Introduction: This study aimed to determine the relationship between the expression of epidermal growth factor receptor (EGFR) and pathological indicators in papillary thyroid carcinoma (PTC).
Evidence acquisition: PubMed, Embase, Web of Science, MEDLINE, and Cochrane Library databases were searched for relevant clinical trials. The odds ratio (OR) and 95% confidence interval (CI) showed the effect magnitude of the expression of EGFR, age, gender, tumor size, lymph node metastasis (LNM), extrathyroid extension, and tumor, lymph node, metastasis) stage. Stata 12.0 was used for statistical analysis of data.
Evidence synthesis: A total of 845 cases of PTC were included through the retrieval of 8 studies performed abroad. EGFR significantly correlated with extrathyroid extension (OR=3.25; 95% CI: 1.25-8.43; Z=2.42; P=0.015), LNM (OR=8.40; 95% CI: 5.44-12.97; Z=9.61; P=0.000), TNM stage (OR=2.30, 95% CI: 1.51-3.51; Z=3.87; P=0.000), and tumor size (OR=1.68; 95% CI: 1.06-2.68; Z=2.19; P=0.03). EGFR had no correlation with age (OR=1.13; 95% CI: 0.83-1.53; Z=0.77; P=0.44), gender (OR=0.93; 95% CI: 0.66-1.33; Z=0.38; P=0.70). Sensitivity analysis demonstrated that the studies by Cui Tang and Alfred King Yin Lam in LNM impacted the pooled OR. After removing these two studies, relatively stable results between the expression of EGFR and LNM were obtained.
Conclusions: The results in the expression of EGFR is frequent and cancer-specific event in PTC. Besides, the expression of EGFR was involved in the progression and metastasis of PTC.
{"title":"Clinicopathological significance of epidermal growth factor receptor expression in papillary thyroid carcinoma: a meta-analysis.","authors":"Xiao-Ru Qin, Jin-Ke Huang, Qi-Fan Yin, Xiao-Ming Shi, Jia-Chen Tang, Ling-Ling Hao, Peng-Fei Li, Jia Zhu, Yue-Xin Wang","doi":"10.23736/S2724-6507.20.03388-X","DOIUrl":"10.23736/S2724-6507.20.03388-X","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to determine the relationship between the expression of epidermal growth factor receptor (EGFR) and pathological indicators in papillary thyroid carcinoma (PTC).</p><p><strong>Evidence acquisition: </strong>PubMed, Embase, Web of Science, MEDLINE, and Cochrane Library databases were searched for relevant clinical trials. The odds ratio (OR) and 95% confidence interval (CI) showed the effect magnitude of the expression of EGFR, age, gender, tumor size, lymph node metastasis (LNM), extrathyroid extension, and tumor, lymph node, metastasis) stage. Stata 12.0 was used for statistical analysis of data.</p><p><strong>Evidence synthesis: </strong>A total of 845 cases of PTC were included through the retrieval of 8 studies performed abroad. EGFR significantly correlated with extrathyroid extension (OR=3.25; 95% CI: 1.25-8.43; Z=2.42; P=0.015), LNM (OR=8.40; 95% CI: 5.44-12.97; Z=9.61; P=0.000), TNM stage (OR=2.30, 95% CI: 1.51-3.51; Z=3.87; P=0.000), and tumor size (OR=1.68; 95% CI: 1.06-2.68; Z=2.19; P=0.03). EGFR had no correlation with age (OR=1.13; 95% CI: 0.83-1.53; Z=0.77; P=0.44), gender (OR=0.93; 95% CI: 0.66-1.33; Z=0.38; P=0.70). Sensitivity analysis demonstrated that the studies by Cui Tang and Alfred King Yin Lam in LNM impacted the pooled OR. After removing these two studies, relatively stable results between the expression of EGFR and LNM were obtained.</p><p><strong>Conclusions: </strong>The results in the expression of EGFR is frequent and cancer-specific event in PTC. Besides, the expression of EGFR was involved in the progression and metastasis of PTC.</p>","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":" ","pages":"175-181"},"PeriodicalIF":4.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38811003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-07DOI: 10.1007/s11024-023-09507-x
Nicole Philippczyck, Jan Grundmann, Simon Oertel
{"title":"The Framing of Diversity Statements in European Universities: The Role of Imprinting and Institutional Legacy","authors":"Nicole Philippczyck, Jan Grundmann, Simon Oertel","doi":"10.1007/s11024-023-09507-x","DOIUrl":"https://doi.org/10.1007/s11024-023-09507-x","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"60 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85994975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1007/s11024-023-09512-0
Ehler Voss
{"title":"Correction to: Conjuration and Conspiracy. The Controversy Over the German Covid Policy as a Mediumistic Trial, or: The Medium is the Mess","authors":"Ehler Voss","doi":"10.1007/s11024-023-09512-0","DOIUrl":"https://doi.org/10.1007/s11024-023-09512-0","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"34 1","pages":"459-460"},"PeriodicalIF":4.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82176905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1007/s11024-023-09511-1
Jaron Harambam, Ehler Voss
{"title":"The Corona Truth Wars: Epistemic Disputes and Societal Conflicts around a Pandemic—An Introduction to the Special Issue","authors":"Jaron Harambam, Ehler Voss","doi":"10.1007/s11024-023-09511-1","DOIUrl":"https://doi.org/10.1007/s11024-023-09511-1","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"273 1","pages":"299 - 313"},"PeriodicalIF":4.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77547188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.1007/s11024-023-09509-9
Wolfgang Krohn
{"title":"Hans-Jörg Rheinberger, Split and Splice. A Phenomenology of Experimentation","authors":"Wolfgang Krohn","doi":"10.1007/s11024-023-09509-9","DOIUrl":"https://doi.org/10.1007/s11024-023-09509-9","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"381 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76443621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-11DOI: 10.1007/s11024-023-09508-w
Ehler Voss
{"title":"Conjuration and Conspiracy. The Controversy over the German Covid Policy as a Mediumistic Trial, or: The Medium is the Mess","authors":"Ehler Voss","doi":"10.1007/s11024-023-09508-w","DOIUrl":"https://doi.org/10.1007/s11024-023-09508-w","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"13 1","pages":"435 - 458"},"PeriodicalIF":4.1,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73195704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-09DOI: 10.1007/s11024-023-09506-y
Lilian Tang, H. Horta
{"title":"Supporting Academic Women’s Careers: Male and Female Academics’ Perspectives at a Chinese Research University","authors":"Lilian Tang, H. Horta","doi":"10.1007/s11024-023-09506-y","DOIUrl":"https://doi.org/10.1007/s11024-023-09506-y","url":null,"abstract":"","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"97 6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76005479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esta investigación tiene como objetivo fortalecer el aprendizaje de la Biología a través de prácticas experimentales en los estudiantes de bachillerato. Se realizó un diseño cuasiexperimental, con enfoque mixto, cualitativo y cuantitativo, con una metodología explicativa, descriptiva, de campo y comparativa, mediante los métodos inductivo‐deductivo y descriptivo. La muestra fue de 56 estudiantes divididos en un grupo experimental y un grupo de control. Para determinar diferencias entre las notas obtenidas en los test de glúcidos, lípidos, proteínas y ácidos nucleicos se empleó la prueba U de Mann Whitney, y la prueba Wilcoxon se utilizó para establecer si existían diferencias significativas entre el pretest y postest de biomoléculas en cada grupo con un nivel de significancia p<0.05. Al comparar los resultados del pretest y el postest se puede evidenciar que las prácticas experimentales tienen un impacto significativo en el rendimiento académico de los estudiantes. En conclusión, las prácticas experimentales áulicas mejoran en gran medida el rendimiento de los estudiantes
{"title":"Experimental practices to strengthen the learning of Biology in high school students","authors":"Rocio Natividad Morejon Lucio, Lilian Sosa Fernandez‐Aballi","doi":"10.47460/minerva.v4i11.125","DOIUrl":"https://doi.org/10.47460/minerva.v4i11.125","url":null,"abstract":"Esta investigación tiene como objetivo fortalecer el aprendizaje de la Biología a través de prácticas experimentales en los estudiantes de bachillerato. Se realizó un diseño cuasiexperimental, con enfoque mixto, cualitativo y cuantitativo, con una metodología explicativa, descriptiva, de campo y comparativa, mediante los métodos inductivo‐deductivo y descriptivo. La muestra fue de 56 estudiantes divididos en un grupo experimental y un grupo de control. Para determinar diferencias entre las notas obtenidas en los test de glúcidos, lípidos, proteínas y ácidos nucleicos se empleó la prueba U de Mann Whitney, y la prueba Wilcoxon se utilizó para establecer si existían diferencias significativas entre el pretest y postest de biomoléculas en cada grupo con un nivel de significancia p<0.05. Al comparar los resultados del pretest y el postest se puede evidenciar que las prácticas experimentales tienen un impacto significativo en el rendimiento académico de los estudiantes. En conclusión, las prácticas experimentales áulicas mejoran en gran medida el rendimiento de los estudiantes","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"71 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86405988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.47460/minerva.v4i11.126
J. Leon, Mishel Pavon, Diego Murillo, M. León, Damaris Guatumillo, Joel Toroshina
Ecuador's Floriculture Industry is essential as one of the biggest flower producers exporting flowers worldwide. However, flower production generates harmful environmental waste, emitting greenhouse gases. Therefore, it is vital to implement sustainable practices. In this document, an analysis of the supply chain will be conducted to provide a cleaner production system and efficiency for the Floriculture Industry. The objective is to reduce the harmful impact on the environment, searching solutions to minimize water use and develop energy-efficient technology. As a result, we look forward to sustainable flower production, protecting the environment and natural resources.
{"title":"Waste managing plan for floriculture plants","authors":"J. Leon, Mishel Pavon, Diego Murillo, M. León, Damaris Guatumillo, Joel Toroshina","doi":"10.47460/minerva.v4i11.126","DOIUrl":"https://doi.org/10.47460/minerva.v4i11.126","url":null,"abstract":"Ecuador's Floriculture Industry is essential as one of the biggest flower producers exporting flowers worldwide. However, flower production generates harmful environmental waste, emitting greenhouse gases. Therefore, it is vital to implement sustainable practices. In this document, an analysis of the supply chain will be conducted to provide a cleaner production system and efficiency for the Floriculture Industry. The objective is to reduce the harmful impact on the environment, searching solutions to minimize water use and develop energy-efficient technology. As a result, we look forward to sustainable flower production, protecting the environment and natural resources.","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"23 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73988448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.47460/minerva.v4i11.124
Juana D. Pinargote Jimenez, Mirna C. Oviedo
This paper presents an educational design that develops, implements, and evaluates certain educational games to support teaching and learning biology in secondary school. A quasi-experimental design was employed in which biology was taught to an experimental group using educational games while a control group was taught using traditional methods. The quasi-experiment was conducted in the first year of a technical high school, with two biology teachers assigned to each of the groups involved in the study. Both the control group and the experimental group consisted of 40 students. The study used observation guides, surveys, and questionnaires to collect data. The results demonstrate that educational games positively impact the teaching and learning of biology.
{"title":"Playful strategies for effective high school biology teaching","authors":"Juana D. Pinargote Jimenez, Mirna C. Oviedo","doi":"10.47460/minerva.v4i11.124","DOIUrl":"https://doi.org/10.47460/minerva.v4i11.124","url":null,"abstract":"This paper presents an educational design that develops, implements, and evaluates certain educational games to support teaching and learning biology in secondary school. A quasi-experimental design was employed in which biology was taught to an experimental group using educational games while a control group was taught using traditional methods. The quasi-experiment was conducted in the first year of a technical high school, with two biology teachers assigned to each of the groups involved in the study. Both the control group and the experimental group consisted of 40 students. The study used observation guides, surveys, and questionnaires to collect data. The results demonstrate that educational games positively impact the teaching and learning of biology.","PeriodicalId":18592,"journal":{"name":"Minerva endocrinologica","volume":"55 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86787430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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