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The Methodology of the Community-Oriented Primary Care (COPC) Process 社区导向初级保健(COPC)过程的方法学
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2019.7.101-104
M. Zildžić
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引用次数: 1
Evaluation of Hematological Parameters After ESWL and Ureterorenoscopy for the Treatment of Kidney Stones ESWL和输尿管镜治疗肾结石后血液学参数的评价
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2023.29-34
J. Prstojevic, M. Hasanbegovic, V. Mišanović, Almira Lujinović, Azra Metović, J. Mušanović, J. Alić
Background: Bleeding and hematuria can be a consequence of both ESWL and URS treatment.Changes in hematological parameters may be indicative of bleeding events.Objective: The aim of the present study was to explore the hematological parameters after ESWL and ureterorenoscopy for the treatment of kidney stones. Methods: A prospective study included patients (120) with verified ureterolithiasis <10 mm in the upper half of the proximal third of the ureter. Patients were divided into two groups using the random sample method for the application of active stone removal methods ESWL or URS with contact disintegration.Patients were evaluated with routine hematological, biochemical blood parameters, and non-contrast enhanced computed abdominal tomography (CT) before the procedure.Routine laboratory analyzes were performed using standard methods and included determination of the number of erythrocytes, platelets, hemoglobin, hematocrit, glucose, INR, APTTwhich were measured preintervention, the first postoperative day and six months after the intervention. Results: The preintervention hemoglobin value in patients with urolithiasis treated with URS treatment was 140 g/L (136.2–155.7), and was statistically significantly higher compared to the measurement on the first post-intervention day [137.5 g/L (127, 2–156.7) (p<0,05)], as well as in relation to the measurement after six months [139 g/L (134.2–151.7), (p<0,05).The pre-interventional hematocrit value in patients with urolithiasis treated with URS treatment was 0.42 (0.41–0.47), but it dropped statistically significantly on the measurement on the first post-intervention day to a value of 0.41 (0.38–0, 47) (p=0.003). The hematocrit value after six months was 0.44 (0.41–0.47) and was statistically significantly higher compared to the pre-intervention measurement (p=0.002), as well as compared to the measurement on the first post-intervention day (p< 0.001). The pre-intervention INR value in patients with urolithiasis treated with URS treatment was 0.90 (0.86–1.1), and on the first post-intervention day, it increased statistically significantly to a value of 0.99 (0.89–1.1), (p=0.005).The INR value after six months continued to grow to a value of 1.02 (0.96–1.2), which was statistically significantly higher compared to the INR value measured on the first post-intervention day (p<0.001), as and in relation to the INR value measured before the intervention (p=0.007).Conclusion: The results of this study, in terms of hematological parameters, showed more favorable outcomes in patients treated with ESWL compared to URS lithotripsy. Significantly lower hemoglobin values six months after URS treatment, as well as a decrease in the number of platelets on the first postoperative day, lead to the conclusion that URS lithotripsy, which represents a more aggressive method compared to ESWL, may have less favorable consequences for patients.
背景:出血和血尿可能是ESWL和尿路治疗的结果。血液学参数的变化可能是出血事件的指示。目的:探讨体外冲击波碎石联合输尿管镜治疗肾结石后的血液学参数。方法:一项前瞻性研究纳入了输尿管近三分之一上部小于10毫米的输尿管结石患者(120例)。采用随机抽样法将患者分为两组,分别采用主动取石方法ESWL或尿路尿路合并接触性崩解。术前对患者进行常规血液学、血液生化参数和非增强腹部计算机断层扫描(CT)评估。采用标准方法进行常规实验室分析,包括测定干预前、术后第一天和干预后6个月的红细胞、血小板、血红蛋白、红细胞压积、葡萄糖、INR、apt的数量。结果:尿石症患者经URS治疗后干预前血红蛋白值为140 g/L(136.2 ~ 155.7),高于干预后第1天的137.5 g/L (127.2 ~ 156.7) (p< 0.05),高于6个月后的139 g/L(134.2 ~ 151.7),差异有统计学意义(p< 0.05)。尿石症患者行URS治疗时,介入前红细胞压积值为0.42(0.41 - 0.47),干预后第1天测量时,红细胞压积值为0.41(0.38 - 0.47),差异有统计学意义(p=0.003)。6个月后的红细胞压积值为0.44(0.41-0.47),与干预前比较(p=0.002),与干预后第1天比较(p< 0.001),差异有统计学意义。尿石症患者经URS治疗后干预前INR值为0.90(0.86-1.1),干预后第1天INR值上升至0.99(0.89-1.1),差异有统计学意义(p=0.005)。6个月后的INR值继续增长至1.02(0.96-1.2),与干预后第一天测量的INR值相比(p<0.001),与干预前测量的INR值相比(p=0.007),有统计学意义上的显著提高(p<0.001)。结论:本研究结果显示,在血液学参数方面,ESWL治疗患者比URS碎石治疗更有利。尿路碎石治疗6个月后血红蛋白值明显降低,术后第一天血小板数量减少,这表明尿路碎石比ESWL更积极,但对患者的影响可能更差。
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引用次数: 0
Bibliometric Indices and its Role for the Quality Assessment of the Authors Published Content in the Scientific Journals 文献计量指标及其在科技期刊作者发表内容质量评价中的作用
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2021.9.244-253
I. Masic
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引用次数: 4
Non-medical Measures for Infectious Disease Control Should Be More Evidence-based 传染病控制的非医学措施应更多地以证据为基础
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2021.9.50-51
S. Janković
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引用次数: 0
Altered Vaginal pH Value and Enterobacteria as a Risk Factor in the Development of Precancerous Lesions of the Cervix 阴道pH值改变和肠杆菌是子宫颈癌前病变发展的危险因素
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2022.10.102-105
A. Barakovic, Mahira Jahić, A. Cerovac, A. Hadžimehmedović
Background: Vaginal microflora plays an important role in cervical carcinogenesis. An increase in vaginal pH is associated with the severity of squamous intraepithelial lesion (SIL) and a decrease in the number of lactobacilli. Microbial dysbiosis contributes to the damage of the epithelial barrier, as well as the reprogramming of immune and metabolic signaling. Dysbiotic bacteria cause damage to the epithelial barrier, immune dysregulation and genotoxicity and create a tumor-permissive microenvironment. Objective: The aim of this study was to determine the presence of risk factors (abnormal colposcopic and microbiological status, elevated pH of the vaginal environment) in regular Pap tests and LSIL. Methods: Retrospective prospective study 2021-2022. 90 women with pap smears were analyzed: 40 with LSIL at the Gynecological Center “Dr. Mahira Jahić” Tuzla and 50 with normal findings at the Tesanj Health Center. General data such as: age of the subjects, reproductive status, contraception, smoking and data on colposcopic examination, microbiological findings and vaginal pH value were analyzed. Statistical data processing was done in the SPSS program. Results: The average age of the test subjects is 39.94, in normal Pap 41.20 years, and in LSIL 38.38 years. The vital characteristics of the subjects did not differ significantly, except for smoking, where in LSIL findings, they consumed cigarettes significantly more often. Abnormal colposcopic examination were found in 85% (N-34) of women with LSIL. In subjects with LSIL, a positive microbiological test for enterobacteria was found in 47.5% (N-19) and a normal pap test in 12% (N-6). Statistically significant difference p=0.00523 p<0.05, E faecalis and E coli had the highest prevalence in LSIL. The mean pH value of the vaginal environment in LSIL is 5.38, and 4.96 in a regular pap test. Subjects with LSIL in 10% (N-4) had a normal pH test, and 48% (N-24) had a normal Pap test. P=0.00129 p < (0.05). A normal pH value was significantly more common in subjects with a normal Pap test. Microbiological flora, especially enterogenic bacteria, are more common in LSIL than in women with a regular pap test. Conclusion: when monitoring women with LSIL, special attention should be paid to the elimination of present enterobacteria (E.faecalis and E.coli) as a possible risk factor in the development of precancerous lesions (SIL) and cervical cancer.
背景:阴道菌群在宫颈癌发生中起重要作用。阴道pH值的升高与鳞状上皮内病变(SIL)的严重程度和乳酸菌数量的减少有关。微生物生态失调有助于上皮屏障的损伤,以及免疫和代谢信号的重编程。益生菌导致上皮屏障损伤、免疫失调和遗传毒性,并创造肿瘤容许的微环境。目的:本研究的目的是确定在常规巴氏试验和LSIL中存在的危险因素(阴道镜和微生物状态异常,阴道环境pH升高)。方法:2021-2022年回顾性前瞻性研究。对90名接受子宫颈抹片检查的妇女进行了分析:40名在图兹拉妇科中心“Mahira jahiki博士”患有LSIL, 50名在特桑吉健康中心检查结果正常。分析研究对象的年龄、生育状况、避孕、吸烟等一般资料,以及阴道镜检查、微生物学检查和阴道pH值等资料。统计数据处理在SPSS软件中完成。结果:受试者平均年龄39.94岁,正常Pap组平均年龄41.20岁,低sil组平均年龄38.38岁。受试者的重要特征没有显著差异,除了吸烟,在LSIL研究结果中,他们吸烟的频率明显更高。阴道镜检查异常的女性占85% (N-34)。在LSIL患者中,肠道菌群检测阳性的占47.5% (N-19),巴氏试验正常的占12% (N-6)。差异有统计学意义p=0.00523 p<0.05,粪肠杆菌和大肠杆菌在LSIL中患病率最高。LSIL患者阴道环境的平均pH值为5.38,常规巴氏试验为4.96。10% (N-4) LSIL患者pH试验正常,48% (N-24) Pap试验正常。P=0.00129 P <(0.05)。正常的pH值在巴氏试验正常的受试者中更为常见。微生物菌群,特别是肠源性细菌,在LSIL中比在常规巴氏涂片检查的妇女中更常见。结论:在监测LSIL妇女时,应特别注意消除存在的肠杆菌(粪肠杆菌和大肠杆菌),这是癌前病变(SIL)和宫颈癌发展的可能危险因素。
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引用次数: 0
In Opportunity Losses for Non-COVID-19 Patients Due to Restricted Access Healthcare 非covid -19患者因获得医疗服务受限而遭受的机会损失
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2021.9.294/295
S. Jankovic
letter, would like to draw attention to the necessity of investing in extensive epidemiological and pharmacoeconomic research on the benefits and harms (costs) of interventions and measures taken in the fight against the COVID 19 pandemic, so that rational decisions can be made in close future.
信中,我想提请大家注意,有必要投资于广泛的流行病学和药物经济学研究,研究在抗击COVID - 19大流行中采取的干预措施和措施的利弊(成本),以便在不久的将来做出理性决策。
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引用次数: 0
The Importance of IOL Selection in Patients With Young-age Cataracts: a Case Report 青年白内障患者人工晶状体选择的重要性:1例报告
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2022.10.176-182
Bobana Petrovic, Alma Biscevic, M. Pjano, Ajla Salkica
Background: A cataract is a type of degenerative change of the lens, which is characterized by the clouding of the lens followed by symptoms of optical deterioration. Over 70 years ago, Sir Harold Ridley implanted the first useable modern-day intraocular lens (IOL) implant. A lot has happened since then. The IOL is arguably the most life-changing and innovative implant in the history of medicine. Currently, there are several types of intraocular lenses on the market. The main classification could be monofocal lenses, multifocal, trifocal, extended depth of focus (EDOF) lenses, and toric lenses. Objective: The aim of this case report is to report the importance of IOL selection in patients with young-age cataracts. Case report: A 35-year-old patient presented first time at our Clinic. In the last six months, he noticed poor vision in his left eye, even with spectacles. The right eye was operated on in another institution in 2020, due to the presence of a young-age cataract. After a complete preoperative ophthalmological examination, we discovered the presence of a cataract in the left eye. UDVA of the left eye was 0.4, and CDVA was +0.50/+0.50/30°=0.5. UNVA and DCNVA was J2. We decided to implant TECNIS Synergy™ IOL (Johnson & Johnson Vision, Santa Ana, CA, USA) during the cataract surgery. That EDOF IOL bridges the gap between the performance of monofocal and multifocal IOLs and delivers continuous high-contrast vision for patients with cataracts from far through near, even in low-light conditions. There were no intraoperative or postoperative complications. On a 7-day, check-up UDVA of the left eye was 1.0, and UNVA was J1. The patient was satisfied with the vision in the left eye, so he wanted to correct the vision of the right eye which was implanted with SENSAR® IOL (Johnson & Johnson Vision, Santa Ana, CA, USA), with a residual diopter of +2.00/+1.00/120 for distance, and +4.50/+1.00/120 for near vision. This choice of IOL in the other institution was not an ideal solution for this patient due to his young age and occupation. The capsular bag was already in slight fibrosis, so the explantation of the existing IOL and implantation of the new one was not a reasonable option. We decided to go with the multifocal AddOn® toric lens (1stQ GmbH, Mannheim, Germany), the refractive-surgery platform for vision enhancement of pseudophakic eyes, that also correct residual astigmatism. On a 7-day check-up, this patient’s UDVA was 1.0 and UNVA was J1. The result was a happy patient, who could go back to his everyday life without spectacle independence. Conclusion: Good unaided distance visual acuity (VA) is now a realistic expectation following cataract surgery and intraocular lens (IOL) implantation.  We should be aware of patient expectations and demands, especially when having a patient with young-age cataracts. Often more time should be spent on preoperative IOL planning than cataract surgery itself.
背景:白内障是一种晶状体的退行性改变,其特征是晶状体混浊,随后出现光学退化症状。70多年前,哈罗德·雷德利爵士植入了第一个可用的现代人工晶状体(IOL)。从那以后发生了很多事情。人工晶状体可以说是医学史上最能改变生活、最具创新性的植入物。目前,市场上有几种类型的人工晶状体。主要分类为单焦点透镜、多焦点透镜、三焦点透镜、扩展焦深透镜和环面透镜。目的:本病例报告的目的是报告年轻白内障患者选择人工晶状体的重要性。病例报告:一位35岁的病人首次来我诊所就诊。在过去的六个月里,即使戴着眼镜,他也发现左眼视力不佳。由于年轻时出现白内障,右眼于2020年在另一家机构接受了手术。术前全面的眼科检查后,我们发现左眼有白内障。左眼UDVA为0.4,CDVA为+0.50/+0.50/30°=0.5。UNVA和DCNVA是J2。我们决定在白内障手术期间植入TECNIS Synergy™IOL (Johnson & Johnson Vision, Santa Ana, CA, USA)。EDOF人工晶状体弥补了单焦点和多焦点人工晶状体之间的差距,即使在低光条件下,也能从远到近为白内障患者提供连续的高对比度视力。无术中、术后并发症。第7天复查左眼UDVA 1.0, UNVA J1。患者对左眼视力满意,希望矫正右眼视力,右眼植入SENSAR®人工晶体(Johnson & Johnson vision, Santa Ana, CA, USA),远视残余屈光度为+2.00/+1.00/120,近视残余屈光度为+4.50/+1.00/120。由于该患者的年龄和职业,在其他机构选择人工晶状体并不是理想的解决方案。囊袋已发生轻微纤维化,现有人工晶状体植入术不是合理的选择。我们决定使用多焦AddOn®环形晶状体(1stQ GmbH, Mannheim, Germany),这是一种用于增强假性晶状眼视力的屈光手术平台,也可以纠正残留的散光。7天复查,UDVA为1.0,UNVA为J1。结果是一个快乐的病人,他可以回到他的日常生活,没有眼镜的独立性。结论:白内障手术和人工晶状体植入术后,良好的无辅助距离视力(VA)是一个现实的期望。我们应该了解患者的期望和要求,特别是在治疗年轻白内障患者时。通常,术前人工晶状体计划比白内障手术本身要花费更多的时间。
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引用次数: 0
The Most Influential Scientists in the Development of Biomedicine: Carlos Juan Finlay (1833-1915) 对生物医学发展最有影响的科学家:卡洛斯·胡安·芬利(1833-1915)
Pub Date : 1900-01-01 DOI: 10.5455/IJBH.2020.8.144-144
I. Masic
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引用次数: 0
Economic Aspect of Managing Health Services 管理卫生服务的经济方面
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2022.10.70-70
I. Masic
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引用次数: 0
Introducing the Textbook "Pharmacology and Toxicology Manual", 6th Edition 介绍教材《药理学与毒理学手册》第六版
Pub Date : 1900-01-01 DOI: 10.5455/ijbh.2021.9.135-135
L. Žunić
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引用次数: 0
期刊
International Journal on Biomedicine and Healthcare
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