Nitric oxide : biology and chemistry最新文献_第6页

Generation of high-concentration medical-grade nitric oxide via air-sourced pulsed arc discharge 空气源脉冲电弧放电产生高浓度医用级一氧化氮

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-05-12 DOI: 10.1016/j.niox.2025.05.001

Weiming Ni , Haixiao Wu , Guangqing Liu , Jun Li , Yegang Lu

Inhaled nitric oxide (NO) is a selective pulmonary vasodilator that has been shown to be effective in treating pulmonary hypertension in both adults and children with respiratory and heart failure. The most common method for delivering NO in clinical practice relies on compressed high-concentration NO gas stored in cylinders. This NO gas is typically synthesized through chemical methods and stored in high-concentration form within gas cylinders, making NO therapy equipment bulky and expensive. Moreover, chemical synthesis requires specific materials, and the production and storage of NO are two separate steps, both of which are complex and costly. These factors limit the widespread adoption of NO therapy. To address the issues associated with high-concentration NO cylinder therapy, this study explores a method for generating NO gas through the ionization of air via pulsed arc discharge, and further investigates strategies to increase its concentration. A portable NO generator is designed to produce high-concentration NO gas on-demand, providing a potential alternative to cylinder storage. The results show that the four-electrode NO generator can quickly and safely produce 545.2 ± 10 ppm of NO and reduce the co-production of other gases. The pulsed arc NO generator designed in this study generates sufficiently high concentrations of NO gas to replace cylinder storage with lightweight, portable, and capable of immediate on-demand generation. The generator produces NO gas from ambient air, thus significantly reducing the cost of inhaled NO therapy and paving the way for wider application of this therapy.

吸入型一氧化氮（NO）是一种选择性肺血管扩张剂，已被证明可有效治疗呼吸和心力衰竭的成人和儿童肺动脉高压。在临床实践中，最常用的方法是将压缩的高浓度NO气体储存在钢瓶中。这种NO气体通常是通过化学方法合成的，并以高浓度的形式储存在气瓶中，这使得NO治疗设备体积庞大且昂贵。此外，化学合成需要特定的材料，而NO的生产和储存是两个独立的步骤，两者都是复杂和昂贵的。这些因素限制了NO疗法的广泛应用。为了解决高浓度NO气瓶治疗的相关问题，本研究探索了一种通过脉冲电弧放电电离空气产生NO气体的方法，并进一步研究了提高NO浓度的策略。便携式NO发生器设计用于按需生产高浓度NO气体，为钢瓶存储提供了一种潜在的替代方案。结果表明，四电极NO发生器能够快速、安全地产生545.2±10 ppm的NO，并减少了其他气体的共生。本研究设计的脉冲电弧NO发生器可产生足够高浓度的NO气体，以轻便、便携、可即时按需生成的方式取代钢瓶储存。该发生器从环境空气中产生NO气体，从而大大降低了吸入NO疗法的成本，为该疗法的更广泛应用铺平了道路。

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引用次数: 0

New directions for Nitric Oxide – Focused, rapid, and forward-looking 一氧化氮的新方向——聚焦、快速和前瞻性。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-04-22 DOI: 10.1016/j.niox.2025.04.005

Miriam M. Cortese-Krott , Lorenzo Berra , Adrian Hobbs , Katrina M. Miranda , Hozumi Motohashi , Jesus Tejero

Nitric Oxide is entering a new phase, marked by a redefinition of its scope, editorial policies, and structural organization. Reflecting the evolution of the nitric oxide field toward a broader focus on small molecule signaling in redox biology and medicine, the journal now explicitly welcomes mechanistic, translational, and interdisciplinary studies, including work on hydrogen sulfide, persulfides, and carbon monoxide. Key editorial changes include a streamlined peer review process eliminating major revisions, invitation-only review articles, and accelerated decision timelines. A newly appointed Editorial Board and a dedicated Reviewer Board aim to enhance scientific rigor and mentorship. Additional initiatives include curated method collections and a strengthened social media presence to improve reproducibility, engagement, and visibility. These changes are designed to position Nitric Oxide as a focused and responsive journal serving the evolving needs of the redox biology community.

《一氧化氮》正在进入一个新的阶段，其标志是其范围、编辑政策和结构组织的重新定义。反映了一氧化氮领域向氧化还原生物学和医学中更广泛关注小分子信号的发展，该杂志现在明确欢迎机制、转化和跨学科的研究，包括硫化氢、过硫化物和一氧化碳的研究。关键的编辑变化包括精简的同行评审流程，消除重大修改，仅限邀请的评审文章，以及加快决策时间表。新任命的编辑委员会和专门的审稿委员会旨在加强科学严谨性和指导。其他计划包括策划方法集合和加强社会媒体的存在，以提高再现性、参与度和可见性。这些变化的目的是定位一氧化氮作为一个专注和响应杂志服务于氧化还原生物界不断发展的需求。

引用次数: 0

Hydrogen sulfide detection: Recent advancement and future perspectives towards fluorescence as a versatile Biophysical method 硫化氢检测：荧光作为一种多功能生物物理方法的最新进展和未来展望

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-04-22 DOI: 10.1016/j.niox.2025.04.004

Vivek Pandey , Tejasvi Pandey

Hydrogen Sulfide (H₂S) is an essential gaseous signaling molecule involved in various physiological processes, including vasodilation, neurotransmission, and anti-inflammatory responses. Accurate detection and quantification of H₂S in biological systems are crucial for elucidating its physiological and pathological roles. Fluorescent probes have emerged as indispensable tools for H₂S detection, offering high sensitivity, specificity, and the ability for real-time and non-invasive monitoring. This review discusses recent advances in the design and development of fluorescent probes for H₂S detection, focusing on their mechanisms, properties, and applications. We explore the different strategies employed in probe design, including reduction-based mechanisms, nucleophilic addition reactions, and cleavage of sulfide bonds. Innovations such as ratiometric probes, two-photon fluorescent probes, and multi-functional probes have significantly enhanced the capabilities of H₂S detection. These advancements have facilitated cellular and subcellular imaging, real-time monitoring in live organisms, and the investigation of H₂S-related pathologies. Despite these progresses, challenges remain, including improving probe selectivity, stability, and biocompatibility, as well as developing methods for accurate quantification in complex biological matrices. Future research directions include designing probes with higher selectivity and sensitivity, integrating advanced computational modeling, and combining fluorescent probes with mass spectrometry for precise quantification. The continued development of sophisticated fluorescent probes will expand our understanding of H₂S biology, offering new insights into its physiological and pathological roles and paving the way for novel therapeutic strategies.

硫化氢（H2S）是一种重要的气态信号分子，参与各种生理过程，包括血管扩张、神经传递和抗炎反应。准确检测和量化生物系统中的 H2S 对阐明其生理和病理作用至关重要。荧光探针已成为检测 H2S 不可或缺的工具，它具有高灵敏度、高特异性以及实时和无创监测的能力。本综述讨论了用于 H2S 检测的荧光探针设计和开发方面的最新进展，重点关注其机制、特性和应用。我们探讨了探针设计中采用的不同策略，包括基于还原的机制、亲核加成反应和硫化键的裂解。比率探针、双光子荧光探针和多功能探针等创新技术大大提高了 H2S 的检测能力。这些进步促进了细胞和亚细胞成像、活体生物体内的实时监测以及 H2S 相关病理的研究。尽管取得了这些进展，但挑战依然存在，包括提高探针的选择性、稳定性和生物相容性，以及开发在复杂生物基质中准确定量的方法。未来的研究方向包括设计具有更高选择性和灵敏度的探针，整合先进的计算模型，以及将荧光探针与质谱技术相结合进行精确定量。精密荧光探针的不断发展将拓展我们对 H2S 生物学的认识，为我们了解 H2S 的生理和病理作用提供新的视角，并为新的治疗策略铺平道路。

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引用次数: 0

Nitric oxide detection by electrochemistry selective probe: calibration in the study environment is mandatory 电化学选择性探针检测一氧化氮：在研究环境中校准是强制性的

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-04-19 DOI: 10.1016/j.niox.2025.04.002

Roberta Albino Dos Reis , Ariane Boudier , Flavian Piquard , Joana C. Piereti , Amedea B. Seabra , Igor Clarot

Nitric oxide (NO) plays a crucial role in various physiological processes, making its detection and controlled release significant for both therapeutic and environmental contexts. Electrochemical sensors are widely used for NO detection due to their high sensitivity and real-time monitoring capabilities. However, challenges such as interference from other gasotransmitters, sensor degradation, and calibration difficulties—especially in complex biological matrices—hinder accurate NO measurement. This review discusses recent advancements in electrochemical NO detection, with a focus on the impact of complex biological matrices, calibration strategies, and sensor designs. The release of NO from nanoparticles, such as S-nitrosoglutathione (GSNO)-encapsulating chitosan nanoparticles, is used as a case study for improving NO detection accuracy. Future innovations in sensor technology and nanoparticle design are expected to expand the applicability of NO detection in personalized medicine and environmental monitoring.

一氧化氮（NO）在各种生理过程中起着至关重要的作用，使其检测和控制释放在治疗和环境背景下都具有重要意义。电化学传感器以其高灵敏度和实时监测能力被广泛应用于NO检测。然而，来自其他气体发射器的干扰、传感器退化和校准困难等挑战——特别是在复杂的生物基质中——阻碍了NO的准确测量。本文综述了电化学NO检测的最新进展，重点讨论了复杂生物基质、校准策略和传感器设计的影响。以s -亚硝基谷胱甘肽（GSNO）包封壳聚糖纳米颗粒为例，研究了纳米颗粒释放NO的方法，以提高NO检测的准确性。传感器技术和纳米颗粒设计的未来创新有望扩大一氧化氮检测在个性化医疗和环境监测中的适用性。

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引用次数: 0

Synergistic interaction of sodium nitroprusside and Serratia marcescens in mitigation of nematode stress in tomato 硝普钠和肉质沙雷氏菌在缓解番茄线虫胁迫方面的协同作用

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-04-19 DOI: 10.1016/j.niox.2025.04.003

Deepak Kumar , Rajesh Kumari Manhas , Puja Ohri

Plant growth and development are negatively impacted by root-knot nematodes (RKNs), which in turn affects plant production. Chemical nematicides are one of the effective strategies for managing RKNs. But, high concentration of these chemicals is toxic to plants, environment and humans. Therefore, an in-vivo study was conducted to unravel the synergistic interplay sodium nitroprusside (SNP: nitric oxide donor) and, Serratia marcescens in M. incognita-stressed tomato plants. Results revealed that treatment with SNP and bacterial culture cells reduced gall formation and improved morphology. It also reduced nematode-induced oxidative stress in M. incognita-infested tomato plants as compared to untreated plants. Increased photosynthetic parameters including photosynthetic pigments and gas-exchange parameters was also observed in treated plants. Additionally, treated plants exhibited increased antioxidant defense system in terms of upregulated activities of enzymatic antioxidants (Ascorbate peroxidase, guaiacol peroxidase, polyphenol oxidase, catalase, glutathione-S-transferase and superoxide dismutase). Content of non-enzymatic antioxidants (Glutathione, ascorbic acid and tocopherol) was also enhanced in treated plants as compared to untreated nematode-infected plants. Further, treatment with SNP and S. marcescens increased secondary metabolites (total phenol, flavonoid and anthocyanin) and proline content. Reduction in nematode-induced nuclear and membrane damage was also observed in SNP and bacterial culture cells treated tomato plants. The integrative application of SNP and S. marcescens exhibited synergism and overpowered their individual application in reducing the negative effects of nematode stress. The findings of the current investigation suggest the integrative use of SNP and bacteria is more beneficial in alleviating nematode stress in plants.

根结线虫（root-knot nematodes, RKNs）对植物的生长发育产生负面影响，进而影响植物的产量。化学杀线虫剂是控制RKNs的有效策略之一。但是，高浓度的这些化学物质对植物、环境和人类都是有毒的。因此，一项体内研究揭示了硝普钠（SNP：一氧化氮供体）和粘质沙雷氏菌在M. incognita胁迫下番茄植株中的协同相互作用。结果显示，SNP和细菌培养细胞减少了胆的形成，改善了胆的形态。与未经处理的番茄植株相比，它还减少了线虫诱导的氧化应激。处理后的植物光合参数增加，包括光合色素和气体交换参数。此外，处理植株抗氧化防御系统增强，酶抗氧化剂（抗坏血酸过氧化物酶、愈创木酚过氧化物酶、多酚氧化酶、过氧化氢酶、谷胱甘肽- s转移酶和超氧化物歧化酶）活性上调。非酶促抗氧化剂（谷胱甘肽、抗坏血酸和生育酚）的含量也比未处理的线虫感染植物高。此外，SNP和粘多糖处理增加了次级代谢物（总酚、类黄酮和花青素）和脯氨酸含量。在SNP和细菌培养细胞处理的番茄植株中，线虫诱导的细胞核和膜损伤也有所减少。在减少线虫胁迫的负面影响方面，SNP和粘质葡萄球菌的综合应用显示出协同效应，并且超过了它们单独应用的效果。目前的研究结果表明，SNP和细菌的综合利用更有利于减轻植物的线虫胁迫。

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引用次数: 0

Is there a link between the abundance of nitrate-reducing bacteria and arterial hypertension? A systematic review 减少硝酸盐的细菌和动脉高血压之间是否存在联系？系统回顾

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-04-11 DOI: 10.1016/j.niox.2025.04.001

Esthela M. Puel , Lillian F. Taruhn , Nailê Damé-Teixeira , Cristine M. Stefani , Renata M. Lataro

Context

Nitric oxide is a vasodilator molecule that acts on blood pressure (BP) control, and its production can occur through the reduction of nitrates by oral or intestinal nitrate-reducing bacteria. However, the relationship between nitrate-reducing bacteria and arterial hypertension (HTN) remains under debate.

Objective

Systematically review if there is an association between the abundance of oral and intestinal nitrate-reducing bacteria and the occurrence of HTN in humans.

Databases and eligibility criteria

MEDLINE, Scopus, Cochrane Library, EMBASE, LILACS, Web of Science, Livivo, ProQuest Dissertations, and Google Scholar were searched for eligible articles until February 10th, 2024. Studies were included if they: (1) were observational studies or clinical trials; (2) included adults (≥18 years old) with HTN (systolic BP ≥ 130 mmHg and/or diastolic BP > 80 mmHg and/or use of BP lowering medication); (3) compared (or not) to no-HTN adults; and (4) used next-generation sequencing microbiome analysis to identify bacterial taxa in the oral and/or gut nitrate-reducing bacteria.

Results

The search identified 9365 articles, and 28 were included in the study after applying the inclusion and exclusion criteria; 23 articles assessed the gut microbiota, 4 assessed the oral microbiota, and 1 assessed both. Depletion of nitrate-reducing bacteria was not consistently shown in the studies. The included studies reported reduction, increase, and no change in the nitrate-reducing bacteria genera or species in oral or gut microbiota.

Conclusion

We found no association between the abundance of oral and gut nitrate-reducing bacteria and the occurrence of HTN in humans.

Registration

PROSPERO identification number CRD42022315891.

一氧化氮是一种血管扩张分子，作用于血压（BP）控制，其产生可通过口服或肠道硝酸盐还原细菌减少硝酸盐。然而，硝酸盐还原菌与动脉高血压（HTN）之间的关系仍存在争议。目的系统回顾口腔和肠道硝酸盐还原菌的丰度与人类HTN的发生之间是否存在关联。检索数据库和入选标准：检索edline、Scopus、Cochrane Library、EMBASE、LILACS、Web of Science、Livivo、ProQuest Dissertations和谷歌Scholar，检索截止日期为2024年2月10日。以下研究被纳入：(1)观察性研究或临床试验；(2)纳入HTN（收缩压≥130 mmHg和/或舒张压≤gt）的成人（≥18岁）；80 mmHg和/或使用降压药物)；(3)与非htn成人比较（或不比较）；(4)利用新一代测序微生物组分析鉴定口腔和/或肠道硝酸盐还原菌的细菌分类群。结果共检索到9365篇文献，按照纳入和排除标准纳入研究28篇；23篇文章评估肠道微生物群，4篇评估口腔微生物群，1篇评估两者。研究中并没有一致地显示硝酸盐还原细菌的消耗。纳入的研究报告了口腔或肠道微生物群中硝酸盐还原菌属或种类的减少、增加和无变化。结论口腔和肠道硝酸盐还原菌的丰度与人类HTN的发生无相关性。普洛斯普洛斯识别号CRD42022315891。

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引用次数: 0

From methionine to sulfide: Exploring the diagnostic and therapeutic potential of sulfur-containing biomolecules in hypertension 从蛋氨酸到硫化物：探索含硫生物分子在高血压中的诊断和治疗潜力。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-03-27 DOI: 10.1016/j.niox.2025.03.006

Anton Misak, Marian Grman, Karol Ondrias, Lenka Tomasova

Sulfur-containing amino acids are involved in the regulation of vascular activity and blood pressure. Clinically, a positive correlation was found between serum homocysteine levels and blood pressure. On the other hand, methionine and cysteine levels were reduced in hypertensive patients. Recently, the redox state of sulfur-containing amino acids has emerged as potential diagnostic marker of cardiovascular health. Metabolomic studies have revealed a shift in thiol/disulfide ratio toward oxidized forms and overproduction of thiyl radicals in hypertensive patients. Although accumulating evidence confirms that sulfur-containing amino acids are essential for the maintaining of redox homeostasis and blood pressure control, their hypotensive and antioxidant properties have been primarily demonstrated in animal studies. While several groups are developing new targeted and triggered sulfur-based donors, standardized pharmacological interventions for hypertensive patients are largely absent and pose a challenge for future research. In this review, we summarize recent studies that investigate the role of sulfur-containing amino acids and their redox-active metabolites, including glutathione and sulfide, in blood pressure control and the development of systemic hypertension.

含硫氨基酸参与血管活动和血压的调节。临床发现血清同型半胱氨酸水平与血压呈正相关。另一方面，高血压患者的蛋氨酸和半胱氨酸水平降低。最近，含硫氨基酸的氧化还原状态已成为心血管健康的潜在诊断指标。代谢组学研究揭示了高血压患者硫醇/二硫比向氧化形式和过量生产硫基自由基的转变。尽管越来越多的证据证实含硫氨基酸对维持氧化还原稳态和控制血压至关重要，但它们的降压和抗氧化特性主要在动物研究中得到证实。虽然有几个小组正在开发新的靶向和触发硫基供体，但对高血压患者的标准化药理学干预在很大程度上是缺失的，这对未来的研究构成了挑战。本文综述了含硫氨基酸及其氧化还原活性代谢物（包括谷胱甘肽和硫化物）在血压控制和全身性高血压发生中的作用。

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引用次数: 0

Appraising diverse metrics of nitric oxide in salt stress tolerance of high yielding wheat genotypes 高产小麦基因型耐盐胁迫中一氧化氮不同指标的评价。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-03-24 DOI: 10.1016/j.niox.2025.03.005

Sayeda Khatoon, Sarika Kumari, Muskan Gandhi, Kritika Nagarwal, Rudra Narayan Sahoo, Noushina Iqbal, M. Iqbal R. Khan

Staple crop vulnerability has been escalating with significant approach due to climatic variations leading to persistent salt accumulation as inimical environmental stressors, and thus endangering food security. To address this global concern, there is a need to elucidate the growth, physiological and yield responses, entailing plant salt tolerance modifications. Recent years have been advocated with studies focusing on the integration of nitric oxide (NO), however there is a need of critical decipherment on NO synthesis is regulated under salt stress conditions. With this focus, the present investigation has assessed the salt-mediated differential impacts on the plant growth, root architecture, photosynthetic pigment, carbon metabolites (carbohydrate and starch), and stomatal frequency, leading to restrained plant metabolisms in the 49 wheat genotypes. Further, the accumulation of secondary metabolites (flavonoids and phenols) was found concomitant with the improved NO biosynthesis in salt-stressed tolerant wheat genotype. To validate the involvement of endogenous NO as salt stress tolerance criterion, use of NO scavenger (cPTIO) suggests the involvement of NO in enhancing salt tolerance and stress defense metabolites mainly lignin biosynthesis, and cellulose to attain plant stress tolerance. These underlying interactions could pave the way to convey wheat tolerance for the future breeding programs.

由于气候的变化，主粮作物的脆弱性不断增加，导致盐分持续积累，成为不利的环境压力因素，从而危及粮食安全。为解决这一全球关注的问题，有必要阐明植物耐盐性改变所带来的生长、生理和产量反应。近年来的研究主要集中在一氧化氮（NO）的整合上，但需要对盐胁迫条件下一氧化氮合成的调控进行关键性的解读。有鉴于此，本研究评估了盐胁迫对 49 个小麦基因型的植物生长、根系结构、光合色素、碳代谢物（碳水化合物和淀粉）以及气孔频率的不同影响，从而导致植物代谢受限。此外，在耐盐胁迫的小麦基因型中，次生代谢物（类黄酮和酚类）的积累与 NO 生物合成的改善同时进行。为了验证内源 NO 参与盐胁迫耐受性的标准，使用 NO 清除剂（cPTIO）表明 NO 参与提高耐盐性和胁迫防御代谢物，主要是木质素的生物合成和纤维素，以实现植物的胁迫耐受性。这些潜在的相互作用可为今后的育种计划铺平道路，提高小麦的耐受性。

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引用次数: 0

Exploring the therapeutic potential of beetroot juice in patients with peripheral artery disease: A Narrative review 探讨甜菜根汁治疗外周动脉疾病的潜力：一个叙述性的回顾

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-03-24 DOI: 10.1016/j.niox.2025.03.003

Hao Wang , Mingming Chen , Yang Li , Wenjun Cui , Qian An , Xiangyang Yin , Bing Wang

Peripheral artery disease (PAD) is a circulatory disorder caused by atherosclerosis, leading to the narrowing or blockage of peripheral arteries, often affecting the arteries in the lower limbs. This condition can result in intermittent claudication and severe limb ischemia, significantly reducing patients' quality of life. In recent years, increasing evidence suggests that dietary interventions play a crucial role in the prevention and management of PAD, offering a safe and non-invasive treatment option. Beetroot, a natural root vegetable, demonstrates significant health benefits through its various bioactive compounds. It is rich in nitrate and betaine, which are metabolized in the body via the nitrate-nitrite- nitric oxide (NO) pathway, increasing the bioavailability of NO. NO is an important vasodilator that can improve blood flow and lower blood pressure. Additionally, the active compounds in beetroot may further enhance its health effects by altering the activity of the oral microbiome. This review explores the potential therapeutic effects of beetroot juice (BRJ) in the management of PAD. The findings indicate that BRJ can improve exercise performance, lower blood pressure, improve endothelial function, enhance skeletal muscle microvascular function and central autonomic nervous system function. Based on these findings, beetroot and its rich bioactive compounds hold promise as a novel supportive therapy for improving PAD.

外周动脉疾病（PAD）是一种由动脉粥样硬化引起的循环系统疾病，导致外周动脉变窄或阻塞，常累及下肢动脉。这种情况可导致间歇性跛行和严重肢体缺血，显著降低患者的生活质量。近年来，越来越多的证据表明，饮食干预在PAD的预防和管理中起着至关重要的作用，提供了一种安全、无创的治疗选择。甜菜根，一种天然根茎类蔬菜，通过其多种生物活性化合物显示出显著的健康益处。它富含硝酸盐和甜菜碱，通过硝酸盐-亚硝酸盐-一氧化氮（NO）途径在体内代谢，提高NO的生物利用度。一氧化氮是一种重要的血管扩张剂，可以改善血液流动和降低血压。此外，甜菜根中的活性化合物可能通过改变口腔微生物群的活性进一步增强其健康效果。本文综述了甜菜根汁（BRJ）在PAD治疗中的潜在治疗作用。研究结果表明，BRJ可以提高运动成绩，降低血压，改善内皮功能，增强骨骼肌微血管功能和中枢自主神经系统功能。基于这些发现，甜菜根及其丰富的生物活性化合物有望成为改善PAD的新型支持疗法。

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引用次数: 0

Innovative nitric oxide-releasing nanomaterials: Current progress, trends, challenges, and perspectives in cardiovascular therapies 创新一氧化氮释放纳米材料：心血管治疗的最新进展、趋势、挑战和前景

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry

Pub Date : 2025-03-24 DOI: 10.1016/j.niox.2025.03.004

Renan S. Nunes, Kelli C. Freitas Mariano, Joana C. Pieretti, Roberta A. dos Reis, Amedea B. Seabra

Cardiovascular diseases remain the leading cause of death worldwide, imposing a substantial impact on healthcare systems due to high morbidity, mortality, and associated economic costs. Nitric oxide (NO), a key signaling molecule in the cardiovascular system, plays a critical role in regulating vascular homeostasis, angiogenesis, and inflammation. Despite its therapeutic potential, direct NO delivery in the cardiovascular system is limited by its reactivity, short half-life, and poor bioavailability. The development of NO-releasing nanomaterials addresses these challenges by enabling controlled, targeted, and sustained NO delivery, mitigating systemic toxicity and improving therapeutic outcomes. This review provides a comprehensive overview of recent advancements in the design, functionalization, and application of NO-releasing nanomaterials for cardiovascular therapies. Key topics include the use of in vitro and in vivo models to evaluate efficacy in conditions such as myocardial ischemia-reperfusion injury, thrombosis, and atherosclerosis, as well as the role of stimuli-responsive systems and hybrid nanomaterials in enhancing delivery precision. Advances in nanotechnology, such as stimuli-responsive systems and hybrid functionalized nanomaterials for targeted delivery, have enhanced the precision and effectiveness of NO therapeutic effects for treating a wide spectrum of cardiovascular conditions. However, challenges like scalable production, biocompatibility, and integration with existing therapies remain. Future research should focus on interdisciplinary approaches to optimize these materials for clinical translation, ensuring accessibility and addressing the global problem of cardiovascular diseases.

心血管疾病仍然是世界范围内死亡的主要原因，由于其高发病率、高死亡率和相关的经济成本，对卫生保健系统造成了重大影响。一氧化氮（NO）是心血管系统中重要的信号分子，在调节血管稳态、血管生成和炎症等方面起着重要作用。尽管具有治疗潜力，但心血管系统中的直接NO递送受到其反应性、半衰期短和生物利用度差的限制。NO释放纳米材料的开发通过控制、靶向和持续的NO递送、减轻全身毒性和改善治疗结果来解决这些挑战。本文综述了一氧化氮释放纳米材料在心血管治疗中的设计、功能化和应用方面的最新进展。关键主题包括使用体外和体内模型来评估在心肌缺血再灌注损伤、血栓形成和动脉粥样硬化等情况下的疗效，以及刺激反应系统和混合纳米材料在提高递送精度方面的作用。纳米技术的进步，如刺激反应系统和靶向递送的混合功能化纳米材料，提高了NO治疗效果的准确性和有效性，用于治疗广泛的心血管疾病。然而，诸如可扩展生产、生物相容性以及与现有疗法的整合等挑战仍然存在。未来的研究应侧重于跨学科的方法，以优化这些材料的临床翻译，确保可及性和解决心血管疾病的全球性问题。

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引用次数: 0