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Assessment of knowledge and awareness among North Indian populations about oral precancerous lesions (OPL): A cross-sectional survey study 北印度人口关于口腔癌前病变(OPL)的知识和意识评估:一项横断面调查研究
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_150_22
Rini Tiwari, Navin Singh, Akhilanand Chaurasia, Akhilesh Kumar Singh
Background: A precancerous lesion is a morphologically altered tissue in which oral cancer is more likely to occur than its apparently normal counterpart. They are quite common in the Indian population due to the habitual habit of chewing tobacco. The aim of this study was to evaluate the awareness of oral precancerous lesions by a questionnaire-based survey among the study subjects having been diagnosed with it. Methods: In this descriptive study, a structured questionnaire having 11 survey questions has been used to record the response from study subjects who have been diagnosed and reported for treatment for oral premalignant lesions in the Department of Oral Medicine and Radiology. A total of 1013 study subjects were assessed for awareness about OPL and its consequences. Results: 44.3% of the study population was addicted to smoking tobacco (cigarettes) while 57.9% of study subjects were addicted to non-smoking tobacco (Pan masala). The reason behind their addiction was reported to be stress (54.9%) and workload (25.3%). Most of the study subjects were diagnosed with oral sub-mucous fibrosis (53.4%). 78.6% of study subjects diagnosed with OPL were not aware of it and 94% were willing to quit the addiction. Conclusion: The awareness about OPL among patients was found to be low. Although many wanted to quit their addiction to smoking and chewing tobacco but were unable to do so. So it is a need for time to develop a national policy on tobacco use and related diseases. This policy will definitely reduce the burden of oral premalignant lesions and oral cancer in Indian population.
背景:癌前病变是一种形态学改变的组织,在这种组织中,口腔癌比表面上正常的组织更容易发生。由于咀嚼烟草的习惯,它们在印度人口中很常见。本研究的目的是通过对被诊断为口腔癌前病变的研究对象进行问卷调查来评估对口腔癌前病变的认识。方法:在本描述性研究中,采用一份包含11个调查问题的结构化问卷,记录在口腔医学与放射科诊断并报告治疗口腔癌前病变的研究对象的反应。共有1013名研究对象被评估了对OPL及其后果的认识。结果:44.3%的研究人群有吸烟成瘾(卷烟),57.9%的研究对象有非吸烟成瘾(Pan masala)。据报道,他们上瘾的原因是压力(54.9%)和工作量(25.3%)。大多数研究对象被诊断为口腔粘膜下纤维化(53.4%)。被诊断为OPL的研究对象中,78.6%的人不知道这一点,94%的人愿意戒掉成瘾。结论:患者对OPL的认知度较低。虽然很多人想戒掉吸烟和嚼烟的瘾,但却做不到。因此,制定一项有关烟草使用和相关疾病的国家政策需要时间。这一政策必将减轻印度人口口腔癌前病变和口腔癌的负担。
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引用次数: 0
Efficacy of bioresorbable plating system in the treatment of pediatric maxillary fractures: A short clinical study. 生物可吸收钢板系统治疗儿童上颌骨折的疗效:一项简短的临床研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.NJMS_342_21
Mahinder Singh, Barjinder Singh, Jyotsna Jha, Deepak Passi, Abhimanyu Sharma, Jyoti Goyal
ABSTRACT Aim: The aim of this study was to evaluate the efficacy, stability, and clinical outcomes of a bioresorbable plating system in the treatment of pediatric maxillary fractures. Materials and Methods: Twenty pediatric patients with maxillary fractures (13 males and 7 females) were included in this study. The 1.5- and 2.0-mm resorbable plates were used and secured with monocortical resorbable screws 6 mm and 7 mm in length. All patients were followed up for 6 months. Clinical parameters, such as pain, swelling, soft-tissue infection, malocclusion, nerve injury, and bite force for stability, were prospectively assessed. Results: Fall from height (50%) was the most common cause of etiology, followed by road traffic accidents (35%). Maxillary alveolar # (40) was the most common fracture site, followed by nasal complex # (25%) and zygomatic complex # (25%). Appropriate fixation and adequate primary bone healing was achieved in 100% of the cases. Few minor complications were observed: (1) soft-tissue infection (5%) and (2) paresthesia (10%). There was a significant increase in bite force in the incisor and molar regions. Observation in clinical parameters shows that there was a significant reduction in postoperative pain and swelling at different follow-up periods. Conclusion: Bioresorbable plating system is used as a load-sharing plate in a semirigid fixation technique after anatomic fracture reduction. Although its high costs limit its feasibility for use low infection rates, minimized second surgery for implant removal attracts its use. 1.5- and 2-mm resorbable plating system along is a good treatment modality for moderately displaced maxillary fractures in pediatric patients. Larger sample size and longer follow-up studies are required for conclusive results.
目的:本研究的目的是评估生物可吸收钢板系统治疗儿童上颌骨折的疗效、稳定性和临床结果。材料和方法:20名儿童上颌骨折患者(13名男性和7名女性)被纳入本研究。使用1.5和2.0毫米的可吸收板,并用6毫米和7毫米长的单皮质可吸收螺钉固定。所有患者均进行了6个月的随访。前瞻性评估了临床参数,如疼痛、肿胀、软组织感染、错牙合、神经损伤和稳定性咬合力。结果:高处坠落(50%)是最常见的病因,其次是道路交通事故(35%)。上颌牙槽骨#(40)是最常见的骨折部位,其次是鼻复合体#(25%)和颧骨复合体#(25%)。在100%的病例中实现了适当的固定和充分的初次骨愈合。很少观察到轻微并发症:(1)软组织感染(5%)和(2)感觉异常(10%)。切牙和臼齿区域的咬合力显著增加。临床参数观察表明,在不同的随访期,术后疼痛和肿胀明显减轻。结论:在解剖性骨折复位后的半刚性固定技术中,生物可吸收钢板系统是一种负载分担钢板。尽管其高昂的成本限制了其使用低感染率的可行性,但最小化的第二次植入物切除手术吸引了其使用。1.5和2毫米可吸收钢板系统是治疗儿童中度移位上颌骨折的良好方法。需要更大的样本量和更长的随访研究才能得出结论性结果。
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引用次数: 0
Incidence and prevalence of oral candidal colonization in patients with cleft lip and palate. 唇腭裂患者口腔念珠菌定植的发生率和患病率。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_127_22
Imran Khan, Saiema Ahmedi, Tanveer Ahmad, M Moshaid Alam Rizvi, Nikhat Manzoor

Aims and objectives: This study aims to assess and compare the incidence and rate of oral candidal colonization in patients with cleft lip and palate and collate it with healthy individuals. The objectives of this study were to evaluate the factors that may affect the incidence, rate, and polycolonity of colonization of oral Candida species in patients with cleft lip and palate (CLP) as compared to healthy individuals.

Materials and methods: The current prospective study involved the collection and assessment of oral samples from 50 CLP patients and compared it with oral samples from 50 healthy individuals. Colonies of Candida albicans and other Candida species were identified by using germ tube test and differential chromogenic media. Assessment of the distribution trend of various Candida species and their variation based on age, gender, type of cleft, number of surgeries, and oral hygiene status were recorded.

Results: A highly significant (P value < 0.001) statistical difference was seen in the oral carriage rate of Candida species between the two groups with values more in the study group (60.75 ± 71.43) than in controls (1.62 ± 2.22). Individually comparing the different Candida species, significant difference in presence of C albicans (P value = 0.004), C parapsilosis (P value = 0.015), and C dubliensis (P value = 0.027) was seen as compared to other species. In the context of the type of cleft and the presence of Candida species Candida albicans was the most prevalent in patients with the cleft alveolus (60.0% n = 15), unilateral CLP (66.7% n = 8), and bilateral CLP (100.0% n = 3) respectively. Nonsignificant variation in prevalence was seen in the various fungal species based on an individual's gender and oral hygiene and the number of surgeries status was observed.

Conclusion: The anatomical alteration in the oral cavity of patients with CLP contributes to the high incidence and prevalence of Candida species.

目的和目的:本研究旨在评估和比较唇腭裂患者口腔念珠菌定植的发生率和比率,并与健康人进行比较。本研究的目的是评估与健康人相比,可能影响唇腭裂患者口腔念珠菌定植的发生率、比率和多克隆性的因素。材料和方法:目前的前瞻性研究涉及收集和评估50名CLP患者的口腔样本,并将其与50名健康人的口腔样本进行比较。用菌管试验和差异显色培养基对白色念珠菌和其他念珠菌进行了菌落鉴定。记录了各种念珠菌的分布趋势及其基于年龄、性别、腭裂类型、手术次数和口腔卫生状况的变化。结果:两组念珠菌的口腔携带率有非常显著的统计学差异(P值<0.001),研究组(60.75±71.43)高于对照组(1.62±2.22),与其他物种相比,观察到C Dublinsis(P值=0.027)。在腭裂类型和念珠菌存在的情况下,白色念珠菌分别在肺泡裂患者(60.0%n=15)、单侧CLP患者(66.7%n=8)和双侧CLP患者(100.0%n=3)中最为常见。根据个体的性别和口腔卫生状况,在不同的真菌种类中,患病率存在无显著差异,并观察到手术次数。结论:CLP患者口腔解剖结构的改变导致念珠菌的高发病率和高患病率。
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引用次数: 0
Assessment of gingival biotype in different facial patterns: A cross-sectional study. 不同面部模式下牙龈生物型的评估:一项横断面研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_490_21
Vipul Kumar Sharma, Deepak Singh, Roopal Srivastava, T P Chaturvedi, Mahesh Khairnar, Akhilesh Kumar Singh

Objective: The aim of the present study is to evaluate the relationship of gingival biotype in different malocclusions.

Methods: A total of 157 periodontally healthy subjects (88 males and 69 females) were enrolled in this cross-sectional study. The study participants were divided into three groups of skeletal class I, class II, and class III. The probe transparency method was used to determine the quality and gingival tissue into thick and thin biotype.

Results: There was significant difference in gingival biotype among different skeletal malocclusion with high prevalence of thin gingival biotype in class I subjects and more prevalence of thick biotype in class II and class III individuals (P-value: 0.022). Pairwise comparison of gingival biotype in class I versus class II showed significant difference (P-value: 0.032); however in class I versus class III and class II versus class III, the test result was nonsignificant. The overall frequency of thin gingival biotype was significantly less in female subjects with respect to males (P-value: 0.025).

Conclusion: A significant relationship is present between skeletal malocclusion and quality of gingival biotype. The prevalence of thick gingival biotype is found more in females as compared to male individuals. The thin gingival biotype is more commonly seen in skeletal class I than class II and class III.

目的:本研究旨在评估不同错牙合的牙龈生物型之间的关系。方法:共有157名牙周健康受试者(88名男性和69名女性)参加了这项横断面研究。研究参与者被分为骨骼I类、II类和III类三组。探针透明法用于确定牙龈组织的质量和生物类型。结果:不同骨性错牙合的牙龈生物型存在显著差异,其中I类受试者的薄牙龈生物型患病率较高,II类和III类个体的厚牙龈生物型发病率较高(P值:0.022);然而,在I类与III类以及II类与III级中,测试结果并不显著。女性受试者的薄牙龈生物型总频率明显低于男性(P值:0.025)。结论:骨骼错牙合与牙龈生物型质量之间存在显著关系。与男性相比,厚牙龈生物型在女性中的患病率更高。薄牙龈生物型在骨骼I类中比II类和III类更常见。
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引用次数: 0
Adenoid squamous cell carcinoma of buccal mucosa – A rare case report 口腔黏膜腺样鳞状细胞癌1例报告
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_158_22
Akhilesh Prathap, Nidhin Rajagopalan Sreeja, Sunil Sukumaran Nair, Sharlene S. Babu
Adenoid squamous cell carcinoma is a rare variant of squamous cell carcinoma. It is mainly reported in the sun-exposed areas of the head and neck. In literature, adenoid variants of squamous cell carcinoma are reported in the lip and tongue. Documented cases of buccal mucosa are very few. In this case report, we describe an adenoid variant of squamous cell carcinoma, which is an unusual presentation of a rare carcinoma.
腺样鳞状细胞癌是一种罕见的鳞状细胞癌。它主要发生在头部和颈部暴露在阳光下的区域。在文献中,鳞状细胞癌的腺样变被报道在嘴唇和舌头。有文献记载的口腔黏膜病例很少。在这个病例报告中,我们描述了一个腺样变的鳞状细胞癌,这是一个罕见的癌症的不寻常的表现。
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引用次数: 0
Accuracy of magnetic resonance imaging in the assessment of depth of invasion in tongue carcinoma: A systematic review and meta-analysis 磁共振成像评估舌癌浸润深度的准确性:一项系统回顾和荟萃分析
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_174_22
Kondajji Ramachandra Vijayalakshmi, Vanshika Jain
Tongue carcinoma constitutes 10.4–46.9% of all oral squamous cell carcinomas (OSCCs) and is notoriously known for invading tissues deeper than the evident gross margins. The deeper the tumor invades, the higher are its chances of future morbidity and mortality due to extensive neck dissection and risk of recurrence. Magnetic resonance imaging (MRI) is a noninvasive diagnostic aid used for measuring a preoperative tumor's depth of invasion (DOI) as it can efficiently outline soft tissue tumors from adjacent normal tissue. To assess various MRI modalities used in measuring DOI in tongue carcinoma and their reliability compared with other DOI measuring modalities. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42022330866), and the following Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) Diagnostic Test Accuracy guidelines were performed. PubMed electronic database was searched using a combination of keywords for relevant articles in the English language since 2016. Critical appraisal was carried out using the Quality Assessment of Diagnostic Accuracy Studies-Comparative (QUADAS-C) risk-of-bias (RoB) assessment tool. A weighted mean difference (WMD) was calculated between MRI and histopathological DOI along with pooled correlation and subgroup analysis, where possible. A total of 795 records were retrieved of which 17 were included in the final review with 13 included for meta-analysis. A high RoB was found for most studies for all parameters except flow and timing. WMD showed a statistically significant MRI overestimation of 1.90 mm compared with histopathology. Subgroup analysis showed the 1.5 Tesla machine to be superior to the 3.0 Tesla machine, while imaging sequence subgroup analysis could not be performed. MRI is a viable preoperative DOI measurement modality that can help in efficient treatment planning to decrease surgical morbidity and mortality.
舌癌占所有口腔鳞状细胞癌(oscc)的10.4-46.9%,众所周知,它侵入的组织比明显的毛边缘更深。肿瘤浸润越深,由于广泛的颈部剥离和复发的风险,其未来发病率和死亡率的机会就越高。磁共振成像(MRI)可以有效地从邻近正常组织中勾勒出软组织肿瘤,是一种用于术前测量肿瘤浸润深度(DOI)的无创诊断工具。评估用于测量舌癌DOI的各种MRI方式及其与其他DOI测量方式的可靠性。该方案已在国际前瞻性系统评价注册(PROSPERO)数据库(CRD42022330866)中注册,并执行了以下系统评价和荟萃分析(PRISMA)诊断测试准确性指南的首选报告项目。自2016年以来,使用关键词组合搜索PubMed电子数据库中的相关英语文章。使用诊断准确性研究质量评估-比较(QUADAS-C)偏倚风险(RoB)评估工具进行批判性评估。在可能的情况下,计算MRI和组织病理学DOI之间的加权平均差(WMD),并进行合并相关性和亚组分析。共检索到795份记录,其中17份纳入最终评价,13份纳入meta分析。除流量和时间外,大多数研究发现所有参数的罗布都很高。与组织病理学相比,WMD MRI高估了1.90 mm,具有统计学意义。亚组分析显示1.5 Tesla机器优于3.0 Tesla机器,但无法进行成像序列亚组分析。MRI是一种可行的术前DOI测量方式,可以帮助有效的治疗计划,降低手术发病率和死亡率。
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引用次数: 0
Assessment of oral health status amongst the Sevayats of Shree Jagannath Temple, Puri, Odisha: A cross sectional study 奥里萨邦普里Shree Jagannath寺庙的Sevayats口腔健康状况评估:一项横断面研究
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_26_23
Gunjan Kumar, Samikshya Jena, Payal Dash, Yagnaseni Mandal, Alok Kumar Sethi
Aim: To assess the oral health status amongst the Sevayats of Shree Jagannath temple, Puri, Odisha. Methodology: A cross-sectional study was conducted to evaluate the oral health status among 488 Sevayats of Shree Jagannath Temple, Puri, using a simple random sampling technique. Data were obtained by utilizing the WHO oral health assessment form for adults-2013. The documented data were assembled, entered into an MS Excel spreadsheet, and analyzed using SPSS version 26. The statistical tests applied for the analysis were one-way analysis of variance and the Chi-square test. The P value of < 0.05 was considered statistically significant. Results: The majority of the participants, around 30.3%, had an educational qualification of higher secondary, followed by high school, 26.2%. A total of 84.4% of participants cleaned their teeth with a toothbrush. Around 48.0% of participants were consuming paan and 11.7% were gutkha. The majority, 77.8% of the participants had periodontal pockets, and 79.09% of them had 4-5 mm of periodontal loss of attachment. The mean DMFT of all the participants was 5.23 ± 4.71. In the 25-44 and 45-60 years of age groups, 34.2% and 31.4% of the participants had tobacco pouch keratosis. About 72% of the subjects had bleeding gums. Conclusion: There was a higher prevalence of dental caries and periodontal disease among the subjects. The majority of the servitors who had a history of consuming paan were diagnosed with oral mucosal lesions.
目的:了解奥里萨邦普里市Shree Jagannath寺庙的僧侣口腔健康状况。方法:采用简单随机抽样的方法,对印度普里市Shree Jagannath寺488名圣僧的口腔健康状况进行了调查。数据采用世卫组织2013年成人口腔健康评估表获得。收集记录的数据,输入到MS Excel电子表格中,并使用SPSS版本26进行分析。分析采用的统计检验为单因素方差分析和卡方检验。<0.05认为有统计学意义。结果:大多数参与者具有高中学历,约占30.3%,其次是高中学历,占26.2%。总共有84.4%的参与者用牙刷清洁牙齿。大约48.0%的参与者食用paan, 11.7%食用gutkha。大多数(77.8%)的参与者有牙周袋,79.09%的人有4-5毫米的牙周附着丧失。所有参与者的DMFT平均值为5.23±4.71。在25-44岁和45-60岁年龄组中,34.2%和31.4%的参与者有烟袋角化病。大约72%的受试者有牙龈出血。结论:调查对象龋齿和牙周病患病率较高。有paan消费史的大多数被诊断为口腔黏膜病变。
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引用次数: 0
Evaluation of effect of single vector mandibular distraction for correction of postankylotic mandibular hypoplasia requiring multiplanar correction: A prospective case series. 单载体下颌骨牵张术治疗需要多平面矫正的强直后下颌骨发育不全的疗效评价:一个前瞻性病例系列。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_447_21
Mayank Singhal, Manoj Goyal, Neeti Mittal

Introduction: Uniplanar devices have been criticized for being insufficient to correct complex mandibular deformities and associated problems of open bite and cross bite. The use of oblique vector to correct complex multiplanar deformities using uniplanar mandibular distraction devices is the uniqueness of the present case series.

Aim and objective: The aim of the present case series is to describe the successful use of uniplanar mandibular distraction devices for the correction of complex multiplanar deformities.

Material and method: The technique of callous molding was employed to overcome any open bite. A total of 40 mandibular distractors in 20 patients (mean age 13 ± 2.67 years) were placed on the mandible for correction of the facial deformity associated with the lower jaw(mandible) in vertical, horizontal and/or sagittal plane, secondary to temporomandibular joint ankylosis. The distraction was done before and after the gap arthroplasty in 15 and 5 patients, respectively. A latency period of 3-5 days was applied, and distraction was performed at a rate of 1 mm/day with the rhythm of 0.5 mm twice daily.

Results: The significant lengthening was observed in both mandibular height (Ar Go) (50.40 ± 1.52 mm from 38.80 ± 4.38mm, P = 0.006) as well as in mandibular corpus length (Go Pg) (79.40 ± 2.28 from 58.80 ± 4.09, P = 0.001). Statistically significant changes in mandibular dimensions, facial proportions, and soft tissue profile were seen, which was assessed with the help of COGS analysis done on lateral cephalogram taken preoperatively and postoperatively.

Conclusion: With intelligent vector planning and callus molding multiplanar complex deformities can be corrected by using semiburieduniplanar devices.

引言:单平面装置被批评为不足以纠正复杂的下颌畸形以及开放咬合和交叉咬合的相关问题。使用倾斜矢量矫正复杂的多平面畸形使用单平面下颌牵引装置是本病例系列的独特之处。目的和目的:本系列病例的目的是描述单平面下颌牵引装置在复杂多平面畸形矫正中的成功应用。材料和方法:采用老茧成型技术克服任何开放性咬合。在20名患者(平均年龄13±2.67岁)的下颌骨上放置40个下颌牵引器,用于矫正颞下颌关节强直继发的与下颌相关的垂直、水平和/或矢状面面部畸形。分别在15例和5例患者的间隙关节成形术前后进行牵张。应用3-5天的潜伏期,并以1毫米/天的速率以0.5毫米的节律每天进行两次牵张。结果:下颌高度(Ar-Go)(从38.80±4.38mm变为50.40±1.52mm,P=0.006)和下颌体长(Go-Pg)(从58.80±4.09变为79.40±2.28,P=0.001)均显著延长,这是在术前和术后对侧位头影进行COGS分析的帮助下进行评估的。结论:利用智能载体规划和骨痂成型技术,利用半埋式平面矫正器可以矫正多平面复杂畸形。
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引用次数: 0
Platelet-rich plasma protein as a therapeutic regimen for oral lichen planus: An evidence-based systematic review. 富含血小板的血浆蛋白作为口腔扁平苔藓的治疗方案:一项循证系统综述。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_504_21
Nisha Maddheshiya, Adit Srivastava, Varun Rastogi, Amlendu Shekhar, Neha Sah, Ajay Kumar

Oral Lichen Planus (OLP), an autoimmune disorder of unclear pathogenesis affects quality of life of affected individual. Intervention regimens are multiple and still evolving due to its resistance to recover and ability to recur. Platelet rich Plasma (PRP) is a newer, promising treatment modality tested by researchers because of its low cost and negligible adverse effects. Articles were retrieved from search engines of PubMed / Medline, Scopus and Web of Science which fulfilled the eligibility criteria. Cochrane risk of bias tool assessed quality of clinical studies and Joanna Briggs Institute for case reports. A total of 4 articles were included for the systematic review, of which 2 are clinical trials and 2 case reports. All cases were of erosive nature. PRP in case reports were administered when patients did not respond to conventional therapy. PRP demonstrated effective therapeutic benefit in regards to outcome of pain and lesion appearance. PRP can be considered as a potential alternative therapy in treating non-responsive OLP. Further studies are recommended to arrive at a definitive conclusion.

口腔扁平苔藓(OLP)是一种自身免疫性疾病,其发病机制尚不清楚,会影响患者的生活质量。由于其对恢复的抵抗力和复发的能力,干预方案是多种多样的,并且仍在发展。富含血小板血浆(PRP)是研究人员测试的一种新的、有前景的治疗方式,因为它的成本低,副作用可以忽略不计。从PubMed/Medline、Scopus和Web of Science的搜索引擎中检索到符合资格标准的文章。Cochrane偏倚风险工具评估了临床研究的质量和乔安娜·布里格斯研究所的病例报告。系统综述共收录4篇文章,其中2篇为临床试验,2篇为病例报告。所有病例均为侵蚀性。病例报告中的PRP是在患者对常规治疗没有反应时给药的。PRP在疼痛和病变外观方面显示出有效的治疗益处。PRP可以被认为是治疗无反应性OLP的一种潜在的替代疗法。建议进行进一步的研究以得出明确的结论。
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引用次数: 0
Efficacy of calcium sulfate dihydrate as a bone graft substitute in odontogenic cystic defects of jaws following enucleation: A clinical study. 二水硫酸钙作为骨移植替代物治疗牙源性颌骨囊性缺损的疗效:一项临床研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.NJMS_350_21
Radhika Shashank Tayshetye, Nitin Bhola, Nupoor Deshpande, Anchal Agrawal

Background: The treatment of osseous bone defects created following enucleation of a cyst is an arduous challenge. Autogenous bone grafts despite being the gold standard have various drawbacks such as donor site morbidity, limited availability of bone graft, and increased operative time. Hence, there are various bone grafts which are being investigated which could overcome the limitations of autografts. Thus, this study was conducted to evaluate the efficacy of calcium sulfate (CS), a bone graft substitute, for spontaneous bone regeneration of cystic defects.

Objectives: The purpose of this study is to evaluate bone formation in odontogenic cystic defects following enucleation and reconstruction with bone graft substitute by three-dimensional radiographic and clinical evaluation.

Methodology: A total of twenty patients diagnosed with odontogenic cysts were randomly divided into two groups, out of which the study group had undergone enucleation with bone grafting (tobramycin-impregnated CS dihydrate) and the control group had undergone enucleation without bone grafting. The patients were evaluated clinically and radiographically at the 1st, 3rd, 6th, and 12th months postoperatively.

Results: There was no bone formation observed at 1 month postoperative in both the groups. There was a statistically significant higher bone defect reduction observed radiologically on orthopantomogram and computed tomography scan in the study group than the control group at the 3rd, 6th, and 12th months postoperative. The rate of reduction in cystic volume of the study group at the 12th month was 94.4% and in the control group was 37.16%.

Conclusion: Immediate grafting of cystic cavity can avoid complications such as pathological fracture due to less bone support, delayed healing, etc., The utilization of a graft with a property of inducing rapid bone formation should be taken into consideration. The use of CS as a grafting material accelerated the rate of bone regeneration in the cystic defects, with minimal complications.

背景:囊肿摘除术后骨缺损的治疗是一项艰巨的挑战。尽管自体骨移植物是金标准,但它有各种缺点,如供骨部位发病率高、骨移植物可用性有限和手术时间增加。因此,有各种各样的骨移植物正在研究中,它们可以克服自体骨移植物的局限性。因此,本研究旨在评估骨移植替代品硫酸钙(CS)对囊性缺损自发骨再生的疗效。目的:本研究的目的是通过三维放射学和临床评估来评估牙源性囊性缺损的骨形成。方法:将20例诊断为牙源性囊肿的患者随机分为两组,其中研究组接受了带骨移植的眼球摘除术(妥布霉素浸渍CS二水合物),对照组接受了不带骨移植术的眼球摘除。在术后第1、3、6和12个月对患者进行临床和放射学评估。结果:两组术后1个月均未观察到骨形成。术后第3、6和12个月,研究组在正射影像学和计算机断层扫描上观察到的骨缺损减少率高于对照组,具有统计学意义。第12个月时,研究组的囊体积减少率为94.4%,对照组为37.16%。CS作为移植材料的使用加速了囊性缺损的骨再生速度,并发症最小。
{"title":"Efficacy of calcium sulfate dihydrate as a bone graft substitute in odontogenic cystic defects of jaws following enucleation: A clinical study.","authors":"Radhika Shashank Tayshetye,&nbsp;Nitin Bhola,&nbsp;Nupoor Deshpande,&nbsp;Anchal Agrawal","doi":"10.4103/njms.NJMS_350_21","DOIUrl":"10.4103/njms.NJMS_350_21","url":null,"abstract":"<p><strong>Background: </strong>The treatment of osseous bone defects created following enucleation of a cyst is an arduous challenge. Autogenous bone grafts despite being the gold standard have various drawbacks such as donor site morbidity, limited availability of bone graft, and increased operative time. Hence, there are various bone grafts which are being investigated which could overcome the limitations of autografts. Thus, this study was conducted to evaluate the efficacy of calcium sulfate (CS), a bone graft substitute, for spontaneous bone regeneration of cystic defects.</p><p><strong>Objectives: </strong>The purpose of this study is to evaluate bone formation in odontogenic cystic defects following enucleation and reconstruction with bone graft substitute by three-dimensional radiographic and clinical evaluation.</p><p><strong>Methodology: </strong>A total of twenty patients diagnosed with odontogenic cysts were randomly divided into two groups, out of which the study group had undergone enucleation with bone grafting (tobramycin-impregnated CS dihydrate) and the control group had undergone enucleation without bone grafting. The patients were evaluated clinically and radiographically at the 1<sup>st</sup>, 3<sup>rd</sup>, 6<sup>th</sup>, and 12<sup>th</sup> months postoperatively.</p><p><strong>Results: </strong>There was no bone formation observed at 1 month postoperative in both the groups. There was a statistically significant higher bone defect reduction observed radiologically on orthopantomogram and computed tomography scan in the study group than the control group at the 3<sup>rd</sup>, 6<sup>th</sup>, and 12<sup>th</sup> months postoperative. The rate of reduction in cystic volume of the study group at the 12<sup>th</sup> month was 94.4% and in the control group was 37.16%.</p><p><strong>Conclusion: </strong>Immediate grafting of cystic cavity can avoid complications such as pathological fracture due to less bone support, delayed healing, etc., The utilization of a graft with a property of inducing rapid bone formation should be taken into consideration. The use of CS as a grafting material accelerated the rate of bone regeneration in the cystic defects, with minimal complications.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"14 1","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/34/NJMS-14-125.PMC10235741.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9950371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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National Journal of Maxillofacial Surgery
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