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Evaluation of sub-brow approach to the frontozygomatic suture for Open Reduction and Internal Fixation (ORIF) of Zygomatico maxillary complex (ZMC) fractures: A prospective cohort study. 额翼缝线眉下入路用于颧骨-上颌复合体(ZMC)骨折切开复位内固定术(ORIF)的评价:一项前瞻性队列研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_106_22
Avadh R Pandya, Elavenil Panneerselvam, Arun Vignesh, V B Raja Krishnakumar

Introduction: Contemporary incisions used to access the frontozygomatic (FZ) sutures are the lateral brow and upper blepharoplasty incisions which are associated with specific limitations and complications. The authors describe the use of sub-brow incision as an alternate approach for exposure of the FZ region.

Methods: This is a prospective cohort study involving patients requiring surgical management of zygomatico maxillary complex (ZMC) fractures with fixation at FZ suture alone or along with fixation at infra-orbital rim and/or zygomaticomaxillary buttress. A sub-brow incision was used to expose the fracture and fixation was done with a 4-hole miniplate. The parameters evaluated were specific to the FZ region (sub-brow incision), namely surgical access, bleeding, fracture exposure time, post-operative scar, and pain. Each patient was reviewed on 1st, 5th, 7th, 10th, 30th, and 90th day.

Results: The study sample included eight male patients. The mean age was 30 years. The sub-brow incision demonstrated favorable postoperative outcomes; adequate exposure was achieved in all 8 patients. The scar formation was found to be higher on the 7th day and the least scar formation was seen by the third month. The mean pain score was found to be high on first post-operative day and the least pain was seen by the 10th day. The mean score of surgical field bleeding was found to be 1.75 which signified mild bleeding according to Fromme's scale. The mean time taken for adequate exposure of the fracture was 6.62 min. All the assessment parameters were statistically significant (P value <0.01).

Conclusion: Sub-brow incision is an effective approach for ORIF of zygomatic fractures at FZ suture. The technique is quick, simple, and associated with minimal complications.

引言:目前用于额翼缝合的切口是眉侧和上眼睑整形术切口,这些切口有特定的局限性和并发症。作者描述了使用眉下切口作为FZ区域暴露的替代方法。方法:这是一项前瞻性队列研究,涉及需要手术治疗颧骨-上颌复合体(ZMC)骨折的患者,仅在FZ缝线处固定,或同时在眶下缘和/或颧颌支墩处固定。眉下切口暴露骨折,并用4孔微型钢板固定。评估的参数针对FZ区域(眉下切口),即手术入路、出血、骨折暴露时间、术后疤痕和疼痛。每个患者在第1、5、7、10、30和90天接受检查。结果:研究样本包括8名男性患者。平均年龄为30岁。眉下切口显示良好的术后效果;所有8名患者都获得了足够的暴露量。发现瘢痕形成在第7天更高,并且在第3个月时瘢痕形成最少。术后第一天的平均疼痛评分较高,第10天疼痛程度最低。根据Fromme量表,手术现场出血的平均得分为1.75,表示轻度出血。骨折充分暴露的平均时间为6.62min。所有评估参数均具有统计学意义(P值)。结论:眉下切口是FZ缝合颧骨骨折ORIF的有效方法。该技术快速、简单,并发症最小。
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引用次数: 0
Recovery and post-operative analgesic efficacy from fentanyl- versus dexmedetomidine-based anesthesia in head and neck cancer surgery: A prospective comparative trial. 癌症头颈部手术中芬太尼与右美托咪定麻醉的恢复和术后镇痛效果:一项前瞻性比较试验。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_3_22
Sumit Kumar, Prem Raj Singh, Vinod Kumar Srivastava, Mohammad P Khan, Manish Kumar Singh, Radhey Shyam

Background: Opioids such as fentanyl are being used frequently in the management of postoperative period, whereas non-opioid drugs such as dexmedetomidine are now commonly being used as adjuvants during the perioperative period to hasten the fast recovery and better outcome in the post-operative period because of their anesthetic and analgesic property. The recovery profile was measured by the emergence of anesthesia and pain characteristics. We aimed to evaluate and compare the efficacy of dexmedetomidine and fentanyl in the surgery of head and neck cancer patients.

Methods: Prospective double-blind study on 60 patients with the American Society Anesthesiologists (ASA) grade I and II were randomly divided into two groups. Group DM received a loading dose of dexmedetomidine 1 µg/kg over 10 min followed by a maintenance dose of 0.5 µg/kg/h and Group FM received a loading dose of fentanyl 2 µg/kg/h for over 10 min followed by 1 µg/kg/h maintenance dose. Data were analyzed using a Chi-square test or Student's 't' test.

Results: The group DM was hemodynamic stable as compared to group FM. The perturbation during extubation emergence was significantly lower in group DM as compared to that in group FM. A total of four patients were severely agitated in group FM, whereas it was absent in group DM. Severe agitation was significantly different between Group FM and Group DM. The visual analog scale (VAS) was lower among patients of Group DM as compared to Group FM at all times except at 4 h.

Conclusions: The infusion of dexmedetomidine was better in controlling emergence agitation, postoperative pain, and achieving peri-operative hemodynamic stability as compared to fentanyl.

背景:芬太尼等阿片类药物在术后管理中经常使用,而右美托咪定等非阿片类药由于其麻醉和镇痛特性,现在通常在围手术期用作佐剂,以加快术后的快速恢复和更好的结果。通过麻醉的出现和疼痛特征来衡量恢复情况。我们旨在评估和比较右美托咪定和芬太尼在癌症头颈部手术中的疗效。方法:对60例美国麻醉师协会(ASA)I级和II级患者进行前瞻性双盲研究,随机分为两组。DM组在10分钟内接受1µg/kg的右美托咪定负荷剂量,然后维持0.5µg/kg/h的剂量;FM组在10 min内接受2µg/kg/h芬太尼负荷剂量,随后维持1µg/kg/小时的剂量。数据采用卡方检验或学生t检验进行分析。结果:与FM组相比,DM组血流动力学稳定。与FM组比较,DM组拔管出现时的扰动显著降低。FM组共有4名患者出现严重扰动,而DM组则没有。FM组和DM组之间的严重扰动有显著差异。除4小时外,DM组患者的视觉模拟评分(VAS)在所有时间都低于FM组。结论:与芬太尼相比,右美托咪定输注在控制苏醒期躁动、术后疼痛和实现围手术期血液动力学稳定性方面更好。
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引用次数: 0
Effects of curcumin on oral cancer at molecular level: A systematic review. 姜黄素在分子水平上对口腔癌症的影响:系统综述。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_29_22
Akhilesh Kumar Singh, Naresh Kumar Sharma, Nitesh Mishra, Arjun Mahajan, Aswathi Krishnan, Ravina Rajpoot, Janani Anand Kumar, Arun Pandey

This systematic review mainly focuses on the effects of curcumin on oral cancer cells at the molecular level and summarizes the results of the studies. We searched and analyzed various databases such as Pub Med, ProQuest, Google Scholar, Science Direct, and Scopus. Searches were conducted from 2006 to 2021. This systematic review evaluated various effects of curcumin on oral cancer at the molecular level. All the studies related to the effects of curcumin on oral cancer, both in-vivo and in-vitro, were included. After abstract and text screening a total of 13 articles were finally selected for the study based on the inclusion and exclusion criteria. All most all the included studies reported that after treating the cell lines with curcumin there is a reduction in cell proliferation and cell growth, analyzed using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. Curcumin also induces S phase cell cycle arrest and also prevents Tregs migration. The curcumin reverses the process of epithelial mesenchymal transition (EMT) back to mesenchymal epithelial transition (MET). From this review, it is concluded that curcumin inhibited proliferation, migration, invasion, and metastasis, and induced apoptosis via modulating multiple signaling pathways in oral cancer cell lines. But further clinical trials are needed for a detailed evaluation of the effects of curcumin on patients with oral cancer.

本文系统综述了姜黄素在分子水平上对口腔癌症细胞的作用,并对研究结果进行了总结。我们搜索并分析了各种数据库,如Pub-Med、ProQuest、Google Scholar、Science Direct和Scopus。搜查于2006年至2021年进行。这篇系统综述在分子水平上评估了姜黄素对口腔癌症的各种影响。所有与姜黄素对口腔癌症影响相关的研究,包括体内和体外研究。经过摘要和文本筛选,根据纳入和排除标准,最终选择了13篇文章进行研究。所有纳入的研究报告称,用姜黄素处理细胞系后,细胞增殖和细胞生长减少,使用MTT(3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑啉)分析。姜黄素还诱导S期细胞周期停滞,并阻止Tregs迁移。姜黄素逆转上皮-间充质转化(EMT)向间充质-上皮转化(MET)的过程。从这篇综述中得出结论,姜黄素通过调节多种信号通路抑制口腔癌症细胞系的增殖、迁移、侵袭和转移,并诱导细胞凋亡。但还需要进一步的临床试验来详细评估姜黄素对口腔癌症患者的影响。
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引用次数: 0
From flint tools to robotics: The Journey of OMFS through time! 从燧石工具到机器人:OMFS穿越时间之旅!
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_43_23
Sanjay Singh
The earliest recorded evidence of oral surgery dates back to the great Indian surgeon Sushruta, who has described a unique technique of a forehead flap for the reconstruction of nasal defects. Ancient Egypt records evidence of dental problems treated using crude tools made of flint, bone, and copper. In ancient Greece, Hippocrates, the father of modern medicine, wrote about the treatment of facial injuries and the use of dental splints to immobilize fractured jaws. In the Middle Ages, barbers and blacksmiths performed tooth extractions and other dental procedures, as the dental profession did not exist at that time. However, in the eighteenth century, Pierre Fauchard, a French dentist, introduced modern dentistry and developed new tools and techniques for treating dental problems.
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引用次数: 0
Single linear miniplate versus rectangular grid plate in the treatment of mandibular angle fractures: A prospective, clinico-radiographic, comparative study. 单一线性微型钢板与矩形网格钢板治疗下颌角骨折:一项前瞻性临床放射学对比研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_129_22
Manthan Kumar Das, Madan Mishra, Gaurav Singh, Shubhamoy Mondal

Study design: Randomized Control Trial.

Objective: A prospective, clinico-radiographic, comparative study was planned to evaluate the treatment outcome and postoperative complications in isolated mandibular angle fractures using 2.0-mm system single linear 4 hole with gap miniplate versus 4 hole rectangular grid plate, both stabilized with 4 8-mm monocortical screws.

Methods: Thirty patients with isolated mandibular angle fractures were randomly categorized into two groups with 15 patients each. Group 1 patients were treated with single 2.0 mm × 4 hole linear miniplate along the superior border and Group 2 patients were treated with a 2.0 mm × 4 hole rectangular grid plate on lateral cortex of mandible. Pain, swelling, occlusion, bite force, maximum inter-incisal opening, intraoperative time, facial nerve injury, fracture stability, and postoperative complications were assessed and compared at regular intervals up to 12 months.

Results: There was no major difference in terms of treatment outcome in both systems and both were equally effective without any statistically significant difference in any of the parameters. None of the patients presented with any of the complications except for postoperative infection which was reported by 1 patient from each group at 3 months postoperatively and were managed conservatively.

Conclusion: Both plating systems are equally effective; however, the rectangular grid plate could be a safe and effective alternative to the single miniplate when adaptation and fixation is not possible along the external oblique ridge of the mandible (e.g., fracture with bone loss along the superior border).

研究设计:随机对照试验。目的:计划进行一项前瞻性、临床放射学、比较研究,评估使用2.0mm系统单线性4孔间隙微型钢板与4孔矩形网格钢板治疗孤立性下颌角骨折的疗效和术后并发症,两种钢板均用4颗8-mm单皮质螺钉固定。方法:将30例孤立性下颌角骨折患者随机分为两组,每组15例。第1组采用单块2.0mm×4孔上缘线性微型钢板,第2组采用2.0mm×。每隔12个月定期评估和比较疼痛、肿胀、咬合、最大切迹间开口、术中时间、面神经损伤、骨折稳定性和术后并发症。结果:两种系统的治疗结果没有重大差异,两种系统都同样有效,任何参数都没有任何统计学显著差异。除了术后感染外,没有任何患者出现任何并发症。术后3个月,每组1名患者报告了术后感染,并进行了保守治疗。结论:两种电镀系统效果相同;然而,当无法沿着下颌骨的外斜嵴进行适应和固定时(例如,沿着上边界的骨折伴骨丢失),矩形网格板可能是单个微型板的安全有效的替代方案。
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引用次数: 0
Low-level laser for the management of head-and-neck burn wounds 低能激光治疗头颈部烧伤
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_440_21
Regina Maria Raffaele, Mario Eduardo Baldo, Luiz Felipe Palma, Luana Campos
Burn injuries are of serious concern worldwide not only because of the physical impact but also because of severe mental and emotional distress and reduced quality of life. The usual management comprises topical and systemic medications, and supportive care; however, conventional therapy may be expensive and insufficient for many cases. Thus, we describe herein a unique case in which a low-level laser was used concomitantly with the conventional approach for the management of head and neck burn wounds and could improve the patient's clinical condition within a short period.
烧伤在世界范围内受到严重关注,不仅是因为身体上的影响,还因为严重的精神和情绪困扰以及生活质量的降低。通常的治疗包括局部和全身药物治疗以及支持性护理;然而,对于许多病例来说,传统疗法可能是昂贵且不充分的。因此,我们在此描述了一个独特的案例,其中低水平激光与传统方法一起用于头颈部烧伤创面的治疗,并能在短时间内改善患者的临床状况。
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引用次数: 0
Temporomandibular joint patient specific implant as treatment for hemifacial microsomia 颞下颌关节患者特异性植入治疗面肌短小症
Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_14_22
Leonardo A. P. F. Pinto, Bernardo C. Lima, Michelle A. Coutinho, Viviane F. Ramos
Hemifacial microsomia (HFM) is a complex congenital malformation with an extremely variable phenotypic presentation. It usually involves structures of the first and second pharyngeal arches. Anomalies of the cardiac, pulmonary, renal, and gastrointestinal systems are present, but the main characteristic is the mandibular hypoplasia. This is commonly treated with orthodontic hardware and various surgical modalities. Most recently, a total joint replacement with a customized prosthesis is idealized to provide the best outcomes to these patients, so it has been used in some cases. The following case is of a 23-year-old female with congenital hypoplastic mandibular head and the absence of mandibular fossa. The proposed treatment was to reconstruct the mandible with a customized prosthesis and orthognathic surgery to correct the asymmetry and provide better phonation, speech, and facial contour. The patient is under six years follow-up with a complete adaptation of the prosthesis.
半面小畸形(HFM)是一种复杂的先天性畸形,具有极其可变的表型表现。它通常涉及第一和第二咽弓的结构。心脏、肺、肾和胃肠系统均有异常,但主要特征是下颌骨发育不全。这通常是治疗正畸硬件和各种手术方式。最近,使用定制假体进行全关节置换术是理想的,可以为这些患者提供最好的结果,因此在某些情况下已被使用。下面的病例是一个23岁的女性先天性下颌头发育不全和下颌窝缺失。建议的治疗方法是使用定制的假体和正颌手术重建下颌骨,以纠正不对称并提供更好的发音,言语和面部轮廓。患者在六年的随访中完全适应了假体。
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引用次数: 0
Comparison between LMA ProSeal and I-gel airway in anesthetized patients on spontaneous ventilation during daycare procedures: A prospective randomized study. LMA ProSeal和I-gel气道在日托过程中自主通气麻醉患者中的比较:一项前瞻性随机研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_500_21
Hemlata, Neha Singh, Ajay K Chaudhary, Reetu Verma, Dinesh Singh, Brij B Kushwaha

Background: General anesthesia remains the most popular technique for ambulatory surgeries with patients, surgeons, and anesthesia providers. The supraglottic airway (SGA) devices result in fewer incidences of sore throat, laryngospasm, coughing, and hoarseness as compared to inserting a tracheal tube. This study was conducted to compare two second-generation SGA devices, LMA ProSeal and I-gel airway, in anesthetized patients on spontaneous ventilation during daycare procedures to establish the superior SGA device.

Methodology: This prospective randomized study was done on 90 patients of either sex aged 15-60 years, ASA grade I-II, Mallampatti grade I and II, and BMI between 20 and 30 kg/m2 scheduled for elective surgeries of duration less than 90 min. Patients were randomly allocated into two groups-group A (I-gel) and group B (LMA ProSeal). Insertion parameters, hemodynamic responses, oxygenation, ventilation, peak airway pressure (PAP), and postoperative complications were recorded. Statistical analysis was done using SPSS version 21.0 statistical analysis software.

Results: Mean insertion time of LMA ProSeal was found to be significantly higher as compared to I-gel (33.27 ± 3.88 vs 18.49 ± 3.18 s; P < 0.001). No significant difference was found between the groups in the number of attempts and of operators attempted for insertion, as well as in hemodynamic response, oxygenation, and ventilation. Postoperative complications were lesser in group A.

Conclusion: I-gel is an easy-to-insert cuffless SGA device requiring lesser time for insertion, provides adequate ventilation with lesser postoperative complications and thus appears to be better than LMA ProSeal.

背景:全身麻醉仍然是门诊手术中最受患者、外科医生和麻醉提供者欢迎的技术。与插入气管导管相比,声门上气道(SGA)装置可减少喉咙痛、喉痉挛、咳嗽和声音嘶哑的发生率。本研究旨在比较两种第二代SGA装置,LMA ProSeal和I-gel气道,用于在日托过程中进行自主通气的麻醉患者,以建立优越的SGA装置。方法:这项前瞻性随机研究对90名年龄在15-60岁、ASA I-II级、Mallamatti I级和II级、BMI在20-30 kg/m2之间的患者进行,计划进行持续时间小于90分钟的选择性手术。患者被随机分为A组(I-gel)和B组(LMA ProSeal)。记录插入参数、血液动力学反应、氧合、通气、峰值气道压(PAP)和术后并发症。采用SPSS 21.0版统计分析软件进行统计分析。结果:与I-gel相比,LMA ProSeal的平均插入时间显著增加(33.27±3.88 vs 18.49±3.18 s;P<0.001)。两组在尝试插入的次数和操作次数以及血液动力学反应、氧合和通气方面均无显著差异。A组术后并发症较少。结论:I-gel是一种易于插入的无套SGA装置,插入时间更短,提供了足够的通气,术后并发症更少,因此似乎比LMA ProSeal更好。
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引用次数: 1
Gap areas in mitigation of oral cancer: A cross-sectional study evaluating awareness and knowledge of risk factors in oral cancer in a tertiary hospital. 缓解口腔癌症的差距领域:一项横断面研究,评估三级医院对口腔癌症危险因素的认识和知识。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_427_21
Ankita Chugh, Amanjot Kaur, Pankaj Bhardwaj, Jeewan Ram Vishnoi, Nitin Joshi, Shailendra Kumar, Shivkumar Chopane, Pravin Kumar

Purpose and objectives: One of the main causes of the increasing oral cancer (OC) burden in India is a lack of awareness and a significant gap in knowledge about risk factors and symptomology of OC.

Materials and methods: A questionnaire-based cross-sectional study was to evaluate the knowledge and awareness about OC among 500 random patients presenting for care at a tertiary hospital in western Rajasthan which serves a wide area of western, northern, and central Rajasthan.

Results: A total of 446 participants, among which 83.6% were males enrolled in the study. Much to our despair, the results showed 35.23% of the participants (P = 0.007) started their habit at age <15 years. Nearly 60.3% of the participants were well aware of the harmful temporary or permanent effects of the tobacco. Around 40.85% of the participants taking tobacco products were ignorant about their changes in the tissues (site of tobacco placement). TV and Radio (50.5%) were the main source of information of the ill effects of tobacco and form a major contribution in public awareness. More than 90% of the participants had read the warnings on the tobacco packets. No doubt participants have knowledge about the ill effects of tobacco still there was a lack in behavioral modifications for tobacco cessation, leading to nonsuccess in quitting, with actual nonunderstanding about the ill effects of tobacco and overall lack of belief in the tobacco control measures.

Conclusion: Our findings have found a gap in the awareness efforts of OC for the general population and will make public health professionals, clinicians, policymakers, and government a better judge and motivate them to strengthen existing national tobacco control efforts.

目的和目的:印度口腔癌症(OC)负担增加的主要原因之一是对OC的危险因素和症状缺乏认识和知识上的显著差距。材料和方法:一项基于问卷的横断面研究旨在评估在西部一家三级医院接受治疗的500名随机患者对OC的认识和认识拉贾斯坦邦服务于拉贾斯坦邦西部、北部和中部的广大地区。结果:共有446名参与者,其中83.6%为男性。令我们非常失望的是,研究结果显示,35.23%的参与者(P=0.007)在年龄时就开始了吸烟习惯。结论:我们的研究结果发现,在普通人群对OC的认识方面存在差距,这将使公共卫生专业人员、临床医生、政策制定者和政府成为更好的判断者,并激励他们加强现有的国家烟草控制工作。
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引用次数: 0
Assessment of oral health status among Bhoi community of Nimapara block in Puri district, Odisha: A cross-sectional study. 奥里萨邦普里区Nimapara街区Bhoi社区口腔健康状况评估:一项横断面研究。
Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_74_22
Gunjan Kumar, Mohammad Jalaluddin, Payal Dash

Aim: The aim of this study was to assess the oral health status of the adult population of the Bhoi community of Nimapara block in Puri district of Odisha.

Methodology: A cross-sectional survey was carried out among 433 adults Bhois using a multistage randomized sampling method in Nimapara Block of Dhanua Gram Panchayat, Puri District. Data were collected using the modified WHO Oral Health Assessment Form, 2013. Number and percentages were derived using MS Excel and SPSS package version 26.0. Comparison between discrete and continuous data was done using the Chi-square test and ANOVA. The P value of 0.05 was considered to be statistically significant.

Results: The mean Decayed, missing, filled teeth (DMFT) for all study participants was 3.94 ± 3.106. The average DMFT scores for males and females were 3.89 ± 2.938 and 4.0 ± 3.30 respectively. The average shallow and deep pocket presences were 1.20 ± 0.680 and 1.90 ± 0.310, respectively. The mean calculus was 2.13 ± 0.476. The highest loss of attachment of 6 to 8 mm was seen in 92 (21.2%) subjects.

Conclusion: The prevalence of dental caries and periodontal diseases was high. As there is a lack of knowledge about oral hygiene maintenance, proper health education should be administered.

目的:本研究旨在评估奥里萨邦普里区Nimapara区Bhoi社区成年人口的口腔健康状况。方法:采用多阶段随机抽样方法,在普里区Dhanua Gram Panchayat的Nimapara区块对433名成年Bhois进行了横断面调查。使用修订后的世界卫生组织2013年口腔健康评估表收集数据。使用MS Excel和SPSS软件包版本26.0导出数字和百分比。使用卡方检验和方差分析对离散数据和连续数据进行比较。0.05的P值被认为具有统计学意义。结果:所有研究参与者的平均蛀牙、缺牙、补牙(DMFT)为3.94±3.106。男性和女性的DMFT平均得分分别为3.89±2.938和4.0±3.30。浅袋和深袋的平均存在分别为1.20±0.680和1.90±0.310。平均微积分为2.13±0.476。在92名(21.2%)受试者中发现了6至8mm的最大附着损失。结论:龋病和牙周病患病率较高。由于缺乏口腔卫生知识,应进行适当的健康教育。
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引用次数: 0
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National Journal of Maxillofacial Surgery
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