Pub Date : 2026-02-06DOI: 10.1007/s10072-026-08865-0
Xin Wang, Lu Tian
{"title":"Predictive factors of global cognitive impairment in de novo Parkinson disease with normal cognition at baseline: a 10-year cohort study.","authors":"Xin Wang, Lu Tian","doi":"10.1007/s10072-026-08865-0","DOIUrl":"https://doi.org/10.1007/s10072-026-08865-0","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"236"},"PeriodicalIF":2.4,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Multiple sclerosis (MS) results in histological alterations, which in turn leads to behavioral deficits. Bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential in MS. This study aimed to assess whether intranasally delivered BMSCs improve cerebellar structure and motor function in an intermittent cuprizone-induced (INT-CPZ) MS model. METHODS: The mice were divided into five groups: control, CPZ, CPZ + BMSC, INT-CPZ, and INT-CPZ + BMSC. BMSCs were intranasally delivered at weeks 4 and 10. Motor performance was evaluated using beam walking, pole, and ladder rung walking tests. Stereological analyses were performed to estimate cortex and white matter volumes and Purkinje cell number. RESULTS: BMSC treatment improved motor coordination and balance, particularly in INT-CPZ + BMSC mice, which outperformed the CPZ + BMSC group. Stereological results showed reduced volume loss in cortex and white matter and higher Purkinje cell number in BMSC-treated groups, with INT-CPZ + BMSC showing the most pronounced effect. CONCLUSION: Intranasal BMSC therapy effectively preserved cerebellar structure and motor function in cuprizone-exposed mice. Intermittent cuprizone exposure enhanced BMSC efficacy, likely through mechanisms involving neuroregeneration, and neuroprotection.
{"title":"Bone marrow mesenchymal stem cells ameliorate intermittent multiple sclerosis: quantitative cerebellar microscopy and functional analysis in cuprizone-induced mice.","authors":"Maedeh Hashemi, Iraj Ragerdi Kashani, Parichehr Pasbakhsh, Babak Ebrahimi, Shiva Amirizadeh, Davood Zarini, Mohammad Hassan Tajik, Reza Asadi-Golshan","doi":"10.1007/s10072-025-08799-z","DOIUrl":"https://doi.org/10.1007/s10072-025-08799-z","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) results in histological alterations, which in turn leads to behavioral deficits. Bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential in MS. This study aimed to assess whether intranasally delivered BMSCs improve cerebellar structure and motor function in an intermittent cuprizone-induced (INT-CPZ) MS model. METHODS: The mice were divided into five groups: control, CPZ, CPZ + BMSC, INT-CPZ, and INT-CPZ + BMSC. BMSCs were intranasally delivered at weeks 4 and 10. Motor performance was evaluated using beam walking, pole, and ladder rung walking tests. Stereological analyses were performed to estimate cortex and white matter volumes and Purkinje cell number. RESULTS: BMSC treatment improved motor coordination and balance, particularly in INT-CPZ + BMSC mice, which outperformed the CPZ + BMSC group. Stereological results showed reduced volume loss in cortex and white matter and higher Purkinje cell number in BMSC-treated groups, with INT-CPZ + BMSC showing the most pronounced effect. CONCLUSION: Intranasal BMSC therapy effectively preserved cerebellar structure and motor function in cuprizone-exposed mice. Intermittent cuprizone exposure enhanced BMSC efficacy, likely through mechanisms involving neuroregeneration, and neuroprotection.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"235"},"PeriodicalIF":2.4,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1007/s10072-026-08813-y
Martina Tosi, Francesco Favero, Miriam Zuccalà, Endri Visha, Fjorilda Caushi, Nadia Barizzone, Nicola Pomella, Laura Follia, Lucia Corrado, Davide Corà, Loredana Martignetti, Maurizio Leone, Sandra D'Alfonso
{"title":"A multi-omics study on monozygotic twins discordant for amyotrophic lateral sclerosis and literature review underline a potential role for innate immunity and epigenetic dysregulation in disease mechanisms.","authors":"Martina Tosi, Francesco Favero, Miriam Zuccalà, Endri Visha, Fjorilda Caushi, Nadia Barizzone, Nicola Pomella, Laura Follia, Lucia Corrado, Davide Corà, Loredana Martignetti, Maurizio Leone, Sandra D'Alfonso","doi":"10.1007/s10072-026-08813-y","DOIUrl":"10.1007/s10072-026-08813-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"230"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1007/s10072-026-08838-3
Guangman Li, Guanglu Li
Background: Growing evidence suggests that diabetes mellitus (DM) is associated with higher incidence and faster progression of Parkinson's disease (PD), but the association between DM and prodromal PD has yet to be explored.
Methods: To evaluate the effect of DM in prodromal PD, we classified 63 prodromal PD into two groups according to a prior diagnosis of DM: prodromal PD without DM (n = 51) and prodromal PD with DM (n = 12). At baseline, between-group comparisons of clinical symptoms, brain structure, and cerebral spinal fluid (CSF) pathology were performed. We then compared longitudinal changes in motor and cognitive symptoms between the two groups. Finally, the incidence of disease conversion in the two groups was compared using Cox proportional hazard regression analysis.
Results: Compared to prodromal PD without DM, prodromal PD with DM had significantly lower global cognitive scores (p < 0.001), higher CSF p-tau (p = 0.005), decreased grey matter volume in the frontal lobe (FWE corrected, p < 0.05), and contracted shape in the bilateral putamina (TFCE FWE corrected p < 0.05). The linear mixed models demonstrated that prodromal PD with DM had significantly faster motor progression (p = 0.009) and cognitive decline (p = 0.012) than those without. Additionally, DM was associated with increased risk of disease conversion in prodromal PD (HR = 6.526, p = 0.003).
Conclusion: Theses findings indicate that pre-existing DM may confer a detrimental effect on disease phenotype and conversion in prodromal PD.
{"title":"The impact of diabetes mellitus in prodromal Parkinson's disease.","authors":"Guangman Li, Guanglu Li","doi":"10.1007/s10072-026-08838-3","DOIUrl":"https://doi.org/10.1007/s10072-026-08838-3","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence suggests that diabetes mellitus (DM) is associated with higher incidence and faster progression of Parkinson's disease (PD), but the association between DM and prodromal PD has yet to be explored.</p><p><strong>Methods: </strong>To evaluate the effect of DM in prodromal PD, we classified 63 prodromal PD into two groups according to a prior diagnosis of DM: prodromal PD without DM (n = 51) and prodromal PD with DM (n = 12). At baseline, between-group comparisons of clinical symptoms, brain structure, and cerebral spinal fluid (CSF) pathology were performed. We then compared longitudinal changes in motor and cognitive symptoms between the two groups. Finally, the incidence of disease conversion in the two groups was compared using Cox proportional hazard regression analysis.</p><p><strong>Results: </strong>Compared to prodromal PD without DM, prodromal PD with DM had significantly lower global cognitive scores (p < 0.001), higher CSF p-tau (p = 0.005), decreased grey matter volume in the frontal lobe (FWE corrected, p < 0.05), and contracted shape in the bilateral putamina (TFCE FWE corrected p < 0.05). The linear mixed models demonstrated that prodromal PD with DM had significantly faster motor progression (p = 0.009) and cognitive decline (p = 0.012) than those without. Additionally, DM was associated with increased risk of disease conversion in prodromal PD (HR = 6.526, p = 0.003).</p><p><strong>Conclusion: </strong>Theses findings indicate that pre-existing DM may confer a detrimental effect on disease phenotype and conversion in prodromal PD.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"231"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1007/s10072-026-08854-3
Lanfranco De Carolis, Pierre Pacilio, Edoardo Bianchini, Marco Salvetti, Domiziana Rinaldi
{"title":"Sleep quality improvement after switching from levodopa/carbidopa intestinal gel to continuous subcutaneous foslevodopa/foscarbidopa infusion in advanced Parkinson's disease: a case report.","authors":"Lanfranco De Carolis, Pierre Pacilio, Edoardo Bianchini, Marco Salvetti, Domiziana Rinaldi","doi":"10.1007/s10072-026-08854-3","DOIUrl":"https://doi.org/10.1007/s10072-026-08854-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"233"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1007/s10072-026-08840-9
Jiaxiang Bian, Xiaoyang Wang, Lixia Cheng, Yuting Wang, Quancai Li
{"title":"Development and validation of a machine learning model based on interpretable clinical characteristics for preoperative prediction of Ki-67 expression in pituitary adenomas.","authors":"Jiaxiang Bian, Xiaoyang Wang, Lixia Cheng, Yuting Wang, Quancai Li","doi":"10.1007/s10072-026-08840-9","DOIUrl":"https://doi.org/10.1007/s10072-026-08840-9","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"232"},"PeriodicalIF":2.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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