Pub Date : 2026-01-05DOI: 10.1016/j.mocell.2026.100310
Eun-Ji Lee , Jae-Geun Lee , Jeong-Soo Lee
In vivo cell ablation technologies are essential tools for understanding biological processes within living animal models. The nitroreductase (NTR)/metronidazole system enables highly effective spatiotemporal cell ablation. Using transgenic zebrafish that combine NTR2.0 with the QF3/QUAS binary gene expression system, conditions to achieve efficient cell type–specific chemogenetic ablation were optimized. This approach provides a versatile in vivo platform for investigating developmental processes and regeneration, as well as for disease modeling and drug discovery.
{"title":"A brief guide to the in vivo chemogenetic cell ablation approach in zebrafish","authors":"Eun-Ji Lee , Jae-Geun Lee , Jeong-Soo Lee","doi":"10.1016/j.mocell.2026.100310","DOIUrl":"10.1016/j.mocell.2026.100310","url":null,"abstract":"<div><div>In vivo cell ablation technologies are essential tools for understanding biological processes within living animal models. The nitroreductase (NTR)/metronidazole system enables highly effective spatiotemporal cell ablation. Using transgenic zebrafish that combine NTR2.0 with the QF3/QUAS binary gene expression system, conditions to achieve efficient cell type–specific chemogenetic ablation were optimized. This approach provides a versatile in vivo platform for investigating developmental processes and regeneration, as well as for disease modeling and drug discovery.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 2","pages":"Article 100310"},"PeriodicalIF":6.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-04DOI: 10.1016/j.mocell.2026.100311
Yikhyeon Seo , Jimin Pak , Jiyun Han , Joonbeom Bae , Soo Seok Hwang
Viral transduction of primary T cells enables stable genetic engineering for research and immunotherapy, supporting both transgene overexpression and gene deletion. Although the overall workflow can be similar to transduction in other mammalian cell lines, primary T cell culture imposes distinct requirements such as cell-state-dependent nuances shaped by T cell activation and proliferation, which can make it challenging to obtain a sufficient number of genetically engineered T cells. This article provides practical guidance for researchers new to T cells but familiar with basic mammalian cell culture.
{"title":"Viral transduction for T cell engineering in immunotherapy","authors":"Yikhyeon Seo , Jimin Pak , Jiyun Han , Joonbeom Bae , Soo Seok Hwang","doi":"10.1016/j.mocell.2026.100311","DOIUrl":"10.1016/j.mocell.2026.100311","url":null,"abstract":"<div><div>Viral transduction of primary T cells enables stable genetic engineering for research and immunotherapy, supporting both transgene overexpression and gene deletion. Although the overall workflow can be similar to transduction in other mammalian cell lines, primary T cell culture imposes distinct requirements such as cell-state-dependent nuances shaped by T cell activation and proliferation, which can make it challenging to obtain a sufficient number of genetically engineered T cells. This article provides practical guidance for researchers new to T cells but familiar with basic mammalian cell culture.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 2","pages":"Article 100311"},"PeriodicalIF":6.5,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mocell.2025.100302
Jiwon Choi , Geert De Jaeger , Hoo Sun Chung
Cytokinesis, the final stage of cell division, physically partitions the cytoplasm between daughter cells through mechanisms evolved to accommodate unique cellular constraints. Plant cells divide by the formation of rigid cell walls using the phragmoplast—a specialized structure guiding centrifugal cell plate formation from the cell center outward. Despite structural differences from the animal contractile ring mechanism, plant and animal cytokinesis share fundamental similarities in division plane determination, vesicle trafficking, and conserved proteins, including kinesins and microtubule-associated proteins. This conservation alongside kingdom-specific adaptations makes plant cytokinesis an excellent model for understanding evolutionary divergence. Recent technological advances have enabled detailed characterization of molecular components and regulatory networks controlling spatiotemporal progression through post translational modifications. In this review, we provide an integrated perspective of plant cytokinesis, examining cellular dynamics from division plane determination to cell plate maturation, molecular machinery driving these processes, and kinase-mediated regulatory networks ensuring precise coordination of this complex process.
{"title":"Cellular dynamics and molecular signaling networks of plant cytokinesis","authors":"Jiwon Choi , Geert De Jaeger , Hoo Sun Chung","doi":"10.1016/j.mocell.2025.100302","DOIUrl":"10.1016/j.mocell.2025.100302","url":null,"abstract":"<div><div>Cytokinesis, the final stage of cell division, physically partitions the cytoplasm between daughter cells through mechanisms evolved to accommodate unique cellular constraints. Plant cells divide by the formation of rigid cell walls using the phragmoplast—a specialized structure guiding centrifugal cell plate formation from the cell center outward. Despite structural differences from the animal contractile ring mechanism, plant and animal cytokinesis share fundamental similarities in division plane determination, vesicle trafficking, and conserved proteins, including kinesins and microtubule-associated proteins. This conservation alongside kingdom-specific adaptations makes plant cytokinesis an excellent model for understanding evolutionary divergence. Recent technological advances have enabled detailed characterization of molecular components and regulatory networks controlling spatiotemporal progression through post translational modifications. In this review, we provide an integrated perspective of plant cytokinesis, examining cellular dynamics from division plane determination to cell plate maturation, molecular machinery driving these processes, and kinase-mediated regulatory networks ensuring precise coordination of this complex process.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 1","pages":"Article 100302"},"PeriodicalIF":6.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mocell.2025.100308
Dajeong Bong , Hyunwoo C. Kwon , Seung-Jae V. Lee
Aging in Caenorhabditis elegans is regulated by evolutionarily conserved pathways that coordinate cellular maintenance and systemic homeostasis. Here, we review recent advances on four major longevity regimens, including reduced insulin/insulin-like growth factor 1 signaling (IIS), dietary restriction (DR), mild inhibition of mitochondrial respiration, and germline deficiency. Each longevity-promoting regimen enhances protein and RNA quality control, metabolic remodeling, and stress resistance to delay functional declines with age. Reduced IIS strengthens proteostasis and RNA surveillance. DR remodels metabolism and activates autophagy. Mild mitochondrial inhibition elicits adaptive redox signaling and quality control responses. Germline deficiency links reproductive cues to somatic maintenance. We highlight that longevity arises from the integrated regulation of transcriptional, metabolic, and inter-tissue signaling networks. Our review will provide valuable insights obtained from C. elegans into the conserved mechanisms of aging, facilitating the development of interventions that promote healthy longevity in humans.
{"title":"Multilayered regulation of longevity in Caenorhabditis elegans","authors":"Dajeong Bong , Hyunwoo C. Kwon , Seung-Jae V. Lee","doi":"10.1016/j.mocell.2025.100308","DOIUrl":"10.1016/j.mocell.2025.100308","url":null,"abstract":"<div><div>Aging in <em>Caenorhabditis elegans</em> is regulated by evolutionarily conserved pathways that coordinate cellular maintenance and systemic homeostasis. Here, we review recent advances on four major longevity regimens, including reduced insulin/insulin-like growth factor 1 signaling (IIS), dietary restriction (DR), mild inhibition of mitochondrial respiration, and germline deficiency. Each longevity-promoting regimen enhances protein and RNA quality control, metabolic remodeling, and stress resistance to delay functional declines with age. Reduced IIS strengthens proteostasis and RNA surveillance. DR remodels metabolism and activates autophagy. Mild mitochondrial inhibition elicits adaptive redox signaling and quality control responses. Germline deficiency links reproductive cues to somatic maintenance. We highlight that longevity arises from the integrated regulation of transcriptional, metabolic, and inter-tissue signaling networks. Our review will provide valuable insights obtained from <em>C. elegans</em> into the conserved mechanisms of aging, facilitating the development of interventions that promote healthy longevity in humans.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 1","pages":"Article 100308"},"PeriodicalIF":6.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/S1016-8478(26)00005-1
{"title":"Cover and caption","authors":"","doi":"10.1016/S1016-8478(26)00005-1","DOIUrl":"10.1016/S1016-8478(26)00005-1","url":null,"abstract":"","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 1","pages":"Article 100314"},"PeriodicalIF":6.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.mocell.2025.100303
Shinae Park, Kyungmin Lee, Junsoo Oh, Jung-Shin Lee
Histone H3 lysine 4 trimethylation (H3K4me3) has been associated with active transcription, yet whether it plays a causative role in gene activation remains an open question. In this study, we reveal that the deletion of Paf1 complex subunit Leo1 in Saccharomyces cerevisiae induces robust transcriptional activation at a subset of genes, particularly those involved in sterol transport, without altering global H3K4me3 levels. These induced genes acquire de novo H3K4me3 at promoter-proximal regions, and this transcriptional induction is entirely dependent on Set1, the sole methyltransferase responsible for H3K4me3. Strikingly, loss of Set1 abolishes expression of these genes, even in the presence of previously established H3K4me3, and their expression is fully restored upon Set1 reintroduction. These effects are specific to Leo1 deficiency and not observed in other Paf1C mutants. Furthermore, Set1-dependent gene activation enhances sterol uptake, underscoring its physiological relevance. Our findings provide direct in vivo evidence that Set1-catalyzed H3K4me3 is not merely a transcriptional correlate, but a context-dependent driver of gene expression.
组蛋白H3赖氨酸4三甲基化（H3K4me3）与活性转录有关，但它是否在基因激活中起致病作用仍然是一个悬而未决的问题。在这项研究中，我们揭示了酿酒酵母中Paf1复合物亚基Leo1的缺失诱导了一部分基因的强大转录激活，特别是那些参与固醇运输的基因，而不会改变全球H3K4me3水平。这些诱导基因在启动子-近端区域重新获得H3K4me3，这种转录诱导完全依赖于Set1，这是唯一负责H3K4me3的甲基转移酶。引人注目的是，即使在先前建立的H3K4me3存在的情况下，Set1的缺失也会消除这些基因的表达，并且在Set1重新引入后，它们的表达完全恢复。这些影响仅针对Leo1缺乏症，而在其他Paf1C突变体中未观察到。此外，set1依赖性基因激活增强了甾醇摄取，强调了其生理相关性。我们的研究结果提供了直接的体内证据，证明set1催化的H3K4me3不仅是转录相关的，而且是基因表达的上下文依赖驱动因素。数据可用性：本研究中讨论的ChIP-seq和RNA-seq数据已存储在NCBI的Gene Expression Omnibus （Edgar et al., 2002）中，可通过GEO Series登录号GSE303595 （https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303595）和GSE303407 （https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303407）访问。
{"title":"Set1-dependent H3K4 methylation is essential for sustained gene expression at newly activated loci","authors":"Shinae Park, Kyungmin Lee, Junsoo Oh, Jung-Shin Lee","doi":"10.1016/j.mocell.2025.100303","DOIUrl":"10.1016/j.mocell.2025.100303","url":null,"abstract":"<div><div>Histone H3 lysine 4 trimethylation (H3K4me3) has been associated with active transcription, yet whether it plays a causative role in gene activation remains an open question. In this study, we reveal that the deletion of Paf1 complex subunit Leo1 in <em>Saccharomyces cerevisiae</em> induces robust transcriptional activation at a subset of genes, particularly those involved in sterol transport, without altering global H3K4me3 levels. These induced genes acquire de novo H3K4me3 at promoter-proximal regions, and this transcriptional induction is entirely dependent on Set1, the sole methyltransferase responsible for H3K4me3. Strikingly, loss of Set1 abolishes expression of these genes, even in the presence of previously established H3K4me3, and their expression is fully restored upon Set1 reintroduction. These effects are specific to Leo1 deficiency and not observed in other Paf1C mutants. Furthermore, Set1-dependent gene activation enhances sterol uptake, underscoring its physiological relevance. Our findings provide direct in vivo evidence that Set1-catalyzed H3K4me3 is not merely a transcriptional correlate, but a context-dependent driver of gene expression.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 1","pages":"Article 100303"},"PeriodicalIF":6.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-29DOI: 10.1016/j.mocell.2025.100309
Yujing Wang , Zhixiang Le , Rujie Shi , Kun Li
Fibrosis is a chronic, progressive disease characterized by the excessive accumulation of extracellular matrix (ECM) in tissues and organs during damage-repair responses. This pathological process can involve almost any tissue or organ and may eventually lead to organ failure, posing a major threat to human health. ECM production is closely related to intercellular communication. As one of the biologically active substances participating in intercellular communication, exosomes have attracted increasing attention in recent years. In particular, noncoding RNAs (ncRNAs) enriched in exosomes regulate gene expression at multiple levels and influence the fibrosis process. Common ncRNAs include miRNA, long ncRNAs, circRNA, and tRNA, which can be selectively loaded into exosomes by various cells to modulate receptor cell functions. In fibrosis-related diseases, the primary sources of exosome-derived ncRNAs (Exo-ncRNAs) include mesenchymal stem cells, macrophages, epithelial cells, and fibroblasts. These Exo-ncRNAs regulate macrophage polarization, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation within the microenvironment. In this review, we summarize the regulatory roles and molecular mechanisms of these ncRNAs in the fibrosis process, and discuss Exo-ncRNAs with potential therapeutic effects. Understanding Exo-ncRNAs from different cell sources may provide new research directions for pathological intervention and the treatment of multiorgan fibrosis.
{"title":"Roles of Exosome–Derived Noncoding RNA in Fibrosis","authors":"Yujing Wang , Zhixiang Le , Rujie Shi , Kun Li","doi":"10.1016/j.mocell.2025.100309","DOIUrl":"10.1016/j.mocell.2025.100309","url":null,"abstract":"<div><div>Fibrosis is a chronic, progressive disease characterized by the excessive accumulation of extracellular matrix (ECM) in tissues and organs during damage-repair responses. This pathological process can involve almost any tissue or organ and may eventually lead to organ failure, posing a major threat to human health. ECM production is closely related to intercellular communication. As one of the biologically active substances participating in intercellular communication, exosomes have attracted increasing attention in recent years. In particular, noncoding RNAs (ncRNAs) enriched in exosomes regulate gene expression at multiple levels and influence the fibrosis process. Common ncRNAs include miRNA, long ncRNAs, circRNA, and tRNA, which can be selectively loaded into exosomes by various cells to modulate receptor cell functions. In fibrosis-related diseases, the primary sources of exosome-derived ncRNAs (Exo-ncRNAs) include mesenchymal stem cells, macrophages, epithelial cells, and fibroblasts. These Exo-ncRNAs regulate macrophage polarization, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation within the microenvironment. In this review, we summarize the regulatory roles and molecular mechanisms of these ncRNAs in the fibrosis process, and discuss Exo-ncRNAs with potential therapeutic effects. Understanding Exo-ncRNAs from different cell sources may provide new research directions for pathological intervention and the treatment of multiorgan fibrosis.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"49 2","pages":"Article 100309"},"PeriodicalIF":6.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/S1016-8478(25)00128-1
{"title":"Cover and caption","authors":"","doi":"10.1016/S1016-8478(25)00128-1","DOIUrl":"10.1016/S1016-8478(25)00128-1","url":null,"abstract":"","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 12","pages":"Article 100304"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.mocell.2025.100298
Weichun Zhu , Zehao Chen , Yunqian Gao , Chungang Zhai , Xia Li , Ning Wang , Kang Fu , Wentao Chen , Jieqiong Peng , Dan Xu , Lei Qiao , Wenqiang Chen
Chaperone-mediated autophagy (CMA) is a highly selective form of autophagy responsible for the degradation of specific cytosolic proteins within lysosomes. Recent research has established a significant correlation between CMA and colorectal cancer (CRC). However, the majority of current research focuses on tumor parenchymal cells, with limited attention paid to the expression and role of CMA in tumor stromal cells, particularly in tumor-associated macrophages (TAMs). In this study, we generated myeloid-specific LAMP2A-knockout and knock-in mice to investigate the role of macrophage CMA in dextran sodium sulfate (DSS)-induced colitis and azoxymethane/dextran sodium sulfate-induced CRC. Our findings indicated that the expression of LAMP2A, the rate-limiting component of CMA, was reduced in tumor-associated macrophages of both human and mouse CRC tissues. The knockout of LAMP2A in macrophages exacerbated experimentally induced colitis and colitis-related CRC, whereas its overexpression in macrophages alleviated the progression of colitis and CRC in mice. Notably, we observed increased angiogenesis within the tumor mass of CRC tissues from LAMP2A-mØKO mice. Mechanistically, LAMP2A deficiency elevated the protein levels of HIF-1α, thereby enhancing the secretion of its target genes, vascular endothelial growth factor A and IL-1β, which are 2 important proangiogenic cytokines. Our study suggests that the activation of CMA in macrophages may represent a promising therapeutic strategy for the treatment of CRC.
{"title":"Deficient chaperone-mediated autophagy in macrophages aggravates colitis and colitis-associated tumorigenesis in mice","authors":"Weichun Zhu , Zehao Chen , Yunqian Gao , Chungang Zhai , Xia Li , Ning Wang , Kang Fu , Wentao Chen , Jieqiong Peng , Dan Xu , Lei Qiao , Wenqiang Chen","doi":"10.1016/j.mocell.2025.100298","DOIUrl":"10.1016/j.mocell.2025.100298","url":null,"abstract":"<div><div>Chaperone-mediated autophagy (CMA) is a highly selective form of autophagy responsible for the degradation of specific cytosolic proteins within lysosomes. Recent research has established a significant correlation between CMA and colorectal cancer (CRC). However, the majority of current research focuses on tumor parenchymal cells, with limited attention paid to the expression and role of CMA in tumor stromal cells, particularly in tumor-associated macrophages (TAMs). In this study, we generated myeloid-specific LAMP2A-knockout and knock-in mice to investigate the role of macrophage CMA in dextran sodium sulfate (DSS)-induced colitis and azoxymethane/dextran sodium sulfate-induced CRC. Our findings indicated that the expression of LAMP2A, the rate-limiting component of CMA, was reduced in tumor-associated macrophages of both human and mouse CRC tissues. The knockout of LAMP2A in macrophages exacerbated experimentally induced colitis and colitis-related CRC, whereas its overexpression in macrophages alleviated the progression of colitis and CRC in mice. Notably, we observed increased angiogenesis within the tumor mass of CRC tissues from LAMP2A-mØKO mice. Mechanistically, LAMP2A deficiency elevated the protein levels of HIF-1α, thereby enhancing the secretion of its target genes, vascular endothelial growth factor A and IL-1β, which are 2 important proangiogenic cytokines. Our study suggests that the activation of CMA in macrophages may represent a promising therapeutic strategy for the treatment of CRC.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 12","pages":"Article 100298"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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