{"title":"Clinical study on the efficacy of self-designed elimination soup in the accumulation of qi stagnation and blood stasis based on transient elasticity of liver and spleen.","authors":"Xinfeng Huang, Lina Xu, Yurong Li, Mingyue Song, Dongwang Zhan","doi":"10.23736/S0026-4806.23.08787-6","DOIUrl":"10.23736/S0026-4806.23.08787-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"100-102"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2021-02-22DOI: 10.23736/S0026-4806.21.07171-8
Alessandro DI Marco Berardino, Federica Sambuco, Francesco Travaglino, Antonina Re, Emanuele Gilardi
{"title":"Blood gas analysis changes and body position in patients with pneumonia due to SARS-CoV-2.","authors":"Alessandro DI Marco Berardino, Federica Sambuco, Francesco Travaglino, Antonina Re, Emanuele Gilardi","doi":"10.23736/S0026-4806.21.07171-8","DOIUrl":"10.23736/S0026-4806.21.07171-8","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"85-86"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25398478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of fiberoptic bronchoscopy assisted local injection of budesonide in improving the prognosis of severe pneumonia.","authors":"Linjuan Tian, Yunping Wu, Dong Wang, Wei Liu, Yongding Wei, Zhihe Zhou, Dongyue Zhang","doi":"10.23736/S0026-4806.21.07609-6","DOIUrl":"10.23736/S0026-4806.21.07609-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"88-89"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39046711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2023-05-19DOI: 10.23736/S0026-4806.23.08538-5
Yuki Kotani, Giovanni Landoni, Tommaso Scquizzato, Nadia Mohamed, Martina Baiardo Redaelli, Rosaria Sofia, Stefano Fresilli, Alberto Zangrillo, Maria L Azzolini
Introduction: Antiandrogen therapy can reduce the expression of transmembrane protease 2, which is essential for severe acute respiratory syndrome coronavirus-2 to enter the host cells. Prior trials suggested the efficacy of antiandrogen agents in patients with COVID-19. We investigated whether antiandrogen agents reduce mortality compared to placebo or usual care.
Evidence acquisition: We searched for randomized controlled trials comparing antiandrogen agents with placebo or usual care alone in adults with COVID-19 in PubMed, EMBASE, the Cochrane Library, the reference lists of retrieved articles, and publications by manufacturers of antiandrogen agents. The primary outcome was mortality at the longest follow-up available. The secondary outcomes included clinical worsening, the need for invasive mechanical ventilation, admission to the intensive care unit, hospitalization, and thrombotic events. We registered this systematic review and meta-analysis in PROSPERO International Prospective Register of Systematic Reviews (CRD42022338099).
Evidence synthesis: We included 13 randomized controlled trials enrolling 1934 COVID-19 patients. We found that antiandrogen agents reduced mortality at the longest follow-up available (91/1021 [8.9%] vs. 245/913 [27%]; risk ratio =0.40; 95% confidence interval, 0.25-0.65; P=0.0002; I2=54%). Antiandrogen therapy also reduced clinical worsening (127/1016 [13%] vs. 298/911 [33%]; risk ratio =0.44; 95% confidence interval, 0.27-0.71; P=0.0007; I2=70%) and hospitalization (97/160 [4.4%] vs. 24/165 [15%]; risk ratio =0.24; 95% confidence interval, 0.10-0.58; P=0.002; I2=44%). There was no significant difference in the other outcomes between the two treatment groups.
Conclusions: Antiandrogen therapy reduced mortality and clinical worsening in adult patients with COVID-19.
简介抗雄激素疗法可减少跨膜蛋白酶2的表达，而跨膜蛋白酶2是严重急性呼吸系统综合征冠状病毒-2进入宿主细胞的必要条件。之前的试验表明，抗雄激素药物对COVID-19患者有疗效。我们研究了与安慰剂或常规护理相比，抗雄激素药物是否能降低死亡率：我们在 PubMed、EMBASE、Cochrane 图书馆、检索到的文章的参考文献列表以及抗雄激素药物制造商的出版物中搜索了抗雄激素药物与安慰剂或单纯常规治疗对 COVID-19 成人患者的随机对照试验。主要结果是最长随访时间内的死亡率。次要结果包括临床恶化、有创机械通气需求、入住重症监护室、住院和血栓事件。我们在 PROSPERO 国际前瞻性系统综述注册中心（CRD42022338099）注册了这项系统综述和荟萃分析：我们纳入了13项随机对照试验，共招募了1934名COVID-19患者。我们发现，抗雄激素药物可降低最长随访时间内的死亡率（91/1021 [8.9%] vs. 245/913 [27%]；风险比 =0.40；95% 置信区间，0.25-0.65；P=0.0002；I2=54%）。抗雄激素治疗也减少了临床恶化（127/1016 [13%] vs. 298/911 [33%]；风险比 =0.44；95% 置信区间，0.27-0.71；P=0.0007；I2=70%）和住院（97/160 [4.4%] vs. 24/165 [15%]；风险比 =0.24；95% 置信区间，0.10-0.58；P=0.002；I2=44%）。结论：抗雄激素治疗可降低死亡率和并发症：抗雄激素治疗降低了COVID-19成年患者的死亡率和临床恶化程度。
{"title":"Antiandrogen agents in COVID-19: a meta-analysis of randomized trials.","authors":"Yuki Kotani, Giovanni Landoni, Tommaso Scquizzato, Nadia Mohamed, Martina Baiardo Redaelli, Rosaria Sofia, Stefano Fresilli, Alberto Zangrillo, Maria L Azzolini","doi":"10.23736/S0026-4806.23.08538-5","DOIUrl":"10.23736/S0026-4806.23.08538-5","url":null,"abstract":"<p><strong>Introduction: </strong>Antiandrogen therapy can reduce the expression of transmembrane protease 2, which is essential for severe acute respiratory syndrome coronavirus-2 to enter the host cells. Prior trials suggested the efficacy of antiandrogen agents in patients with COVID-19. We investigated whether antiandrogen agents reduce mortality compared to placebo or usual care.</p><p><strong>Evidence acquisition: </strong>We searched for randomized controlled trials comparing antiandrogen agents with placebo or usual care alone in adults with COVID-19 in PubMed, EMBASE, the Cochrane Library, the reference lists of retrieved articles, and publications by manufacturers of antiandrogen agents. The primary outcome was mortality at the longest follow-up available. The secondary outcomes included clinical worsening, the need for invasive mechanical ventilation, admission to the intensive care unit, hospitalization, and thrombotic events. We registered this systematic review and meta-analysis in PROSPERO International Prospective Register of Systematic Reviews (CRD42022338099).</p><p><strong>Evidence synthesis: </strong>We included 13 randomized controlled trials enrolling 1934 COVID-19 patients. We found that antiandrogen agents reduced mortality at the longest follow-up available (91/1021 [8.9%] vs. 245/913 [27%]; risk ratio =0.40; 95% confidence interval, 0.25-0.65; P=0.0002; I<sup>2</sup>=54%). Antiandrogen therapy also reduced clinical worsening (127/1016 [13%] vs. 298/911 [33%]; risk ratio =0.44; 95% confidence interval, 0.27-0.71; P=0.0007; I<sup>2</sup>=70%) and hospitalization (97/160 [4.4%] vs. 24/165 [15%]; risk ratio =0.24; 95% confidence interval, 0.10-0.58; P=0.002; I<sup>2</sup>=44%). There was no significant difference in the other outcomes between the two treatment groups.</p><p><strong>Conclusions: </strong>Antiandrogen therapy reduced mortality and clinical worsening in adult patients with COVID-19.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"37-44"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2023-06-13DOI: 10.23736/S0026-4806.23.08730-X
Hairu Sun, Xuexia Ji, Yan Jiao, Lei Wang, Jiao Wang
{"title":"Risk factors for ovarian hyperstimulation syndrome during IVF embryo transfer based on logistic regression analysis and construction of a forecasting model.","authors":"Hairu Sun, Xuexia Ji, Yan Jiao, Lei Wang, Jiao Wang","doi":"10.23736/S0026-4806.23.08730-X","DOIUrl":"10.23736/S0026-4806.23.08730-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"112-114"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The application value of circulating tumor DNA methylation biomarkers in early diagnosis of non-small cell lung cancer.","authors":"Dongping Wu, Jiwei Mao, Jianjiang Liu, Xiaoyu Zhang, Shenpeng Ying","doi":"10.23736/S0026-4806.23.08752-9","DOIUrl":"10.23736/S0026-4806.23.08752-9","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"107-109"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9662056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2023-08-03DOI: 10.23736/S0026-4806.23.08677-9
Gianni Belcaro, Maria R Cesarone, Andrea Ledda, Claudia Scipione, Valeria Scipione, Marcello Corsi, David Cox, Roberto Cotellese, Beatrice Feragalli
{"title":"Altitude trekking and Robuvit®: fatigue prevention and recovery.","authors":"Gianni Belcaro, Maria R Cesarone, Andrea Ledda, Claudia Scipione, Valeria Scipione, Marcello Corsi, David Cox, Roberto Cotellese, Beatrice Feragalli","doi":"10.23736/S0026-4806.23.08677-9","DOIUrl":"10.23736/S0026-4806.23.08677-9","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"83-84"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research on the digital application of telemedicine based on internet big data in the era of artificial intelligence.","authors":"Wenyu Huo, Kaihua Xie, Zakeerjiang Abudoukelimu, Yanping Zeng, Yunfei Wei, Jianquan Wang","doi":"10.23736/S0026-4806.23.08814-6","DOIUrl":"10.23736/S0026-4806.23.08814-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"92-95"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9981793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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