Zinc oxide nanoparticles (ZnO-NPs) are of interest in biomedical applications, environmental remediation, and agriculture. ZnO-NPs inhibit the growth of phytopathogenic fungi and bacteria. We have evaluated their effects on mitochondrial function and the induction of membrane damage, apoptosis, and DNA damage in human peripheral blood mononuclear cells (PBMC) in vitro. ZnO-NPs caused significant reduction in cell viability and LDH release, indicating damage to cell membranes. Late apoptosis was significant and necrosis was significant at higher concentrations tested. ZnO-NPs did not induce micronucleus formation.
{"title":"Cytotoxicity and genotoxicity of zinc oxide nanoparticles in human peripheral blood mononuclear cells","authors":"Jovanna Vanessa Ramos Angulo , Juliana Fernández Valenzuela , Sofía Isabel Freire-Bernal , Victoria Eugenia Niño-Castaño , Jorge Enrique Rodríguez Paez , Rosa Amalia Dueñas-Cuellar","doi":"10.1016/j.mrgentox.2024.503838","DOIUrl":"10.1016/j.mrgentox.2024.503838","url":null,"abstract":"<div><div>Zinc oxide nanoparticles (ZnO-NPs) are of interest in biomedical applications, environmental remediation, and agriculture. ZnO-NPs inhibit the growth of phytopathogenic fungi and bacteria. We have evaluated their effects on mitochondrial function and the induction of membrane damage, apoptosis, and DNA damage in human peripheral blood mononuclear cells (PBMC) <em>in vitro</em>. ZnO-NPs caused significant reduction in cell viability and LDH release, indicating damage to cell membranes. Late apoptosis was significant and necrosis was significant at higher concentrations tested. ZnO-NPs did not induce micronucleus formation.</div></div>","PeriodicalId":18799,"journal":{"name":"Mutation research. Genetic toxicology and environmental mutagenesis","volume":"901 ","pages":"Article 503838"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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IF 2.5 4区 医学Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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