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Intrauterine Insemination (IUI) Pregnancy Rates After COVID-19 Vaccination [ID: 1376042] 新型冠状病毒疫苗接种后宫内人工授精(IUI)妊娠率[ID: 1376042]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000929704.34094.4a
Savannah Groves, A. Hsu
INTRODUCTION: Public concern over the potential negative effect of COVID-19 vaccines on fertility has persisted, as confidence in COVID-19 vaccines remains low, especially in certain Midwestern populations. We evaluated the success of intrauterine inseminations (IUIs) in achieving pregnancy in women who self-report receiving at least one dose of the vaccine against SARS-CoV-2, compared with women who self-report declining the vaccine. METHODS: This is a retrospective cohort study of 109 IUI procedures in women receiving fertility treatment at the University of Missouri Reproductive Endocrinology and Infertility clinic from October 2021 through September 2022. Participants were grouped based on self-reported COVID-19 vaccination status, prior to their IUI. The primary outcome was pregnancy after IUI, as verified by a serum pregnancy test. This study was performed under University of Missouri IRB approval (IRB #MU2062683). RESULTS: In comparing women self-reporting COVID-19 vaccination versus nonvaccination, no statistical differences were found for positive serum pregnancy tests after IUI (17.3% among vaccinated; 21.7% among nonvaccinated). Although these IUI success rates are higher than the national average, there was no significant difference in pregnancy rates (P=.6331). CONCLUSION: In this limited sample, self-reported COVID-19 vaccination status does not appear to have a significant negative effect on the ability to conceive a pregnancy with IUI. Further prospective studies should evaluate the effect of male partner or sperm donor vaccination, the number and type of COVID-19 vaccines received, pregnancy outcomes, and confounders. This study may help address the ongoing questions of whether the COVID-19 vaccines have a significant negative effect on fertility and pregnancy outcomes.
导语:公众对COVID-19疫苗对生育的潜在负面影响的担忧持续存在,因为对COVID-19疫苗的信心仍然很低,特别是在某些中西部人群中。我们评估了自我报告接受至少一剂SARS-CoV-2疫苗的妇女与自我报告拒绝接种疫苗的妇女相比,宫内人工授精(IUIs)在实现妊娠方面的成功。方法:这是一项回顾性队列研究,对2021年10月至2022年9月在密苏里大学生殖内分泌和不孕症诊所接受生育治疗的妇女进行109例IUI手术。参与者根据IUI前自我报告的COVID-19疫苗接种状况进行分组。经血清妊娠试验证实,主要结局是IUI后妊娠。本研究在密苏里大学IRB批准下进行(IRB #MU2062683)。结果:比较自我报告接种COVID-19疫苗的妇女与未接种疫苗的妇女,IUI后血清妊娠试验阳性无统计学差异(接种疫苗者17.3%;21.7%未接种疫苗)。虽然IUI成功率高于全国平均水平,但妊娠率差异无统计学意义(P=.6331)。结论:在这个有限的样本中,自我报告的COVID-19疫苗接种状况似乎对IUI妊娠的受孕能力没有显著的负面影响。进一步的前瞻性研究应评估男性伴侣或精子供体接种疫苗的效果、接种的COVID-19疫苗的数量和类型、妊娠结局和混杂因素。这项研究可能有助于解决COVID-19疫苗是否对生育和妊娠结局有显着负面影响的持续问题。
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引用次数: 0
The Effect of Implementation of a Standardized Multidisciplinary Placenta Accreta Spectrum Team: A Quality Improvement Initiative [ID: 1377806] 实施标准化多学科胎盘增生谱小组的效果:一项质量改进倡议[ID: 1377806]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000930548.19621.cb
M. Lardy, M. Caliendo, M. Gallo, Sarah Nims
INTRODUCTION: Placenta accreta spectrum (PAS) is associated with significant morbidity and mortality. A multidisciplinary team and standardized protocol for identified PAS cases were created to provide a clear preoperative plan for mitigation of intraoperative blood loss, and surgical and postoperative complications. METHODS: This is an ongoing quality improvement study. The PAS team was implemented January 2021. All cases of PAS resulting in cesarean hysterectomy from January 2018 through August 2022 at a single regional perinatal center were included. Estimated blood loss (EBL), number of blood products (packed red cells, platelets, fresh frozen plasma), whether surgical complication was incurred, intensive care unit (ICU) length of stay (LOS), and hospital LOS were compared. T tests and χ2 were used to calculate significance. RESULTS: Thirty-eight cases were reviewed, 18 cases before implementation of the PAS team, 20 after. Average EBL was 3,800 mL pre-team, 3,191 mL post-team (P=.522). Pre-team average units of packed red cells were 4.67, 3.55 post-team (P=.199); platelets 1.72 versus 1.35 units (P=.424); fresh frozen plasma 0.67 versus 0.55 units (P=.581). Average ICU LOS and hospital LOS pre-team were 0.67 and 3.56 days, 0.30 (P=.121) and 3.35 (P=.434) days, respectively, post-team. CONCLUSION: Estimated blood loss, total blood products, occurrence of surgical complication, ICU LOS, and hospital LOS were decreased after implementation of a PAS multidisciplinary team. Statistical insignificance in all parameters was attributable to small sample size necessitating further future analysis with additional cases. A standardized multidisciplinary approach to PAS may demonstrate morbidity reduction.
简介:胎盘增生谱(PAS)与显著的发病率和死亡率相关。建立了一个多学科团队和标准化方案,以确定PAS病例,提供明确的术前计划,以减轻术中失血,手术和术后并发症。方法:这是一项正在进行的质量改进研究。PAS团队于2021年1月实施。纳入了2018年1月至2022年8月在单个区域围产中心进行的所有PAS导致剖宫产子宫切除术的病例。比较估计失血量(EBL)、血制品数量(红细胞、血小板、新鲜冷冻血浆)、是否发生手术并发症、重症监护病房(ICU)住院时间(LOS)和医院LOS。采用T检验和χ2计算显著性。结果:共回顾38例,PAS组实施前18例,实施后20例。治疗前平均EBL为3800 mL,治疗后平均EBL为3191 mL (P= 0.522)。组前平均红细胞密度为4.67个,组后平均红细胞密度为3.55个(P= 0.199);血小板1.72对1.35单位(P= 0.424);新鲜冷冻血浆0.67 vs 0.55单位(P=.581)。ICU组平均LOS为0.67天和3.56天,医院组平均LOS为0.30 (P= 0.121)天和3.35 (P= 0.434)天。结论:实施PAS多学科团队后,估计失血量、总血制品、手术并发症发生率、ICU LOS和医院LOS均有所降低。所有参数的统计不显著是由于样本量小,需要进一步分析其他病例。PAS的标准化多学科方法可能会降低发病率。
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引用次数: 0
Integrating Lawyers into the Perinatal Health Care Team: Initial Findings From an Innovative Medical–Legal Partnership [ID: 1377957] 将律师融入围产期保健团队:创新医疗-法律伙伴关系的初步发现[ID: 1377957]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930236.89093.3c
Roxana Richardson, Lisa P. Kessler, L. Patchen, D. Perry, Caitlin Schille Jensen, A. Thomas
INTRODUCTION: Health-harming legal needs (HHLNs), social determinants of health that have a legal remedy, are drivers of poor health outcomes for Black women and children. HHLNs include inadequate access to safe housing, employment accommodations, and income supports. A medical–legal partnership (MLP) adds an attorney to the health care team to address patients’ HHLNs in a variety of health care settings. The Perinatal LAW Project (P-LAW), an MLP between the Georgetown University Health Justice Alliance and MedStar Washington Hospital Center Women’s & Infants’ Services, addresses perinatal patients’ HHLNs in an obstetrics and gynecology practice. METHODS: Perinatal LAW Project attorneys record client and case data in a legal case management system. The research team analyzed data for the first 18 months of the program (March 2021 to September 2022). RESULTS: One hundred thirty-one patients were referred for legal assistance, primarily by social workers and health navigators. Most patients were in their second and third trimesters. The majority of patients were Black or African American, aged 20–34, and lived under 200% FPL. The most common legal issues were in the areas of employment (parental leave, discrimination), housing (conditions, eviction), public benefits (food stamps, disability benefits), and family law (child support, domestic violence). The P-LAW addressed 150 legal issues and served 117 patients. CONCLUSION: Medical–legal partnership is a novel approach to addressing maternal health disparities. In our experience, legal services have a high utilization rate and patients often have more than one legal need. Future efforts to measure patient outcomes, including reduced maternal stress and medical appointment attendance, will build the evidence base for MLP in the perinatal context.
简介:危害健康的法律需求(hhln)是具有法律补救措施的健康的社会决定因素,是黑人妇女和儿童健康结果不佳的驱动因素。健康问题包括获得安全住房、就业场所和收入支持的机会不足。医疗-法律合作伙伴关系(MLP)在医疗团队中增加一名律师,以解决各种医疗保健环境中患者的hhln问题。围产期法律项目(P-LAW)是乔治城大学健康正义联盟和MedStar华盛顿医院中心妇女和婴儿服务之间的MLP,解决围产期患者在妇产科实践中的hhln问题。方法:围产期法律项目律师在法律案件管理系统中记录客户和案件数据。研究小组分析了该项目前18个月(2021年3月至2022年9月)的数据。结果:131名患者获得法律援助,主要由社会工作者和卫生导航员提供。大多数患者处于妊娠中期和晚期。大多数患者为黑人或非裔美国人,年龄在20-34岁,生活在200% FPL以下。最常见的法律问题是在就业(育儿假、歧视)、住房(条件、驱逐)、公共福利(食品券、残疾福利)和家庭法(子女抚养、家庭暴力)领域。P-LAW解决了150个法律问题,服务了117名患者。结论:医疗-法律伙伴关系是解决孕产妇健康差距的新途径。根据我们的经验,法律服务的使用率很高,病人往往有不止一种法律需求。未来努力衡量患者的结果,包括减少产妇压力和医疗预约出勤,将建立围产儿背景下MLP的证据基础。
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引用次数: 1
A Rare Case of Biparental Placental Mesenchymal Dysplasia: A Case Report and Literature Review [ID: 1336615] 双代胎盘间充质发育不良1例报告并文献复习[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000930060.19431.a8
Francisco Ruiloba Portilla, Megan Barragan Wolff, Montserrat Cuevas, Salvador Jiménez Chaidez, Yolotzin Valdespino Vázquez, Ximena Alexandra van Tienhoven
INTRODUCTION: Placental mesenchymal dysplasia (PMD) is a rare placental anomaly associated with high perinatal mortality; it is predominantly seen in female fetuses and very few cases have been reported. The evaluation of first- and second-trimester products of conception is of the utmost importance when assessing molar pathologies such as complete hydatidiform moles, partial hydatidiform moles, and nonmolar samples. METHODS: We report a monochorionic 46XX,69XXY pregnancy with placental mesenchymal dysplasia (PMD) with possible androgenetic biparental mosaicism etiology (Instituto Nacional de Perinatología Isidro Espinosa de los Reyes approval number P-270-18). RESULTS: The patient is a 28-year-old gravida 2, para 1, female with no notable past medical history. She had a previous pregnancy resulting in an uncomplicated abdominal delivery at 39 weeks of gestation 5 years prior. The patient was transferred to our health center at 24.2 weeks of gestation with a molar component because of USG data consistent with a probable hepatic tumor, perimembranous ventricular septal defect, and probable PMD. Ultrasound at 24.3 weeks of gestation demonstrated a single intrauterine pregnancy with one-third of the placenta appearing normal, the second third showing irregular cystic masses, and the remaining third with larger cysts. Placental mesenchymal dysplasia was diagnosed retrospectively based on data from the gross, histologic, and genetic components. CONCLUSION: To our knowledge, this is the first reported case of PMD with a 46XX,69XXY karyotype. A radical and cautious approach to PMD cases is needed because of the lack of sufficient data and reports.
简介:胎盘间充质发育不良(PMD)是一种罕见的胎盘异常,与高围产期死亡率相关;它主要见于女性胎儿,很少有病例报道。在评估臼齿病变(如完全葡萄胎、部分葡萄胎和非葡萄胎)时,妊娠早期和中期产物的评估是最重要的。方法:我们报告了一个单绒毛膜46XX,69XXY妊娠胎盘间质发育不良(PMD),可能的雄激素性双亲本嵌合病因(Instituto Nacional de Perinatología Isidro Espinosa de los Reyes批准号P-270-18)。结果:患者28岁,妊娠2期,女,1期,既往无明显病史。5年前,她有过一次妊娠,在妊娠39周时进行了一次简单的腹部分娩。由于USG数据与可能的肝肿瘤、膜外室间隔缺损和可能的PMD一致,该患者在妊娠24.2周时因磨牙成分转移到我们的健康中心。妊娠24.3周超声显示单次宫内妊娠,1 / 3胎盘正常,2 / 3出现不规则囊性团块,其余1 / 3出现较大囊肿。根据大体、组织学和遗传成分的资料回顾性诊断胎盘间充质发育不良。结论:据我们所知,这是首例核型为46XX、69XXY的PMD病例。由于缺乏足够的数据和报告,需要对PMD病例采取激进和谨慎的方法。
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引用次数: 0
Early Treatment of Gestational Diabetes Mellitus and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [ID: 1377137] 妊娠期糖尿病和前驱糖尿病的早期治疗:随机临床试验的系统回顾和meta分析[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930124.76180.1e
K. Hessami, Lorie M. Harper, A. Shamshirsaz, E. Werner
INTRODUCTION: This meta-analysis aims to determine whether early treatment of hyperglycemia in gestational diabetes mellitus (GDM) and prediabetic pregnancies improve perinatal outcomes. METHODS: PubMed/Medline, EMBASE, ClinicalTrials.gov and Web of Science were systematically searched up to June 30, 2022. Randomized clinical trials (RCTs) of early treatment for gestational diabetes mellitus (International Association of the Diabetes and Pregnancy Study Groups [IADPSG] or Carpenter and Coustan [C&C] criteria) and prediabetes (HbA1c 5.7–6.4%) before 20 weeks of gestation were considered eligible. Random-effects model meta-analysis was used to pool the odds ratios (OR) and/or mean differences (MD) with 95% CI. Furthermore, subgroup analysis was performed stratifying by indication for intervention (GDM versus prediabetic). RESULTS: Seven RCTs including 2,757 pregnant individuals, of whom 647 had positive screening before 20 weeks of gestation, were included. Of 647 individuals, 346 were allocated to early treatment and 301 to the routine treatment. There was no significant difference in terms of gestational age at delivery (MD –0.21 [95% CI: −0.44, 0.02], P=.089), rate of cesarean delivery (OR 0.93 [95% CI: 0.64, 1.34], P=.394), hypertensive disorder of pregnancy (OR 1.19 [95% CI: 0.59, 2.39], P=.341), any diabetic medication use (OR 1.31 [95% CI: 0.89, 1.93], P=.177), and neonatal hypoglycemia (OR 1.02 [95% CI: 0.50, 2.08], P=.952). However, there was a decreased risk of macrosomia (OR 0.42 [95% CI: 0.19, 0.92], P=.031) and increased need for insulin use (OR 2.23 [95% CI: 1.30, 3.84], P=.004) for early treatment group. After separate analyses on GDM and prediabetics as distinct groups, the risk of macrosomia was not decreased for GDM and prediabetic subgroups after early treatment. CONCLUSION: Treatment in early pregnancy for GDM or prediabetes does not appear to improve the maternal or neonatal outcomes.
本荟萃分析旨在确定早期治疗妊娠期糖尿病(GDM)和糖尿病前期妊娠的高血糖是否能改善围产儿结局。方法:系统检索截至2022年6月30日的PubMed/Medline、EMBASE、ClinicalTrials.gov和Web of Science。早期治疗妊娠期糖尿病(国际糖尿病与妊娠研究组协会[IADPSG]或Carpenter and Coustan [C&C]标准)和妊娠20周前前驱糖尿病(HbA1c 5.7-6.4%)的随机临床试验(rct)被认为符合条件。随机效应模型荟萃分析采用95% CI合并优势比(OR)和/或平均差异(MD)。此外,根据干预适应症(GDM与前驱糖尿病)进行亚组分析。结果:纳入7项随机对照试验,共纳入2757例孕妇,其中647例妊娠20周前筛查阳性。在647个人中,346人被分配到早期治疗,301人被分配到常规治疗。分娩时胎龄(MD = -0.21 [95% CI: - 0.44, 0.02], P= 0.089)、剖宫产率(OR = 0.93 [95% CI: 0.64, 1.34], P= 0.394)、妊娠高血压疾病(OR = 1.19 [95% CI: 0.59, 2.39], P= 0.341)、任何糖尿病药物的使用(OR 1.31 [95% CI: 0.89, 1.93], P= 0.177)和新生儿低血糖(OR 1.02 [95% CI: 0.50, 2.08], P= 0.952)均无显著差异。然而,早期治疗组发生巨大儿的风险降低(OR为0.42 [95% CI: 0.19, 0.92], P= 0.031),胰岛素使用需求增加(OR为2.23 [95% CI: 1.30, 3.84], P= 0.004)。在将GDM和前驱糖尿病作为不同的组进行单独分析后,GDM和前驱糖尿病亚组在早期治疗后发生巨大儿的风险并未降低。结论:妊娠早期治疗GDM或前驱糖尿病并不能改善产妇或新生儿的预后。
{"title":"Early Treatment of Gestational Diabetes Mellitus and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [ID: 1377137]","authors":"K. Hessami, Lorie M. Harper, A. Shamshirsaz, E. Werner","doi":"10.1097/01.aog.0000930124.76180.1e","DOIUrl":"https://doi.org/10.1097/01.aog.0000930124.76180.1e","url":null,"abstract":"INTRODUCTION: This meta-analysis aims to determine whether early treatment of hyperglycemia in gestational diabetes mellitus (GDM) and prediabetic pregnancies improve perinatal outcomes. METHODS: PubMed/Medline, EMBASE, ClinicalTrials.gov and Web of Science were systematically searched up to June 30, 2022. Randomized clinical trials (RCTs) of early treatment for gestational diabetes mellitus (International Association of the Diabetes and Pregnancy Study Groups [IADPSG] or Carpenter and Coustan [C&C] criteria) and prediabetes (HbA1c 5.7–6.4%) before 20 weeks of gestation were considered eligible. Random-effects model meta-analysis was used to pool the odds ratios (OR) and/or mean differences (MD) with 95% CI. Furthermore, subgroup analysis was performed stratifying by indication for intervention (GDM versus prediabetic). RESULTS: Seven RCTs including 2,757 pregnant individuals, of whom 647 had positive screening before 20 weeks of gestation, were included. Of 647 individuals, 346 were allocated to early treatment and 301 to the routine treatment. There was no significant difference in terms of gestational age at delivery (MD –0.21 [95% CI: −0.44, 0.02], P=.089), rate of cesarean delivery (OR 0.93 [95% CI: 0.64, 1.34], P=.394), hypertensive disorder of pregnancy (OR 1.19 [95% CI: 0.59, 2.39], P=.341), any diabetic medication use (OR 1.31 [95% CI: 0.89, 1.93], P=.177), and neonatal hypoglycemia (OR 1.02 [95% CI: 0.50, 2.08], P=.952). However, there was a decreased risk of macrosomia (OR 0.42 [95% CI: 0.19, 0.92], P=.031) and increased need for insulin use (OR 2.23 [95% CI: 1.30, 3.84], P=.004) for early treatment group. After separate analyses on GDM and prediabetics as distinct groups, the risk of macrosomia was not decreased for GDM and prediabetic subgroups after early treatment. CONCLUSION: Treatment in early pregnancy for GDM or prediabetes does not appear to improve the maternal or neonatal outcomes.","PeriodicalId":19405,"journal":{"name":"Obstetrics & Gynecology","volume":"65 1","pages":"32S - 32S"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84413357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Policies Aiming to Restrict Ultrasound Use [ID: 1375832] 限制超声波使用的政策效果[ID: 1375832]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000929700.03453.26
Anna Hemminger, J. Louis, Corley Rachelle Price
INTRODUCTION: During the early months of the COVID-19 pandemic, policies were implemented that sought to reduce in-person prenatal visits and ultrasounds. We sought to evaluate the effect of those policies on the rate of diagnosed fetal growth restriction and infant low birth weight. METHODS: We performed a cohort study of patients delivered at an academic center. Participants who received prenatal care during the time period of restricted visits were matched in a 1:1 ratio to patients receiving care during an equivalent time period when there were no such restrictions (group I: July 1, 2019, to December 31, 2019; and group II: March 23, 2020, to September 23, 2020). Medical records were reviewed for clinical and demographic characteristics. Neonatal morbidity was defined as any of the following: stillbirth, neonatal death, preterm birth, neonatal intensive care unit admission, low birth weight. Data were analyzed using chi-square and Mann-Whitney U test where appropriate. P<.05 was significant. RESULTS: Our cohort included 580 patients. Overall, the group had a 13% preterm birth rate, 8.2% were diagnosed with fetal growth restriction, and 26% had the composite neonatal morbidity. All patients in the cohort had at least one ultrasound. Compared to group I, group II had more individuals who had only one ultrasound during the pregnancy (3.1 versus 0%, P=.004), but overall the group had more total ultrasounds performed (1.5 [1–3] versus 1 [1–2], P=.02) and had more patients who required fetal surveillance for maternal and fetal conditions (56 versus 44, P=.014). Group II was more likely to have a neonatal demise (1.4 versus 0.3%, P<.01), but there was no difference in the rate of prenatal diagnosis of fetal growth restriction or low birth weight. CONCLUSION: Policies to reduce prenatal ultrasounds were not effective in reducing ultrasounds performed, and there was no difference in the diagnosis of fetal growth restriction despite an increase in comorbidity.
导语:在COVID-19大流行的最初几个月,实施了旨在减少亲自产前检查和超声波检查的政策。我们试图评估这些政策对诊断出胎儿生长受限和婴儿低出生体重率的影响。方法:我们对在某学术中心分娩的患者进行了一项队列研究。在限制访问期间接受产前护理的参与者与在没有此类限制的等效时间段接受护理的患者按1:1的比例进行匹配(第一组:2019年7月1日至2019年12月31日;第二组:2020年3月23日至2020年9月23日)。审查了医疗记录的临床和人口特征。新生儿发病率定义为以下任何一种:死产、新生儿死亡、早产、新生儿重症监护病房入院、低出生体重。数据分析采用卡方检验和Mann-Whitney U检验。P <。0.05显著。结果:我们的队列包括580例患者。总体而言,该组有13%的早产率,8.2%被诊断为胎儿生长受限,26%有新生儿综合发病率。队列中的所有患者都至少做过一次超声波检查。与I组相比,II组在怀孕期间只进行一次超声检查的个体较多(3.1%对0%,P= 0.004),但总体而言,II组进行了更多的超声波检查(1.5次[1 - 3]对1次[1 - 2],P= 0.02),并且有更多的患者需要对母胎和胎儿状况进行监测(56次对44次,P= 0.014)。II组新生儿死亡的可能性更高(1.4% vs 0.3%, P< 0.01),但产前诊断胎儿生长受限或低出生体重的比例没有差异。结论:减少产前超声检查的政策在减少超声检查方面没有效果,尽管合并症增加,但胎儿生长受限的诊断没有差异。
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引用次数: 0
Timing of Fetal Growth Restriction Development in Patients With Preeclampsia [ID: 1363469] 子痫前期胎儿生长发育受限的时机研究[ID: 1363469]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000931016.50292.eb
Matilda Francis, T. Kawakita, Juliana Martins
INTRODUCTION: Preeclampsia (PEC) and fetal growth restriction (FGR) share common pathophysiology of placental insufficiency. In pregnancies complicated by PEC, the incidence of FGR increases significantly. We sought to examine the timing of FGR development in patients with PEC. METHODS: This was a retrospective cohort study of patients with PEC and singleton pregnancy who delivered at 23 weeks or greater. Patients who had been diagnosed with FGR prior to PEC diagnosis, those who were diagnosed with FGR at the same time as PEC, and those who delivered immediately after PEC diagnosis were excluded. Demographics were compared between patients with FGR and those without FGR. We plotted Kaplan-Meier curves for the interval from the diagnosis of PEC to the development of FGR. A Cox proportional hazards model was used to estimate the adjusted hazard ratios (HRs) for FGR. Our IRB approved this analysis. RESULTS: Of 392 patients with PEC, 31 (7.9%) developed FGR. Compared to patients who did not develop FGR, patients who developed FGR were more likely to have early-onset PEC and lower maternal weight and were less likely to have gestational diabetes (P<.05). The incidence rate of FGR increased by 11.6% each week from the PEC diagnosis. Compared to patients with late-onset PEC, those with early-onset PEC had a significantly higher cumulative incidence of FGR (P<.01). The Cox proportional hazards model showed that early-onset PEC was associated with FGR (adjusted HR 4.12, 95% CI 1.19–14.33) compared to late-onset PEC. CONCLUSION: Patients with early-onset PEC had a significantly higher incidence of FGR compared to those with late-onset PEC. There was a high cumulative incidence rate of FGR in patients with early-onset PEC. Patients with PEC should be followed by serial fetal growth ultrasound.
子痫前期(PEC)和胎儿生长受限(FGR)有共同的胎盘功能不全病理生理。在合并PEC的妊娠中,FGR的发生率显著增加。我们试图研究在PEC患者中FGR发展的时间。方法:这是一项回顾性队列研究,研究对象是分娩时间在23周或更大的PEC和单胎妊娠患者。排除在PEC诊断前已诊断为FGR的患者、与PEC同时诊断为FGR的患者以及PEC诊断后立即分娩的患者。比较FGR患者和非FGR患者的人口统计学特征。我们绘制了从诊断为PEC到发展为FGR的时间间隔的Kaplan-Meier曲线。采用Cox比例风险模型估计FGR的调整风险比(hr)。我们的IRB批准了这个分析。结果:392例PEC患者中,31例(7.9%)发生FGR。与未发生FGR的患者相比,发生FGR的患者更容易发生早发性PEC和较低的母亲体重,更不容易发生妊娠糖尿病(P< 0.05)。自PEC诊断以来,FGR的发病率每周增加11.6%。与迟发性PEC患者相比,早发性PEC患者FGR累积发生率显著高于晚发性PEC患者(P< 0.01)。Cox比例风险模型显示,与迟发性PEC相比,早发性PEC与FGR相关(校正HR 4.12, 95% CI 1.19-14.33)。结论:早发性PEC患者FGR发生率明显高于晚发性PEC患者。早发性PEC患者FGR的累积发病率较高。患有PEC的患者应进行连续的胎儿生长超声检查。
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引用次数: 0
Emergency Department Readmission for Early Pregnancy Concerns Among Patients Who Speak Spanish [ID: 1366721] 会说西班牙语的早期妊娠患者的再入院问题[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000929904.21738.96
Gabrielle Taper, M. Álvarez, L. Thaxton, S. Tristan
INTRODUCTION: The purpose of this study was to compare readmission rates for early pregnancy concerns in the emergency department (ED) among patients that speak English versus Spanish as their primary language. METHODS: From January 1, 2020 to June 1, 2021, we conducted a chart review to identify pregnant patients presenting to the ED using ICD-10 codes for pregnancy and first-trimester diagnoses (n=383). Charts were excluded if pregnancy was beyond 13 weeks or an ultrasound-confirmed ectopic pregnancy. Readmission was a separate ED encounter during the first trimester of that same pregnancy. Preventable readmission was one that could have been prevented if the patient had received correct counseling, diagnosis, or management at the index admission. Our primary outcome was frequency of ED readmission among English versus Spanish speakers. This protocol was approved for IRB exemption by the University of Texas. RESULTS: Threatened abortion was the most common diagnosis among both groups. Readmissions were more frequent among Spanish speakers (40% versus 26% [P=.01]). Preventable readmissions were more common among Spanish speakers (31% versus 25%). The majority of preventable readmissions (81%) among Spanish speakers could have been prevented if correct management was offered, compared to 25% in English speakers (P=.03). CONCLUSION: Spanish and English speakers present with similar types of early pregnancy concerns, but Spanish speakers are not offered management of early pregnancy concerns at the same frequency. Standardization of care for early pregnancy concerns in the ED may help reduce language-based disparities in quality and equity of care.
简介:本研究的目的是比较以英语和西班牙语为主要语言的早期妊娠患者在急诊科(ED)的再入院率。方法:从2020年1月1日至2021年6月1日,我们进行了一项图表回顾,以确定使用ICD-10代码进行妊娠和早期妊娠诊断的妊娠患者(n=383)。如果怀孕超过13周或超声确认宫外孕,则排除图表。再入院是一个单独的ED遭遇在同一怀孕的前三个月。可预防的再入院是指如果患者在入院时接受了正确的咨询、诊断或管理,就可以预防的再入院。我们的主要结局是英语和西班牙语患者再入院的频率。该方案已获得德克萨斯大学IRB豁免批准。结果:先兆流产是两组中最常见的诊断。西班牙语患者的再入院率更高(40% vs 26% [P= 0.01])。可预防的再入院在说西班牙语的人群中更为常见(31%对25%)。如果提供正确的管理,西班牙语患者中大多数可预防的再入院(81%)是可以避免的,而英语患者中这一比例为25% (P=.03)。结论:西班牙语和英语患者出现的早孕问题类型相似,但西班牙语患者未获得相同频率的早孕问题管理。在急诊科对早孕问题的标准化护理可能有助于减少基于语言的护理质量和公平性的差异。
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引用次数: 0
Elagolix Plus Add-Back Consistently Improves Uterine Fibroids-Associated Bleeding and Nonbleeding Symptoms Across Subpopulations [ID: 1368059] Elagolix Plus Add-Back持续改善子宫肌瘤相关出血和非出血症状[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000931260.84787.fb
J. Simon, S. Jewell, Moming Li, J. Ng, B. Pinsky
INTRODUCTION: Patients with heavy menstrual bleeding (HMB) associated with uterine fibroids (UFs) have significantly improved menstrual blood loss (MBL) when taking elagolix+estradiol/norethindrone acetate add-back therapy (ELA+AB) versus placebo. However, data on the effect of ELA+AB on nonbleeding symptoms are limited. METHODS: This post hoc analysis from the duplicate, IRB-approved, randomized, double-blind, placebo-controlled, 6-month, phase 3 Elaris UF-1 and UF-2 studies (NCT02654054 and NCT02691494) evaluated the Patients Global Impression of Change (PGIC). Patients rated symptom change for menstrual bleeding (MB) and nonbleeding symptoms on a 7-point scale from “very much improved” (1) to “very much worse” (7). RESULTS: By 6 months, scores for the PGIC-MB and the domains of “abdominal or pelvic pain,” “abdominal or pelvic pressure,” “abdominal or pelvic cramping,” “back pain,” and “abdominal bloating” were significantly better (P<.001 for all; no adjustment for multiple comparisons were made) in the ELA+AB versus placebo groups, regardless of patient age (<40 years, 40 to <45 years, ≥45 years), baseline MBL (less than median [187.0 mL], greater than or equal to median), International Federation of Gynecology and Obstetrics (FIGO) classification (0–3, 4, 5–8), or baseline uterine volume (less than median [356.5 cm3], greater than or equal to median). Patients receiving ELA+AB reported PGIC domain scores that consistently exceeded “minimally improved” (≤3) and often reached or exceeded “much improved” (≤2) by 6 months. CONCLUSION: ELA+AB provides better bleeding and nonbleeding symptom improvement versus placebo for patients with HMB associated with UFs, regardless of subpopulation investigated. In all populations, PGIC-MB and domain scores consistently reached or exceeded “much improved” by 6 months with ELA+AB.
子宫肌瘤(UFs)相关的重度月经出血(HMB)患者在接受elagolix+雌二醇/醋酸去甲炔诺酮加回治疗(ELA+AB)时,与安慰剂相比,月经失血量(MBL)显著改善。然而,ELA+AB对非出血症状的影响数据有限。方法:这项来自重复、irb批准、随机、双盲、安慰剂对照、6个月的3期Elaris UF-1和UF-2研究(NCT02654054和NCT02691494)的事后分析评估了患者整体变化印象(PGIC)。患者对月经出血(MB)和非出血症状的症状变化进行评分,评分范围为7分,从“非常改善”(1)到“非常恶化”(7)。结果:6个月时,pgc -MB和“腹部或盆腔疼痛”、“腹部或盆腔压力”、“腹部或盆腔痉挛”、“背痛”和“腹胀”的评分明显改善(P< 0.05)。001代表所有人;ELA+AB组与安慰剂组相比,无论患者年龄(<40岁,40至<45岁,≥45岁),基线MBL(小于中位数[187.0 mL],大于或等于中位数),国际妇产科学联合会(FIGO)分类(0 - 3,4,5 - 8),或基线子宫体积(小于中位数[356.5 cm3],大于或等于中位数)。接受ELA+AB治疗的患者报告PGIC结构域评分在6个月时持续超过“最低改善”(≤3),并经常达到或超过“非常改善”(≤2)。结论:与安慰剂相比,ELA+AB对合并UFs的HMB患者的出血和非出血症状改善更好,无论调查的亚群如何。在所有人群中,pgc - mb和域评分在ELA+AB治疗6个月后一直达到或超过“显著改善”。
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引用次数: 0
Multidisciplinary High-Risk Obstetrical Simulation Improves Periviability Counseling [ID: 1366577] 多学科高危产科模拟改善临产期咨询[ID: 1366577]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930872.37320.85
Sabrina C Burn, Lou Clark, Sarah Cross, Julie Johnson Rolfes, Joseph M. Miller
INTRODUCTION: The objective of this study was to determine the feasibility and effectiveness of multidisciplinary simulation in the development of skills required for high-risk periviability counseling. METHODS: Trainees were recruited from the University of Minnesota to participate in a faculty-observed standardized high-risk periviability patient simulation. The simulation was unique in that multiple specialties collaborated in the evaluation, counseling, and management of their patient. Trainees completed presimulation and postsimulation knowledge and comfort self-assessment surveys to evaluate skill improvement and merit of the study. Evaluations were also performed by faculty and simulated patients. An IRB waiver was obtained. RESULTS: Of the 18 participants, there were 6 neonatal intensive care unit fellows, 2 maternal–fetal medicine fellows, and 10 senior ob-gyn residents. Presimulation and postsimulation Likert surveys with scale 1–5, showed improvement in the ability of trainees to elicit patient values and tailor their conversations (pre-mean 2.84, SD 0.67; post-mean 3.39, SD 0.59), use patient-centered language (pre-mean 3.37, SD 0.74; post-mean 3.89, SD 0.57), ally with patients (pre-mean 3.37, SD 0.93; post-mean 3.94, SD 0.52), provide difficult medical information (pre-mean 3.32, SD 1.03; post-mean 3.67, SD 0.58), discuss medical uncertainty (pre-mean 3.11, SD 0.79; post-mean 3.50, SD 0.60), and understand their own implicit biases (pre-mean 3.26, SD 0.71; post-mean 3.50, SD 0.60). Trainees also reported an increased use of hopeful language that did not focus on statistical outcomes (pre-mean 3.00, SD 0.65; post-mean 3.33, SD 0.47) and discussion of multiple management options, including comfort cares (pre-mean 2.05, SD 1.05; post-mean 2.94, SD 0.85). The post surveys also reflected that trainees felt the simulation was useful, provided a safe environment to practice counseling (mean 4.83, SD 0.37), and better prepared them for future high-risk obstetrical scenarios (mean 4.83, SD 0.37). CONCLUSION: Multidisciplinary high-risk obstetrical simulation offers a unique opportunity for trainees to receive structured training and improve their ability to collaboratively counsel in rare high-risk obstetrical scenarios.
简介:本研究的目的是确定多学科模拟在高风险生存咨询所需技能发展中的可行性和有效性。方法:从明尼苏达大学招募受训者参加教师观察的标准化高危患者模拟。模拟的独特之处在于多个专业在评估、咨询和管理患者方面进行了合作。学员完成了模拟前和模拟后的知识和舒适度自我评估调查,以评估技能的提高和研究的价值。教师和模拟患者也进行了评估。获得了内部审查委员会的豁免。结果:18名参与者中,新生儿重症监护病房研究员6名,母胎医学研究员2名,高级妇产科住院医师10名。模拟前和模拟后李克特量表1-5的调查显示,受训者引出患者价值观和定制对话的能力有所提高(前均值2.84,标准差0.67;后均值3.39,SD 0.59),使用以患者为中心的语言(前均值3.37,SD 0.74;后均值3.89,SD 0.57),与患者一致(前均值3.37,SD 0.93;后均值3.94,SD 0.52),提供困难的医疗信息(前均值3.32,SD 1.03;后均值3.67,SD 0.58),讨论医疗不确定性(前均值3.11,SD 0.79;后均值3.50,SD 0.60),并了解自己的内隐偏见(前均值3.26,SD 0.71;后均值3.50,标准差0.60)。受训人员还报告说,他们更多地使用不关注统计结果的充满希望的语言(平均前值3.00,标准差0.65;后均值3.33,SD 0.47),并讨论了多种管理方案,包括舒适护理(前均值2.05,SD 1.05;后均值2.94,标准差0.85)。后期调查也反映受训人员认为模拟是有用的,提供了一个安全的环境来练习咨询(平均4.83,SD 0.37),并更好地为未来的高危产科情况做好准备(平均4.83,SD 0.37)。结论:多学科高危产科模拟为受训者提供了一个独特的机会,可以接受结构化的培训,提高他们在罕见的高危产科情况下的协作咨询能力。
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引用次数: 0
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Obstetrics & Gynecology
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