NeuroImage最新文献_第6页

Brain dynamic organization at the acute stage of severe brain injury 重型颅脑损伤急性期脑动态组织的研究。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121657

Gabriel Della Bella , Benjamine Sarton , Giulia Maria Mattia , Patrice Peran , Walter Lamberti , Pablo Barttfeld , Stein Silva

Acute Disorders of consciousness (DoC) poses significant clinical challenges, including early and accurate prognostication of neurological outcomes. Current assessment tools are limited in their predictive power, leaving many patients in a "gray zone" of uncertainty. While acute DoC are traditionally associated with structural brain damage, emerging evidence suggests that they are primarily driven by a withdrawal of excitatory synaptic activity across key cortical and subcortical regions, which can be captured through the dynamic analysis of resting-state brain activity. This study investigates the temporal dynamics of brain connectivity, shortly after severe brain injury (average of 13.9 days from onset), hypothesizing that acute DoC is marked by a global reorganization of functional connectivity and a shift toward less informative brain states, with distinct patterns emerging based on the underlying injury mechanism. Using functional magnetic resonance imaging (fMRI), we identify six distinct brain states across severely brain injured patients and healthy controls. These states, when sorted by decreasing entropy, span a continuum from state 1, characterized by high entropy, widespread positive long-distance coordination, and high global connectivity, predominantly observed in healthy controls, to state 6, which exhibits low entropy and minimal functional connectivity, and is predominantly associated with acute DoC. We demonstrate that the probability of occurrence of the more complex brain state correlates with improved neurological recovery at 3 months, as assessed by the Coma Recovery Scale–Revised (CRS-R). Hence, we were able to train a classifier based on brain state dynamics that achieved an accuracy of 78.5% in predicting patients' recovery potential (AUC = 0.864). Overall, our findings suggest that dynamic brain connectivity, particularly the entropy of brain states, can be a reliable early predictor of recovery from acute DoC, bridging the divide between theoretical advances and bedside medical decision-making.

急性意识障碍（DoC）提出了重大的临床挑战，包括早期和准确的神经预后预测。目前的评估工具的预测能力有限，使许多患者处于不确定的“灰色地带”。虽然急性DoC通常与结构性脑损伤有关，但新出现的证据表明，它们主要是由关键皮层和皮层下区域的兴奋性突触活动的退出所驱动的，这可以通过静息状态大脑活动的动态分析来捕捉。本研究调查了严重脑损伤后不久（平均发病后13.9天）大脑连接的时间动态，假设急性DoC的特征是功能连接的全球重组和向信息较少的大脑状态的转变，基于潜在的损伤机制出现了不同的模式。使用功能磁共振成像（fMRI），我们在严重脑损伤患者和健康对照中识别出六种不同的大脑状态。当按熵递减排序时，这些状态跨越了一个连续体，从状态1（主要在健康对照中观察到）到状态6（表现出低熵和最小功能连通性，主要与急性DoC相关），状态1的特征是高熵、广泛的正远程协调和高全局连通性。根据昏迷恢复量表修订（CRS-R）的评估，我们证明，更复杂的大脑状态发生的概率与3个月时神经恢复的改善相关。因此，我们能够训练基于脑状态动力学的分类器，在预测患者恢复潜力方面达到78.5%的准确率（AUC = 0.864）。总的来说，我们的研究结果表明，动态大脑连接，特别是大脑状态的熵，可以作为急性DoC恢复的可靠早期预测指标，弥合了理论进步和床边医疗决策之间的鸿沟。

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引用次数: 0

Partial volume correction for quantifying venous oxygen saturation levels using contrast-enhanced MRI 使用增强磁共振成像定量静脉氧饱和度的部分体积校正。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121682

Sagar Buch , Yifan Lv , Mingming Wang , Bo Wu , Ryan M. Smith , Yu Luo , E. Mark Haacke

Quantifying brain oxygenation is crucial for diagnosing and managing neurological conditions like stroke. Quantitative susceptibility mapping (QSM), an MRI technique, can measure venous oxygen saturation (Yv) but is hampered by partial volume effects (PVEs) in small vessels, leading to inaccurate measurements. This study aims to develop a robust method to mitigate these PVEs for the QSM-derived Yv and oxygen extraction fraction (OEF) in small cerebral veins. We integrated QSM with high-resolution, contrast-enhanced T1-weighted imaging to generate regional cerebral blood volume (rCBV) maps, which were used to correct for PVEs in QSM data from 30 stroke patients. The corrected QSM images showed a significant increase in venous susceptibility (Δχ) values compared to the uncorrected images (441.46 ± 61.14 ppb vs. 163.26 ± 19.66 ppb; p < 0.001), translating to a physiologically plausible mean Yv of 70.42 ± 4.09%. The method also improved the distinction of asymmetrically prominent cortical veins (APCVs), revealing lower Yv values in these areas for some cases, consistent with reduced oxygenation. Our findings demonstrate that using contrast-enhanced rCBV maps can correct PVEs in QSM, providing more reliable measurements of Yv and OEF in small cerebral veins. This approach offers valuable clinical insight into assessing cerebral hemodynamics in patients with stroke and other neurological conditions.

量化脑氧合对于诊断和治疗中风等神经系统疾病至关重要。定量敏感性测绘（QSM）是一种MRI技术，可以测量静脉氧饱和度（Yv），但受小血管部分体积效应（pve）的阻碍，导致测量不准确。本研究旨在开发一种强大的方法来减轻脑小静脉中qsm衍生的Yv和氧提取分数（OEF）的pve。我们将QSM与高分辨率、对比度增强的t1加权成像相结合，生成区域脑血容量（rCBV）图，用于校正30例脑卒中患者的QSM数据中的pve。校正后的QSM图像显示，与未校正的图像相比，静脉敏感性（Δχ）值显著增加(441.46±61.14 ppb vs. 163.26±19.66 ppb

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引用次数: 0

Assessing chance in neuro-vascular interactions 评估神经血管相互作用的机会。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121676

D.P. Aksenov , E.D. Doubovikov , N.A. Serdyukova , D.A. Gascoigne , M.J. Miller , A. Drobyshevsky , R.A. Linsenmeier

Interpreting correlations between neuronal activity and hemodynamic signals is complicated by their inherently strong autocorrelation. Standard parametric tests underestimate false positives, creating the appearance of widespread neurovascular coupling during rest. Here we present a surrogate-based statistical framework designed to calibrate inference in autocorrelated physiological signals. Using simultaneous recordings of cortical oxygen tension (PO₂), single-unit firing, and local field potentials (LFP) in awake rabbits, we applied amplitude-adjusted Fourier surrogates to generate null distributions that preserve temporal structure but remove cross-dependence. This workflow embeds lag optimization, controls for multiple comparisons across windows and units, and scales to population-level inference.

Applying the method to 43 experiments, we found that PO₂ correlations with delta-band LFP and a minority of single neurons exceeded chance levels, while correlations with other LFP bands were not significant under surrogate testing. Aggregated activity such as multi-unit signals failed to predict PO₂, but small synchronized subpopulations produced robust associations, highlighting the role of limited synchronization rather than global activity.

These findings refine resting-state neurovascular coupling: broad apparent correlations reduce to selective and reproducible effects once calibrated testing is applied. More broadly, the framework demonstrates how surrogate-based inference prevents misinterpretation of autocorrelated data and offers a generalizable approach for electrophysiology, neuroimaging, and other time-series domains where genuine interactions must be distinguished from random associations.

解释神经元活动和血流动力学信号之间的相关性是复杂的，因为它们本身具有很强的自相关性。标准参数检验低估了假阳性，在休息时造成了广泛的神经血管耦合。在这里，我们提出了一个基于代理的统计框架，旨在校准自相关生理信号的推断。通过同时记录清醒家兔的皮质氧张力（PO₂）、单单元放电和局部场电位（LFP），我们应用调整振幅的傅立叶替代来生成零分布，该零分布保留了时间结构，但消除了交叉依赖。该工作流嵌入了延迟优化，控制跨窗口和单元的多个比较，并扩展到人口水平推断。将该方法应用于43个实验，我们发现PO₂与δ波段LFP和少数单个神经元的相关性超过机会水平，而与其他LFP波段的相关性在替代测试中不显著。像多单元信号这样的聚集活动无法预测po2，但小的同步亚种群产生了强大的关联，突出了有限同步的作用，而不是全球活动。这些发现完善了静息状态神经血管耦合：一旦应用校准测试，广泛的明显相关性就会减少为选择性和可重复的效应。更广泛地说，该框架展示了基于代理的推理如何防止对自相关数据的误解，并为电生理学、神经影像学和其他时间序列领域提供了一种可推广的方法，在这些领域，真正的相互作用必须与随机关联区分开来。

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引用次数: 0

Neuroticism is associated with increased amygdala connectivity to hippocampal and prefrontal regions during emotional face processing 在情绪面部处理过程中，神经质与杏仁核与海马和前额叶区域的连接增加有关。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121655

Marvin S. Meiering , David Weigner , Simone Grimm , Sören Enge

Neuroticism, a stable personality trait marked by heightened negative affect and emotional volatility, is a well-established transdiagnostic risk factor for internalizing psychopathology. While early research emphasized amygdala hyperreactivity as a core neural correlate, emerging evidence suggests that neuroticism may be more accurately characterized by dysfunctional connectivity between the amygdala and broader regulatory networks involved in emotion processing and cognitive control.

In this cross-sectional fMRI study, 115 healthy adults completed a classification task involving negative emotional facial expressions. Neuroticism was assessed using a latent factor score derived from five validated self-report instruments. Brain activity and psychophysiological interaction analyses were conducted using both region-of-interest and whole-brain approaches. Associations between neural measures and neuroticism were tested using robust regression, controlling for age and sex.

No evidence was found for an association between neuroticism and regional brain activity. However, higher neuroticism was associated with increased task-dependent functional connectivity between the amygdala and both the hippocampus and dorsolateral prefrontal cortex. Whole-brain analyses further revealed associations between neuroticism and amygdala coupling with regions implicated in emotion regulation and salience processing, including the anterior insula and dorsal cingulate cortex.

These findings support the conceptualization of neuroticism as a network-level phenomenon, characterized by dysregulated interactions within fronto-limbic and salience circuits, rather than by localized changes in brain activity. Specifically, increased amygdala-hippocampal and amygdala-prefrontal connectivity may underlie the persistence and regulation difficulties of negative emotions that characterize the neurotic phenotype.

神经质是一种稳定的人格特征，其特征是负面情绪和情绪波动加剧，是一种公认的精神病理内化的跨诊断风险因素。虽然早期的研究强调杏仁核的高反应性是一种核心的神经关联，但新出现的证据表明，杏仁核与更广泛的涉及情绪处理和认知控制的调节网络之间的功能失调可能更准确地表征了神经质。在这项横断面功能磁共振成像研究中，115名健康成年人完成了一项涉及负面情绪面部表情的分类任务。神经质的评估使用的潜在因素评分源自五种有效的自我报告工具。脑活动和心理生理相互作用分析是使用兴趣区和全脑方法进行的。在控制年龄和性别的情况下，使用稳健回归测试了神经测量和神经质之间的关联。没有证据表明神经质和局部大脑活动之间存在联系。然而，较高的神经质与杏仁核与海马体和背外侧前额皮质之间的任务依赖功能连接增加有关。全脑分析进一步揭示了神经质和杏仁核与情绪调节和显著性处理相关区域之间的联系，包括前岛和背扣带皮层。这些发现支持了神经质是一种网络水平现象的概念，其特征是额边缘和突出回路之间的相互作用失调，而不是大脑活动的局部变化。具体来说，杏仁核-海马和杏仁核-前额叶连接性的增加可能是神经症表型特征的负面情绪持续和调节困难的基础。

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引用次数: 0

Interoceptive rhythms and perceptual experience: Mechanisms, contexts, and strategies for real-world research 内感受节奏和知觉经验：现实世界研究的机制、背景和策略。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121650

Genaro Lopez-Martin , Angelia Caparco , Chloe van Steenoven , Mateo Leganes-Fonteneau , Alejandro Galvez-Pol

A growing body of evidence highlights the significant role of internal rhythmic signals from the heart, lungs, and stomach in shaping perception. These physiological cycles influence sensory processing across various tasks, ranging from basic detection to complex functions such as emotion recognition and decision-making. The first section of this review discusses the physiological underpinnings of each organ-brain axis and synthesizes research illustrating how cardiac, respiratory, and gastric rhythms impact perceptual experience. Altogether, these findings highlight the influence of interoceptive rhythms on moment-to moment perception. Although effects may vary based on specific task demands, a key trend emerges: perception may fluctuate as signal processing resources are dynamically required between external sensory demands and internal bodily cycles. Acknowledging limitations of existing research, the second section indicates strategies to enhance the ecological validity and generalizability of interoception-perception studies. Our review of participant demographics reveals a pressing need for greater diversity. Also, we propose incorporating multimodal physiological recordings, wearable technologies, and active paradigms that better reflect real-world behaviors. Finally, we examine emerging theoretical models integrated into ecologically relevant research designs. By proposing a novel model of Perception-Interoception interactions, as well as bridging traditional laboratory methods with naturalistic settings, our novel ecological framework may advance the understanding of how interoceptive signals shape embodied perception in daily life.

越来越多的证据强调了来自心脏、肺和胃的内部节律信号在形成感知方面的重要作用。这些生理周期影响着各种任务的感觉处理，从基本的检测到复杂的功能，如情绪识别和决策。本综述的第一部分讨论了每个器官-脑轴的生理基础，并综合了说明心脏、呼吸和胃节律如何影响感知体验的研究。总之，这些发现强调了内感受节奏对瞬间感知的影响。尽管效果可能会根据特定的任务需求而变化，但一个关键趋势出现了：感知可能会随着信号处理资源在外部感官需求和内部身体周期之间的动态需求而波动。承认现有研究的局限性，第二部分指出了提高内感受-知觉研究的生态有效性和普遍性的策略。我们对参与者人口统计的回顾表明，迫切需要更大的多样性。此外，我们建议结合多模态生理记录、可穿戴技术和更好地反映现实世界行为的主动范例。最后，我们考察了整合到生态学相关研究设计中的新兴理论模型。通过提出一种感知-内感受相互作用的新模型，以及将传统的实验室方法与自然环境相结合，我们的新生态框架可能会促进对内感受信号如何在日常生活中塑造具身感知的理解。

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引用次数: 0

Functional MRI following sensory stimulation in rat monosodium iodoacetate model of osteoarthritis pain as a tool for drug therapy discovery 感觉刺激后大鼠骨关节炎疼痛模型的功能MRI作为药物治疗的工具。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121670

Paula Lehtinen , Petteri Stenroos , Raimo Salo , Hennariikka Koivisto , Sami Virtanen , Hanne Laakso , Heikki Tanila , Andrii Domanskyi , Olli Gröhn , Carina Stenfors

Chronic pain management in osteoarthritis (OA) remains a significant challenge, with current analgesic treatments often failing to provide adequate pain relief. A major issue in developing new therapies is the translational gap between preclinical animal models and clinical outcomes. This study investigates the use of functional magnetic resonance imaging (fMRI) to assess pain processing in the brain of a monosodium iodoacetate (MIA) -induced rat model of OA, combined with the pharmacological intervention of pregabalin (PGL). Thirty-two male Wistar rats were divided into sham and MIA groups, with the MIA group receiving intra-articular MIA injections to induce OA. Mechanical sensitivity was measured using the von Frey test, and fMRI was performed at baseline, on day 21, and post-PGL treatment on day 22. Results showed significant hypersensitivity in the MIA group by day 21, with altered brain activity in pain-related regions such as the thalamus and retrosplenial cortex. PGL treatment on day 22 significantly alleviated mechanical hypersensitivity and reduced brain activity in the pain-related regions, including the thalamus, frontal cortex, insula, and cingulate cortex. These findings suggest that fMRI can provide objective measures of pain processing and the efficacy of analgesic treatments in preclinical models, potentially bridging the gap between animal studies and clinical trials. The study highlights the potential of fMRI as a tool for drug discovery in chronic pain management, emphasizing the need for further research with different analgesics to fully understand its utility.

骨关节炎（OA）的慢性疼痛管理仍然是一个重大挑战，目前的镇痛治疗往往不能提供足够的疼痛缓解。开发新疗法的一个主要问题是临床前动物模型和临床结果之间的转化差距。本研究利用功能磁共振成像（fMRI）评估碘乙酸钠（MIA）诱导的OA大鼠模型的大脑疼痛加工，并结合普瑞巴林（PGL）的药物干预。32只雄性Wistar大鼠分为假手术组和MIA组，MIA组关节内注射MIA诱导OA。采用von Frey试验测量机械敏感性，并在基线、第21天和pgl治疗后的第22天进行功能磁共振成像（fMRI）。结果显示，在第21天，MIA组出现了明显的超敏反应，丘脑和脾后皮质等疼痛相关区域的大脑活动发生了改变。第22天的PGL治疗显著缓解了机械超敏反应，并降低了丘脑、额叶皮层、脑岛和扣带皮层等疼痛相关区域的脑活动。这些发现表明，fMRI可以在临床前模型中提供疼痛处理和镇痛治疗效果的客观测量，有可能弥合动物研究和临床试验之间的差距。该研究强调了功能磁共振成像作为慢性疼痛治疗药物发现工具的潜力，强调需要进一步研究不同的镇痛药以充分了解其用途。

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引用次数: 0

Advancing inter-brain synchrony measurement: A Comparative hyperscanning study of diffuse optical tomography and functional near-infrared spectroscopy 推进脑间同步测量：漫射光学断层扫描和功能近红外光谱的超扫描比较研究。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121663

Shuo Guan , Yuhang Li , Yingbo Geng , Dongyun Li , Qiong Xu , Peisong Niu , Dalin Yang , Adam Eggebrecht , Yingchun Zhang , Rihui Li

Inter-brain synchrony (IBS), measured by hyperscanning, refers to the synchronization of multiple individuals' brain activities during social interactions. Traditional fNIRS-based hyperscanning suffers shortcomings like low spatial resolution and high susceptibility to superficial interference, causing imprecise estimation of IBS in complex social tasks. This study aims to fill the knowledge gap by comprehensively assessing diffuse optical tomography (DOT), an enhanced alternative to fNIRS, can benefit hyperscanning studies of complex social interactions. Sixteen dyads were engaged in both collaborative and individual tangram puzzle tasks, and their brain activities were recorded simultaneously using DOT and fNIRS. We found that DOT demonstrated significantly stronger IBS and identified more brain regions with significant IBS compared to fNIRS during the collaborative task. Specifically, while fNIRS detected IBS only in the dorsolateral prefrontal cortex (DLPFC) and supramarginal gyrus (SMG), DOT revealed additional IBS in the superior temporal gyrus (STG). Additionally, compared to the individual task, the collaborative task showed increased IBS in DOT, not only in the DLPFC but also in the SMG, frontal eye fields (FEF), and inferior frontal gyrus (IFG). By highlighting the superior spatial resolution and sensitivity of DOT in capturing detailed and extensive neural activity during complex social interactions, our findings for the first time clarified the potential strengths of DOT in measuring IBS over traditional fNIRS. These advances provide a stronger empirical foundation for investigating the neural basis of social interaction, paving the way for future research on real-world, dynamic group behaviors.

脑间同步性（Inter-brain synchronony， IBS）是指多个个体在社会交往过程中大脑活动的同步性。传统的基于fnir的超扫描存在空间分辨率低、易受表面干扰等缺点，导致在复杂社会任务中对IBS的估计不精确。本研究旨在通过全面评估漫射光学断层扫描（DOT）来填补知识空白，这是一种增强的替代fNIRS的方法，可以促进复杂社会互动的超扫描研究。16对二人组同时参与了合作和单独的七巧板拼图任务，他们的大脑活动同时被DOT和fNIRS记录下来。我们发现，与fNIRS相比，DOT在协作任务中表现出更强的IBS，并识别出更多具有显著IBS的脑区。具体来说，虽然fNIRS仅在背外侧前额叶皮层（DLPFC）和边缘上回（SMG）中检测到IBS，但DOT在颞上回（STG）中发现了额外的IBS。此外，与单独任务相比，协作任务不仅在DLPFC，而且在SMG，额叶视野（FEF）和额下回（IFG）中都显示出DOT的IBS增加。通过强调DOT在捕捉复杂社会互动过程中详细和广泛的神经活动方面的优越空间分辨率和灵敏度，我们的研究结果首次阐明了DOT在测量IBS方面比传统近红外光谱仪的潜在优势。这些进展为研究社会互动的神经基础提供了更坚实的经验基础，为未来对现实世界动态群体行为的研究铺平了道路。

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引用次数: 0

Cerebellar and cerebral contributions to dual physical-cognitive impairment in middle-aged and older adults: Potential biomarkers and therapeutic targets for healthy aging 小脑和大脑在中老年人身体认知双重障碍中的作用：健康老龄化的潜在生物标志物和治疗靶点。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121668

Pei-Lin Lee , Chih-Ping Chung , Kun-Hsien Chou , Wei-Ju Lee , Ching-Po Lin , Chih-Kuang Liang , Liang-Kung Chen

Dual physical and cognitive decline, or physio-cognitive decline syndrome (PCDS), significantly increases disability, dementia, and mortality risks in older adults. To elucidate the neurobiological mechanisms underlying PCDS, we used an innovative, cerebellum-centered, data-driven approach to establish structural covariance networks (SCNs) and identify specific cerebellar SCNs associated with simultaneous physical and cognitive impairments. This analysis was based on MRI data from 1193 adults aged ≥50 and older (mean age ± SD: 62.8 ± 8.7 years) in the I-Lan Longitudinal Aging Study. Through non-negative matrix factorization analysis, we identified seven cerebellar SCNs, among which SCN-2, predominantly located in the posterior lobe (63% in lobule VI, 10% in Crus I), showed significant association with dual-domain impairment (ρ = 0.083 for physical domain and ρ = 0.154 for cognitive domain, p < 0.007 by Bonferroni-correction). Voxel-wise mediation analyses, adjusted for age, sex, education, and intracranial volume, revealed that specific cerebral regions, including bilateral thalamus, left frontal orbital cortex, left amygdala/hippocampus, right hippocampus, right occipital fusiform gyrus, and right temporal pole, significantly mediated the relationship between SCN-2 and dual impairments. Our findings establish SCN-2 and its mediated cerebral regions as potential biomarkers for understanding and treating PCDS, suggesting that preserving cerebellar SCNs integrity could be crucial for developing targeted interventions in healthy aging strategies.

身体和认知双重衰退或身体-认知衰退综合征（PCDS）显著增加老年人的残疾、痴呆和死亡风险。为了阐明PCDS的神经生物学机制，我们采用了一种创新的、以小脑为中心的、数据驱动的方法来建立结构协方差网络（scn），并识别与同时发生的身体和认知障碍相关的特定小脑scn。该分析基于I-Lan纵向衰老研究中1193名年龄≥50岁的成年人（平均年龄±SD: 62.8±8.7岁）的MRI数据。通过非负矩阵分解分析，我们发现了7个小脑scn，其中SCN-2主要位于后叶（63%位于第六小叶，10%位于第一小叶），与双域损伤有显著关联（物理域ρ = 0.083，认知域ρ = 0.154，经bonferroni校正p < 0.007）。对年龄、性别、教育程度和颅内容量进行校正后的体素调解分析显示，特定的大脑区域，包括双侧丘脑、左额眶皮质、左杏仁核/海马、右海马、右枕梭状回和右颞极，显著地介导了SCN-2与双重损伤之间的关系。我们的研究结果表明，SCN-2及其介导的大脑区域是理解和治疗PCDS的潜在生物标志物，这表明保持小脑scn的完整性对于制定健康衰老策略的靶向干预措施至关重要。

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引用次数: 0

Immediate TMS-EEG responses reveal motor cortex excitability 即时TMS-EEG反应显示运动皮质兴奋性。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2025.121666

Antonietta Stango , Agnese Zazio , Guido Barchiesi , Natale Salvatore Bonfiglio , Elisa Dognini , Eleonora Marcantoni , Marta Bortoletto

The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is typically used to probe cortical excitability at the network level, as local excitability measures were previously not feasible. However, a recent study revealed immediate TMS-evoked potentials (i-TEPs) following primary motor cortex (M1) stimulation, yet their physiological origin remains uncertain. Here, we aimed to test whether this immediate activity is replicable, physiological, and related to motor cortex excitability.

Analyses were conducted on data from 28 healthy participants who underwent M1 stimulation using two opposite biphasic current directions. We run a minimal preprocessing and then, upon visual inspection, we divided the sample according to the presence/absence of muscle artifacts (Muscle/NoMuscle groups). First, we successfully replicated i-TEPs for both current directions. Second, source localization revealed that the i-TEPs signal originated in the precentral gyrus of the stimulated hemisphere. Third, we computed the immediate TMS-related power (i-TRP) to disentangle the components contributing to the i-TEP signal. Two oscillatory peaks emerged at 100–200 Hz and 600–800 Hz. Finally, we tested the relationship between i-TRP components and motor evoked potentials (MEPs) amplitude in NoMuscle groups (n = 8 for both current directions, n = 14 for anterior-to-posterior and posterior-to-anterior induced current). The analysis showed a robust positive association between i-TRP in the 600–800 Hz range and MEP amplitude, suggesting that this component reflects M1 excitability.

Overall, our findings converge in indicating the physiological nature of immediate TMS-EEG responses, suggesting that they reflect the excitability of the stimulated cortex.

经颅磁刺激和脑电图（TMS-EEG）的结合通常用于在网络水平上探测皮层兴奋性，因为局部兴奋性测量以前是不可行的。然而，最近的一项研究揭示了初级运动皮层（M1）刺激后的即时tms诱发电位（i-TEPs），但其生理起源仍不确定。在这里，我们的目的是测试这种即时活动是否可复制，生理上的，并与运动皮层兴奋性有关。对28名健康参与者的数据进行了分析，这些参与者使用两个相反的双相电流方向进行M1刺激。我们运行一个最小的预处理，然后，在目视检查，我们根据存在/不存在肌肉伪影（肌肉/非肌肉组）来划分样品。首先，我们成功地复制了当前两个方向的i- tep。第二，来源定位表明，i-TEPs信号起源于受刺激半球的中央前回。第三，我们计算了瞬时tms相关功率（i-TRP），以解开构成i-TEP信号的组件。两个振荡峰出现在100-200 Hz和600-800 Hz。最后，我们测试了NoMuscle组i-TRP成分与运动诱发电位（MEPs）振幅之间的关系（两个电流方向n=8，前后侧和后前侧诱导电流n=14）。分析显示，600-800 Hz范围内的i-TRP与MEP振幅之间存在显著正相关，表明该成分反映了M1兴奋性。总的来说，我们的研究结果集中在表明即时TMS-EEG反应的生理性质上，表明它们反映了受刺激皮层的兴奋性。

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引用次数: 0

The impact of chronic psychosocial stress on corticomuscular responses to thermal pain stimulation 慢性社会心理应激对热痛刺激皮质肌肉反应的影响。

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage

Pub Date : 2026-01-01 DOI: 10.1016/j.neuroimage.2026.121683

Lili Li , Hui Ma , Yang Zheng , Zhongliang Yu

Psychosocial stress refers to the subjective experience and appraisal of real or potentially threatening psychosocial conditions. Pain is a complex physiological and psychological phenomenon, referring to unpleasant sensory and emotional experience associated with actual or potential tissue damage. To investigate the impact of chronic psychosocial stress on neural circuit responses to thermal pain, this study analyzed corticomuscular activities by electroencephalograph and electromyography. The results demonstrate that chronic psychosocial stress can change the cortical synchronization at α and γ frequencies and enhance motor unit recruitment under heat pain at both initial and progressive stages. Moreover, under progressive stimulation, pain-related neural feedback and localization functions may be disrupted, presenting impaired corticomuscular coherence. Therefore, chronic psychosocial stress can alter the integrated processing across both central and peripheral pathways, indicating a disintegration of the cortical-motor integration function of heat pain at initial and progressive stages.

心理社会压力是指对真实的或潜在威胁的心理社会状况的主观体验和评价。疼痛是一种复杂的生理和心理现象，是指与实际或潜在的组织损伤相关的不愉快的感觉和情绪体验。为了研究慢性社会心理应激对热痛神经回路反应的影响，本研究通过脑电图和肌电图分析了皮质肌肉活动。结果表明，慢性社会心理应激可以改变热痛初始和进展阶段的α和γ频率的皮质同步，并增强运动单位的招募。此外，在进行性刺激下，疼痛相关的神经反馈和定位功能可能被破坏，表现为皮质肌肉一致性受损。因此，慢性社会心理应激可以改变中枢和外周通路的整合加工，表明热痛在初始和进展阶段的皮质-运动整合功能瓦解。

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引用次数: 0