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Optimized treatment of woven coronary artery by optical coherence tomography combined with coronary fractional flow reserve. 通过光学相干断层扫描结合冠状动脉分数血流储备优化冠状动脉编织治疗。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-06-01 Epub Date: 2023-07-06 DOI: 10.23736/S0026-4806.23.08719-0
Shize Sun, Zhi Zhao, Xiaoqun Zheng
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引用次数: 0
SNHG7 regulates spinal cord injury-induced inflammatory response, oxidative stress, and apoptosis via the miR-199b-5p/TRAF3 axis. SNHG7通过miR-199b-5p/TRAF3轴调节脊髓损伤诱导的炎症反应、氧化应激和细胞凋亡
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-06-01 Epub Date: 2023-06-13 DOI: 10.23736/S0026-4806.23.08689-5
Xiangli Luo, Zhan Wang, Jiancheng Xu, Zhao Gao, Zhengdong Song, Wenji Wang
{"title":"SNHG7 regulates spinal cord injury-induced inflammatory response, oxidative stress, and apoptosis via the miR-199b-5p/TRAF3 axis.","authors":"Xiangli Luo, Zhan Wang, Jiancheng Xu, Zhao Gao, Zhengdong Song, Wenji Wang","doi":"10.23736/S0026-4806.23.08689-5","DOIUrl":"10.23736/S0026-4806.23.08689-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"405-408"},"PeriodicalIF":4.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on neurological impairment and structural characteristics of primary open-angle glaucoma and normal tension glaucoma. 原发性开角型青光眼和正常张力型青光眼的神经损伤和结构特征研究。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-06-01 Epub Date: 2021-09-21 DOI: 10.23736/S0026-4806.21.07728-4
Jiyun Gao, Dabo Wang, Yuanxiao Ma, Feng Ding
{"title":"Study on neurological impairment and structural characteristics of primary open-angle glaucoma and normal tension glaucoma.","authors":"Jiyun Gao, Dabo Wang, Yuanxiao Ma, Feng Ding","doi":"10.23736/S0026-4806.21.07728-4","DOIUrl":"10.23736/S0026-4806.21.07728-4","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"420-422"},"PeriodicalIF":4.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39435740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LINC00858 facilitates the malignant development of Wilms' Tumor by targeting miR-653-5p. LINC00858 通过靶向 miR-653-5p 促进了 Wilms 肿瘤的恶性发展。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-06-01 Epub Date: 2020-06-12 DOI: 10.23736/S0026-4806.20.06566-0
Dan Zhou, Jilan Wang, Suping Xu, Zengming Li, Dan Kou

Background: To uncover the clinical significance of LINC00858 in the development of Wilms' Tumor and the potential molecular mechanism.

Methods: LINC00858 levels in Wilms' Tumor species and cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The clinical significance of LINC00858 in influencing pathological features and prognosis in patients with Wilms' Tumor was analyzed. Proliferative and migratory changes in Wilms' Tumor cells with LINC00858 knockdown were assessed. The downstream gene of LINC00858 was verified by luciferase assay, and its involvement in the development of Wilms' Tumor was further explored.

Results: LINC00858 was highly expressed in Wilms' Tumor tissues and cell lines. High level of LINC00858 was correlated to high rate of lymphatic metastasis and poor prognosis in patients with Wilms' Tumor. Knockdown of LINC00858 suppressed proliferative and migratory potentials in HFWT and 17-94 cells. MiR-653-5p was targeted by LINC00858. It was lowly expressed in Wilms' Tumor tissues and negatively regulated by LINC00858. Knockdown of miR-653-5p partially abolished the regulatory effects of LINC00858 on proliferative and migratory potentials in Wilms' Tumor cells.

Conclusions: LINC00858 is highly expressed in Wilms' Tumor species and correlated to lymphatic metastasis rate and overall survival in patients with Wilms' Tumor. Knockdown of LINC00858 suppresses Wilms' Tumor cells to proliferate and migrate via targeting miR-653-3p.

背景：揭示LINC00858在Wilms's肿瘤发生中的临床意义及潜在的分子机制：揭示LINC00858在Wilms's肿瘤发生发展中的临床意义和潜在的分子机制：方法：通过实时定量聚合酶链式反应（qRT-PCR）测定Wilms'肿瘤物种和细胞系中的LINC00858水平。分析了 LINC00858 在影响 Wilms 肿瘤患者病理特征和预后方面的临床意义。评估了 LINC00858 基因敲除后 Wilms 肿瘤细胞的增殖和迁移变化。通过荧光素酶实验验证了LINC00858的下游基因，并进一步探讨了其在Wilms'肿瘤发生发展中的参与作用：结果：LINC00858在Wilms'肿瘤组织和细胞系中高表达。结果：LINC00858在Wilms'肿瘤组织和细胞系中高表达，其高水平与Wilms'肿瘤患者的高淋巴转移率和预后不良相关。敲除 LINC00858 可抑制 HFWT 和 17-94 细胞的增殖和迁移潜能。LINC00858靶向了MiR-653-5p。它在 Wilms 肿瘤组织中低表达，并受 LINC00858 的负调控。敲除 miR-653-5p 可部分消除 LINC00858 对 Wilms 肿瘤细胞增殖和迁移潜能的调控作用：LINC00858在Wilms'肿瘤中高表达，并与Wilms'肿瘤患者的淋巴转移率和总生存率相关。敲除 LINC00858 可通过靶向 miR-653-3p 抑制 Wilms 肿瘤细胞的增殖和迁移。
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引用次数: 0
Imaging characteristics of left ventricular diastolic function in patients with dilated cardiomyopathy using three-dimensional speckle tracking imaging and MRI. 利用三维斑点追踪成像和核磁共振成像观察扩张型心肌病患者左心室舒张功能的成像特征。
IF 4.7 4区 医学 N/A MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-04-01 Epub Date: 2023-05-11 DOI: 10.23736/S0026-4806.23.08625-1
Yingjie Xu, Jing Zhu
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引用次数: 0
The improvement effect of acupuncture combined with massage on shoulder pain after stroke and its impact on limb function. 针灸结合推拿对中风后肩痛的改善效果及其对肢体功能的影响
IF 4.7 4区 医学 Q1 Medicine
Minerva medica
Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09269-3
Xiaonan Wang, Shaofeng Sun, Dongsheng Yu, Hua Yu
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引用次数: 0
The role of gut microbiota in host immune response mechanisms. 肠道微生物群在宿主免疫反应机制中的作用。
IF 4.7 4区 医学 Q1 Medicine
Minerva medica
Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09224-3
Jiaping Song, Yongcheng Xu, Tingting Wang, He Yu, He Dong
{"title":"The role of gut microbiota in host immune response mechanisms.","authors":"Jiaping Song, Yongcheng Xu, Tingting Wang, He Yu, He Dong","doi":"10.23736/S0026-4806.24.09224-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09224-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"131 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomal leptin accelerates gallbladder carcinoma by promoting M2-subtype macrophage polarization. 外泌体瘦素通过促进M2亚型巨噬细胞极化加速胆囊癌的发生
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-04-01 Epub Date: 2023-05-04 DOI: 10.23736/S0026-4806.23.08612-3
Lixin Liu, Yunxia Liu, Ya Zhu, Qiang Kang, Songling Zhao, Wei Wang, Hao Zou
{"title":"Exosomal leptin accelerates gallbladder carcinoma by promoting M2-subtype macrophage polarization.","authors":"Lixin Liu, Yunxia Liu, Ya Zhu, Qiang Kang, Songling Zhao, Wei Wang, Hao Zou","doi":"10.23736/S0026-4806.23.08612-3","DOIUrl":"10.23736/S0026-4806.23.08612-3","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"253-254"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical effect of Guizhi Fuling Pill combined with metformin on chronic pelvic inflammatory disease and its influence on inflammatory reaction in rats. 桂枝茯苓丸联合二甲双胍对慢性盆腔炎的临床疗效及其对大鼠炎症反应的影响
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-04-01 Epub Date: 2023-05-04 DOI: 10.23736/S0026-4806.23.08616-0
Shuang Han, Yinhui Ji, Yaping Song, Shiqin Wang
{"title":"Clinical effect of Guizhi Fuling Pill combined with metformin on chronic pelvic inflammatory disease and its influence on inflammatory reaction in rats.","authors":"Shuang Han, Yinhui Ji, Yaping Song, Shiqin Wang","doi":"10.23736/S0026-4806.23.08616-0","DOIUrl":"10.23736/S0026-4806.23.08616-0","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"245-248"},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How primary care research can be improved in clinical practice? An Italian case study. 如何在临床实践中改进初级保健研究？意大利案例研究。
IF 4.7 4区 医学 Q1 Medicine
Minerva medica
Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09044-X
A. Roveta, G. Pacileo, Mauro Cappelletti, Donatella Alesso, Alberto Bonissone, Lorenzo Fossati, Maria C Giaccari, Fabio Maccapani, Camillo Milano, Nicolò Parodi, Federico Torregiani, Francesca Ugo, Costanza Massarino, Luigi M Castello, A. Maconi
BACKGROUNDPrimary care is considered essential for the sustainability of the Health System. Practice-Based Research Networks (PBRN) play a strategic role in translation of primary care research into practice. Research Capacity Building in primary care requires a improvement and development strategy and well-developed research infrastructures to support physicians.METHODSWe used the system development methodology referring to the Lean Thinking to create and support a research team in primary and pediatric care. In particular a "cascade" deployment model and the X-Matrix, a framework used in management studies to support strategy definition and management process.RESULTSA research unit in primary and pediatric care has been created, by sharing vision, mission, core values, long-term strategies. The definition of a annual planning led to monitoring actions to guarantee the expected goals.CONCLUSIONSLean methodology is useful to adapt to various managerial and operational contexts, including healthcare. In our case it allowed team members to spread the culture of research, its importance and role to improve the health of patients, thank to the organizational support of a hospital IR, the Research and Innovation Department.
背景：初级保健被认为是卫生系统可持续发展的关键。基于实践的研究网络（PBRN）在将初级保健研究成果转化为实践方面发挥着战略性作用。初级医疗保健的研究能力建设需要改进和发展战略，以及完善的研究基础设施来支持医生。方法：我们采用了系统开发方法，参考精益思维，创建并支持初级和儿科医疗保健研究团队。通过分享愿景、使命、核心价值观和长期战略，我们创建了一个初级和儿科护理研究单位。结论精益方法适用于包括医疗保健在内的各种管理和运营环境。在我们的案例中，它使团队成员能够传播研究文化、研究的重要性以及在改善患者健康方面的作用，这要归功于医院内部研究与创新部的组织支持。
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引用次数: 0
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