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Patient-reported outcomes are the strongest predictors of disease disability in intramuscular interferon β-1a users. 患者报告的结果是肌内干扰素β-1a使用者疾病失能的最强预测因子。
IF 2.6 Q3 Medicine Pub Date : 2023-06-01 DOI: 10.2217/nmt-2022-0008
Caila B Vaughn, Katelyn S Kavak, Dejan Jakimovski, Natasha Qutab, Robin Avila, Megan Vignos, Bianca Weinstock-Guttman

Introduction: Patient-reported outcomes (PROs) are valuable measures for routine clinical care of people with multiple sclerosis (pwMS). Materials: 646 pwMS treated with interferon-β-1a (IFN-β-1a) were retrospectively included from the New York State Multiple Sclerosis Consortium. Clinical and PRO data at enrollment and 3 year follow-up were collected. PwMS with stable disease and disability worsening were matched (1:1) based on age, Expanded Disability Status Scale (EDSS) scores and disease duration. Disability worsening was determined based on trial criteria. Results: PwMS with future EDSS worsening had higher baseline and follow-up timed-25-foot walk (6.6 vs 5.5 s; 9.1 vs 5.5 s; p < 0.001) when compared with stable pwMS. Worsening pwMS reported higher baseline difficulties in getting up (odds ratio [OR] = 2.4; p = 0.009), climbing stairs (OR = 1.6; p = 0.024) and standing (OR = 2.2; p < 0.001). Worsening pwMS reported greater lower limb limitations (OR = 2.3; p = 0.004) and fatigue (OR = 1.8; p = 0.002). Conclusion: Higher fatigue and lower limb functional limitations are significant predictors of future disability worsening in pwMS.

患者报告结果(PROs)是多发性硬化症(pwMS)患者常规临床护理的重要指标。材料:从纽约州多发性硬化症协会中回顾性纳入干扰素-β-1a (IFN-β-1a)治疗的646例pwMS。收集入组时和3年随访时的临床和PRO数据。根据年龄、扩展残疾状态量表(EDSS)评分和疾病持续时间对病情稳定和残疾恶化的PwMS进行1:1匹配。根据试验标准确定残疾恶化。结果:未来EDSS恶化的PwMS有更高的基线和随访时间-25英尺步行(6.6 vs 5.5 s;9.1 vs 5.5 s;结论:重度疲劳和下肢功能受限是pwMS患者未来残疾恶化的重要预测因素。
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引用次数: 3
5-HT1A agonists for levodopa-induced dyskinesia in Parkinson's disease. 5-HT1A激动剂治疗帕金森病左旋多巴诱导的运动障碍。
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2022-0039
Jawad Al-Kassmy, Christine Sun, Philippe Huot

Levodopa is the most effective agent for treating the symptoms of Parkinson's disease (PD). However, levodopa-induced dyskinesia remains a significant complication that manifests after few years of treatment, for which therapeutic options remain limited. Several agonists of the serotonin type 1A (5-HT1A) receptor with varying levels of efficacy and interaction at other sites, have been tested in the clinic. Clinical trials testing 5-HT1A agonists have yielded inconsistent results in alleviating dyskinesia, especially that the antidyskinetic benefit observed was often accompanied by an adverse effect on motor function. In this article, we summarize and analyze the various clinical trials performed with 5-HT1A agonists in PD patients with dyskinesia and offer perspectives on the future of this class of agents in PD.

左旋多巴是治疗帕金森病(PD)症状最有效的药物。然而,左旋多巴诱导的运动障碍仍然是一个重要的并发症,在治疗几年后表现出来,治疗选择仍然有限。几种5-羟色胺1A (5-HT1A)受体激动剂具有不同程度的疗效和在其他部位的相互作用,已经在临床中进行了测试。测试5-HT1A激动剂的临床试验在缓解运动障碍方面得出了不一致的结果,特别是观察到的抗运动障碍益处往往伴随着对运动功能的不利影响。在这篇文章中,我们总结和分析了5-HT1A激动剂在帕金森病患者运动障碍中的各种临床试验,并对这类药物在帕金森病患者中的未来发展提出了展望。
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引用次数: 0
Parkinson's disease research in Morocco: a review. 摩洛哥帕金森病研究综述
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2022-0021
Mohamed Daghi, Abdelhakim Lakhdar, Hicham El Otmani

Aim: To quantify and provide an overview on the scientific productivity made by Moroccan academics in the research on Parkinson's disease (PD) and parkinsonism. Materials & methods: Scientific articles, in either English or French, were gathered from published literature in three recognized databases: PubMed, ScienceDirect and Scopus. Results: We identified 95 published papers from which 39 articles have been extracted after removing inadequate publications and duplications between databases. All articles were published between 2006 and 2021. The selected articles were subdivided into five categories. Conclusion: The Moroccan academia is presently facing a low productivity issues and a lack of research laboratories focusing on PD research. We anticipate that providing more budgetary funds will significantly improve the productivity of PD research.

目的:量化并概述摩洛哥学者在帕金森氏病(PD)和帕金森氏症研究中的科学生产力。材料与方法:科学文章,英文或法文,从PubMed, ScienceDirect和Scopus这三个公认的数据库中已发表的文献中收集。结果:我们确定了95篇已发表的论文,其中39篇论文在删除不充分的出版物和数据库之间的重复后被提取出来。所有文章发表于2006年至2021年之间。入选的文章被细分为五类。结论:摩洛哥学术界目前面临生产力低下和缺乏专注于PD研究的研究实验室的问题。我们预计,提供更多的预算资金将大大提高PD研究的生产力。
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引用次数: 0
Interview with Nobutaka Hattori: a life researching Parkinson's disease pathogenesis. 专访服部信孝:研究帕金森病发病机制的一生。
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2023-0010
Nobutaka Hattori
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引用次数: 0
Early approaches of YKL-40 as a biomarker and therapeutic target for Parkinson's disease. YKL-40作为帕金森病生物标志物和治疗靶点的早期研究
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2022-0010
Mai M Anwar, Mohamed H Fathi

Aim: To investigate whether the estimation of cerebrospinal fluid (CSF) and brain YKL-40 levels may be used as an efficient biomarker for Parkinson's disease (PD). Methods: Lipopolysaccharides (LPS) was injected into the right substantia nigra pars compacta (SNpc). Rats were divided into: control group, early LPS-induced PD group (14 days), and advanced LPS-induced PD group (28 days). YKL-40 and other related factors were detected in CSF and brain tissue. Results: Increased expression of YKL-40 was observed in brain tissue and CSF of PD-induced rats associated with triggered inflammatory cytokine release. Conclusion: The current study was limited to detecting YKL-40 and other inflammatory factors in brain and CSF. YKL-40 may be considered as an early biomarker and therapeutic target for PD.

目的:探讨脑脊液(CSF)和脑YKL-40水平的测定是否可作为帕金森病(PD)的有效生物标志物。方法:将脂多糖(LPS)注入右侧黑质致密部(SNpc)。将大鼠分为:对照组、早期lps诱导PD组(14 d)和晚期lps诱导PD组(28 d)。脑脊液及脑组织中检测YKL-40等相关因子。结果:pd诱导大鼠脑组织和脑脊液中YKL-40的表达升高,与触发炎性细胞因子释放有关。结论:目前的研究仅限于检测脑和脑脊液中的YKL-40等炎症因子。YKL-40可能被认为是PD的早期生物标志物和治疗靶点。
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引用次数: 4
The effect of auditory cues on gait variability in people with Parkinson's disease and older adults: a systematic review. 听觉提示对帕金森病患者和老年人步态变异性的影响:一项系统综述。
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2021-0050
Elinor C Harrison, Gammon M Earhart

Aim: The goal of this study was to analyze the effects of external rhythmic auditory stimulation (RAS) on gait variability in older adults and people with Parkinson's disease (PD). Methods: Academic databases searched included PubMed, Web of Science, PEDro and Cochrane, from inception to September 2021. Eligible articles scored a minimum of 4 on the PEDro scale. Results: Twenty-three papers were included. People with PD show varied responses in gait variability to RAS during cued walking trials. Healthy older adults tended to increase variability during cued trials. Cue rates below preferred walking cadence tend to increase gait variability. Conclusion: Gait variability is closely associated with fall risk and an important consideration in development of gait rehabilitation techniques.

目的:本研究的目的是分析外部节律性听觉刺激(RAS)对老年人和帕金森病(PD)患者步态变异性的影响。方法:检索PubMed、Web of Science、PEDro和Cochrane等学术数据库,检索时间为成立至2021年9月。符合条件的文章在佩德罗量表上得分至少为4分。结果:共纳入23篇论文。在提示步行试验中,PD患者对RAS的步态变异性表现出不同的反应。在提示试验中,健康老年人倾向于增加变异性。提示率低于首选步行节奏倾向于增加步态变异性。结论:步态变异性与跌倒风险密切相关,是发展步态康复技术的重要考虑因素。
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引用次数: 2
Motor response with apomorphine sublingual film and levodopa in patients with OFF episodes. 阿波啡舌下膜和左旋多巴对OFF发作患者的运动反应。
IF 2.6 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.2217/nmt-2022-0038
Stuart H Isaacson, Alyssa Bowling, Ian Zhang, Eric Pappert, Fabrizio Stocchi

Aim: Evaluate timing of motor improvement with carbidopa/levodopa (CD/LD) and apomorphine sublingual film (SL-APO) in patients with Parkinson's disease and OFF episodes. Methods: A post hoc pooled analysis from two studies assessed Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III) scores and investigator-rated FULL ON. Results: At 15 and 30 min following the prescribed first daily CD/LD dose, mean improvements in MDS-UPDRS-III scores were -6.7 and -16.3, respectively, and FULL ON was achieved by 6.5 and 41.8% of patients. Following an optimized SL-APO dose, mean improvements in MDS-UPDRS-III scores were -13.9 and -22.9, and FULL ON was achieved by 34.7 and 81.0% of patients. Conclusion: Concomitant administration of SL-APO with carbidopa/levodopa may be useful for delayed ON.

目的:评价卡比多巴/左旋多巴(CD/LD)和阿波啡舌下膜(SL-APO)对帕金森病和OFF发作患者运动改善的时机。方法:对两项研究进行事后汇总分析,评估运动障碍学会统一帕金森病评定量表第三部分(MDS-UPDRS-III)评分和研究者评定的FULL ON评分。结果:在规定的首次每日CD/LD剂量后15分钟和30分钟,MDS-UPDRS-III评分的平均改善分别为-6.7和-16.3,达到FULL ON的患者分别为6.5%和41.8%。在优化SL-APO剂量后,MDS-UPDRS-III评分的平均改善为-13.9和-22.9,34.7%和81.0%的患者达到了FULL ON。结论:SL-APO与卡比多巴/左旋多巴合用可有效治疗迟发性ON。
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引用次数: 1
Updates and advances in multiple sclerosis neurotherapeutics. 多发性硬化症神经疗法的最新进展。
IF 2.6 Q3 Medicine Pub Date : 2023-02-01 Epub Date: 2022-10-31 DOI: 10.2217/nmt-2021-0058
Moein Amin, Carrie M Hersh

The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding pipeline of agents with novel mechanisms, provide more options for patients with MS. While treatment of MS neuroinflammation is well tailored in the existing DMT armamentarium, concerted efforts are currently underway for identifying neuropathological targets and drug discovery for progressive MS. There is also ongoing research to develop agents for remyelination and neuroprotection. Further insights are needed to guide DMT initiation and sequencing as well as to determine the role of autologous stem cell transplantation in relapsing and progressive MS. This review provides a summary of these updates.

多发性硬化症(MS)神经治疗领域正在迅速发展。新的疾病改变疗法(DMT)的疗效和安全性都有所提高,此外,具有新机制的药物管线也在不断扩大,这为多发性硬化症患者提供了更多选择。虽然现有的 DMT 药物已能很好地治疗多发性硬化症的神经炎症,但目前仍在协力确定神经病理学靶点和发现治疗进展性多发性硬化症的药物。目前还在研究开发用于髓鞘再形成和神经保护的药物。还需要进一步的深入了解,以指导DMT的启动和排序,并确定自体干细胞移植在复发性和进展性多发性硬化症中的作用。本综述概述了这些最新进展。
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引用次数: 0
Expert opinion on COVID-19 vaccines and cladribine tablets in MS: A plain language summary. 专家意见对COVID-19疫苗和克拉德里滨片在MS:一个简单的语言总结。
IF 2.6 Q3 Medicine Pub Date : 2023-02-01 DOI: 10.2217/nmt-2022-0027
Peter Rieckmann, Diego Centonze, Gavin Giovannoni, Le H Hua, Celia Oreja-Guevara, Daniel Selchen, Per Soelberg Sørensen, Patrick Vermersch, Heinz Wiendl, Hashem Salloukh, Bassem Yamout

What is this summary about?: People with multiple sclerosis (shortened to MS) who are taking cladribine tablets may have concerns about whether they can be vaccinated against COVID-19. This summary details the findings from a previously published article, in which an international committee of 10 MS experts developed recommendations to answer some important questions about COVID-19 vaccines in people with MS (including relapsing-remitting or active secondary progressive disease) taking cladribine tablets.

What were the results?: The committee identified 13 recommendations, which were all agreed upon by at least three-quarters (75%) of the 38 voting MS experts. Generally, they recommended that people with MS taking cladribine tablets should be vaccinated for COVID-19 as soon as possible, because the vaccine is thought to be both safe and effective, and vaccine responses were not likely to be affected by cladribine tablets.

What do the results mean?: Overall, people with MS taking cladribine tablets should receive the COVID-19 vaccine to protect themselves, unless advised differently by their healthcare provider.

这个总结是关于什么的?患有多发性硬化症(简称MS)的人服用克拉德滨片剂可能会担心他们是否能接种COVID-19疫苗。本摘要详细介绍了先前发表的一篇文章的研究结果,其中一个由10名多发性硬化症专家组成的国际委员会制定了建议,以回答有关服用克拉德滨片剂的多发性硬化症患者(包括复发缓解型或活动性继发性进行性疾病)接种COVID-19疫苗的一些重要问题。结果如何?委员会确定了13项建议,38名投票的MS专家中至少有四分之三(75%)同意这些建议。一般来说,他们建议服用克拉德里滨片剂的MS患者应尽快接种COVID-19疫苗,因为该疫苗被认为既安全又有效,疫苗反应不太可能受到克拉德里滨片剂的影响。这些结果意味着什么?总体而言,服用克拉德滨片剂的多发性硬化症患者应接种COVID-19疫苗以保护自己,除非医疗保健提供者有不同建议。
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引用次数: 0
A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets. 用克拉德里滨片治疗多发性硬化症患者,对流感和水痘疫苗的影响的简单语言总结。
IF 2.6 Q3 Medicine Pub Date : 2023-02-01 DOI: 10.2217/nmt-2022-0026
Klaus Schmierer, Heinz Wiendl, Celia Oreja-Guevara, Diego Centonze, Anita Chudecka, Sanjeev Roy, Ursula Boschert

What is this summary about?: This is a summary of an article originally published in the Multiple Sclerosis Journal. Cladribine tablets (MAVENCLAD®) are an oral (taken by mouth) medication, approved for the treatment of people with relapsing forms of multiple sclerosis (MS, with episodes of new or worsening symptoms). They are administered for a maximum of 10 days per year, over a period of 2 years. Cladribine tablets work by temporarily reducing the number of lymphocytes, which are immune cells that help to fight off infections. Because of this, people with MS (also called PwMS) may have concerns about the effect of cladribine tablets on vaccines, as these work via immune cells to build protection against infection.

What happened in the magnify-ms study?: A study called MAGNIFY-MS investigated how long it takes for cladribine tablets to begin to work in people with a type of MS called highly active relapsing MS. During the study, some participants received their usual vaccinations against flu (influenza) and against the chickenpox virus (also called varicella zoster virus) as part of their routine medical care. The MAGNIFY-MS study gave the researchers an opportunity to look at how cladribine tablets affect the way the flu and chickenpox virus vaccines work in the body.

What were the results?: Cladribine tablets do not affect how well the body responds to flu and chickenpox vaccines.

What do the results mean?: PwMS taking cladribine tablets who are vaccinated against chickenpox, flu or both can be protected against these diseases.

这个总结是关于什么的?这是最初发表在《多发性硬化症杂志》上的一篇文章的摘要。Cladribine片剂(MAVENCLAD®)是一种口服(口服)药物,被批准用于治疗复发型多发性硬化症(MS)患者,伴有新症状发作或症状恶化。它们每年最多使用10天,为期2年。克拉宾片剂的作用是暂时减少淋巴细胞的数量,淋巴细胞是帮助抵抗感染的免疫细胞。正因为如此,患有多发性硬化症(也称为PwMS)的人可能会担心克拉德里滨片对疫苗的影响,因为这些疫苗是通过免疫细胞来建立防止感染的保护的。在放大质谱研究中发生了什么?当前位置一项名为“MAGNIFY-MS”的研究调查了克拉德宾片剂对一种名为“高活性复发性多发性硬化症”的多发性硬化症患者需要多长时间才能开始起作用。在研究期间,一些参与者接受了常规的流感(流感)和水痘病毒(也称为水痘带状疱疹病毒)疫苗接种,这是他们日常医疗保健的一部分。MAGNIFY-MS研究为研究人员提供了一个观察克拉德滨片如何影响流感和水痘病毒疫苗在体内的作用的机会。结果如何?克拉宾片剂不会影响人体对流感和水痘疫苗的反应。这些结果意味着什么?服用克拉德滨片剂的妇女接种过水痘、流感或两者的疫苗,可预防这些疾病。
{"title":"A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets.","authors":"Klaus Schmierer,&nbsp;Heinz Wiendl,&nbsp;Celia Oreja-Guevara,&nbsp;Diego Centonze,&nbsp;Anita Chudecka,&nbsp;Sanjeev Roy,&nbsp;Ursula Boschert","doi":"10.2217/nmt-2022-0026","DOIUrl":"https://doi.org/10.2217/nmt-2022-0026","url":null,"abstract":"<p><strong>What is this summary about?: </strong>This is a summary of an article originally published in the <i>Multiple Sclerosis Journal</i>. Cladribine tablets (MAVENCLAD<sup>®</sup>) are an oral (taken by mouth) medication, approved for the treatment of people with relapsing forms of multiple sclerosis (MS, with episodes of new or worsening symptoms). They are administered for a maximum of 10 days per year, over a period of 2 years. Cladribine tablets work by temporarily reducing the number of lymphocytes, which are immune cells that help to fight off infections. Because of this, people with MS (also called PwMS) may have concerns about the effect of cladribine tablets on vaccines, as these work via immune cells to build protection against infection.</p><p><strong>What happened in the magnify-ms study?: </strong>A study called MAGNIFY-MS investigated how long it takes for cladribine tablets to begin to work in people with a type of MS called highly active relapsing MS. During the study, some participants received their usual vaccinations against flu (influenza) and against the chickenpox virus (also called varicella zoster virus) as part of their routine medical care. The MAGNIFY-MS study gave the researchers an opportunity to look at how cladribine tablets affect the way the flu and chickenpox virus vaccines work in the body.</p><p><strong>What were the results?: </strong>Cladribine tablets do not affect how well the body responds to flu and chickenpox vaccines.</p><p><strong>What do the results mean?: </strong>PwMS taking cladribine tablets who are vaccinated against chickenpox, flu or both can be protected against these diseases.</p>","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9361631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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