Pub Date : 2022-12-01DOI: 10.3103/S0096392522040150
D. T. Tuyen, L. V. Thang, G. Boukharev
{"title":"Effects of Freezing Treatments and Protective Agents on the Stability of Weissella cibaria TSL24.10 after Freeze-Drying","authors":"D. T. Tuyen, L. V. Thang, G. Boukharev","doi":"10.3103/S0096392522040150","DOIUrl":"https://doi.org/10.3103/S0096392522040150","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69562386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040149
Q. K. Nguyen, M. Pham, G. V. Phung, Q. Nguyen, T. Ngo, L. Nguyen, I. Kotlov, D. Nguyen
{"title":"Spatial Distribution of Biodiversity Risk Index in Truong Sa Islands Marine Zone, Vietnam","authors":"Q. K. Nguyen, M. Pham, G. V. Phung, Q. Nguyen, T. Ngo, L. Nguyen, I. Kotlov, D. Nguyen","doi":"10.3103/S0096392522040149","DOIUrl":"https://doi.org/10.3103/S0096392522040149","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41265017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040137
I. Mukhammedov, D. Ruzieva, T. Gulyamova
{"title":"Comparative Evaluation of Antidiabetic and Antioxidant Activities of Methanol Fractions of Penicillium brevicaulealba CC200 and Aspergillus egypticus HT166S","authors":"I. Mukhammedov, D. Ruzieva, T. Gulyamova","doi":"10.3103/S0096392522040137","DOIUrl":"https://doi.org/10.3103/S0096392522040137","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41775513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040083
Dmitry D. Zworykin
{"title":"Mate Choice and Size-Assortative Mating in the Climbing Perch Anabas testudineus (Actinopteri: Anabantidae)","authors":"Dmitry D. Zworykin","doi":"10.3103/S0096392522040083","DOIUrl":"https://doi.org/10.3103/S0096392522040083","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41817280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040046
E. I. Lebedeva, A. Babenka, A. Shchastny
{"title":"CXCL12 mRNA Expression as an Independent Marker of Liver Fibrogenesis in Rats","authors":"E. I. Lebedeva, A. Babenka, A. Shchastny","doi":"10.3103/S0096392522040046","DOIUrl":"https://doi.org/10.3103/S0096392522040046","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41493162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040095
S. N. Ahmad, K. R. Ahmad, S. Suleman, S. Ahmad, I. Inayat, U. Abdullah, T. Ishaq
{"title":"Hepato-Rehabilitative Capabilities of Basella alba, Grewia asiatica, Solanum nigrum, and Ficus carica Fruit Extracts in Male Mice (Mus musculus) against CCl4 Exposure","authors":"S. N. Ahmad, K. R. Ahmad, S. Suleman, S. Ahmad, I. Inayat, U. Abdullah, T. Ishaq","doi":"10.3103/S0096392522040095","DOIUrl":"https://doi.org/10.3103/S0096392522040095","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47301242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040022
N. Gerasimova, M. S. Akhtar, V. M. Studitskii
{"title":"Effect of Single-Strand DNA Breaks on Transcription of Nucleosomes","authors":"N. Gerasimova, M. S. Akhtar, V. M. Studitskii","doi":"10.3103/S0096392522040022","DOIUrl":"https://doi.org/10.3103/S0096392522040022","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040101
P. Kadkhodaei Elyaderani, A. Asgharian, M. Salehi
{"title":"Research on the Effect of Amino Acid Substitution of Cyclosaplin Peptide in Breast Cancer Cell Line (MDA-MB-231) and in a Human Leukemia Cell Line (K562)","authors":"P. Kadkhodaei Elyaderani, A. Asgharian, M. Salehi","doi":"10.3103/S0096392522040101","DOIUrl":"https://doi.org/10.3103/S0096392522040101","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43673402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.3103/S0096392522040034
A. Khokhlov
{"title":"On the Cholesterol Theory of Aging–2022","authors":"A. Khokhlov","doi":"10.3103/S0096392522040034","DOIUrl":"https://doi.org/10.3103/S0096392522040034","url":null,"abstract":"","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46971412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-06DOI: 10.3103/s0096392522020067
N. A. Orlov, S. A. Yakimov, O. V. Nekrasova, A. V. Feofanov
Abstract
A technique has been developed for obtaining recombinant functionally active peptides Ce1 and Ce4 from the venom of the scorpion Centruroides elegans in the Escherichia coli expression system. The yields of peptides Ce1 and Ce4 were 6.5 and 12 mg per liter of culture, respectively. The properties of the obtained peptides were studied using bioengineered systems based on hybrid channels KcsA-Kv1.x (x = 1, 3, 6) containing blocker binding sites of the corresponding eukaryotic potassium channels of Kv1-family. It has been shown that recombinant Ce1 and Ce4 do not exhibit affinity to the binding sites of Kv1.1 and Kv1.6 channels up to micromolar concentrations and, like natural peptides, selectively interact with the binding site of the Kv1.3 channel: the apparent dissociation constants of KcsA-Kv1.3 complexes with recombinant Ce1 and Ce4 are 50 ± 10 and 200 ± 30 nM (mean ± SEM), respectively.
{"title":"Recombinant Peptides Ce1 and Ce4 from the Venom of Scorpion Centruroides elegans and Their Interactions with Hybrid Channels KcsA-Kv1.x (x = 1, 3, 6)","authors":"N. A. Orlov, S. A. Yakimov, O. V. Nekrasova, A. V. Feofanov","doi":"10.3103/s0096392522020067","DOIUrl":"https://doi.org/10.3103/s0096392522020067","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A technique has been developed for obtaining recombinant functionally active peptides Ce1 and Ce4 from the venom of the scorpion <i>Centruroides elegans</i> in the Escherichia <i>coli</i> expression system. The yields of peptides Ce1 and Ce4 were 6.5 and 12 mg per liter of culture, respectively. The properties of the obtained peptides were studied using bioengineered systems based on hybrid channels KcsA-K<sub>v</sub>1.x (x = 1, 3, 6) containing blocker binding sites of the corresponding eukaryotic potassium channels of K<sub>v</sub>1-family. It has been shown that recombinant Ce1 and Ce4 do not exhibit affinity to the binding sites of K<sub>v</sub>1.1 and K<sub>v</sub>1.6 channels up to micromolar concentrations and, like natural peptides, selectively interact with the binding site of the K<sub>v</sub>1.3 channel: the apparent dissociation constants of KcsA-K<sub>v</sub>1.3 complexes with recombinant Ce1 and Ce4 are 50 ± 10 and 200 ± 30 nM (mean ± SEM), respectively.</p>","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138518193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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