the organic electroluminescence. This current systematic review examines and summarizes the latest research on copolyfluorene-based materials for light emitting layers of OLEDs over the past decades.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.030
A herein proposed PdAu/Al2O3 egg-shell catalyst for selective acetylene hydrogenation combines two factors to provide perfect performance: isolation of Pd1 active sites by Au and an egg-shell distribution of the active phase across the catalyst pellets. The PdAu/Al2O3 catalyst exhibits high acetylene hydrogenation activity at the level of Pd-catalysts and high intrinsic ethylene selectivity of Au-catalysts.
本文提出的一种用于选择性乙炔加氢的 PdAu/Al2O3 蛋壳催化剂结合了两个因素以提供完美的性能：用金隔离 Pd1 活性位点以及活性相在催化剂颗粒上的蛋壳分布。PdAu/Al2O3 催化剂在 Pd 催化剂的水平上表现出较高的乙炔氢化活性，在 Au 催化剂的水平上表现出较高的内在乙烯选择性。
{"title":"Performance of PdAu/Al2O3 egg-shell catalyst with isolated Pd1 sites for selective hydrogenation of acetylene","authors":"","doi":"10.1016/j.mencom.2024.09.030","DOIUrl":"10.1016/j.mencom.2024.09.030","url":null,"abstract":"<div><div>A herein proposed PdAu/Al<sub>2</sub>O<sub>3</sub> egg-shell catalyst for selective acetylene hydrogenation combines two factors to provide perfect performance: isolation of Pd<sub>1</sub> active sites by Au and an egg-shell distribution of the active phase across the catalyst pellets. The PdAu/Al<sub>2</sub>O<sub>3</sub> catalyst exhibits high acetylene hydrogenation activity at the level of Pd-catalysts and high intrinsic ethylene selectivity of Au-catalysts.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.039
The single-crystal X-ray study of ClSi(OCH2CH2)3N showed the formation of a cluster of three silatrane molecules with one acetonitrile molecule featuring hypercoordinated Si atoms in a trigonal-bipyramidal coordination environment with O atom in the equatorial plane. A number of solid-phase structural parameters and the conformation of the fivemembered rings of 1-chlorosilatrane were thus clarified.
ClSi(OCH2CH2)3N 的单晶 X 射线研究表明，由三个硅烷分子与一个乙腈分子组成的硅烷簇具有超配位硅原子，处于三叉双锥配位环境中，O 原子位于赤道面上。因此，1-氯硅烷的一些固相结构参数和五元环的构象得到了澄清。
{"title":"X-ray structural study of 3:1 solvate of 1-chlorosilatrane with MeCN","authors":"","doi":"10.1016/j.mencom.2024.09.039","DOIUrl":"10.1016/j.mencom.2024.09.039","url":null,"abstract":"<div><div>The single-crystal X-ray study of ClSi(OCH<sub>2</sub>CH<sub>2</sub>)<sub>3</sub>N showed the formation of a cluster of three silatrane molecules with one acetonitrile molecule featuring hypercoordinated Si atoms in a trigonal-bipyramidal coordination environment with O atom in the equatorial plane. A number of solid-phase structural parameters and the conformation of the fivemembered rings of 1-chlorosilatrane were thus clarified.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.034
Direct N-vinylation of lactams with calcium carbide water system was performed under super-basic conditions. The vinylation occurred exclusively at NH group leaving CO function intact to afford cyclic N-vinyl amides in yields up to 97%. The obtained products are prospective monomers for the preparation of synthetic peptides.
{"title":"N-Vinylation of lactams with calcium carbide water system","authors":"","doi":"10.1016/j.mencom.2024.09.034","DOIUrl":"10.1016/j.mencom.2024.09.034","url":null,"abstract":"<div><div>Direct <em>N</em>-vinylation of lactams with calcium carbide water system was performed under super-basic conditions. The vinylation occurred exclusively at NH group leaving C<img>O function intact to afford cyclic <em>N</em>-vinyl amides in yields up to 97%. The obtained products are prospective monomers for the preparation of synthetic peptides.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mencom.2024.09.040
A one-step reaction was discovered giving the h3-allyl complex [Pd(h3-C6H9O)(μ-Cl)]2. The formation of the substituted h3-allyl ligand in the complex occurs as a result of the condensation of acetone at room temperature in a solution containing [Pd(PhCN)2Cl2] and organic acids. The structure of the resulting Pdii complex was determined by single crystal X-ray diffraction analysis.
发现了一种一步反应生成 h3-烯丙基配合物 [Pd(h3-C6H9O)(μ-Cl)]2。在室温下，丙酮在含有[Pd(PhCN)2Cl2]和有机酸的溶液中缩合，形成了该配合物中的取代 h3-烯丙基配体。通过单晶 X 射线衍射分析确定了 Pdii 复合物的结构。
{"title":"Unusual condensation of acetone giving η3-allyl ligand in the [Pd(η3-C6H9O)(μ-Cl)]2 complex","authors":"","doi":"10.1016/j.mencom.2024.09.040","DOIUrl":"10.1016/j.mencom.2024.09.040","url":null,"abstract":"<div><div>A one-step reaction was discovered giving the h<sup>3</sup>-allyl complex [Pd(h<sup>3</sup>-C<sub>6</sub>H<sub>9</sub>O)(μ-Cl)]<sub>2</sub>. The formation of the substituted h<sup>3</sup>-allyl ligand in the complex occurs as a result of the condensation of acetone at room temperature in a solution containing [Pd(PhCN)<sub>2</sub>Cl<sub>2</sub>] and organic acids. The structure of the resulting Pd<sup>ii</sup> complex was determined by single crystal X-ray diffraction analysis.</div></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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