Pub Date : 2025-10-30DOI: 10.1038/s41557-025-01906-9
Jeyun Jo, Matthew Bogyo
In the growing field of chemical proteomics, there is a need for general methods to map the reactivity profiles of covalent probes in complex proteomes. Now, a completely unbiased proteomic workflow has been developed that enables global characterization of the amino acid residues, chemically labelled by reactive electrophilic probes.
{"title":"A pipeline for proteome-wide analysis of electrophile selectivity","authors":"Jeyun Jo, Matthew Bogyo","doi":"10.1038/s41557-025-01906-9","DOIUrl":"10.1038/s41557-025-01906-9","url":null,"abstract":"In the growing field of chemical proteomics, there is a need for general methods to map the reactivity profiles of covalent probes in complex proteomes. Now, a completely unbiased proteomic workflow has been developed that enables global characterization of the amino acid residues, chemically labelled by reactive electrophilic probes.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1638-1640"},"PeriodicalIF":20.2,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145397312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-23DOI: 10.1038/s41557-025-01976-9
Judy I. Wu
The discovery of benzene two centuries ago marked a turning point in chemistry. From contributing to the development of chemical bonding concepts, to its practical use in the chemical industry, the story of this ring-shaped molecule is a combination of curiosity, science, and human kindness.
{"title":"The human story of benzene","authors":"Judy I. Wu","doi":"10.1038/s41557-025-01976-9","DOIUrl":"10.1038/s41557-025-01976-9","url":null,"abstract":"The discovery of benzene two centuries ago marked a turning point in chemistry. From contributing to the development of chemical bonding concepts, to its practical use in the chemical industry, the story of this ring-shaped molecule is a combination of curiosity, science, and human kindness.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1621-1623"},"PeriodicalIF":20.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1038/s41557-025-01958-x
Yanan Du,Anyarat Thanapipatsiri,Jesús J Blancas Cortez,Xavier E Salas-Solá,Chi-Yun Lin,Amie K Boal,Carsten Krebs,J Martin Bollinger,Kenichi Yokoyama
Azetidine, a four-membered aza-cycle, is a crucial structure in many bioactive compounds and drugs. However, their biosynthesis is frequently enigmatic. Here we report the mechanism of azetidine amino acid (polyoximic acid) biosynthesis in the polyoxin antifungal pathway. Genetic, enzymological and structural experiments revealed that PolF is a member of haem-oxygenase-like dimetal oxidase and/or oxygenase (HDO) superfamily, and this enzyme alone is sufficient for the transformation of L-isoleucine (L-Ile) and L-valine to their azetidine derivatives via a 3,4-desaturated intermediate. Mechanistic studies of PolF suggested that a μ-peroxo-Fe(III)2 intermediate is directly responsible for the unactivated C-H bond cleavage, and the post-H-abstraction reactions, including the C-N bond formation, probably proceed through radical mechanisms. We also found that PolE, a member of the DUF6421 family, is an Fe and pterin-dependent oxidase that catalyses the desaturation of L-Ile, assisting PolF by increasing the flux of L-Ile desaturation. The results provide important insights into azetidine biosynthesis and the catalytic mechanisms of HDO enzymes in general.
氮杂环是一个四元氮杂环，是许多生物活性化合物和药物的重要结构。然而，它们的生物合成常常是神秘的。本文报道了氮杂啶氨基酸（多肟酸）生物合成在多毒素抗真菌途径中的作用机制。遗传、酶学和结构实验表明，PolF是血红加氧酶样二金属氧化酶和/或加氧酶（HDO）超家族的成员，该酶本身就足以通过3,4-去饱和中间体将l -异亮氨酸（L-Ile）和l -缬氨酸转化为它们的氮杂啶衍生物。对PolF的机理研究表明，μ-过氧化物- fe (III)2中间体直接导致了未活化的C-H键断裂，而h萃取后的反应，包括C-N键的形成，可能是通过自由基机制进行的。我们还发现，作为DUF6421家族的一员，PolE是一种铁和蝶呤依赖的氧化酶，它可以催化L-Ile的去饱和，通过增加L-Ile的去饱和通量来辅助PolF。这些结果为氮杂胞苷的生物合成和HDO酶的催化机制提供了重要的见解。
{"title":"Azetidine amino acid biosynthesis by non-haem iron-dependent enzymes.","authors":"Yanan Du,Anyarat Thanapipatsiri,Jesús J Blancas Cortez,Xavier E Salas-Solá,Chi-Yun Lin,Amie K Boal,Carsten Krebs,J Martin Bollinger,Kenichi Yokoyama","doi":"10.1038/s41557-025-01958-x","DOIUrl":"https://doi.org/10.1038/s41557-025-01958-x","url":null,"abstract":"Azetidine, a four-membered aza-cycle, is a crucial structure in many bioactive compounds and drugs. However, their biosynthesis is frequently enigmatic. Here we report the mechanism of azetidine amino acid (polyoximic acid) biosynthesis in the polyoxin antifungal pathway. Genetic, enzymological and structural experiments revealed that PolF is a member of haem-oxygenase-like dimetal oxidase and/or oxygenase (HDO) superfamily, and this enzyme alone is sufficient for the transformation of L-isoleucine (L-Ile) and L-valine to their azetidine derivatives via a 3,4-desaturated intermediate. Mechanistic studies of PolF suggested that a μ-peroxo-Fe(III)2 intermediate is directly responsible for the unactivated C-H bond cleavage, and the post-H-abstraction reactions, including the C-N bond formation, probably proceed through radical mechanisms. We also found that PolE, a member of the DUF6421 family, is an Fe and pterin-dependent oxidase that catalyses the desaturation of L-Ile, assisting PolF by increasing the flux of L-Ile desaturation. The results provide important insights into azetidine biosynthesis and the catalytic mechanisms of HDO enzymes in general.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"92 1","pages":""},"PeriodicalIF":21.8,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Achieving high enantioselectivity in asymmetric catalysis, especially with very reactive species such as radicals, often comes at the expense of generality. Radicals with exceptionally high reactivity are typically unsuitable for existing asymmetric methodologies. Here we present a general catalytic approach to asymmetric radical cross-coupling that combines copper-catalysed enantioselective stereocentre resolution or formation with copper-mediated, chirality-transferring radical substitution. This sequential strategy enables the efficient coupling of over 50 distinct carbon-, nitrogen-, oxygen-, sulfur- and phosphorus-centred radicals, including highly reactive methyl, tert-butoxyl and phenyl radicals, yielding structurally diverse C-, P- and S-chiral compounds with outstanding enantioselectivity. Our method thus provides a unified platform for the synthesis of carbon, phosphorus and sulfur stereocentres, with important implications for the preparation of chiral molecules relevant to medicinal chemistry and related disciplines. Furthermore, this sequential stereodiscrimination and chirality transfer strategy offers a promising blueprint for the development of highly enantioselective methodologies applicable to other classes of highly reactive species beyond radicals. Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.
{"title":"Copper-catalysed asymmetric cross-coupling reactions tolerant of highly reactive radicals","authors":"Li-Wen Fan, Jun-Bin Tang, Li-Lei Wang, Zeng Gao, Ji-Ren Liu, Yu-Shuai Zhang, Dai-Lei Yuan, Li Qin, Yu Tian, Zhi-Chao Chen, Fu Liu, Jin-Min Xiang, Pei-Jie Huang, Wei-Long Liu, Chen-Yu Xiao, Cheng Luan, Zhong-Liang Li, Xin Hong, Zhe Dong, Qiang-Shuai Gu, Xin-Yuan Liu","doi":"10.1038/s41557-025-01970-1","DOIUrl":"10.1038/s41557-025-01970-1","url":null,"abstract":"Achieving high enantioselectivity in asymmetric catalysis, especially with very reactive species such as radicals, often comes at the expense of generality. Radicals with exceptionally high reactivity are typically unsuitable for existing asymmetric methodologies. Here we present a general catalytic approach to asymmetric radical cross-coupling that combines copper-catalysed enantioselective stereocentre resolution or formation with copper-mediated, chirality-transferring radical substitution. This sequential strategy enables the efficient coupling of over 50 distinct carbon-, nitrogen-, oxygen-, sulfur- and phosphorus-centred radicals, including highly reactive methyl, tert-butoxyl and phenyl radicals, yielding structurally diverse C-, P- and S-chiral compounds with outstanding enantioselectivity. Our method thus provides a unified platform for the synthesis of carbon, phosphorus and sulfur stereocentres, with important implications for the preparation of chiral molecules relevant to medicinal chemistry and related disciplines. Furthermore, this sequential stereodiscrimination and chirality transfer strategy offers a promising blueprint for the development of highly enantioselective methodologies applicable to other classes of highly reactive species beyond radicals. Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"18 1","pages":"142-151"},"PeriodicalIF":20.2,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1038/s41557-025-01981-y
Souvik Ghosh, Mathieu G. Baltussen, Anna C. Knox, Rianne Haije, Quentin Duez, Anastasia T. Tsitsimeli, Man Him Chak, Jonathon E. Beves, Wilhelm T. S. Huck
Living cells understand their environment by combining, integrating and interpreting chemical and physical stimuli. Despite considerable advances in the design of enzymatic reaction networks that mimic hallmarks of living systems, these approaches lack the complexity to fully capture biological information processing. Here we introduce a scalable approach to design complex enzymatic reaction networks capable of reservoir computation based on recursive competition of substrates. This protease-based network can perform a broad range of classification tasks based on peptide and physicochemical inputs and can simultaneously perform an extensive set of discrete and continuous information processing tasks. The enzymatic reservoir can act as a temperature sensor from 25 °C to 55 °C with 1.3 °C accuracy, and performs decision-making, activation and tuning tasks common to neurological systems. We show a possible route to temporal information processing and a direct interface with optical systems by demonstrating the extension of the network to incorporate sensitivity to light pulses. Our results show a class of competition-based molecular systems capable of increasingly powerful information-processing tasks. Designing enzymatic reaction networks capable of mimicking the complexity of biological information processing is challenging. Now, an in chemico reservoir sensor based on a recursive enzymatic competition network has been designed that can process diverse physical and chemical inputs and perform several information-processing tasks.
{"title":"A recursive enzymatic competition network capable of multitask molecular information processing","authors":"Souvik Ghosh, Mathieu G. Baltussen, Anna C. Knox, Rianne Haije, Quentin Duez, Anastasia T. Tsitsimeli, Man Him Chak, Jonathon E. Beves, Wilhelm T. S. Huck","doi":"10.1038/s41557-025-01981-y","DOIUrl":"10.1038/s41557-025-01981-y","url":null,"abstract":"Living cells understand their environment by combining, integrating and interpreting chemical and physical stimuli. Despite considerable advances in the design of enzymatic reaction networks that mimic hallmarks of living systems, these approaches lack the complexity to fully capture biological information processing. Here we introduce a scalable approach to design complex enzymatic reaction networks capable of reservoir computation based on recursive competition of substrates. This protease-based network can perform a broad range of classification tasks based on peptide and physicochemical inputs and can simultaneously perform an extensive set of discrete and continuous information processing tasks. The enzymatic reservoir can act as a temperature sensor from 25 °C to 55 °C with 1.3 °C accuracy, and performs decision-making, activation and tuning tasks common to neurological systems. We show a possible route to temporal information processing and a direct interface with optical systems by demonstrating the extension of the network to incorporate sensitivity to light pulses. Our results show a class of competition-based molecular systems capable of increasingly powerful information-processing tasks. Designing enzymatic reaction networks capable of mimicking the complexity of biological information processing is challenging. Now, an in chemico reservoir sensor based on a recursive enzymatic competition network has been designed that can process diverse physical and chemical inputs and perform several information-processing tasks.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"18 2","pages":"302-308"},"PeriodicalIF":20.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41557-025-01981-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1038/s41557-025-01975-w
Jumreang Tummatorn, Charnsak Thongsornkleeb
Achieving enantioselectivity directly through light absorption is a long-standing challenge in photochemistry. Now, light can resolve racemic mixtures at the very moment of photon capture — enabling elegant kinetic resolution via chiral electron donor–acceptor complexes.
{"title":"Enantioselective light absorption drives kinetic resolution","authors":"Jumreang Tummatorn, Charnsak Thongsornkleeb","doi":"10.1038/s41557-025-01975-w","DOIUrl":"10.1038/s41557-025-01975-w","url":null,"abstract":"Achieving enantioselectivity directly through light absorption is a long-standing challenge in photochemistry. Now, light can resolve racemic mixtures at the very moment of photon capture — enabling elegant kinetic resolution via chiral electron donor–acceptor complexes.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1636-1637"},"PeriodicalIF":20.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1038/s41557-025-01972-z
Benjamin A. Baker, Grace G. D. Han
The high energetic demand of direct air capture of CO2 challenges its large-scale, industrial application. Now, the use of a photo-base allows for reversible capture of atmospheric CO2 driven by sunlight-induced pH swings.
{"title":"Light-driven direct air capture of CO2","authors":"Benjamin A. Baker, Grace G. D. Han","doi":"10.1038/s41557-025-01972-z","DOIUrl":"10.1038/s41557-025-01972-z","url":null,"abstract":"The high energetic demand of direct air capture of CO2 challenges its large-scale, industrial application. Now, the use of a photo-base allows for reversible capture of atmospheric CO2 driven by sunlight-induced pH swings.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1630-1631"},"PeriodicalIF":20.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1038/s41557-025-01992-9
Halogen-substituted silylium ions are among the strongest known Lewis superacids with promising synthetic applications, but their synthesis has not been possible using established methods for generating silicon cations. Now, a general approach to these elusive reactive intermediates is reported, based on the protonation of halosilanes with a Brønsted superacid.
{"title":"Making isolable halosilylium Lewis superacids by protonation","authors":"","doi":"10.1038/s41557-025-01992-9","DOIUrl":"10.1038/s41557-025-01992-9","url":null,"abstract":"Halogen-substituted silylium ions are among the strongest known Lewis superacids with promising synthetic applications, but their synthesis has not been possible using established methods for generating silicon cations. Now, a general approach to these elusive reactive intermediates is reported, based on the protonation of halosilanes with a Brønsted superacid.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1643-1644"},"PeriodicalIF":20.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1038/s41557-025-01991-w
Ricardo Martínez-Hincapié, Janis Timoshenko, Timon Wagner, Eduardo Ortega, Jody Druce, Mariana C O Monteiro, Martina Rüscher, Joonbaek Jang, Elif Öykü Alagöz, Samuele Lasagna, Leon Jacobse, Arno Bergmann, Beatriz Roldan Cuenya, Sebastian Z Oener
{"title":"Author Correction: Interfacial solvation pre-organizes the transition state of the oxygen evolution reaction.","authors":"Ricardo Martínez-Hincapié, Janis Timoshenko, Timon Wagner, Eduardo Ortega, Jody Druce, Mariana C O Monteiro, Martina Rüscher, Joonbaek Jang, Elif Öykü Alagöz, Samuele Lasagna, Leon Jacobse, Arno Bergmann, Beatriz Roldan Cuenya, Sebastian Z Oener","doi":"10.1038/s41557-025-01991-w","DOIUrl":"10.1038/s41557-025-01991-w","url":null,"abstract":"","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":" ","pages":""},"PeriodicalIF":20.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1038/s41557-025-01968-9
Johannes Schmoll, Mihajlo Novakovic, Frédéric H-.T. Allain
RNA condensation is implicated in the formation of neurotoxic RNA foci in cells affected by genomic expansions of trinucleotide or hexanucleotide repeats. However, the biophysical properties of repeat-expansion RNA condensates are poorly understood. Using CAG repeat-expansion RNA as a model system, we show that these RNA condensates cannot be observed with conventional nuclear magnetic resonance techniques. Therefore, we developed a nuclear magnetic resonance approach, based on water-detected semi-solid magnetization transfer, to detect and characterize RNA condensates in vitro. Our method, termed condensate detection by semi-solid magnetization transfer (CONDENSE-MT), is broadly applicable, highly sensitive and does not require direct observation of the biomolecules of interest. Using CONDENSE-MT, we could obtain dynamic information about RNA condensates, such as the relative amount and the tumbling rate of condensed RNA, the proton–solvent exchange kinetics and the amount of water molecules transiently bound in the condensate. We find that phase separation dramatically decreases molecular tumbling and is driven by heterotypic interactions between RNA and Mg2+. We further show that increasing CAG repeats decreases condensate hydration. The condensation of repeat-containing RNAs can have neurotoxic effects but is challenging to study. Now a NMR approach termed condensate detection by semi-solid magnetization transfer (CONDENSE-MT) can be used to study RNA condensate dynamics, proton–solvent exchange kinetics and condensate hydration.
{"title":"Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates","authors":"Johannes Schmoll, Mihajlo Novakovic, Frédéric H-.T. Allain","doi":"10.1038/s41557-025-01968-9","DOIUrl":"10.1038/s41557-025-01968-9","url":null,"abstract":"RNA condensation is implicated in the formation of neurotoxic RNA foci in cells affected by genomic expansions of trinucleotide or hexanucleotide repeats. However, the biophysical properties of repeat-expansion RNA condensates are poorly understood. Using CAG repeat-expansion RNA as a model system, we show that these RNA condensates cannot be observed with conventional nuclear magnetic resonance techniques. Therefore, we developed a nuclear magnetic resonance approach, based on water-detected semi-solid magnetization transfer, to detect and characterize RNA condensates in vitro. Our method, termed condensate detection by semi-solid magnetization transfer (CONDENSE-MT), is broadly applicable, highly sensitive and does not require direct observation of the biomolecules of interest. Using CONDENSE-MT, we could obtain dynamic information about RNA condensates, such as the relative amount and the tumbling rate of condensed RNA, the proton–solvent exchange kinetics and the amount of water molecules transiently bound in the condensate. We find that phase separation dramatically decreases molecular tumbling and is driven by heterotypic interactions between RNA and Mg2+. We further show that increasing CAG repeats decreases condensate hydration. The condensation of repeat-containing RNAs can have neurotoxic effects but is challenging to study. Now a NMR approach termed condensate detection by semi-solid magnetization transfer (CONDENSE-MT) can be used to study RNA condensate dynamics, proton–solvent exchange kinetics and condensate hydration.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 11","pages":"1785-1794"},"PeriodicalIF":20.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41557-025-01968-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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