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Molecular Docking, Design and Pharmacokinetics Study of Some Anti-Epilepsy Compounds 一些抗癫痫化合物的分子对接、设计及药代动力学研究
Pub Date : 2021-09-26 DOI: 10.5539/mas.v15n5p67
G. Shallangwa, A. Uzairu, Usman Abdulfatai
To complement experimental study, in-silico molecular docking was carried out to access and understand the interacting binding energy dynamism of some experimental potent anti-epilepsy compounds on the GABAT enzyme’s (A causative agent for epilepsy disorder) binding site. The Autoduck vina docking option of Pyrx multipurpose simulation software was used in this study to perform docking simulations. Four anti-epilepsy drug (AED) candidates was designed (Anti-epilepsy disorders) through a structural based drug technique. All the designed AED candidates shows stable binding interaction energies. Out of the four designed compounds, 9-decyl-8-methyl-6-(1H-1, 2, 4-triazol-1-yl)-9H-purine shows better binding energy with GABAT. The docked energy score of the compound (7.8Kcal/mole) was better than the binding energy scores of the standard anti-epilepsy compounds, Carbamazepine (-6.5kcal/mole) and Valproate (-4.5kcal/mole). With this level of interaction, this drug candidate could bind better on the enzyme’s binding site. Also, the pharmacokinetic properties investigation revealed that all designed AED candidates could be synthesized easily, absorbed, distributed, metabolized and excreted from the body. Therefore, this drug candidate could be synthesized and used effectively for the treatment and management of epilepsy disorder.
为了补充实验研究,我们进行了硅分子对接,以获取和了解一些实验性强效抗癫痫化合物在GABAT酶(癫痫障碍的一种病原体)结合位点上的相互作用结合能动力学。本研究使用Pyrx多用途仿真软件中的Autoduck vina对接选项进行对接仿真。采用基于结构的药物技术设计了4种抗癫痫候选药物(抗癫痫药物)。所有设计的候选AED都表现出稳定的结合相互作用能。在所设计的四种化合物中,9-癸基-8-甲基-6-(1h - 1,2,4 -三唑-1-基)- 9h -嘌呤与GABAT的结合能较好。该化合物的停泊能评分(7.8Kcal/mol)优于标准抗癫痫化合物卡马西平(-6.5kcal/mol)和丙戊酸酯(-4.5kcal/mol)的结合能评分。通过这种水平的相互作用,该候选药物可以更好地结合酶的结合位点。此外,药代动力学研究表明,所有设计的候选AED药物易于合成、吸收、分布、代谢和排出体外。因此,该候选药物可被合成并有效用于癫痫疾病的治疗和管理。
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引用次数: 1
A Comprehensive Study on the Effect of ZnO and ZnAl2O4 Nanoparticles on the Mechanical Properties of Epoxy Coating: Tensile and Hardness ZnO和ZnAl2O4纳米颗粒对环氧涂层力学性能影响的综合研究:拉伸和硬度
Pub Date : 2021-09-22 DOI: 10.5539/mas.v15n5p45
Abeer Shmait, Nour El Ghouch, J. A. Boukhari, A. Abdel-Gaber, R. Awad
ZnO and ZnAl2O4 nanoparticles (NPs) were successfully prepared by the co-precipitation method and characterized by x-ray powder diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. The prepared NPs were incorporated into epoxy (EP) coating with mass ratios 200  800 mg/kg of ZnO NPs/EP and ZnAl2O4 NPs /EP. The prepared coatings were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, and their mechanical properties were investigated, at room temperature, after 5, 10, 15, and 20 days of preparation. Tensile tests showed an improvement in the tensile properties, with the best improvement in ultimate tensile strength (93.2%) for 800 mg/kg ZnAl2O4 NPs/EP coating after 15 days of preparation. The ZnO NPs/EP and ZnAl2O4 NPs/EP coatings exhibited noticeable sensitivity to the stretching rate. Vickers microhardness (Hv) investigations showed normal indentation size effect behavior for all the samples. The best improvement in Hv was attained after 5 days of preparation, for all coatings, with the best improvement (9.15%) for 700 mg/kg ZnO NPs/EP.
采用共沉淀法成功制备了ZnO和ZnAl2O4纳米粒子(NPs),并用x射线粉末衍射、透射电镜和傅里叶变换红外光谱对其进行了表征。将制备的NPs加入到质量比为200 ~ 800 mg/kg的ZnO NPs/EP和ZnAl2O4 NPs/EP的环氧树脂涂层中。采用扫描电子显微镜和傅里叶变换红外光谱对制备的涂层进行了表征,并在室温下、制备5、10、15和20天后对其力学性能进行了研究。拉伸性能得到改善,制备800mg /kg ZnAl2O4 NPs/EP涂层后15天的抗拉强度提高幅度最大,达到93.2%。ZnO NPs/EP和ZnAl2O4 NPs/EP涂层对拉伸速率有明显的敏感性。维氏显微硬度(Hv)测试表明,所有样品的压痕尺寸效应都是正常的。在制备5 d后,所有涂层的Hv都得到了最好的改善,其中700 mg/kg ZnO NPs/EP涂层的改善效果最好(9.15%)。
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引用次数: 1
Community-Based Interventions and Behaviors of HIV+ Persons in Congo-Kinshasa 刚果金沙萨艾滋病毒感染者的社区干预和行为
Pub Date : 2021-09-09 DOI: 10.5539/mas.v15n5p27
Max Ebengho-Bokelo, Jeremy Super-Eloko
Introduction: Sub-Saharan African communities bear the highest burden of HIV/AIDS in the world. Because of identifiable cultural links and local beliefs, people are more likely to engage in sexual mores that could negatively impact their life. Starting in early 2000, Congolese HIV+ patients have undergone a variety of medico-social inputs designed to decrease risky behaviors among people in the program and their family members. Goals: This inquiry aimed to understand how PLWHs assess the influence of community-based incentives within their society, as primarily conceived to improve daily behaviors of each person living with HIV (PLWH), and a few selected family members with unknown HIV-serostatus. Methods: From December 2020 to March 2021, a cross-sectional study was engaged to gather qualitative-driven information from nine in-depth interviews, three focus groups, and two key-informant interviews. Changes were self-assessed through data gotten from 2004-2014 in sexual cleansing, levirate and sororate marriage, Kintwidi phenomenon, stigma and discrimination, sexual gender-based violence (SGBV) and female genital mutilation (FGM), unprotected receptive vaginal or anal intercourse, and behavioral rejection of condoms throughout a decade of Congolese Community-based Interventions (CBIs) implemented from 2004. Grounded on the socioecological model (SEM), this ethnographic study was based on the meaning of the influence of CBIs on cultural behaviors among PLWHs for HIV/AIDS prevention purposes. Results: Data from Kinshasa and Bandundu were coded and analyzed through NVivo R1 and Excel, showing significant negative sentiments for all eight key-cultural components in PLWHs. Conclusion: Out of the holistic approach employed to tackle HIV/AIDS in communities, the comprehensive strategy enabled for social change in Congo-Kinshasa brought specific impactful insights in terms of behavior according to interviewed PLWHs. Findings could be used to inform further preventive activities to alleviate any community HIV burden in sub-Saharan Africa.
导言:撒哈拉以南非洲社区是世界上艾滋病毒/艾滋病负担最重的地区。由于可识别的文化联系和当地信仰,人们更有可能参与可能对他们的生活产生负面影响的性习俗。从2000年初开始,刚果艾滋病毒阳性患者接受了各种医疗社会投入,旨在减少项目参与者及其家庭成员的危险行为。目的:本调查旨在了解艾滋病毒感染者如何评估社区激励措施在其社会中的影响,主要是为了改善每个艾滋病毒感染者(PLWH)的日常行为,以及一些选定的艾滋病毒血清状态未知的家庭成员。方法:从2020年12月至2021年3月,采用横断面研究,从9个深度访谈、3个焦点小组和2个关键信息提供者访谈中收集定性驱动信息。从2004年开始实施的十年刚果社区干预(cbi)中,通过从2004-2014年获得的数据自我评估了在性净化、同性婚姻和姐妹婚姻、Kintwidi现象、耻辱和歧视、基于性别的性暴力(SGBV)和女性生殖器切割(FGM)、无保护的接受性阴道或肛门性交以及对避孕套的行为拒绝方面的变化。本研究以社会生态学模型(SEM)为基础,探讨了以HIV/AIDS预防为目的的CBIs对艾滋病感染者文化行为影响的意义。结果:通过NVivo R1和Excel对金沙萨和班顿杜的数据进行编码和分析,显示了PLWHs中所有八个关键文化成分的显着负面情绪。结论:在解决社区艾滋病毒/艾滋病问题的整体方法中,根据受访的艾滋病毒/艾滋病妇女,在刚果-金沙萨实现社会变革的综合战略在行为方面带来了具体的有影响力的见解。研究结果可用于为进一步的预防活动提供信息,以减轻撒哈拉以南非洲的任何社区艾滋病毒负担。
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引用次数: 0
Beacon-Based Non-Delay Tolerant Routing Protocols for VANET: A Systematic Comparison VANET中基于信标的非容忍延迟路由协议的系统比较
Pub Date : 2021-08-31 DOI: 10.5539/mas.v15n5p12
Mahmoud Ali Al Shugran
A Vehicular ad hoc network (VANET) is a sort of wireless ad hoc network which are used to provide communications between nodes. The frequent topology change is considered a unique feature of VANET nature due to the high movement of its participating vehicles. Thus, the design of a routing protocol that could cope with VANET characteristics is very challenging. Position-based routing protocols are the most suitable approaches for VANET. In this paper researcher broadly discussed Beacon-based Non-Delay Tolerant Geographical-based routing protocols for VANET. The main concern is to discuss the characteristics disadvantages of those protocols. Finally, several research directions relevant to the focus of this survey are identified that define preferred features of the appropriate routing protocol that can cope with VANET challenges.
车辆自组织网络(VANET)是一种无线自组织网络,用于提供节点之间的通信。由于其参与车辆的高运动,频繁的拓扑变化被认为是VANET性质的独特特征。因此,设计一个能够处理VANET特征的路由协议是非常具有挑战性的。基于位置的路由协议是最适合VANET的方法。本文对基于信标的VANET非容延迟地理路由协议进行了广泛的讨论。主要关注的是讨论这些协议的特点和缺点。最后,确定了与本调查重点相关的几个研究方向,这些方向定义了能够应对VANET挑战的适当路由协议的首选特性。
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引用次数: 0
Palestinian University Students' Perceptions of Distance Education in Light of the Coronavirus Crisis 冠状病毒危机下巴勒斯坦大学生对远程教育的看法
Pub Date : 2021-08-17 DOI: 10.5539/mas.v15n5p1
Rima Wajih Hamed Daraghmeh
A study aimed to identify Palestinian university students' perceptions of using distance education in light of the Coronavirus crisis from the students' point of view, depending on the differences between gender or the university in which they study. The descriptive approach was used for the current research. The 25-paragraph questionnaire was distributed electronically through social media sites due to the closure of universities. The sample of the study was formed from (73) distributed among (16) males and (57) females and distributed to universities came (42) students of Palestine Technical University Khudouri, and (19) students of Al-Najah University and (12) students of Arab American University. The study found that Distance Education was a problem for students because of the constant need for Internet service, while Distance Education helped them with multiple sources of information. Moreover, Distance Education did not make it easier to understand teaching subjects better, nor did it make education popular for students. They preferred education that was more remote than Distance Education. The study also did not find any differences in the perceptions of Palestinian university students to use distance education in light of the Coronavirus crisis due to the variable of gender or university. The most important recommendations are providing an appropriate educational structure for implementing e-learning in Palestinian universities and removing all human, material and technical obstacles that prevent its spread in the educational system in various stages and fields. And that there is a need for Palestinian universities to offer materials that provide students with e-learning skills and techniques to facilitate the process of interaction and benefit by students with Educational materials provided electronically.
一项研究旨在从学生的角度确定巴勒斯坦大学生在冠状病毒危机下使用远程教育的看法,这取决于性别或他们所学习的大学之间的差异。本研究采用描述性方法。由于大学关闭,这份25段的调查问卷通过社交媒体网站以电子方式分发。本研究的样本由(73)人组成,分布在(16)名男性和(57)名女性中,分布在大学中,其中巴勒斯坦技术大学Khudouri的学生(42)名,Al-Najah大学的学生(19)名,阿拉伯裔美国大学的学生(12)名。研究发现,远程教育对学生来说是一个问题,因为他们不断需要互联网服务,而远程教育帮助他们获得多种信息来源。此外,远程教育并没有使更好地理解教学科目更容易,也没有使教育受到学生的欢迎。他们更喜欢比远程教育更远程的教育。研究还发现,在新冠肺炎疫情背景下,巴勒斯坦大学生对远程教育的看法没有因性别或大学而有任何差异。最重要的建议是为在巴勒斯坦各大学实施电子学习提供适当的教育结构,并消除妨碍电子学习在教育系统各个阶段和领域推广的一切人力、物力和技术障碍。巴勒斯坦大学需要提供材料,向学生提供电子学习技能和技术,以促进互动过程,并使学生受益于电子提供的教育材料。
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引用次数: 2
Reviewer Acknowledgements, Vol. 15, No. 4, August 2021 审稿人致谢,卷15,第4期,2021年8月
Pub Date : 2021-07-30 DOI: 10.5539/mas.v15n4p69
Sunny Lee
Reviewer Acknowledgements, Vol. 15, No. 4, August 2021
审稿人致谢,卷15,第4期,2021年8月
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引用次数: 0
Yield Performance of Newly Developed Cassava Varieties in Response to Inorganic Fertilizers 木薯新品种产量对无机肥料的响应
Pub Date : 2021-07-22 DOI: 10.5539/MAS.V15N4P60
S. Katuromunda, Benson Ekwaro, Boniface Wanaku
A study was conducted at Kyambogo University Farm in randomized complete block design with three replications to assess the effect of NPK (17:17:17) fertilizer on the growth and tuber yields of two newly developed cassava (Manihot esculenta Crantz) varieties, NAROCASS 1 and NASE 14. Cassava varieties were assigned to the main plots, while fertilizer rates (zero/control, 200, 400, 600 kg/ha) were sub-plots. Fertilizer was applied in two splits, at planting and four months after planting. Fertilizer application significantly (P<0.05) increased the cassava stem heights to first branching and at harvest, and the number of stems per plant when compared with the control treatments. Mean stem heights to first branching and at harvest of plants that received NPK were higher than those of the respective control treatments by 62.8 and 70.5% for NAROCASS 1, and 57.0 and 76.5% for NASE 14, respectively. Fertilizer rate of 400 kg/ha significantly increased the lengths, numbers of tubers and tuber yields per plant when compared with the control treatments. Mean lengths, numbers of tubers and tuber yields of plants that received NPK were higher than those of respective control treatments by 48.2, 36.9 and 68.3% for NAROCASS 1, and 39.9, 50.5 and 67.6% for NASE 14, respectively. Therefore, to achieve optimum tuber yields of newly developed cassava varieties, farmers should integrate NPK fertilizer application into already existing management practices, particularly the use of high quality planting materials and integrated pest, disease and weed management. However, government ministries concerned should ensure that inorganic fertilizers are readily accessible and affordable to farmers.
在Kyambogo大学农场,采用3个重复的随机完全区组设计,研究了氮磷钾(17:17:17)肥对木薯新品种NAROCASS 1和NASE 14生长和块茎产量的影响。木薯品种被分配到主地块,而施肥量(零/对照、200、400、600公斤/公顷)为次地块。施肥分播种时和播种后4个月两次施用。与对照处理相比,施肥处理显著(P<0.05)提高了木薯首枝高和收获时的茎高以及单株茎数。施用氮磷钾的植株至第一次分枝的平均茎高和收获时的平均茎高分别比对照处理高62.8和70.5%,比对照处理高57.0和76.5%。与对照处理相比,施用400 kg/ hm2肥显著增加了植株的块茎长度、块茎数和单株块茎产量。氮磷钾处理的植株平均长度、块茎数和块茎产量分别比对照处理高48.2%、36.9%和68.3%,比对照处理高39.9%、50.5%和67.6%。因此,为了使新开发的木薯品种获得最佳块茎产量,农民应将氮磷钾肥料施用与现有的管理实践相结合,特别是使用优质种植材料和综合病虫害和杂草管理。然而,政府有关部门应确保无机肥料对农民来说是容易获得和负担得起的。
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引用次数: 1
The Influence of Turkish Drama on Socio-Cultural Values of Saudi Women 土耳其戏剧对沙特女性社会文化价值观的影响
Pub Date : 2021-07-07 DOI: 10.5539/MAS.V15N4P47
Merfat Alardawi, Ayman Bajnaid, P. Brereton
Dramas made in Turkey are the most popular soap opera-type in the Arab world and are often watched by women. This study aimed to investigate, from a critical perspective, the impact that Turkish dramas (TDs) might have on developing attitudes of Saudi women. While more than 60 country-specific studies in the Middle East and North Africa have investigated the impact of dramas on audiences, Research regarding Saudi Arabia is surprisingly lacking. Therefore, the effect of TDs on Saudi women was examined as part of this study. Qualitative methodology was used, and semi-structured interviews were conducted with eight Saudi women (aged between 18 and 40) who have watched TDs. Following the groupings, qualitative analysis techniques were employed as part of thematic analysis (TA). The responses of Saudi women highlighted the different types of impacts that TDs have on Saudi audiences: positive, negative, and neutral. The study made a small but essential contribution to an under-researched issue of pleasures of TDs and their representational heuristics in capturing both positive, negative, and so much in between for a particular cohort of Saudi women. It is the first qualitative examination of the impact of TDs on Saudi women's attitudes.  
土耳其制作的电视剧是阿拉伯世界最受欢迎的肥皂剧类型,通常由女性观看。本研究旨在从批判性的角度调查土耳其电视剧(td)可能对沙特女性态度发展的影响。虽然在中东和北非有超过60项针对特定国家的研究调查了电视剧对观众的影响,但令人惊讶的是,关于沙特阿拉伯的研究却很少。因此,TDs对沙特女性的影响是本研究的一部分。采用定性方法,对8名观看电视节目的沙特女性(年龄在18岁至40岁之间)进行了半结构化访谈。在分组之后,定性分析技术被用作主题分析(TA)的一部分。沙特女性的反应凸显了电视节目对沙特受众的不同影响:正面、负面和中性。这项研究对一个尚未得到充分研究的问题做出了微小但至关重要的贡献,即td的乐趣,以及它们在捕捉特定沙特女性群体的积极、消极和介于两者之间的代表性启发式。这是对TDs对沙特妇女态度影响的首次定性研究。
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引用次数: 0
The Effectiveness of Electronic Software in Developing English Language Skills for Eighth Grade Students in Wadi Al-Seer Directorate of Education/Jordan 电子软件在培养约旦Wadi Al-Seer教育局八年级学生英语语言技能方面的有效性
Pub Date : 2021-06-16 DOI: 10.5539/MAS.V15N4P37
Hamza Maharmah
The purpose of the study is to investigate the effect of using electronic software in the development the English language skills among students at primary stage, the researcher used a semi-experimental approach, and he chose an intentional sample, which consisted of (100) eighth grade students from Marj Al-Hamam Elementary School in the Directorate of Education in Wadi Al-Seer in Amman during the first semester of 2019/2020. The study sample was randomly distributed into two groups: the experimental and control with (50) students in each. The study tool was prepared, which is an achievement test (before and after me) and their validity and reliability were verified. The results showed that there were statistically significant differences at the level (a = 0.05) between the mean scores of the control group and the experimental group, in favor of the experimental group in the post-test first studied using the electronic software. The study showed that there is an effect of electronic software in the development of English language skills. In light of the results, the researcher recommended the use of electronic software in schools.
本研究的目的是调查使用电子软件对小学阶段学生英语语言技能发展的影响,研究者采用半实验方法,并选择了一个有意样本,该样本由2019/2020年第一学期安曼Wadi Al-Seer教育局Marj Al-Hamam小学的(100)名八年级学生组成。研究样本随机分为两组:实验组和对照组,每组各有50名学生。准备了学习工具,这是一个成就测试(我之前和之后),并验证了它们的效度和信度。结果显示,对照组和实验组的平均得分在水平上有统计学差异(a = 0.05),实验组在后测中先用电子软件进行研究。研究表明,电子软件对英语语言技能的发展有一定的影响。根据研究结果,研究人员建议在学校使用电子软件。
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引用次数: 0
Adoption Model of Social Customer Relationship Management in the Palestinian Banking Sector 巴勒斯坦银行业社会客户关系管理采用模式
Pub Date : 2021-06-07 DOI: 10.5539/MAS.V15N4P23
M. Ramadan, Derar Eleyan
Social CRM is a new technology that integrates social networking activities within traditional CRM itself. Social media might be the most effective strategy in the context of CRM technology concerning the availability of efforts and time by owners. Therefore, it’s important for financial institutions to take advantage of it upon this opportunity by considering social CRM as part of development and enhancing relationship with their customers. Nevertheless, little empirical studies have focused on adoption of social CRM in banking sector. This research paper aims to investigate the factors that impact banks’ intention to adopt social CRM, based on combining the Technology-Organization-Environment (TOE) with Technology Acceptance Model (TAM) as the theoretical framework. TOE variables such as top management support and relative advantages found to have a direct impact on the two TAM mediating variables (perceived usefulness and perceived ease of use), and an indirect impact on social CRM adoption. Further, results suggested that consumer pressure and competitive pressure have a direct impact on social CRM adoption. The researcher tested the hypothesis using structural equation modeling (SEM). The findings from a survey of 220 employees in banks in Palestine showed that all eight hypotheses were supported as both consumer pressure and competitive pressure in the environmental context have a significant direct impact on social CRM adoption intention, followed by top management support in organizational and technological contexts; relative advantages have the most significant impact on perceived ease of use and perceived usefulness which in turn, have a direct and significant impact on social CRM adoption intention. The contribution of the study, limitations, future studies and conclusion are presented.
社会化客户关系管理是一种新技术,它将社交网络活动集成到传统的客户关系管理中。在客户关系管理技术的背景下,社交媒体可能是最有效的策略,因为它关系到所有者的努力和时间的可用性。因此,对于金融机构来说,利用这个机会,将社交CRM视为发展和加强与客户关系的一部分是很重要的。然而,很少有实证研究关注银行部门对社交CRM的采用。本文以技术-组织-环境(TOE)和技术接受模型(TAM)为理论框架,探讨影响银行采用社会化CRM意愿的因素。TOE变量,如高层管理支持和相对优势,被发现对两个TAM中介变量(感知有用性和感知易用性)有直接影响,并对社交CRM采用有间接影响。此外,研究结果表明,消费者压力和竞争压力对社交CRM的采用有直接影响。研究人员使用结构方程模型(SEM)验证了这一假设。对巴勒斯坦220名银行员工的调查结果显示,所有8个假设都得到了支持,因为环境背景下的消费者压力和竞争压力对社会CRM采用意愿有显著的直接影响,其次是组织和技术背景下的高层管理支持;相对优势对感知易用性和感知有用性的影响最为显著,而感知易用性和感知有用性又对社交CRM采用意愿产生直接而显著的影响。最后提出了本研究的贡献、局限性、未来研究方向和结论。
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引用次数: 2
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Modern Applied Science
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