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An overview of structural genomics. 结构基因组学综述。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80697
S K Burley

With access to sequences of entire human genomes plus those of various model organisms and many important microbial pathogens, structural biology is on the verge of a dramatic transformation. Our newfound wealth of sequence information will serve as the foundation for an important initiative in structural genomics. We are poised to embark on a systematic program of high-throughput X-ray crystallography and NMR spectroscopy aimed at developing a comprehensive view of the protein structure universe. Structural genomics will yield a large number of experimental protein structures (tens of thousands) and an even larger number of calculated comparative protein structure models (millions). This enormous body of structural data will be freely available, and promises to accelerate scientific discovery in all areas of biological science, including biodiversity and evolution in natural ecosystems, agricultural plant genetics, breeding of farm and domestic animals, and human health and disease.

随着整个人类基因组序列以及各种模式生物和许多重要微生物病原体的序列的获取，结构生物学正处于一个戏剧性转变的边缘。我们新发现的序列信息财富将作为结构基因组学重要举措的基础。我们正准备着手进行高通量x射线晶体学和核磁共振波谱学的系统计划，旨在开发蛋白质结构宇宙的全面视图。结构基因组学将产生大量的实验蛋白质结构(数以万计)和更多的计算比较蛋白质结构模型(数以百万计)。这些庞大的结构数据将免费提供，并有望加速生物科学所有领域的科学发现，包括自然生态系统的生物多样性和进化、农业植物遗传学、农场和家畜育种以及人类健康和疾病。
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引用次数: 227
Protein structure modeling for structural genomics. 结构基因组学的蛋白质结构建模。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80776
R Sánchez, U Pieper, F Melo, N Eswar, M A Martí-Renom, M S Madhusudhan, N Mirković, A Sali

The shapes of most protein sequences will be modeled based on their similarity to experimentally determined protein structures. The current role, limitations, challenges and prospects for protein structure modeling (using information about genes and genomes) are discussed in the context of structural genomics.

大多数蛋白质序列的形状将基于它们与实验确定的蛋白质结构的相似性来建模。在结构基因组学的背景下，讨论了目前蛋白质结构建模(利用基因和基因组信息)的作用、局限性、挑战和前景。
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引用次数: 220
Structural genomics in North America. 结构基因组学在北美。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80700
T C Terwilliger

Structural genomics in North America has moved remarkably quickly from ideas to pilot projects. Just three years ago, the field was only a concept, independently being discussed by its many inventors. Now it is already a well-organized, increasingly-funded, consortium-based effort to determine protein structures on a large scale.

北美的结构基因组学从想法到试点项目的进展非常迅速。就在三年前，这个领域还只是一个概念，由许多发明者独立讨论。现在，它已经是一个组织良好、资金越来越多、以财团为基础的大规模确定蛋白质结构的努力。
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引用次数: 92
Structural genomics in Europe: slow start, strong finish? 欧洲的结构基因组学:起步缓慢，结束强劲?
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80707
U Heinemann

Structural genomics in Europe is slowly coming off the ground. So far, European Commission funding is restricted to methods development projects, whereas structural genomics programs are funded from national sources. The research outlook is more toward techniques for high-throughput structure analysis than toward a systematic coverage of protein fold space. At present, there is little European coordination of the structural genomics effort.

欧洲的结构基因组学正在慢慢起步。到目前为止，欧盟委员会的资助仅限于方法开发项目，而结构基因组学项目则由国家资助。研究的前景是更倾向于高通量结构分析技术，而不是对蛋白质折叠空间的系统覆盖。目前，欧洲在结构基因组学方面的合作很少。
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引用次数: 51
The Protein Data Bank and the challenge of structural genomics. 蛋白质数据库和结构基因组学的挑战。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80734
H M Berman, T N Bhat, P E Bourne, Z Feng, G Gilliland, H Weissig, J Westbrook

The PDB has created systems for the processing, exchange, query, and distribution of data that will enable many aspects of high throughput structural genomics.

PDB已经创建了用于处理、交换、查询和分发数据的系统，这将使高通量结构基因组学的许多方面成为可能。
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引用次数: 525
From structure to function: approaches and limitations. 从结构到功能:方法和限制。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80784
J M Thornton, A E Todd, D Milburn, N Borkakoti, C A Orengo

This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.

本文综述了目前从蛋白质及其复合物的结构数据中提取功能信息的方法。虽然结构同系物可能揭示可能的生化功能(可能隐藏在序列水平上)，但阐明蛋白质在体内的确切生物学作用只能通过包括其他结果，如表达和定位数据。
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引用次数: 205
Structural genomics for science and society. 科学与社会的结构基因组学。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80744
W G Hol

The field of robotics is affecting structural biology, enabling the era of structural genomics. The potential impact on protein fold prediction, biology, protein engineering and medicine is immense. Unraveling mysteries in the protein structure universe will require a dedicated effort for decades to come with computational toxicology as possibly a century long challenge.

机器人领域正在影响结构生物学，使结构基因组学时代成为可能。对蛋白质折叠预测、生物学、蛋白质工程和医学的潜在影响是巨大的。解开蛋白质结构宇宙中的奥秘将需要几十年的努力，计算毒理学可能是一个世纪的挑战。
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引用次数: 32
Protein NMR spectroscopy in structural genomics. 结构基因组学中的蛋白质核磁共振波谱。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80768
G T Montelione, D Zheng, Y J Huang, K C Gunsalus, T Szyperski

Protein NMR spectroscopy provides an important complement to X-ray crystallography for structural genomics, both for determining three-dimensional protein structures and in characterizing their biochemical and biophysical functions.

蛋白质核磁共振波谱为结构基因组学提供了x射线晶体学的重要补充，既可以确定三维蛋白质结构，也可以表征其生化和生物物理功能。
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引用次数: 182
New roles for structure in biology and drug discovery. 结构在生物学和药物发现中的新作用。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80691
R B Russell, D S Eggleston
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引用次数: 164
Structural genomics programs at the US National Institute of General Medical Sciences. 美国国家普通医学科学研究所的结构基因组学项目。
Nature Structural Biology
Pub Date : 2000-11-01 DOI: 10.1038/80694
J C Norvell, A Z Machalek
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引用次数: 71
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