Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09241-3
Chunye Zhang, Liman Fu, Yu Chen, Wei Zhao, Xun Geng, Pin Wang
{"title":"Ultrasound combined with shear wave elastography to observe the pregnancy uterine wall and cervix for pre- and postnatal outcome comparison analysis.","authors":"Chunye Zhang, Liman Fu, Yu Chen, Wei Zhao, Xun Geng, Pin Wang","doi":"10.23736/S0026-4806.24.09241-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09241-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09270-X
R. Pellegrino, Valeria Nacca, F. Paragliola, Erika Martinelli, Alessandro Federico, A. Gravina
{"title":"Endoscopic calcium electroporation for unfit-for-surgery bleeding colorectal cancer: the dawn of a new treatment?","authors":"R. Pellegrino, Valeria Nacca, F. Paragliola, Erika Martinelli, Alessandro Federico, A. Gravina","doi":"10.23736/S0026-4806.24.09270-X","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09270-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09193-6
Siqi Zhu, Xiaolong Chen, Longlong Liu, Zhenlin He, Fa Sun, Kehua Jiang, Kun Chen
{"title":"The research of male Fournier's gangrene.","authors":"Siqi Zhu, Xiaolong Chen, Longlong Liu, Zhenlin He, Fa Sun, Kehua Jiang, Kun Chen","doi":"10.23736/S0026-4806.24.09193-6","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09193-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140787774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09238-3
Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak
BACKGROUND The introduction of direct-acting antivirals (DAAs) with their effectiveness and safety has revolutionized the approach to treating hepatitis C virus (HCV) infections. Nevertheless, elderly patients have often been excluded from clinical trials, so the results of real-world studies are particularly important in the context of the geriatric population. The study aimed to analyze the effectiveness and safety of antiviral DAA treatment in HCV-infected patients over the age of 65, with notable inclusion of those over the age of 85. METHODS The analyzed patients were divided by age into three groups: group A (65-74 years), group B (75-84 years) and group C (85 years or older). Patients started DAA based therapy at 22 hepatology centers between July 2015 and December 2022. RESULTS A total of 3505 elderly patients were included in the analysis, and this group consisted of 2501 patients in group A, 893 in group B, and 111 in group C. The study population, regardless of age, was dominated by women. Patients had a high prevalence of comorbidities (84.9%, 92.2%, and 93.7%, respectively) as well as a high rate of concomitant medications. The sustained virological response was 97.9% in groups A and B and 100% in group C. The therapy was well-tolerated, with a comparable safety profile observed in all analyzed groups. CONCLUSIONS DAA-based therapies are highly effective and well tolerated by the elderly patients, including those over 85. Age should not be a barrier to treatment, but careful management is necessary.
{"title":"Effectiveness and safety of direct-acting antivirals in the therapy of HCV-infected elderly people.","authors":"Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak","doi":"10.23736/S0026-4806.24.09238-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09238-3","url":null,"abstract":"BACKGROUND\u0000The introduction of direct-acting antivirals (DAAs) with their effectiveness and safety has revolutionized the approach to treating hepatitis C virus (HCV) infections. Nevertheless, elderly patients have often been excluded from clinical trials, so the results of real-world studies are particularly important in the context of the geriatric population. The study aimed to analyze the effectiveness and safety of antiviral DAA treatment in HCV-infected patients over the age of 65, with notable inclusion of those over the age of 85.\u0000\u0000\u0000METHODS\u0000The analyzed patients were divided by age into three groups: group A (65-74 years), group B (75-84 years) and group C (85 years or older). Patients started DAA based therapy at 22 hepatology centers between July 2015 and December 2022.\u0000\u0000\u0000RESULTS\u0000A total of 3505 elderly patients were included in the analysis, and this group consisted of 2501 patients in group A, 893 in group B, and 111 in group C. The study population, regardless of age, was dominated by women. Patients had a high prevalence of comorbidities (84.9%, 92.2%, and 93.7%, respectively) as well as a high rate of concomitant medications. The sustained virological response was 97.9% in groups A and B and 100% in group C. The therapy was well-tolerated, with a comparable safety profile observed in all analyzed groups.\u0000\u0000\u0000CONCLUSIONS\u0000DAA-based therapies are highly effective and well tolerated by the elderly patients, including those over 85. Age should not be a barrier to treatment, but careful management is necessary.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-07-04DOI: 10.23736/S0026-4806.23.08638-X
Jiaen Yang, Ning Jia, Zixuan Ou, Guangjin Zhou, Jiaqi Feng
{"title":"The alleviation of variable-frequency aVNS on neuroinflammatory injury in ischemia-reperfusion rats is related to the inhibition of TLR4 expression.","authors":"Jiaen Yang, Ning Jia, Zixuan Ou, Guangjin Zhou, Jiaqi Feng","doi":"10.23736/S0026-4806.23.08638-X","DOIUrl":"10.23736/S0026-4806.23.08638-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-05-25DOI: 10.23736/S0026-4806.23.08640-8
Chuandong Wang, Yi Liu, Xiaojuan Zhang, Bo Hu
{"title":"A study on the correlation between remote radical surgical methods for gastric cancer and the risk of postoperative malnutrition in patients.","authors":"Chuandong Wang, Yi Liu, Xiaojuan Zhang, Bo Hu","doi":"10.23736/S0026-4806.23.08640-8","DOIUrl":"10.23736/S0026-4806.23.08640-8","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2021-07-16DOI: 10.23736/S0026-4806.21.07602-3
Yuanyuan Shao, Zhijun Zhou, Wei Su
{"title":"Effects of isoflurane on rats with cerebral ischemia/reperfusion injury and its potential molecular mechanism.","authors":"Yuanyuan Shao, Zhijun Zhou, Wei Su","doi":"10.23736/S0026-4806.21.07602-3","DOIUrl":"10.23736/S0026-4806.21.07602-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-07-13DOI: 10.23736/S0026-4806.23.08786-4
Aimei Miao, Yali Ni, Xiaoqiong Jiang, Chang Lv, Haohao Huang, Shuangshuang Chen, Xizhen Zhao, Cai Lin
{"title":"Nursing management strategy of stress injury based on skin temperature monitoring by infrared thermal imaging in postural management of paraplegic patients.","authors":"Aimei Miao, Yali Ni, Xiaoqiong Jiang, Chang Lv, Haohao Huang, Shuangshuang Chen, Xizhen Zhao, Cai Lin","doi":"10.23736/S0026-4806.23.08786-4","DOIUrl":"10.23736/S0026-4806.23.08786-4","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.23736/S0026-4806.24.09174-2
Yongchao He, Kaili Wang, Jun Chen, Xiaoyu Liu, Yan Zheng
{"title":"Effectiveness of grid management in emergency operating room for cancer patients.","authors":"Yongchao He, Kaili Wang, Jun Chen, Xiaoyu Liu, Yan Zheng","doi":"10.23736/S0026-4806.24.09174-2","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09174-2","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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