Pub Date : 2025-05-01Epub Date: 2025-03-02DOI: 10.1016/j.ntt.2025.107443
Guilherme Malafaia
This correspondence provides constructive feedback on the study “Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice” by Zhong et al. (2024). While the study attributes reductions in social play, interactions, and aggression to the antagonism of androgen-regulated pathways, we emphasize that unassessed confounding factors—such as locomotor deficits and anxiety-like behavior—may influence these outcomes. Evidence from Wang et al. (2020), Beauty et al. (2025), and Ji et al. (2023) highlights the necessity of evaluating these variables. We suggest incorporating behavioral assessments to ensure a more robust interpretation of BPA's direct effects on neurobehavioral responses.
本通信对 Zhong 等人的研究 "Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice"（2024）提出了建设性的反馈意见。虽然该研究将社交游戏、互动和攻击行为的减少归因于雄激素调节途径的拮抗作用，但我们强调，未评估的混杂因素--如运动障碍和焦虑样行为--可能会影响这些结果。Wang 等人（2020 年）、Beauty 等人（2025 年）和 Ji 等人（2023 年）的研究都强调了评估这些变量的必要性。我们建议纳入行为评估，以确保更准确地解释双酚 A 对神经行为反应的直接影响。
{"title":"Critical considerations on the study “Adolescent exposure to bisphenol a antagonizes androgen regulation of social behavior in male mice” (Zhong et al., 2024): The importance of locomotor and anxiety assessments","authors":"Guilherme Malafaia","doi":"10.1016/j.ntt.2025.107443","DOIUrl":"10.1016/j.ntt.2025.107443","url":null,"abstract":"<div><div>This correspondence provides constructive feedback on the study “Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice” by Zhong et al. (2024). While the study attributes reductions in social play, interactions, and aggression to the antagonism of androgen-regulated pathways, we emphasize that unassessed confounding factors—such as locomotor deficits and anxiety-like behavior—may influence these outcomes. Evidence from Wang et al. (2020), Beauty et al. (2025), and Ji et al. (2023) highlights the necessity of evaluating these variables. We suggest incorporating behavioral assessments to ensure a more robust interpretation of BPA's direct effects on neurobehavioral responses.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107443"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-13DOI: 10.1016/j.ntt.2025.107450
Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette
Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.
越来越多的证据表明，接触农药会对健康造成许多不利影响。农药接触对弱势群体来说尤其成问题，对仍在发育中的弱势群体中的儿童（如拉丁裔儿童）来说更是如此。一些研究已经证明了产前暴露于农药，特别是有机磷农药（OPs）的负面认知影响。我们之前报道了一项基线研究（Dobbins et al., 2022）的结果，该研究旨在比较农村、务农家庭和城市、非务农家庭的8岁儿童的认知能力。我们发现这两个群体的孩子都有相当多的农药接触，但接触的是不同的化学物质。农场工人的孩子更容易接触到有机氯，而非农场工人的孩子更容易接触到有机氯和拟除虫菊酯。使用Weschler儿童智力量表-第五版（WISC-V），基线分析确定非农业工人的儿童表现出较低的认知得分，特别是在VSI（视觉空间）和VCI（言语理解）指数上。目前的研究对同样的参与者进行了为期2 - 3年的纵向研究。我们提供的证据表明，来自非农业家庭的儿童在WISC-V的FRI（流体推理指数）上表现出显著的下降。来自农场工人家庭的孩子没有下降，而且组间的这种纵向差异是显著的。我们的研究结果进一步表明，FRI分数的下降可能是由于整个纵向期间累积的OC暴露增加。
{"title":"A longitudinal study comparing the impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families","authors":"Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette","doi":"10.1016/j.ntt.2025.107450","DOIUrl":"10.1016/j.ntt.2025.107450","url":null,"abstract":"<div><div>Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107450"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107470
Brittany Smith
{"title":"Animal models of prenatal opioid exposure: What have they told us?","authors":"Brittany Smith","doi":"10.1016/j.ntt.2025.107470","DOIUrl":"10.1016/j.ntt.2025.107470","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107470"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107494
Meeyoung Min , Sonia Minnes , Barbara Lewis , Cynthia Bearer , Lynn Singer
{"title":"Fatty acid ethyl esters in meconium and language development in poly-drug exposed children","authors":"Meeyoung Min , Sonia Minnes , Barbara Lewis , Cynthia Bearer , Lynn Singer","doi":"10.1016/j.ntt.2025.107494","DOIUrl":"10.1016/j.ntt.2025.107494","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107494"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simple olfactory memory and working spatial memory tests are not sensitive to the effects of chronic low-level lead exposure in young mice","authors":"Gisel Flores-Montoya, Martha Chan, Natalie Sanchez, Sage McCann, Nithin Poreddy, Edin Xu, Eleanor Johnson, Dylann Cullinane, Keya Mookencherry, Ori Kim, Nishant Mistry","doi":"10.1016/j.ntt.2025.107497","DOIUrl":"10.1016/j.ntt.2025.107497","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107497"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107478
Timothy Wen
{"title":"Why we need segmentation of data in medical records and why we might not want it","authors":"Timothy Wen","doi":"10.1016/j.ntt.2025.107478","DOIUrl":"10.1016/j.ntt.2025.107478","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107478"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107474
Vani Vannappagari
{"title":"Accelerating clinical development for maternal-fetal health: Ensuring access to safe and effective medicines for all","authors":"Vani Vannappagari","doi":"10.1016/j.ntt.2025.107474","DOIUrl":"10.1016/j.ntt.2025.107474","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107474"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107487
C. Marc Luetjens
{"title":"Wisconsin general testing apparatus (WGTA) in nonhuman primates","authors":"C. Marc Luetjens","doi":"10.1016/j.ntt.2025.107487","DOIUrl":"10.1016/j.ntt.2025.107487","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107487"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-04DOI: 10.1016/j.ntt.2025.107448
Elvis Cuevas , Susan M. Lantz , J. César Tobón-Velasco , Glenn D. Newport , Qiangen Wu , Ashraf Virmani , Syed F. Ali , Abel Santamaría
{"title":"Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296]","authors":"Elvis Cuevas , Susan M. Lantz , J. César Tobón-Velasco , Glenn D. Newport , Qiangen Wu , Ashraf Virmani , Syed F. Ali , Abel Santamaría","doi":"10.1016/j.ntt.2025.107448","DOIUrl":"10.1016/j.ntt.2025.107448","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107448"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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