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A multi-omics study on monozygotic twins discordant for amyotrophic lateral sclerosis and literature review underline a potential role for innate immunity and epigenetic dysregulation in disease mechanisms. 一项针对肌萎缩性侧索硬化症异卵双胞胎的多组学研究和文献综述强调了先天免疫和表观遗传失调在疾病机制中的潜在作用。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-05 DOI: 10.1007/s10072-026-08813-y
Martina Tosi, Francesco Favero, Miriam Zuccalà, Endri Visha, Fjorilda Caushi, Nadia Barizzone, Nicola Pomella, Laura Follia, Lucia Corrado, Davide Corà, Loredana Martignetti, Maurizio Leone, Sandra D'Alfonso
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引用次数: 0
The impact of diabetes mellitus in prodromal Parkinson's disease. 糖尿病对前驱帕金森病的影响。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-05 DOI: 10.1007/s10072-026-08838-3
Guangman Li, Guanglu Li

Background: Growing evidence suggests that diabetes mellitus (DM) is associated with higher incidence and faster progression of Parkinson's disease (PD), but the association between DM and prodromal PD has yet to be explored.

Methods: To evaluate the effect of DM in prodromal PD, we classified 63 prodromal PD into two groups according to a prior diagnosis of DM: prodromal PD without DM (n = 51) and prodromal PD with DM (n = 12). At baseline, between-group comparisons of clinical symptoms, brain structure, and cerebral spinal fluid (CSF) pathology were performed. We then compared longitudinal changes in motor and cognitive symptoms between the two groups. Finally, the incidence of disease conversion in the two groups was compared using Cox proportional hazard regression analysis.

Results: Compared to prodromal PD without DM, prodromal PD with DM had significantly lower global cognitive scores (p < 0.001), higher CSF p-tau (p = 0.005), decreased grey matter volume in the frontal lobe (FWE corrected, p < 0.05), and contracted shape in the bilateral putamina (TFCE FWE corrected p < 0.05). The linear mixed models demonstrated that prodromal PD with DM had significantly faster motor progression (p = 0.009) and cognitive decline (p = 0.012) than those without. Additionally, DM was associated with increased risk of disease conversion in prodromal PD (HR = 6.526, p = 0.003).

Conclusion: Theses findings indicate that pre-existing DM may confer a detrimental effect on disease phenotype and conversion in prodromal PD.

背景：越来越多的证据表明，糖尿病（DM）与帕金森病（PD）的高发病率和更快的进展有关，但糖尿病与前驱帕金森病之间的关系尚不清楚。方法：为评价糖尿病对PD前驱期的影响，将63例PD前驱期患者根据既往诊断分为两组：无DM的PD前驱期（n = 51）和有DM的PD前驱期（n = 12）。在基线时，进行临床症状、脑结构和脑脊液病理的组间比较。然后我们比较了两组之间运动和认知症状的纵向变化。最后，采用Cox比例风险回归分析比较两组患者的疾病转归发生率。结果：与未患糖尿病的PD前驱期相比，合并糖尿病的PD前驱期整体认知评分显著降低(p)。结论：这些研究结果表明，预先存在的DM可能对PD前驱期的疾病表型和转化有不利影响。
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引用次数: 0
Sleep quality improvement after switching from levodopa/carbidopa intestinal gel to continuous subcutaneous foslevodopa/foscarbidopa infusion in advanced Parkinson's disease: a case report. 晚期帕金森病患者从左旋多巴/卡比多巴肠凝胶改为持续皮下输注左旋多巴/卡比多巴后睡眠质量改善1例报告
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-05 DOI: 10.1007/s10072-026-08854-3
Lanfranco De Carolis, Pierre Pacilio, Edoardo Bianchini, Marco Salvetti, Domiziana Rinaldi
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引用次数: 0
Development and validation of a machine learning model based on interpretable clinical characteristics for preoperative prediction of Ki-67 expression in pituitary adenomas. 基于可解释临床特征的机器学习模型的开发和验证，用于垂体腺瘤中Ki-67表达的术前预测。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-05 DOI: 10.1007/s10072-026-08840-9
Jiaxiang Bian, Xiaoyang Wang, Lixia Cheng, Yuting Wang, Quancai Li
{"title":"Development and validation of a machine learning model based on interpretable clinical characteristics for preoperative prediction of Ki-67 expression in pituitary adenomas.","authors":"Jiaxiang Bian, Xiaoyang Wang, Lixia Cheng, Yuting Wang, Quancai Li","doi":"10.1007/s10072-026-08840-9","DOIUrl":"https://doi.org/10.1007/s10072-026-08840-9","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"232"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding the cognitive spectrum of mitochondrial diseases. 扩大线粒体疾病的认知范围。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-04 DOI: 10.1007/s10072-026-08827-6
Anna Rita Giovagnoli, Costanza Lamperti, Ioana Raluca Mihai, Alessia Catania
{"title":"Expanding the cognitive spectrum of mitochondrial diseases.","authors":"Anna Rita Giovagnoli, Costanza Lamperti, Ioana Raluca Mihai, Alessia Catania","doi":"10.1007/s10072-026-08827-6","DOIUrl":"https://doi.org/10.1007/s10072-026-08827-6","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"228"},"PeriodicalIF":2.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the generalization ability of graph neural networks in cross-subject EEG emotion recognition. 图神经网络在跨主体脑电情感识别中的泛化能力分析。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-04 DOI: 10.1007/s10072-026-08835-6
Lingyue Wang, Lei Guo, Xinsheng Yang, Ying Li
{"title":"Analysis of the generalization ability of graph neural networks in cross-subject EEG emotion recognition.","authors":"Lingyue Wang, Lei Guo, Xinsheng Yang, Ying Li","doi":"10.1007/s10072-026-08835-6","DOIUrl":"https://doi.org/10.1007/s10072-026-08835-6","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"229"},"PeriodicalIF":2.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed recovery following myasthenic exacerbation and subsequent endplate-protecting treatment. 肌无力加重后的延迟恢复和随后的终末板保护治疗。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-04 DOI: 10.1007/s10072-025-08617-6
Anna Mück, Sonja Genau, Julia Emde, Christoph Best, Steffen Pfeuffer, Heidrun H Krämer

Endplate-protecting therapies have improved treatment of myasthenia gravis and indicate a rapid onset of their treatment effect. Currently, these substances can be used following myasthenic exacerbation (ME). Clinical worsening due to ME however often results in prolonged recovery. We here evaluated the treatment courses of patients having received endplate-protecting treatment following ME. Among 12 patients with ME described here, seven received endplate-protecting therapies. Our findings indicate that acceptable recovery usually takes nine months. In the lights of recent trials for treatment of myasthenia, our findings implicate that the effectiveness of novel substances should be judged only after sufficient observation periods.

终末板保护疗法改善了重症肌无力的治疗，并表明其治疗效果起效快。目前，这些物质可用于肌无力加重（ME）。然而，由于ME引起的临床恶化往往导致恢复时间延长。我们在此评估ME后接受终板保护治疗的患者的疗程。在本文描述的12例ME患者中，7例接受了终板保护治疗。我们的研究结果表明，可接受的恢复通常需要9个月。根据最近治疗重症肌无力的试验，我们的发现表明，只有在足够的观察期后才能判断新物质的有效性。
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引用次数: 0
Dural arteriovenous fistula presenting as temporal venous engorgement. 硬脑膜动静脉瘘表现为颞静脉充血。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-03 DOI: 10.1007/s10072-026-08841-8
Gianluca Stufano, Sergio Soeren Rossi, Salvatore Mazzeo, Pietro Panni, Maria Paola Perini, Massimo Filippi, Maria Salsone
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引用次数: 0
Incidental resolution of pedophilia in a patient undergoing deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD): a case report and long-term follow-up. 接受深部脑刺激（DBS）治疗强迫症（OCD）患者恋童癖的偶然解决：一个病例报告和长期随访。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-03 DOI: 10.1007/s10072-026-08808-9
Saeed Abdollahifard, Nezhla Mostafeenezhad, Omid Yousefi, Hirad Rezaei, Amir Reza Bahadori, Kamyab Shahrivar, Ali Razmkon, Nematollah Jaafari, Kiarash Kavari, Reza Moshfeghinia
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引用次数: 0
Unmasking the cognitive burden of adult tuberculous meningitis: A systematic review and meta analysis. 揭示成人结核性脑膜炎的认知负担：系统回顾和荟萃分析。
IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Neurological Sciences
Pub Date : 2026-02-03 DOI: 10.1007/s10072-026-08853-4
Sanchit Shailendra Chouksey, Akansha Jain, Varun Kumar Singh, Rameshwar Nath Chaurasia, Abhishek Pathak, Shahnawaz Ahmad, Pranjal Kumar Singh, Deepika Joshi, Vijay Nath Mishra, Anand Kumar
{"title":"Unmasking the cognitive burden of adult tuberculous meningitis: A systematic review and meta analysis.","authors":"Sanchit Shailendra Chouksey, Akansha Jain, Varun Kumar Singh, Rameshwar Nath Chaurasia, Abhishek Pathak, Shahnawaz Ahmad, Pranjal Kumar Singh, Deepika Joshi, Vijay Nath Mishra, Anand Kumar","doi":"10.1007/s10072-026-08853-4","DOIUrl":"https://doi.org/10.1007/s10072-026-08853-4","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 2","pages":"225"},"PeriodicalIF":2.4,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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