Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09238-3
Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak
BACKGROUND The introduction of direct-acting antivirals (DAAs) with their effectiveness and safety has revolutionized the approach to treating hepatitis C virus (HCV) infections. Nevertheless, elderly patients have often been excluded from clinical trials, so the results of real-world studies are particularly important in the context of the geriatric population. The study aimed to analyze the effectiveness and safety of antiviral DAA treatment in HCV-infected patients over the age of 65, with notable inclusion of those over the age of 85. METHODS The analyzed patients were divided by age into three groups: group A (65-74 years), group B (75-84 years) and group C (85 years or older). Patients started DAA based therapy at 22 hepatology centers between July 2015 and December 2022. RESULTS A total of 3505 elderly patients were included in the analysis, and this group consisted of 2501 patients in group A, 893 in group B, and 111 in group C. The study population, regardless of age, was dominated by women. Patients had a high prevalence of comorbidities (84.9%, 92.2%, and 93.7%, respectively) as well as a high rate of concomitant medications. The sustained virological response was 97.9% in groups A and B and 100% in group C. The therapy was well-tolerated, with a comparable safety profile observed in all analyzed groups. CONCLUSIONS DAA-based therapies are highly effective and well tolerated by the elderly patients, including those over 85. Age should not be a barrier to treatment, but careful management is necessary.
{"title":"Effectiveness and safety of direct-acting antivirals in the therapy of HCV-infected elderly people.","authors":"Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak","doi":"10.23736/S0026-4806.24.09238-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09238-3","url":null,"abstract":"BACKGROUND\u0000The introduction of direct-acting antivirals (DAAs) with their effectiveness and safety has revolutionized the approach to treating hepatitis C virus (HCV) infections. Nevertheless, elderly patients have often been excluded from clinical trials, so the results of real-world studies are particularly important in the context of the geriatric population. The study aimed to analyze the effectiveness and safety of antiviral DAA treatment in HCV-infected patients over the age of 65, with notable inclusion of those over the age of 85.\u0000\u0000\u0000METHODS\u0000The analyzed patients were divided by age into three groups: group A (65-74 years), group B (75-84 years) and group C (85 years or older). Patients started DAA based therapy at 22 hepatology centers between July 2015 and December 2022.\u0000\u0000\u0000RESULTS\u0000A total of 3505 elderly patients were included in the analysis, and this group consisted of 2501 patients in group A, 893 in group B, and 111 in group C. The study population, regardless of age, was dominated by women. Patients had a high prevalence of comorbidities (84.9%, 92.2%, and 93.7%, respectively) as well as a high rate of concomitant medications. The sustained virological response was 97.9% in groups A and B and 100% in group C. The therapy was well-tolerated, with a comparable safety profile observed in all analyzed groups.\u0000\u0000\u0000CONCLUSIONS\u0000DAA-based therapies are highly effective and well tolerated by the elderly patients, including those over 85. Age should not be a barrier to treatment, but careful management is necessary.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"340 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-05-25DOI: 10.23736/S0026-4806.23.08640-8
Chuandong Wang, Yi Liu, Xiaojuan Zhang, Bo Hu
{"title":"A study on the correlation between remote radical surgical methods for gastric cancer and the risk of postoperative malnutrition in patients.","authors":"Chuandong Wang, Yi Liu, Xiaojuan Zhang, Bo Hu","doi":"10.23736/S0026-4806.23.08640-8","DOIUrl":"10.23736/S0026-4806.23.08640-8","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"251-252"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-07-13DOI: 10.23736/S0026-4806.23.08786-4
Aimei Miao, Yali Ni, Xiaoqiong Jiang, Chang Lv, Haohao Huang, Shuangshuang Chen, Xizhen Zhao, Cai Lin
{"title":"Nursing management strategy of stress injury based on skin temperature monitoring by infrared thermal imaging in postural management of paraplegic patients.","authors":"Aimei Miao, Yali Ni, Xiaoqiong Jiang, Chang Lv, Haohao Huang, Shuangshuang Chen, Xizhen Zhao, Cai Lin","doi":"10.23736/S0026-4806.23.08786-4","DOIUrl":"10.23736/S0026-4806.23.08786-4","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"215-218"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2021-07-16DOI: 10.23736/S0026-4806.21.07602-3
Yuanyuan Shao, Zhijun Zhou, Wei Su
{"title":"Effects of isoflurane on rats with cerebral ischemia/reperfusion injury and its potential molecular mechanism.","authors":"Yuanyuan Shao, Zhijun Zhou, Wei Su","doi":"10.23736/S0026-4806.21.07602-3","DOIUrl":"10.23736/S0026-4806.21.07602-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"256-257"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09174-2
Yongchao He, Kaili Wang, Jun Chen, Xiaoyu Liu, Yan Zheng
{"title":"Effectiveness of grid management in emergency operating room for cancer patients.","authors":"Yongchao He, Kaili Wang, Jun Chen, Xiaoyu Liu, Yan Zheng","doi":"10.23736/S0026-4806.24.09174-2","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09174-2","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"33 8","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09200-0
F. Numeroso, Luca Bottaro, Ali Younes, Andrea Ungar, A. Cabassi
BACKGROUND Hypotensive susceptibility in hypertensive patients could facilitate orthostatic hypotension, syncope and fall. The aim of this study was to identify incidence, clinical form, complications and risk factors for non-cardiac syncope in a cohort of hypertensive patients. METHODS This is an observational, case-controlled, retrospective study carried out on 168 patients, evaluated at the Hypertension Center of the University Hospital of Parma (Italy). Based on the presence of episodes of syncope during the six months prior to enrolment, we identified cases and controls and then we compared them to personal data, comorbidities, current drug regimens, presence of orthostatic hypotension, office and ambulatory blood pressure monitoring (ABPM) blood pressure (BP) values. RESULTS In patients with previous syncopal episodes (29.8% of total), we more frequently found female gender, comorbidities associated with autonomic dysfunction, diuretics and non-CV drugs potentially associated with hypotension in their current drug regimen, orthostatic hypotension and lower office and ABPM BP values. CONCLUSIONS To identify hypertensive patients at higher risk for syncope and falls, physicians should focus on comorbidities and current drug regimens, systematically perform an active standing test to identify orthostatic hypotension, employ ABPM to compare BP values with the pre-established target and highlight systolic BP drops and abnormalities suggesting concomitant autonomic dysfunction. The modulation of antihypertensive therapy is an effective tool to counteract the risk of non-cardiac syncope, with possible trauma or other negative influences.
{"title":"Incidence and risk factors for non-cardiac syncope in a cohort of patients addressing an accredited Arterial Hypertension Center: the Innocent Study.","authors":"F. Numeroso, Luca Bottaro, Ali Younes, Andrea Ungar, A. Cabassi","doi":"10.23736/S0026-4806.24.09200-0","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09200-0","url":null,"abstract":"BACKGROUND\u0000Hypotensive susceptibility in hypertensive patients could facilitate orthostatic hypotension, syncope and fall. The aim of this study was to identify incidence, clinical form, complications and risk factors for non-cardiac syncope in a cohort of hypertensive patients.\u0000\u0000\u0000METHODS\u0000This is an observational, case-controlled, retrospective study carried out on 168 patients, evaluated at the Hypertension Center of the University Hospital of Parma (Italy). Based on the presence of episodes of syncope during the six months prior to enrolment, we identified cases and controls and then we compared them to personal data, comorbidities, current drug regimens, presence of orthostatic hypotension, office and ambulatory blood pressure monitoring (ABPM) blood pressure (BP) values.\u0000\u0000\u0000RESULTS\u0000In patients with previous syncopal episodes (29.8% of total), we more frequently found female gender, comorbidities associated with autonomic dysfunction, diuretics and non-CV drugs potentially associated with hypotension in their current drug regimen, orthostatic hypotension and lower office and ABPM BP values.\u0000\u0000\u0000CONCLUSIONS\u0000To identify hypertensive patients at higher risk for syncope and falls, physicians should focus on comorbidities and current drug regimens, systematically perform an active standing test to identify orthostatic hypotension, employ ABPM to compare BP values with the pre-established target and highlight systolic BP drops and abnormalities suggesting concomitant autonomic dysfunction. The modulation of antihypertensive therapy is an effective tool to counteract the risk of non-cardiac syncope, with possible trauma or other negative influences.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"107 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2023-07-24DOI: 10.23736/S0026-4806.23.08788-8
Shujun Zhao, Xiao Sun, Rui Xu, Yaqin Wang, Muchen Zhang, Yuchen Sun, Yan Zhang
{"title":"Clinical efficacy and mechanism exploration of Tianma Gouteng decoction in improving gestational hypertension by regulating IL-6, NF-kB, and AngII.","authors":"Shujun Zhao, Xiao Sun, Rui Xu, Yaqin Wang, Muchen Zhang, Yuchen Sun, Yan Zhang","doi":"10.23736/S0026-4806.23.08788-8","DOIUrl":"10.23736/S0026-4806.23.08788-8","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"97-100"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9849835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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