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Nature Reviews. Drug Discovery最新文献

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Two-step screen for CARD9 inhibitors. 两步筛选CARD9抑制剂。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-05 DOI: 10.1038/d41573-026-00022-8
Alex Eccleston
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引用次数: 0
Spatiotemporal in vivo protein degradation. 体内蛋白质的时空降解。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-03 DOI: 10.1038/d41573-026-00020-w
Sarah Crunkhorn
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引用次数: 0
Lipid flippase inhibitor tackles drug-resistant fungi. 脂质翻转酶抑制剂处理耐药真菌。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-03 DOI: 10.1038/d41573-026-00018-4
Sarah Crunkhorn
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引用次数: 0
Targeting extrachromosomal DNA in human cancers. 针对人类癌症的染色体外DNA。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-03 DOI: 10.1038/s41573-025-01369-0
Ivy Tsz-Lo Wong, Hyerim Yi, Bruno Melillo, Benjamin F Cravatt, Howard Y Chang, Paul S Mischel

Extrachromosomal DNAs (ecDNAs) are acentric circular DNA elements that frequently mediate oncogene amplification and genomic rearrangements in human cancers. Found across diverse adult and paediatric malignancies, ecDNA drives rapid tumour evolution, metabolic adaptation and treatment resistance. Its presence in precancerous lesions and association with poor outcome underscore the need for improved detection and therapeutic targeting. Recent advances have substantially expanded our understanding of ecDNA biology, revealing mechanisms underlying oncogene plasticity and treatment failure. This Review synthesizes key findings on ecDNA biology, the challenges faced by current therapeutic and detection approaches and the recent discoveries that point to emerging therapeutic vulnerabilities. We propose future directions to ecDNA-focused therapeutic development, including the utility of chemical proteomics approaches, and discuss efforts required to integrate ecDNA diagnostics into the clinic, presenting a roadmap from bench to bedside.

染色体外DNA （ecDNAs）是一种无中心的环状DNA元件，在人类癌症中经常介导癌基因扩增和基因组重排。在多种成人和儿科恶性肿瘤中发现，ecDNA驱动肿瘤快速进化、代谢适应和治疗耐药性。它在癌前病变中的存在和与不良预后的关联强调了改进检测和治疗靶向的必要性。最近的进展大大扩展了我们对ecDNA生物学的理解，揭示了癌基因可塑性和治疗失败的机制。本综述综合了ecDNA生物学的主要发现，当前治疗和检测方法面临的挑战以及最近发现的新治疗脆弱性。我们提出了以ecDNA为中心的治疗发展的未来方向，包括化学蛋白质组学方法的应用，并讨论了将ecDNA诊断整合到临床所需的努力，提出了从实验室到床边的路线图。
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引用次数: 0
Mapping covalent drug targets. 绘制共价药物靶点。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-03 DOI: 10.1038/d41573-026-00019-3
Sarah Crunkhorn
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引用次数: 0
Predicting small-molecule-RNA interactions. 预测小分子- rna相互作用。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-03 DOI: 10.1038/d41573-026-00021-9
Sarah Crunkhorn
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引用次数: 0
Accelerating the drug regulatory process through a federated cloud ecosystem. 通过联合云生态系统加速药品监管流程。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-02-02 DOI: 10.1038/d41573-026-00014-8
Andrew S Robertson, Nahid Latif, Raymond C Votzmeyer, Natalie Tolli, Mark Taisey, Kevin Bugin, Kathy Williams, Michael Garvin, Max Wegner, Antoine Manson, Jennifer Dudinak, Sandra Krogulski, Carlos O Garner, Jeffrey Francer, Sabine Luik, Jerry Stewart, Katrin Rupalla, Ginny Beakes-Read, Sean P Curtis, Jayne Ware, Kevin Carl, Nicole Mahoney, Donna Boyce, David C Isom, Michelle Rohrer, Fabio Bisordi, Peggy Lipp, Lina Aljuburi
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引用次数: 0
Biopharma dealmaking in 2025 2025年的生物制药交易。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-01-21 DOI: 10.1038/d41573-026-00013-9
Patricia Giglio,  Amanda Micklus
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引用次数: 0
2025 FDA approvals: volume maintained, but value remains below average 2025年FDA批准：数量维持，但价值仍低于平均水平。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-01-20 DOI: 10.1038/d41573-026-00012-w
Mathias Baedeker,  Clemens C. Möller
{"title":"2025 FDA approvals: volume maintained, but value remains below average","authors":"Mathias Baedeker,&nbsp;\u0000 Clemens C. Möller","doi":"10.1038/d41573-026-00012-w","DOIUrl":"10.1038/d41573-026-00012-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 2","pages":"91-91"},"PeriodicalIF":101.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41573-026-00012-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redirecting mast cells for antigen-specific cancer immunotherapy 重定向肥大细胞用于抗原特异性癌症免疫治疗。
IF 101.8 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature Reviews. Drug Discovery
Pub Date : 2026-01-14 DOI: 10.1038/d41573-026-00008-6
M. Teresa Villanueva
{"title":"Redirecting mast cells for antigen-specific cancer immunotherapy","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-026-00008-6","DOIUrl":"10.1038/d41573-026-00008-6","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 2","pages":"96-96"},"PeriodicalIF":101.8,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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