Pub Date : 2024-08-19DOI: 10.1038/s41564-024-01790-y
Carolina M. Polonio, Francisco J. Quintana
Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.
在多发性硬化症小鼠模型中，作为神经炎症严重程度的预测指标，微生物网络和宿主与微生物群之间的相互作用，尤其是常驻微生物群的免疫球蛋白 A 涂层，优于细菌丰度。
{"title":"Host–gut microbiota crosstalk predicts neuroinflammation","authors":"Carolina M. Polonio, Francisco J. Quintana","doi":"10.1038/s41564-024-01790-y","DOIUrl":"10.1038/s41564-024-01790-y","url":null,"abstract":"Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2204-2205"},"PeriodicalIF":20.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1038/s41564-024-01783-x
Fusarium oxysporum f. sp. cubense tropical race 4 is threatening worldwide banana production. This study revealed a distinct evolutionary origin of tropical race 4 and how accessory genes and nitrosative pressure may have provided potential weaponries used by the pathogen to infect banana plants.
Fusarium oxysporum f. sp. cubense 热带第 4 种族正威胁着全世界的香蕉生产。这项研究揭示了热带第 4 种族的独特进化起源，以及附属基因和亚硝酸压力是如何为病原体感染香蕉植物提供潜在武器的。
{"title":"Evolutionary origin of the tropical race 4 banana pathogen and mechanisms of its virulence","authors":"","doi":"10.1038/s41564-024-01783-x","DOIUrl":"10.1038/s41564-024-01783-x","url":null,"abstract":"Fusarium oxysporum f. sp. cubense tropical race 4 is threatening worldwide banana production. This study revealed a distinct evolutionary origin of tropical race 4 and how accessory genes and nitrosative pressure may have provided potential weaponries used by the pathogen to infect banana plants.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2212-2213"},"PeriodicalIF":20.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense (Foc), is one of the most damaging plant diseases known. Foc race 1 (R1) decimated the Gros Michel-based banana (Musa acuminata) trade, and now Foc tropical race 4 (TR4) threatens global production of its replacement, the Cavendish banana. Here population genomics revealed that all Cavendish banana-infecting Foc race 4 strains share an evolutionary origin distinct from that of R1 strains. Although TR4 lacks accessory chromosomes, it contains accessory genes at the ends of some core chromosomes that are enriched for virulence and mitochondria-related functions. Meta-transcriptomics revealed the unique induction of the entire mitochondrion-localized nitric oxide (NO) biosynthesis pathway upon TR4 infection. Empirically, we confirmed the unique induction of a NO burst in TR4, suggesting that nitrosative pressure may contribute to virulence. Targeted mutagenesis demonstrated the functional importance of fungal NO production and the accessory gene SIX4 as virulence factors. Population genomics and meta-transcriptomics reveal a role of nitric oxide production and accessory genes in the virulence of the banana wilt-causing fungal pathogen Fusarium oxysporum.
{"title":"Virulence of banana wilt-causing fungal pathogen Fusarium oxysporum tropical race 4 is mediated by nitric oxide biosynthesis and accessory genes","authors":"Yong Zhang, Siwen Liu, Diane Mostert, Houlin Yu, Mengxia Zhuo, Gengtan Li, Cunwu Zuo, Sajeet Haridas, Katie Webster, Minhui Li, Igor V. Grigoriev, Ganjun Yi, Altus Viljoen, Chunyu Li, Li-Jun Ma","doi":"10.1038/s41564-024-01779-7","DOIUrl":"10.1038/s41564-024-01779-7","url":null,"abstract":"Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense (Foc), is one of the most damaging plant diseases known. Foc race 1 (R1) decimated the Gros Michel-based banana (Musa acuminata) trade, and now Foc tropical race 4 (TR4) threatens global production of its replacement, the Cavendish banana. Here population genomics revealed that all Cavendish banana-infecting Foc race 4 strains share an evolutionary origin distinct from that of R1 strains. Although TR4 lacks accessory chromosomes, it contains accessory genes at the ends of some core chromosomes that are enriched for virulence and mitochondria-related functions. Meta-transcriptomics revealed the unique induction of the entire mitochondrion-localized nitric oxide (NO) biosynthesis pathway upon TR4 infection. Empirically, we confirmed the unique induction of a NO burst in TR4, suggesting that nitrosative pressure may contribute to virulence. Targeted mutagenesis demonstrated the functional importance of fungal NO production and the accessory gene SIX4 as virulence factors. Population genomics and meta-transcriptomics reveal a role of nitric oxide production and accessory genes in the virulence of the banana wilt-causing fungal pathogen Fusarium oxysporum.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2232-2243"},"PeriodicalIF":20.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1038/s41564-024-01776-w
Robin C. May
Moving from academia to government was challenging, but learning to translate evidence-based results into policy decisions that impact society is hugely rewarding, writes Robin May.
{"title":"Translating between science and politics as a government adviser","authors":"Robin C. May","doi":"10.1038/s41564-024-01776-w","DOIUrl":"10.1038/s41564-024-01776-w","url":null,"abstract":"Moving from academia to government was challenging, but learning to translate evidence-based results into policy decisions that impact society is hugely rewarding, writes Robin May.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2202-2203"},"PeriodicalIF":20.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-14DOI: 10.1038/s41564-024-01746-2
Yun Deng, Ruyi Yu, Veit Grabe, Thomas Sommermann, Markus Werner, Marine Vallet, Christian Zerfaß, Oliver Werz, Georg Pohnert
The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation resulting in cell death, the arrest of cell division and the aging of surviving cells. Nutrient intake can re-initiate proliferation, but the processes involved are poorly understood. Here we characterize how the bloom-forming diatom Coscinodiscus radiatus recovers from starvation after nutrient influx. Rejuvenation is mediated by extracellular vesicles that shuttle reactive oxygen species, oxylipins and other harmful metabolites out of the old cells, thereby re-enabling their proliferation. By administering nutrient pulses to aged cells and metabolomic monitoring of the response, we show that regulated pathways are centred around the methionine cycle in C. radiatus. Co-incubation experiments show that bacteria mediate aging processes and trigger vesicle production using chemical signalling. This work opens new perspectives on cellular aging and rejuvenation in complex microbial communities. The release of vesicles that shuttle harmful metabolites out of aging cells of the bloom-forming Coscinodiscus radiatus is modulated by bacteria.
{"title":"Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites","authors":"Yun Deng, Ruyi Yu, Veit Grabe, Thomas Sommermann, Markus Werner, Marine Vallet, Christian Zerfaß, Oliver Werz, Georg Pohnert","doi":"10.1038/s41564-024-01746-2","DOIUrl":"10.1038/s41564-024-01746-2","url":null,"abstract":"The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation resulting in cell death, the arrest of cell division and the aging of surviving cells. Nutrient intake can re-initiate proliferation, but the processes involved are poorly understood. Here we characterize how the bloom-forming diatom Coscinodiscus radiatus recovers from starvation after nutrient influx. Rejuvenation is mediated by extracellular vesicles that shuttle reactive oxygen species, oxylipins and other harmful metabolites out of the old cells, thereby re-enabling their proliferation. By administering nutrient pulses to aged cells and metabolomic monitoring of the response, we show that regulated pathways are centred around the methionine cycle in C. radiatus. Co-incubation experiments show that bacteria mediate aging processes and trigger vesicle production using chemical signalling. This work opens new perspectives on cellular aging and rejuvenation in complex microbial communities. The release of vesicles that shuttle harmful metabolites out of aging cells of the bloom-forming Coscinodiscus radiatus is modulated by bacteria.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2356-2368"},"PeriodicalIF":20.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41564-024-01746-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-12DOI: 10.1038/s41564-024-01769-9
Andreacarola Urso, Ian R. Monk, Ying-Tsun Cheng, Camilla Predella, Tania Wong Fok Lung, Erin M. Theiller, Jack Boylan, Sofya Perelman, Swikrity U. Baskota, Ahmed M. Moustafa, Gaurav Lohia, Ian A. Lewis, Benjamin P. Howden, Timothy P. Stinear, Nicolino V. Dorrello, Victor Torres, Alice S. Prince
Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates. Metabolomics of bronchiolar lavage fluid and fibroblast infection, growth assays and analysis of bacterial mutant strains showed that airway fibroblasts produce collagen during S. aureus infection. Host-adapted bacteria upregulate collagenase, which degrades collagen and releases proline. S. aureus then imports proline, which fuels oxidative metabolism via the tricarboxylic acid cycle. Proline metabolism provides host-adapted S. aureus with a metabolic benefit enabling out-competition of non-adapted strains. These data suggest that clinical settings characterized by airway repair processes and fibrosis provide a milieu that promotes S. aureus adaptation and supports infection. Staphylococcus aureus upregulates collagenase and proline transporters to release collagen-derived proline and exploit fibroblasts as a nutrient source during chronic infection.
{"title":"Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection","authors":"Andreacarola Urso, Ian R. Monk, Ying-Tsun Cheng, Camilla Predella, Tania Wong Fok Lung, Erin M. Theiller, Jack Boylan, Sofya Perelman, Swikrity U. Baskota, Ahmed M. Moustafa, Gaurav Lohia, Ian A. Lewis, Benjamin P. Howden, Timothy P. Stinear, Nicolino V. Dorrello, Victor Torres, Alice S. Prince","doi":"10.1038/s41564-024-01769-9","DOIUrl":"10.1038/s41564-024-01769-9","url":null,"abstract":"Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates. Metabolomics of bronchiolar lavage fluid and fibroblast infection, growth assays and analysis of bacterial mutant strains showed that airway fibroblasts produce collagen during S. aureus infection. Host-adapted bacteria upregulate collagenase, which degrades collagen and releases proline. S. aureus then imports proline, which fuels oxidative metabolism via the tricarboxylic acid cycle. Proline metabolism provides host-adapted S. aureus with a metabolic benefit enabling out-competition of non-adapted strains. These data suggest that clinical settings characterized by airway repair processes and fibrosis provide a milieu that promotes S. aureus adaptation and supports infection. Staphylococcus aureus upregulates collagenase and proline transporters to release collagen-derived proline and exploit fibroblasts as a nutrient source during chronic infection.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 10","pages":"2506-2521"},"PeriodicalIF":20.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41564-024-01769-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.1038/s41564-024-01798-4
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
{"title":"Author Correction: Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus.","authors":"Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel","doi":"10.1038/s41564-024-01798-4","DOIUrl":"https://doi.org/10.1038/s41564-024-01798-4","url":null,"abstract":"","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":" ","pages":""},"PeriodicalIF":20.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1038/s41564-024-01785-9
This month’s issue of Nature Microbiology has a focus on microbial ecology, showcasing how these dynamics might be harnessed to better understand and safeguard life on Earth.
{"title":"Bringing microbial ecology into focus","authors":"","doi":"10.1038/s41564-024-01785-9","DOIUrl":"10.1038/s41564-024-01785-9","url":null,"abstract":"This month’s issue of Nature Microbiology has a focus on microbial ecology, showcasing how these dynamics might be harnessed to better understand and safeguard life on Earth.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 8","pages":"1901-1902"},"PeriodicalIF":20.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41564-024-01785-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1038/s41564-024-01764-0
Daniel Sher, Daniel Segrè, Michael J. Follows
Metabolism is the complex network of chemical reactions occurring within every cell and organism, maintaining life, mediating ecosystem processes and affecting Earth’s climate. Experiments and models of microbial metabolism often focus on one specific scale, overlooking the connectivity between molecules, cells and ecosystems. Here we highlight quantitative metabolic principles that exhibit commonalities across scales, which we argue could help to achieve an integrated perspective on microbial life. Mass, electron and energy balance provide quantitative constraints on their flow within metabolic networks, organisms and ecosystems, shaping how each responds to its environment. The mechanisms underlying these flows, such as enzyme–substrate interactions, often involve encounter and handling stages that are represented by equations similar to those for cells and resources, or predators and prey. We propose that these formal similarities reflect shared principles and discuss how their investigation through experiments and models may contribute to a common language for studying microbial metabolism across scales. Mass, electron and energy balances define metabolic networks in a cell, but this framework could also be applied to interactions, ecosystems and global processes, creating a common language for microbial metabolism across scales.
{"title":"Quantitative principles of microbial metabolism shared across scales","authors":"Daniel Sher, Daniel Segrè, Michael J. Follows","doi":"10.1038/s41564-024-01764-0","DOIUrl":"10.1038/s41564-024-01764-0","url":null,"abstract":"Metabolism is the complex network of chemical reactions occurring within every cell and organism, maintaining life, mediating ecosystem processes and affecting Earth’s climate. Experiments and models of microbial metabolism often focus on one specific scale, overlooking the connectivity between molecules, cells and ecosystems. Here we highlight quantitative metabolic principles that exhibit commonalities across scales, which we argue could help to achieve an integrated perspective on microbial life. Mass, electron and energy balance provide quantitative constraints on their flow within metabolic networks, organisms and ecosystems, shaping how each responds to its environment. The mechanisms underlying these flows, such as enzyme–substrate interactions, often involve encounter and handling stages that are represented by equations similar to those for cells and resources, or predators and prey. We propose that these formal similarities reflect shared principles and discuss how their investigation through experiments and models may contribute to a common language for studying microbial metabolism across scales. Mass, electron and energy balances define metabolic networks in a cell, but this framework could also be applied to interactions, ecosystems and global processes, creating a common language for microbial metabolism across scales.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 8","pages":"1940-1953"},"PeriodicalIF":20.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：