Pub Date : 2025-11-21DOI: 10.1038/d41573-025-00178-9
Jasmine Gratton, Peter Arlett, Falk Ehmann, Daniel Prieto-Alhambra, Patrice Verpillat, Emmanuel Cormier, Irene Norstedt, Aimad Torqui, María Jesús Lamas Díaz, Carmen Laplaza Santos, Munir Pirmohamed
The full potential of pharmacogenomics to improve drug development and clinical practice has yet to be realized. Here, we present recommendations to address barriers to its implementation. The full potential of pharmacogenomics to improve drug development and clinical practice has yet to be realized. Here, we present recommendations to address barriers to its implementation.
{"title":"Advancing pharmacogenomics in medicines regulation and clinical practice: a call for collaborative action","authors":"Jasmine Gratton, \u0000 Peter Arlett, \u0000 Falk Ehmann, \u0000 Daniel Prieto-Alhambra, \u0000 Patrice Verpillat, \u0000 Emmanuel Cormier, \u0000 Irene Norstedt, \u0000 Aimad Torqui, \u0000 María Jesús Lamas Díaz, \u0000 Carmen Laplaza Santos, \u0000 Munir Pirmohamed","doi":"10.1038/d41573-025-00178-9","DOIUrl":"10.1038/d41573-025-00178-9","url":null,"abstract":"The full potential of pharmacogenomics to improve drug development and clinical practice has yet to be realized. Here, we present recommendations to address barriers to its implementation. The full potential of pharmacogenomics to improve drug development and clinical practice has yet to be realized. Here, we present recommendations to address barriers to its implementation.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 2","pages":"79-80"},"PeriodicalIF":101.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/d41573-025-00191-y
Adrian Bot, Mark Dudley, Daniel Shelley, Panagiota A. Sotiropoulou
Collaborative translational research and adaptive clinical trial design are needed to accelerate the advancement of novel T cell therapies towards achieving cures in solid tumours. Collaborative translational research and adaptive clinical trial design are needed to accelerate the advancement of novel T cell therapies towards achieving cures in solid tumours.
{"title":"Accelerating progress in immune cell therapy for solid tumours","authors":"Adrian Bot, \u0000 Mark Dudley, \u0000 Daniel Shelley, \u0000 Panagiota A. Sotiropoulou","doi":"10.1038/d41573-025-00191-y","DOIUrl":"10.1038/d41573-025-00191-y","url":null,"abstract":"Collaborative translational research and adaptive clinical trial design are needed to accelerate the advancement of novel T cell therapies towards achieving cures in solid tumours. Collaborative translational research and adaptive clinical trial design are needed to accelerate the advancement of novel T cell therapies towards achieving cures in solid tumours.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 1","pages":"1-2"},"PeriodicalIF":101.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145560165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/d41573-025-00192-x
Katie Kingwell
{"title":"Magnetic microrobots provide targeted drug delivery","authors":"Katie Kingwell","doi":"10.1038/d41573-025-00192-x","DOIUrl":"10.1038/d41573-025-00192-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 1","pages":"19-19"},"PeriodicalIF":101.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/d41573-025-00188-7
Asher Mullard
Industry is still trawling the kinome for drug targets, 24 years on from the landmark approval of imatinib. Industry is still trawling the kinome for drug targets, 24 years on from the landmark approval of imatinib.
{"title":"FDA approves 100th small-molecule kinase inhibitor","authors":"Asher Mullard","doi":"10.1038/d41573-025-00188-7","DOIUrl":"10.1038/d41573-025-00188-7","url":null,"abstract":"Industry is still trawling the kinome for drug targets, 24 years on from the landmark approval of imatinib. Industry is still trawling the kinome for drug targets, 24 years on from the landmark approval of imatinib.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 12","pages":"891-895"},"PeriodicalIF":101.8,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1038/d41573-025-00186-9
Asher Mullard
Jeff Bluestone, CEO of Sonoma Biotherapeutics, discusses the past and future of Treg therapies. Jeff Bluestone, CEO of Sonoma Biotherapeutics, discusses the past and future of Treg therapies.
Jeff Bluestone，索诺玛生物治疗公司的首席执行官，讨论了Treg疗法的过去和未来。Jeff Bluestone，索诺玛生物治疗公司的首席执行官，讨论了Treg疗法的过去和未来。
{"title":"“It’s about time”: Tregs win the Nobel prize","authors":"Asher Mullard","doi":"10.1038/d41573-025-00186-9","DOIUrl":"10.1038/d41573-025-00186-9","url":null,"abstract":"Jeff Bluestone, CEO of Sonoma Biotherapeutics, discusses the past and future of Treg therapies. Jeff Bluestone, CEO of Sonoma Biotherapeutics, discusses the past and future of Treg therapies.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 12","pages":"900-901"},"PeriodicalIF":101.8,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41573-025-00186-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-06DOI: 10.1038/d41573-025-00183-y
Asher Mullard
{"title":"Lilly’s tirzepatide and Novo Nordisk’s semaglutide vie for top drug spot","authors":"Asher Mullard","doi":"10.1038/d41573-025-00183-y","DOIUrl":"10.1038/d41573-025-00183-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 12","pages":"897-897"},"PeriodicalIF":101.8,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145448098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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