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Reward-modulated attention deployment is driven by suppression, not attentional capture 奖赏调节的注意力调配是由抑制而非注意力捕捉驱动的。
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-09-02 DOI: 10.1016/j.neuroimage.2024.120831

One driving factor for attention deployment towards a stimulus is its associated value due to previous experience and learning history. Previous visual search studies found that when looking for a target, distractors associated with higher reward produce more interference (e.g., longer response times). The present study investigated the neural mechanism of such value-driven attention deployment. Specifically, we were interested in which of the three attention sub-processes are responsible for the interference that was repeatedly observed behaviorally: enhancement of relevant information, attentional capture by irrelevant information, or suppression of irrelevant information. We replicated earlier findings showing longer response times and lower accuracy when a target competed with a high-reward compared to a low-reward distractor. We also found a spatial gradient of interference: behavioral performance dropped with increasing proximity to the target. This gradient was steeper for high- than low-reward distractors. Event-related potentials of the EEG signal showed the reason for the reward-induced attentional bias: High-reward distractors required more suppression than low-reward distractors as evident in larger Pd components. This effect was only found for distractors near targets, showing the additional filtering needs required for competing stimuli in close proximity. As a result, fewer attentional resources can be distributed to the target when it competes with a high-reward distractor, as evident in a smaller target-N2pc amplitude. The distractor-N2pc, indicative of attentional capture, was neither affected by distance nor reward, showing that attentional capture alone cannot explain interference by stimuli of high value. In sum our results show that the higher need for suppression of high-value stimuli contributes to reward-modulated attention deployment and increased suppression can prevent attentional capture of high-value stimuli.

注意力向刺激物转移的一个驱动因素是刺激物因先前的经验和学习历史而产生的相关价值。以往的视觉搜索研究发现,在寻找目标时,与高回报相关的分心物会产生更多干扰(如反应时间更长)。本研究调查了这种由价值驱动的注意力调配的神经机制。具体来说,我们感兴趣的是,在行为学上反复观察到的干扰是由三种注意子过程中的哪一种引起的:相关信息的增强、无关信息的注意捕获或无关信息的抑制。我们重复了之前的研究结果,发现当目标与高回报的干扰物竞争时,反应时间更长,准确率更低,而与低回报的干扰物竞争时,反应时间更短,准确率更低。我们还发现了干扰的空间梯度:行为表现随目标距离的增加而下降。高回报干扰物的梯度比低回报干扰物的梯度更大。脑电信号的事件相关电位显示了奖赏引起的注意偏差的原因:高奖赏分心物比低奖赏分心物需要更多的抑制,这在较大的 Pd 分量中很明显。这种效应只出现在目标附近的分心物上,这表明对于近距离的竞争刺激需要额外的过滤。因此,当目标与高回报的分心物竞争时,分配给目标的注意资源就会减少,这表现在目标-N2pc 振幅较小。表明注意力捕获的分心物-N2pc 既不受距离影响,也不受奖励影响,这表明仅靠注意力捕获无法解释高价值刺激的干扰。总之,我们的研究结果表明,高价值刺激对抑制的需求较高,这有助于受奖励调节的注意调配,而抑制的增加可以防止对高价值刺激的注意捕获。
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引用次数: 0
Brain electrical activity and oxygenation by Reflex Locomotion Therapy and massage in preterm and term infants. A protocol study 早产儿和足月儿通过反射运动疗法和按摩进行脑电活动和氧合。方案研究
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-09-01 DOI: 10.1016/j.neuroimage.2024.120765

Background

Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) are techniques for assessing brain electrical activity and oxygenation. There is evidence of brain electrical activity and oxygenation in preterm/full-term infants by tactile stimuli but none by Reflex Locomotion Therapy. Their knowledge will address the delays in motor development that preterm infants often present. The objective will be to establish the differences in preterm and full-term infants in relation to brain electrical activity and oxygenation, and to test differences between Reflex Locomotion Therapy and massage.

Methods

Randomized clinical trial with healthy preterm and non-preterm infants will be included and will be randomly divided into 3 groups: 2 intervention groups (Reflex Locomotion Therapy/massage therapy) and 1 control group (fake Reflex Locomotion Therapy). Outcome variables will be brain electrical activity and oxygenation changes measured by EEG and fNIRS once after breastfeeding.

Discussion

This study will test the application effects of Reflex Locomotion Therapy and massage therapy in newborn infants in relation to brain electrical activity and oxygenation, and to establish the differences between preterm and full-term infants. Several articles have been identified with different auditory, visual and olfactory stimuli; however, evidence on studies related to tactile stimuli is limited.

背景脑电图(EEG)和功能性近红外光谱(fNIRS)是评估脑电活动和氧饱和度的技术。有证据表明,触觉刺激可促进早产儿/足月儿的脑电活动和血氧饱和度,但反射性运动疗法却无法促进早产儿/足月儿的脑电活动和血氧饱和度。他们的知识将解决早产儿经常出现的运动发育迟缓问题。研究目的是确定早产儿和足月儿在脑电活动和氧饱和度方面的差异,并测试反射运动疗法和按摩之间的差异。方法将对健康的早产儿和非早产儿进行随机临床试验,并随机分为 3 组:2 个干预组(反射运动疗法/按摩疗法)和 1 个对照组(假反射运动疗法)。本研究将测试反射运动疗法和按摩疗法在新生儿脑电活动和氧饱和度方面的应用效果,并确定早产儿和足月儿之间的差异。已有多篇文章涉及不同的听觉、视觉和嗅觉刺激,但与触觉刺激相关的研究证据却很有限。
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引用次数: 0
Refining hemodynamic correction in in vivo wide-field fluorescent imaging through linear regression analysis 通过线性回归分析改进活体宽视野荧光成像中的血液动力学校正。
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-30 DOI: 10.1016/j.neuroimage.2024.120816

Accurate interpretation of in vivo wide-field fluorescent imaging (WFFI) data requires precise separation of raw fluorescence signals into neural and hemodynamic components. The classical Beer-Lambert law-based approach, which uses concurrent 530-nm illumination to estimate relative changes in cerebral blood volume (CBV), fails to account for the scattering and reflection of 530-nm photons from non-neuronal components leading to biased estimates of CBV changes and subsequent misrepresentation of neural activity. This study introduces a novel linear regression approach designed to overcome this limitation. This correction provides a more reliable representation of CBV changes and neural activity in fluorescence data. Our method is validated across multiple datasets, demonstrating its superiority over the classical approach.

要准确解读活体宽场荧光成像(WFFI)数据,需要将原始荧光信号精确分离为神经和血液动力学成分。经典的基于比尔-朗伯定律的方法使用并发的 530-nm 照明来估计脑血容量(CBV)的相对变化,这种方法未能考虑到非神经元成分对 530-nm 光子的散射和反射,导致对 CBV 变化的估计存在偏差,进而错误地反映了神经活动。本研究引入了一种新的线性回归方法,旨在克服这一局限性。这种校正方法能更可靠地反映荧光数据中的 CBV 变化和神经活动。我们的方法经过多个数据集的验证,证明其优于传统方法。
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引用次数: 0
Brain age prediction via cross-stratified ensemble learning 通过交叉分层集合学习预测大脑年龄
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-29 DOI: 10.1016/j.neuroimage.2024.120825

As an important biomarker of neural aging, the brain age reflects the integrity and health of the human brain. Accurate prediction of brain age could help to understand the underlying mechanism of neural aging. In this study, a cross-stratified ensemble learning algorithm with staking strategy was proposed to obtain brain age and the derived predicted age difference (PAD) using T1-weighted magnetic resonance imaging (MRI) data. The approach was characterized as by implementing two modules: one was three base learners of 3D-DenseNet, 3D-ResNeXt, 3D-Inception-v4; another was 14 secondary learners of liner regressions. To evaluate performance, our method was compared with single base learners, regular ensemble learning algorithms, and state-of-the-art (SOTA) methods. The results demonstrated that our proposed model outperformed others models, with three metrics of mean absolute error (MAE), root mean-squared error (RMSE), and coefficient of determination (R2) of 2.9405 years, 3.9458 years, and 0.9597, respectively. Furthermore, there existed significant differences in PAD among the three groups of normal control (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), with an increased trend across NC, MCI, and AD. It was concluded that the proposed algorithm could be effectively used in computing brain aging and PAD, and offering potential for early diagnosis and assessment of normal brain aging and AD.

作为神经衰老的重要生物标志物,脑年龄反映了人脑的完整性和健康状况。准确预测脑年龄有助于了解神经衰老的内在机制。本研究提出了一种交叉分层的集合学习算法,该算法采用定标策略,利用 T1 加权磁共振成像(MRI)数据获得脑年龄和推导出的预测年龄差值(PAD)。该方法的特点是实现了两个模块:一个是 3D-DenseNet, 3D-ResNeXt, 3D-Inception-v4 的三个基础学习器;另一个是 14 个衬垫回归的二级学习器。为了评估性能,我们将我们的方法与单一基础学习器、常规集合学习算法和最先进的(SOTA)方法进行了比较。结果表明,我们提出的模型优于其他模型,平均绝对误差(MAE)、均方根误差(RMSE)和决定系数(R2)三项指标分别为 2.9405 年、3.9458 年和 0.9597 年。此外,PAD 在正常对照组(NC)、轻度认知障碍组(MCI)和阿尔茨海默病组(AD)三组之间存在显著差异,且在 NC、MCI 和 AD 之间呈上升趋势。结论是所提出的算法可有效地用于计算脑衰老和PAD,为早期诊断和评估正常脑衰老和AD提供了可能。
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引用次数: 0
An improved spectral clustering method for accurate detection of brain resting-state networks 准确检测大脑静息态网络的改进型频谱聚类方法
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-28 DOI: 10.1016/j.neuroimage.2024.120811

This paper proposes a data-driven analysis method to accurately partition large-scale resting-state functional brain networks from fMRI data. The method is based on a spectral clustering algorithm and combines eigenvector direction selection with Pearson correlation clustering in the spectral space. The method is an improvement on available spectral clustering methods, capable of robustly identifying active brain networks consistent with those from model-driven methods at different noise levels, even at the noise level of real fMRI data.

本文提出了一种数据驱动的分析方法,用于从 fMRI 数据中精确划分大规模静息态脑功能网络。该方法基于频谱聚类算法,将特征向量方向选择与频谱空间中的皮尔逊相关聚类相结合。该方法改进了现有的频谱聚类方法,能够在不同噪声水平下稳健地识别出活跃的大脑网络,与模型驱动方法识别出的网络一致,甚至在真实的 fMRI 数据噪声水平下也是如此。
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引用次数: 0
Large-scale meta-analyses and network analyses of neural substrates underlying human escalated aggression 大规模荟萃分析和人类攻击行为升级的神经基质网络分析
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-28 DOI: 10.1016/j.neuroimage.2024.120824

Escalated aggression represents a frequent and severe form of violence, sometimes manifesting as antisocial behavior. Driven by the pressures of modern life, escalated aggression is of particular concern due to its rising prevalence and its destructive impact on both individual well-being and socioeconomic stability. However, a consistent neural circuitry underpinning it remains to be definitively identified. Here, we addressed this issue by comparing brain alterations between individuals with escalated aggression and those without such behavioral manifestations. We first conducted a meta-analysis to synthesize previous neuroimaging studies on functional and structural alterations of escalated aggression (325 experiments, 2997 foci, 16,529 subjects). Following-up network and functional decoding analyses were conducted to provide quantitative characterizations of the identified brain regions. Our results revealed that brain regions constantly involved in escalated aggression were localized in the subcortical network (amygdala and lateral orbitofrontal cortex) associated with emotion processing, the default mode network (dorsal medial prefrontal cortex and middle temporal gyrus) associated with mentalizing, and the salience network (anterior cingulate cortex and anterior insula) associated with cognitive control. These findings were further supported by additional meta-analyses on emotion processing, mentalizing, and cognitive control, all of which showed conjunction with the brain regions identified in the escalated aggression. Together, these findings advance the understanding of the risk biomarkers of escalated aggressive populations and refine theoretical models of human aggression.

攻击升级是一种频繁发生的严重暴力形式,有时表现为反社会行为。在现代生活压力的驱使下,攻击升级的发生率不断上升,并对个人福祉和社会经济稳定造成破坏性影响,因此格外引人关注。然而,支撑这种行为的一贯神经回路仍有待明确确定。在此,我们通过比较攻击行为升级者与无此类行为表现者的大脑变化来解决这一问题。我们首先进行了一项荟萃分析,综合了之前关于攻击行为升级的功能和结构改变的神经影像学研究(325 项实验,2997 个病灶,16529 名受试者)。我们还进行了后续的网络和功能解码分析,以提供已识别脑区的定量特征。我们的研究结果表明,持续参与攻击行为升级的脑区定位于与情绪处理相关的皮层下网络(杏仁核和外侧眶额叶皮层)、与心智化相关的默认模式网络(背内侧前额叶皮层和颞中回)以及与认知控制相关的显著性网络(前扣带回皮层和前脑岛)。关于情绪处理、思维定势和认知控制的其他荟萃分析进一步支持了这些研究结果,所有这些分析都显示了与在攻击升级中识别出的脑区的联系。这些发现共同推进了对攻击性升级人群风险生物标志物的理解,并完善了人类攻击性的理论模型。
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引用次数: 0
SiMix: A domain generalization method for cross-site brain MRI harmonization via site mixing SiMix:通过部位混合实现跨部位脑磁共振成像协调的领域泛化方法
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-27 DOI: 10.1016/j.neuroimage.2024.120812

Brain magnetic resonance imaging (MRI) is widely used in clinical practice for disease diagnosis. However, MRI scans acquired at different sites can have different appearances due to the difference in the hardware, pulse sequence, and imaging parameter. It is important to reduce or eliminate such cross-site variations with brain MRI harmonization so that downstream image processing and analysis is performed consistently. Previous works on the harmonization problem require the data acquired from the sites of interest for model training. But in real-world scenarios there can be test data from a new site of interest after the model is trained, and training data from the new site is unavailable when the model is trained. In this case, previous methods cannot optimally handle the test data from the new unseen site. To address the problem, in this work we explore domain generalization for brain MRI harmonization and propose Site Mix (SiMix). We assume that images of travelling subjects are acquired at a few existing sites for model training. To allow the training data to better represent the test data from unseen sites, we first propose to mix the training images belonging to different sites stochastically, which substantially increases the diversity of the training data while preserving the authenticity of the mixed training images. Second, at test time, when a test image from an unseen site is given, we propose a multiview strategy that perturbs the test image with preserved authenticity and ensembles the harmonization results of the perturbed images for improved harmonization quality. To validate SiMix, we performed experiments on the publicly available SRPBS dataset and MUSHAC dataset that comprised brain MRI acquired at nine and two different sites, respectively. The results indicate that SiMix improves brain MRI harmonization for unseen sites, and it is also beneficial to the harmonization of existing sites.

脑磁共振成像(MRI)被广泛应用于临床疾病诊断。然而,由于硬件、脉冲序列和成像参数的不同,在不同部位获得的磁共振成像扫描结果可能会有不同的外观。通过脑部核磁共振成像协调减少或消除这种跨部位差异非常重要,这样下游图像处理和分析才能始终如一地进行。以往解决协调问题的工作需要从感兴趣的部位获取数据进行模型训练。但在现实世界中,模型训练完成后可能会有来自新的感兴趣部位的测试数据,而模型训练时无法获得来自新部位的训练数据。在这种情况下,以往的方法无法以最佳方式处理来自新的未知站点的测试数据。为了解决这个问题,我们在这项工作中探索了脑磁共振成像协调的领域泛化,并提出了站点混合(SiMix)。我们假定在几个现有站点获取旅行受试者的图像,用于模型训练。为了让训练数据更好地代表来自未知地点的测试数据,我们首先建议将属于不同地点的训练图像随机混合,这样既能大大增加训练数据的多样性,又能保持混合训练图像的真实性。其次,在测试时,当给出来自未知地点的测试图像时,我们提出了一种多视角策略,在保持真实性的前提下对测试图像进行扰动,并对扰动图像的协调结果进行组合,以提高协调质量。为了验证 SiMix,我们在公开的 SRPBS 数据集和 MUSHAC 数据集上进行了实验。结果表明,SiMix 提高了未见部位的脑磁共振成像协调性,而且也有利于现有部位的协调。
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引用次数: 0
Comparative analysis of brain age prediction using structural and diffusion MRIs in neonates 利用结构和弥散核磁共振成像预测新生儿脑年龄的对比分析
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-25 DOI: 10.1016/j.neuroimage.2024.120815

Using machine learning techniques to predict brain age from multimodal data has become a crucial biomarker for assessing brain development. Among various types of brain imaging data, structural magnetic resonance imaging (sMRI) and diffusion magnetic resonance imaging (dMRI) are the most commonly used modalities. sMRI focuses on depicting macrostructural features of the brain, while dMRI reveals the orientation of major white matter fibers and changes in tissue microstructure. However, their differential capabilities in reflecting newborn age and clinical implications have not been systematically studied. This study aims to explore the impact of sMRI and dMRI on brain age prediction. Comparing predictions based on T2-weighted(T2w) and fractional anisotropy (FA) images, we found their mean absolute errors (MAE) in predicting infant age to be similar. Exploratory analysis revealed for T2w images, areas such as the cerebral cortex and ventricles contribute most significantly to age prediction, whereas FA images highlight the cerebral cortex and regions of the main white matter tracts. Despite both modalities focusing on the cerebral cortex, they exhibit significant region-wise differences, reflecting developmental disparities in macro- and microstructural aspects of the cortex. Additionally, we examined the effects of prematurity, gender, and hemispherical asymmetry of the brain on age prediction for both modalities. Results showed significant differences (p<0.05) in age prediction biases based on FA images across gender and hemispherical asymmetry, whereas no significant differences were observed with T2w images. This study underscores the differences between T2w and FA images in predicting infant brain age, offering new perspectives for studying infant brain development and aiding more effective assessment and tracking of infant development.

利用机器学习技术从多模态数据中预测大脑年龄已成为评估大脑发育的重要生物标记。在各种脑成像数据中,结构磁共振成像(sMRI)和弥散磁共振成像(dMRI)是最常用的模式。sMRI侧重于描绘大脑的宏观结构特征,而dMRI则揭示主要白质纤维的方向和组织微观结构的变化。然而,它们在反映新生儿年龄方面的不同能力和临床意义尚未得到系统研究。本研究旨在探讨 sMRI 和 dMRI 对脑年龄预测的影响。比较基于 T2 加权(T2w)和分数各向异性(FA)图像的预测,我们发现它们在预测婴儿年龄方面的平均绝对误差(MAE)相似。探索性分析表明,在T2w图像中,大脑皮层和脑室等区域对预测年龄的贡献最大,而FA图像则突出了大脑皮层和主要白质束区域。尽管这两种模式都侧重于大脑皮层,但它们在区域上表现出明显的差异,反映了大脑皮层宏观和微观结构方面的发育差异。此外,我们还研究了早产、性别和大脑半球不对称对两种模式的年龄预测的影响。结果显示,两种模式的年龄预测存在明显差异(p
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引用次数: 0
Synergy of the mirror neuron system and the mentalizing system in a single brain and between brains during joint actions 镜像神经元系统和心智系统在单个大脑中的协同作用,以及在联合行动中大脑之间的协同作用。
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-24 DOI: 10.1016/j.neuroimage.2024.120783

Cooperative action involves the simulation of actions and their co-representation by two or more people. This requires the involvement of two complex brain systems: the mirror neuron system (MNS) and the mentalizing system (MENT), both of critical importance for successful social interaction. However, their internal organization and the potential synergy of both systems during joint actions (JA) are yet to be determined. The aim of this study was to examine the role and interaction of these two fundamental systems—MENT and MNS—during continuous interaction. To this hand, we conducted a multiple-brain connectivity analysis in the source domain during a motor cooperation task using high-density EEG dual-recordings providing relevant insights into the roles of MNS and MENT at the intra- and interbrain levels.

In particular, the intra-brain analysis demonstrated the essential function of both systems during JA, as well as the crucial role played by single brain regions of both neural mechanisms during cooperative activities. Specifically, our intra-brain analysis revealed that both neural mechanisms are essential during Joint Action (JA), showing a solid connection between MNS and MENT and a central role of the single brain regions of both mechanisms during cooperative actions. Additionally, our inter-brain study revealed increased inter-subject connections involving the motor system, MENT and MNS. Thus, our findings show a mutual influence between two interacting agents, based on synchronization of MNS and MENT systems. Our results actually encourage more research into the still-largely unknown realm of inter-brain dynamics and contribute to expand the body of knowledge in social neuroscience.

合作行动涉及两个或两个以上的人对行动的模拟和共同表述。这需要两个复杂的大脑系统的参与:镜像神经元系统(MNS)和心智化系统(MENT)。然而,这两个系统的内部组织结构以及在联合行动(JA)过程中的潜在协同作用仍有待确定。本研究旨在探讨这两个基本系统--意念系统(MENT)和思维系统(MNS)--在持续互动过程中的作用和相互作用。为此,我们利用高密度脑电图双重记录,对运动合作任务中的源域进行了多脑连接分析,从而对 MNS 和 MENT 在脑内和脑间的作用有了相关的了解。特别是,脑内分析表明了这两个系统在 JA 过程中的基本功能,以及这两种神经机制在合作活动中的单个脑区所发挥的关键作用。具体来说,我们的脑内分析表明,在联合行动(JA)过程中,这两种神经机制都是必不可少的,表明了 MNS 和 MENT 之间的牢固联系,以及这两种机制的单个脑区在合作行动中的核心作用。此外,我们的脑间研究显示,涉及运动系统、MENT 和 MNS 的受试者间联系增加了。因此,我们的研究结果表明,在 MNS 和 MENT 系统同步的基础上,两个相互作用的主体之间存在着相互影响。我们的研究结果实际上鼓励了更多关于脑间动力学的研究,并有助于扩展社会神经科学的知识体系。
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引用次数: 0
Poor sleep quality is associated with decreased regional brain glucose metabolism in healthy middle-aged adults 睡眠质量差与健康中年人大脑区域葡萄糖代谢减少有关。
IF 4.7 2区 医学 Q1 NEUROIMAGING Pub Date : 2024-08-24 DOI: 10.1016/j.neuroimage.2024.120814

Sleep disturbance is associated with the development of neurodegenerative disease. We aimed to address the effects of sleep quality on brain glucose metabolism measured by 18F-Fl uorodeoxyglucose (18F-FDG) positron emission tomography (PET) in healthy middle-aged adults. A total of 378 healthy men (mean age: 42.8±3.6 years) were included in this study. Participants underwent brain 18F-FDG PET and completed the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K). Additionally, anthropometric measurements were obtained. PETs were spatially normalized to MNI space using PET templates from SPM5 with PMOD. The Automated Anatomical Labeling 2 atlas was used to define regions of interest (ROIs). The mean uptake of each ROI was scaled to the mean of the global cortical uptake of each individual and defined as the standardized uptake value ratio (SUVR). After the logarithmic transformation of the regional SUVR, the effects of the PSQI-K on the regional SUVR were investigated using Bayesian hierarchical modeling. Brain glucose metabolism of the posterior cingulate, precuneus, and thalamus showed a negative association with total PSQI-K scores in the Bayesian model ROI-based analysis. Voxel-based analysis using statistical parametric mapping revealed a negative association between the total PSQI-K scores and brain glucose metabolism of the precuneus, postcentral gyrus, posterior cingulate, and thalamus. Poor sleep quality is negatively associated with brain glucose metabolism in the precuneus, posterior cingulate, and thalamus. Therefore, the importance of sleep should not be overlooked, even in healthy middle-aged adults.

睡眠障碍与神经退行性疾病的发展有关。我们的目的是研究睡眠质量对健康中年人脑葡萄糖代谢的影响(18F-Fl uorodeoxyglucose (18F-FDG) positron emission tomography (PET))。本研究共纳入了 378 名健康男性(平均年龄:42.8±3.6 岁)。参与者接受了脑18F-FDG正电子发射计算机断层扫描,并完成了韩国版匹兹堡睡眠质量指数(PSQI-K)。此外,还进行了人体测量。使用 SPM5 和 PMOD 的 PET 模板将 PET 空间归一化到 MNI 空间。自动解剖标记 2 图集用于定义感兴趣区(ROI)。每个 ROI 的平均摄取量与每个人的全球皮质摄取量的平均值进行缩放,并定义为标准化摄取值比(SUVR)。对区域 SUVR 进行对数转换后,使用贝叶斯层次模型研究 PSQI-K 对区域 SUVR 的影响。在基于贝叶斯模型的 ROI 分析中,后扣带回、楔前区和丘脑的脑糖代谢与 PSQI-K 总分呈负相关。基于体素的统计参数映射分析显示,PSQI-K 总分与楔前、中央后回、扣带回后和丘脑的脑糖代谢呈负相关。睡眠质量差与楔前、扣带回后和丘脑的脑糖代谢呈负相关。因此,即使是健康的中年人也不应忽视睡眠的重要性。
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