More-efficacious therapies for progressive forms of multiple sclerosis (MS) remain an unmet need. Hydroxychloroquine (HCQ) is an antimalarial drug that
{"title":"Might Hydroxychloroquine Treat Primary Progressive Multiple Sclerosis","authors":"R. Naismith","doi":"10.1056/NEJM-JW.NA54192","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54192","url":null,"abstract":"More-efficacious therapies for progressive forms of multiple sclerosis (MS) remain an unmet need. Hydroxychloroquine (HCQ) is an antimalarial drug that","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74288242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bispecific therapeutic monoclonal antibodies are an emerging treatment option for acute lymphoblastic leukemia, non-Hodgkin lymphomas, and multiple
双特异性治疗性单克隆抗体是急性淋巴细胞白血病、非霍奇金淋巴瘤和多发性淋巴瘤的一种新兴治疗选择
{"title":"Bispecific Antibody Therapy for Relapsed Lymphoma","authors":"Michael E. Williams","doi":"10.1056/NEJM-JW.NA54216","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54216","url":null,"abstract":"Bispecific therapeutic monoclonal antibodies are an emerging treatment option for acute lymphoblastic leukemia, non-Hodgkin lymphomas, and multiple","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79520870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Few randomized, controlled trials have been conducted to test treatments for the various forms of autoimmune encephalitis (AE). Investigators have now
很少进行随机对照试验来测试各种形式的自身免疫性脑炎(AE)的治疗方法。调查人员现在
{"title":"Autoimmune Encephalitis and Acute Rituximab Treatment","authors":"R. Naismith","doi":"10.1056/NEJM-JW.NA54194","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54194","url":null,"abstract":"Few randomized, controlled trials have been conducted to test treatments for the various forms of autoimmune encephalitis (AE). Investigators have now","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85341483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lyme disease is increasing in the U.S. due to expansion of vector habitat, human encroachment in previously uninhabited areas, and longer seasonal
莱姆病在美国正在增加，这是由于病媒栖息地的扩大，人类侵入了以前无人居住的地区，以及季节性延长
{"title":"Can a Long-Forgotten Antibiotic Be Repurposed Against Lyme Disease?","authors":"G. Sakoulas","doi":"10.1056/NEJM-JW.NA54189","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54189","url":null,"abstract":"Lyme disease is increasing in the U.S. due to expansion of vector habitat, human encroachment in previously uninhabited areas, and longer seasonal","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88615985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Few studies describe the long-term cognitive dysfunction experienced by people with anti–N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. In
很少有研究描述抗n -甲基- d -天冬氨酸受体(抗nmdar)脑炎患者的长期认知功能障碍。在
{"title":"Recovery of Cognitive Functioning in Anti-NMDA Receptor Encephalitis","authors":"R. Naismith","doi":"10.1056/NEJM-JW.NA54193","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54193","url":null,"abstract":"Few studies describe the long-term cognitive dysfunction experienced by people with anti–N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. In","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81631327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although facioscapulohumeral muscular dystrophy (FSHD) is one of the more common forms of muscular dystrophy, we know little about factors that predict
虽然面肩肱骨肌营养不良症(FSHD)是一种更常见的肌肉营养不良症，但我们对其预测因素知之甚少
{"title":"Predicting Wheelchair Dependence in Facioscapulohumeral Muscular Dystrophy","authors":"Leana Doherty","doi":"10.1056/NEJM-JW.NA54145","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54145","url":null,"abstract":"Although facioscapulohumeral muscular dystrophy (FSHD) is one of the more common forms of muscular dystrophy, we know little about factors that predict","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86360158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Defining the frequency and severity of myocarditis after vaccination has great public health importance. Two retrospective Israeli studies have
确定接种疫苗后心肌炎的发生频率和严重程度具有重要的公共卫生意义。以色列的两项回顾性研究表明
{"title":"Myocarditis After BNT162b2 Vaccine Receipt in Israel","authors":"H. Krumholz, Sm","doi":"10.1056/NEJM-JW.NA54180","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54180","url":null,"abstract":"Defining the frequency and severity of myocarditis after vaccination has great public health importance. Two retrospective Israeli studies have","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81390409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Edema as a Side Effect of Gabapentinoid Drugs","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54218","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54218","url":null,"abstract":"Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87951447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In drug-treated patients with hypertension whose blood pressure (BP) is inadequately controlled, augmentation strategies include maximizing the dose of
在血压控制不充分的高血压药物治疗患者中，增强策略包括最大化剂量
{"title":"Antihypertensive Augmentation: Maximize Dose or Add a New Med?","authors":"D. Dressler, Mhm, Facp.","doi":"10.1056/NEJM-JW.NA54147","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54147","url":null,"abstract":"In drug-treated patients with hypertension whose blood pressure (BP) is inadequately controlled, augmentation strategies include maximizing the dose of","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79591825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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