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Utility of Ferritin at Registration as a Screen for Development of Anemia in Third Trimester [ID: 1362276] 铁蛋白在妊娠晚期贫血筛查中的应用[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930920.33049.bb
Isabelle Crary, Chloe Koski, Asha Rijhsinghani
INTRODUCTION: The objective of this study was to assess the utility of screening ferritin (<20 weeks of gestation) in pregnant patients on hemoglobin (Hgb) and hematocrit (Hct) later in gestation. METHODS: Pregnant patients who received nondiagnostic ferritin labs at less than 20 weeks of gestation from 2019 to 2021 were retrospectively identified. Patients were excluded if ferritin testing was conducted for diagnostic purposes or if the patient had a history of anemia. Labs at the time of registration, 28 weeks of gestation, and at delivery were analyzed. Anemia was defined as Hgb less than 11 g/dL. This study was approved by the University of Washington IRB, and patient consent was waived. RESULTS: Forty-four patients underwent routine ferritin screening at registration, with ferritin levels ranging from 10 to 136 ng/mL (average 52.5 ng/mL). Average Hgb/Hct at registration were 12.6 g/dL and 37.3%, respectively. At 28 weeks of gestation, Hgb/Hct were obtained on 42 patients, of whom 9 patients were diagnosed with anemia. Patients diagnosed with anemia had a screening ferritin level of 33.6 ng/mL, and nonanemic patients had a ferritin level of 57.4 ng/mL ( P =.1). When a cutoff of 50 ng/mL was studied to compare patients with “low” versus “normal” ferritin, ferritin less than or equal to 50 ng/mL had significantly lower Hgb levels at 28 weeks compared to those with ferritin greater than 50 ng/mL ( P =.013). On labor and delivery (L&D), Hgb/Hct was obtained on 44 patients, and 14 were diagnosed with anemia. Anemic patients on L&D had significantly lower screening ferritin compared to nonanemic, 31.9 and 62.2 ng/mL, respectively ( P =.016). CONCLUSION: Ferritin screening in early pregnancy may help predict lower Hgb in later gestation. Using a higher ferritin cutoff of 50 ng/mL in early pregnancy for identifying patients at risk for anemia in the third trimester may be warranted. Larger prospective studies are needed to evaluate further the utility of ferritin screening.
简介:本研究的目的是评估妊娠患者在妊娠后期对血红蛋白(Hgb)和红细胞压积(Hct)筛查铁蛋白(妊娠20周)的效用。方法:回顾性分析2019年至2021年妊娠未满20周接受非诊断性铁蛋白检测的孕妇。如果铁蛋白检测用于诊断目的或患者有贫血史,则排除患者。对登记时、妊娠28周和分娩时的实验室进行分析。贫血定义为血红蛋白低于11 g/dL。本研究已获得华盛顿大学伦理委员会的批准,患者已放弃同意。结果:44例患者在登记时进行了常规铁蛋白筛查,铁蛋白水平范围为10至136 ng/mL(平均52.5 ng/mL)。登记时平均Hgb/Hct分别为12.6 g/dL和37.3%。妊娠28周时,42例患者获得Hgb/Hct,其中9例诊断为贫血。诊断为贫血的患者筛查铁蛋白水平为33.6 ng/mL,非贫血患者筛查铁蛋白水平为57.4 ng/mL (P = 1)。当研究以50 ng/mL的临界值来比较铁蛋白“低”与“正常”的患者时,与铁蛋白大于50 ng/mL的患者相比,铁蛋白小于或等于50 ng/mL的患者在28周时Hgb水平显著降低(P = 0.013)。在分娩(L&D)时,44例患者获得Hgb/Hct,其中14例诊断为贫血。与非贫血患者相比,服用L&D的贫血患者筛查铁蛋白水平明显降低,分别为31.9和62.2 ng/mL (P = 0.016)。结论:妊娠早期铁蛋白筛查有助于预测妊娠后期Hgb的降低。在妊娠早期使用较高的铁蛋白临界值(50 ng/mL)来识别妊娠晚期有贫血风险的患者可能是有保证的。需要更大的前瞻性研究来进一步评估铁蛋白筛选的效用。
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引用次数: 0
The Effect of Advanced Maternal Age on Adverse Outcomes Among Forceps-Assisted Vaginal Deliveries [ID: 1355950] 高龄产妇对产钳辅助阴道分娩不良结局的影响[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930448.60219.0b
Elizabeth Cochrane, Angela Bianco, Chelsea DeBolt, Tahera Doctor, Sarah Roger, Kelly Wang
INTRODUCTION: Delivery rates among patients of advanced maternal age (AMA) are increasing. Prior studies have shown that AMA is associated with increased pregnancy risks and adverse outcomes. This study’s objective was to evaluate whether AMA is associated with an increase in obstetric anal sphincter injury (OASIS) rates among patients who undergo forceps-assisted vaginal deliveries (FAVDs). METHODS: This was an IRB-approved, retrospective cohort study of singleton gestations with FAVD at a single institution between 2017 and 2021. Primary outcome was rate of OASIS among patients with and without AMA. Secondary outcomes included quantitative blood loss (QBL), neonatal composite of subgaleal and cephalohematoma (adverse neonatal composite), and neonatal intensive care unit (NICU) admission. Quantitative blood loss was assessed using Mann-Whitney U test. Remaining outcomes were assessed using multivariate logistic regression models while adjusting for provider clustering and confounding patient characteristics including episiotomy and birth weight. RESULTS: Nine hundred eighty-three records were included, 704 non-AMA and 279 AMA. Patients of AMA were more likely to be Caucasian and were less likely to be Hispanic, nulliparous, experience spontaneous labor, and undergo episiotomy. Patients of AMA did not demonstrate increased odds of OASIS compared to non-AMA patients (odds ratio [OR] 1.21 [0.78, 1.89]). When age was assessed continuously, there was no association between increasing age and rates of OASIS (OR 1.02 [0.98, 1.06]). There was no statistically significant difference in QBL among the two groups (357.0 versus 350.0 cc, P =.20), NICU admission or adverse neonatal composite. CONCLUSION: Advanced maternal age does not appear to be a risk factor for OASIS or other adverse outcomes in patients undergoing FAVD.
导读:高龄产妇(AMA)的分娩率正在上升。先前的研究表明,AMA与妊娠风险增加和不良后果有关。本研究的目的是评估AMA是否与产钳辅助阴道分娩(FAVDs)患者产科肛门括约肌损伤(OASIS)发生率的增加有关。方法:这是一项经irb批准的回顾性队列研究,研究对象是2017年至2021年在单一机构发生的单胎妊娠伴FAVD。主要结局是有或无AMA患者的OASIS发生率。次要结局包括定量失血量(QBL)、新生儿galeal下和头血肿复合(不良新生儿复合)和新生儿重症监护病房(NICU)入住情况。定量失血量采用Mann-Whitney U试验。在调整提供者聚类和混淆患者特征(包括外阴切开术和出生体重)的同时,使用多变量逻辑回归模型评估其余结果。结果:共纳入983例,其中非AMA 704例,AMA 279例。AMA患者多为白种人,西班牙裔、无产、自然分娩和会阴切开术患者较少。与非AMA患者相比,AMA患者的OASIS发生率没有增加(比值比[OR] 1.21[0.78, 1.89])。当持续评估年龄时,年龄的增加与OASIS发生率之间没有关联(OR为1.02[0.98,1.06])。两组间QBL (357.0 vs 350.0 cc, P = 0.20)、新生儿重症监护病房入院或新生儿不良综合情况均无统计学差异。结论:高龄产妇似乎不是FAVD患者发生OASIS或其他不良结局的危险因素。
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引用次数: 0
Evaluation of a Youth-Led Intervention to Improve Adolescent Sexual and Reproductive Health Knowledge, Efficacy, and Autonomy [ID: 1377919] 青少年主导干预提高青少年性健康和生殖健康知识、有效性和自主性的评估[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000931092.06067.d0
Saumya S. Sao, J. Coleman, Lillee Izadi, Runzhi Wang, R. Yu
INTRODUCTION: Youth bear a disproportionate burden of sexually transmitted infections (STIs) and unintended pregnancy. Knowledge about sexual and reproductive health (SRH) is low among this population, and youth face numerous barriers to care. We sought to develop and assess a youth-led intervention to increase youth SRH knowledge, self-efficacy, and autonomy, which are key indicators in developing positive sexual health behaviors and skills to feel confident in accessing health services. METHODS: Nine interactive, youth-led, 2-hour sessions were held virtually or in-person over 9 months. Session topics included human immunodeficiency virus and STIs, contraception, reproductive anatomy, menstrual health, healthy relationships, sexual decision-making, sexual violence, substance use, goal setting, gender identity and sexuality, and navigating health care services as an adolescent. Monetary compensation and transportation were provided. Sexual and reproductive health knowledge, self-efficacy, and autonomy were assessed using validated scales via an electronic questionnaire before and after implementing the intervention (IRB approved). Paired t tests were used to assess intervention effect. RESULTS: Thirty-seven participants with a mean age of 15.8 years (SD 1.13) were enrolled. All lived in the greater Baltimore area, and the majority self-identified as female. 52% were Black/African American, 28% Asian/Asian American, 12% White, and 8% Hispanic/Latino. Average attendance across sessions was 88%. Participants showed improvement in SRH knowledge (P=.02), advocacy and self-efficacy (P<.001), and personal safety and autonomy (P<.01). They reported increased comfort using trusted sites to procure SRH information (P<.01). CONCLUSION: A youth-led SRH intervention effectively increased SRH knowledge, self-efficacy, and autonomy. Further work should be done to explore the effects and expansion of peer-to-peer SRH education.
青少年承受着性传播感染和意外怀孕的不成比例的负担。这一人口对性健康和生殖健康(SRH)的了解很低,青年在获得护理方面面临许多障碍。我们试图发展和评估一项由青年主导的干预措施,以提高青年性健康和生殖健康知识、自我效能和自主性,这些是发展积极性健康行为和技能的关键指标,使他们对获得卫生服务充满信心。方法:在9个月的时间里,以虚拟或面对面的方式举行了9次互动式、青年主导、2小时的会议。会议主题包括人类免疫缺陷病毒和性传播感染、避孕、生殖解剖学、月经健康、健康的关系、性决策、性暴力、药物使用、目标设定、性别认同和性行为,以及青少年如何获得保健服务。提供了金钱补偿和交通。在实施干预(IRB批准)之前和之后,使用有效的量表通过电子问卷对性健康和生殖健康知识、自我效能和自主性进行评估。采用配对t检验评价干预效果。结果:37名参与者入组,平均年龄15.8岁(SD 1.13)。所有人都住在大巴尔的摩地区,大多数人自认为是女性。52%是黑人/非裔美国人,28%是亚裔/亚裔美国人,12%是白人,8%是西班牙裔/拉丁裔。各届会议的平均出勤率为88%。参与者在SRH知识(P=.02)、倡导和自我效能(P<.001)、人身安全和自主性(P<.01)方面均有改善。他们报告使用可信网站获取SRH信息增加了舒适度(P< 0.01)。结论:青年主导的性生殖健康干预有效地提高了性生殖健康知识、自我效能和自主性。应进一步探索点对点性健康与生殖健康教育的效果和推广。
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引用次数: 0
Timing of Fetal Growth Restriction Development in Patients With Preeclampsia [ID: 1363469] 子痫前期胎儿生长发育受限的时机研究[ID: 1363469]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000931016.50292.eb
Matilda Francis, T. Kawakita, Juliana Martins
INTRODUCTION: Preeclampsia (PEC) and fetal growth restriction (FGR) share common pathophysiology of placental insufficiency. In pregnancies complicated by PEC, the incidence of FGR increases significantly. We sought to examine the timing of FGR development in patients with PEC. METHODS: This was a retrospective cohort study of patients with PEC and singleton pregnancy who delivered at 23 weeks or greater. Patients who had been diagnosed with FGR prior to PEC diagnosis, those who were diagnosed with FGR at the same time as PEC, and those who delivered immediately after PEC diagnosis were excluded. Demographics were compared between patients with FGR and those without FGR. We plotted Kaplan-Meier curves for the interval from the diagnosis of PEC to the development of FGR. A Cox proportional hazards model was used to estimate the adjusted hazard ratios (HRs) for FGR. Our IRB approved this analysis. RESULTS: Of 392 patients with PEC, 31 (7.9%) developed FGR. Compared to patients who did not develop FGR, patients who developed FGR were more likely to have early-onset PEC and lower maternal weight and were less likely to have gestational diabetes (P<.05). The incidence rate of FGR increased by 11.6% each week from the PEC diagnosis. Compared to patients with late-onset PEC, those with early-onset PEC had a significantly higher cumulative incidence of FGR (P<.01). The Cox proportional hazards model showed that early-onset PEC was associated with FGR (adjusted HR 4.12, 95% CI 1.19–14.33) compared to late-onset PEC. CONCLUSION: Patients with early-onset PEC had a significantly higher incidence of FGR compared to those with late-onset PEC. There was a high cumulative incidence rate of FGR in patients with early-onset PEC. Patients with PEC should be followed by serial fetal growth ultrasound.
子痫前期(PEC)和胎儿生长受限(FGR)有共同的胎盘功能不全病理生理。在合并PEC的妊娠中,FGR的发生率显著增加。我们试图研究在PEC患者中FGR发展的时间。方法:这是一项回顾性队列研究,研究对象是分娩时间在23周或更大的PEC和单胎妊娠患者。排除在PEC诊断前已诊断为FGR的患者、与PEC同时诊断为FGR的患者以及PEC诊断后立即分娩的患者。比较FGR患者和非FGR患者的人口统计学特征。我们绘制了从诊断为PEC到发展为FGR的时间间隔的Kaplan-Meier曲线。采用Cox比例风险模型估计FGR的调整风险比(hr)。我们的IRB批准了这个分析。结果:392例PEC患者中,31例(7.9%)发生FGR。与未发生FGR的患者相比,发生FGR的患者更容易发生早发性PEC和较低的母亲体重,更不容易发生妊娠糖尿病(P< 0.05)。自PEC诊断以来,FGR的发病率每周增加11.6%。与迟发性PEC患者相比,早发性PEC患者FGR累积发生率显著高于晚发性PEC患者(P< 0.01)。Cox比例风险模型显示,与迟发性PEC相比,早发性PEC与FGR相关(校正HR 4.12, 95% CI 1.19-14.33)。结论:早发性PEC患者FGR发生率明显高于晚发性PEC患者。早发性PEC患者FGR的累积发病率较高。患有PEC的患者应进行连续的胎儿生长超声检查。
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引用次数: 0
A Rare Case of Biparental Placental Mesenchymal Dysplasia: A Case Report and Literature Review [ID: 1336615] 双代胎盘间充质发育不良1例报告并文献复习[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000930060.19431.a8
Francisco Ruiloba Portilla, Megan Barragan Wolff, Montserrat Cuevas, Salvador Jiménez Chaidez, Yolotzin Valdespino Vázquez, Ximena Alexandra van Tienhoven
INTRODUCTION: Placental mesenchymal dysplasia (PMD) is a rare placental anomaly associated with high perinatal mortality; it is predominantly seen in female fetuses and very few cases have been reported. The evaluation of first- and second-trimester products of conception is of the utmost importance when assessing molar pathologies such as complete hydatidiform moles, partial hydatidiform moles, and nonmolar samples. METHODS: We report a monochorionic 46XX,69XXY pregnancy with placental mesenchymal dysplasia (PMD) with possible androgenetic biparental mosaicism etiology (Instituto Nacional de Perinatología Isidro Espinosa de los Reyes approval number P-270-18). RESULTS: The patient is a 28-year-old gravida 2, para 1, female with no notable past medical history. She had a previous pregnancy resulting in an uncomplicated abdominal delivery at 39 weeks of gestation 5 years prior. The patient was transferred to our health center at 24.2 weeks of gestation with a molar component because of USG data consistent with a probable hepatic tumor, perimembranous ventricular septal defect, and probable PMD. Ultrasound at 24.3 weeks of gestation demonstrated a single intrauterine pregnancy with one-third of the placenta appearing normal, the second third showing irregular cystic masses, and the remaining third with larger cysts. Placental mesenchymal dysplasia was diagnosed retrospectively based on data from the gross, histologic, and genetic components. CONCLUSION: To our knowledge, this is the first reported case of PMD with a 46XX,69XXY karyotype. A radical and cautious approach to PMD cases is needed because of the lack of sufficient data and reports.
简介:胎盘间充质发育不良(PMD)是一种罕见的胎盘异常,与高围产期死亡率相关;它主要见于女性胎儿,很少有病例报道。在评估臼齿病变(如完全葡萄胎、部分葡萄胎和非葡萄胎)时,妊娠早期和中期产物的评估是最重要的。方法:我们报告了一个单绒毛膜46XX,69XXY妊娠胎盘间质发育不良(PMD),可能的雄激素性双亲本嵌合病因(Instituto Nacional de Perinatología Isidro Espinosa de los Reyes批准号P-270-18)。结果:患者28岁,妊娠2期,女,1期,既往无明显病史。5年前,她有过一次妊娠,在妊娠39周时进行了一次简单的腹部分娩。由于USG数据与可能的肝肿瘤、膜外室间隔缺损和可能的PMD一致,该患者在妊娠24.2周时因磨牙成分转移到我们的健康中心。妊娠24.3周超声显示单次宫内妊娠,1 / 3胎盘正常,2 / 3出现不规则囊性团块,其余1 / 3出现较大囊肿。根据大体、组织学和遗传成分的资料回顾性诊断胎盘间充质发育不良。结论:据我们所知,这是首例核型为46XX、69XXY的PMD病例。由于缺乏足够的数据和报告,需要对PMD病例采取激进和谨慎的方法。
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引用次数: 0
Racial Differences in Severe Maternal Morbidity Exist for Tricare Beneficiaries [ID: 1377133] Tricare受益人严重产妇发病率的种族差异[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000930252.58330.98
E. Lyon, Veronica M Gonzalez-Brown, E. Keyser, Katherine Porter, R. Tindal
INTRODUCTION: Maternal morbidity and mortality rates in the United States have increased in the last two decades with a disproportionate effect on women of color. Military Tricare coverage models universal health care access; however, in studies looking at births in military treatment facilities, disparities still exist for women of color. This study analyzes maternal delivery outcomes for all women with Tricare coverage including deliveries in the civilian sector. METHODS: Data from 6.2 million births in the Centers for Disease Control and Prevention WONDER Linked Birth/Infant Death Records for 2017–2019 were analyzed for all-cause morbidity (transfusions, perineal lacerations, uterine rupture, unplanned hysterectomy, and intensive care unit admissions), severe maternal morbidity (SMM) (excludes lacerations), and SMM excluding transfusion. Risk ratios were calculated comparing overall maternal morbidity rates between Tricare, Medicaid, self-pay, and private insurance. In addition, risk ratios were calculated between insurance types stratified by race. RESULTS: Compared to private insurance, Tricare insurance had significantly reduced risk of all-cause maternal morbidity. Compared to White women, Black women with Tricare and all other insurances had a decreased risk of all-cause morbidity, but a significantly increased risk of SMM and SMM without transfusion. Asian women had significant increased risk of all-cause, SMM and SMM without transfusion. There was no significant difference in the risk of morbidity for women of color with Tricare insurance compared to women of color with Medicaid, private, or self-pay insurance. CONCLUSION: The risk of severe maternal morbidity remains elevated for women of color despite access to Tricare health insurance.
简介:在过去的二十年中,美国的孕产妇发病率和死亡率有所上升,有色人种妇女的发病率和死亡率尤其高。军事Tricare覆盖模式是全民医疗保健;然而,在对军队治疗设施中分娩的研究中,有色人种女性仍然存在差异。本研究分析了所有Tricare覆盖妇女的分娩结果,包括在民用部门分娩。方法:分析美国疾病控制和预防中心2017-2019年与WONDER相关的出生/婴儿死亡记录中620万例出生的数据,包括全因发病率(输血、会阴撕裂伤、子宫破裂、计划外子宫切除术和重症监护病房入院)、严重孕产妇发病率(不包括撕裂伤)和不包括输血的SMM。计算风险比,比较Tricare、Medicaid、自费和私人保险的总体孕产妇发病率。此外,还计算了按种族分层的保险类型之间的风险比率。结果:与私人保险相比,Tricare保险显著降低了全因孕产妇发病的风险。与白人妇女相比,有Tricare和所有其他保险的黑人妇女全因发病风险降低,但SMM和未输血的SMM风险显著增加。亚洲妇女的全因、SMM和不输血的SMM风险显著增加。有色人种女性在Tricare保险中的发病率与有色人种女性在医疗补助、私人或自费保险中的发病率没有显著差异。结论:尽管有色人种妇女享有Tricare健康保险,但其严重孕产妇发病率的风险仍然较高。
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引用次数: 20
Disparities and Patterns of Pain Management, Pharmacologic Therapies, and Surgical Treatments for Leiomyomas in the 2017–2019 National Survey of Family Growth [ID: 1380252] 2017-2019年全国家庭生长调查中平滑肌瘤疼痛管理、药物治疗和手术治疗的差异和模式[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000929888.98115.b5
C. Rennie, Sanela Andelija, Barbara Prol
INTRODUCTION: Leiomyomas affect most women throughout their lifetime with an incidence of roughly 80%. Approximately 30% of these women develop symptomology that warrants intervention. With such a large prevalence, it is important to highlight patterns in treatment modalities to guide effective management for all women with this condition. METHODS: We utilized weighted survey results from the Centers for Disease Control and Prevention’s 2017–2019 National Survey of Family Growth. After isolating data to those who reported a leiomyoma diagnosis, we performed a test of equal proportions (P<.05) among the nine listed therapies compared to the following socioeconomic factors: race, age, education, and insurance status. RESULTS: The incidence of leiomyomas was 7.3% (449/6,141). Hispanic women and those with state-sponsored or uninsured status were more likely to report receiving none of the listed treatments (P=.05 and .02). Women who marked “Other” were most likely to seek alternative medicine (P=.03). Hysterectomy was most likely for Black, White, and 40- to 49-year-old women (P=.02 and P<.001). Nonhysterectomy procedures were most seen with government-sponsored health care, private insurance, and women with graduate degrees (P<.001 and P=.02). Pharmacologically, White women were more likely to receive progesterone-releasing intrauterine devices (P=.02), women 19–29 were more likely to use hormonal medicine (P<.001), and those with government insurance were more likely to receive narcotics (P=.006). CONCLUSION: All socioeconomic factors held significant inconsistencies in the utilization of various leiomyoma treatments. As this condition will affect most women, this analysis highlights the need for future standardization to ensure optimal treatment implementation and patient outcomes.
简介:平滑肌瘤影响大多数女性一生,发病率约为80%。这些妇女中约有30%出现了需要干预的症状。由于患病率如此之高,强调治疗方式的模式以指导所有患有此病的妇女的有效管理是很重要的。方法:我们利用了美国疾病控制与预防中心2017-2019年全国家庭增长调查的加权调查结果。在对报告平滑肌瘤诊断的患者进行数据隔离后,我们对列出的九种治疗方法与以下社会经济因素(种族、年龄、教育程度和保险状况)进行了同等比例的检验(P< 0.05)。结果:平滑肌瘤的发生率为7.3%(449/ 6141)。西班牙裔妇女和那些有国家资助或没有保险的人更有可能报告没有接受任何列出的治疗(P=。0.05和0.02)。标记为“其他”的女性最有可能寻求替代医学(P=.03)。子宫切除术最有可能发生在黑人、白人和40- 49岁的女性(P=。2和P< 0.001)。非子宫切除手术在政府资助的医疗保健、私人保险和具有研究生学位的妇女中最常见(P< 0.05)。0.001和P=.02)。药理学上,白人女性更倾向于使用释放黄体酮的宫内节育器(P= 0.02), 19-29岁的女性更倾向于使用激素药物(P< 0.001),有政府保险的女性更倾向于使用麻醉品(P= 0.006)。结论:所有社会经济因素在各种平滑肌瘤治疗的使用中具有显著的不一致性。由于这种情况会影响大多数女性,因此该分析强调了未来标准化的必要性,以确保最佳治疗实施和患者预后。
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引用次数: 0
Early Treatment of Gestational Diabetes Mellitus and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [ID: 1377137] 妊娠期糖尿病和前驱糖尿病的早期治疗:随机临床试验的系统回顾和meta分析[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000930124.76180.1e
K. Hessami, Lorie M. Harper, A. Shamshirsaz, E. Werner
INTRODUCTION: This meta-analysis aims to determine whether early treatment of hyperglycemia in gestational diabetes mellitus (GDM) and prediabetic pregnancies improve perinatal outcomes. METHODS: PubMed/Medline, EMBASE, ClinicalTrials.gov and Web of Science were systematically searched up to June 30, 2022. Randomized clinical trials (RCTs) of early treatment for gestational diabetes mellitus (International Association of the Diabetes and Pregnancy Study Groups [IADPSG] or Carpenter and Coustan [C&C] criteria) and prediabetes (HbA1c 5.7–6.4%) before 20 weeks of gestation were considered eligible. Random-effects model meta-analysis was used to pool the odds ratios (OR) and/or mean differences (MD) with 95% CI. Furthermore, subgroup analysis was performed stratifying by indication for intervention (GDM versus prediabetic). RESULTS: Seven RCTs including 2,757 pregnant individuals, of whom 647 had positive screening before 20 weeks of gestation, were included. Of 647 individuals, 346 were allocated to early treatment and 301 to the routine treatment. There was no significant difference in terms of gestational age at delivery (MD –0.21 [95% CI: −0.44, 0.02], P=.089), rate of cesarean delivery (OR 0.93 [95% CI: 0.64, 1.34], P=.394), hypertensive disorder of pregnancy (OR 1.19 [95% CI: 0.59, 2.39], P=.341), any diabetic medication use (OR 1.31 [95% CI: 0.89, 1.93], P=.177), and neonatal hypoglycemia (OR 1.02 [95% CI: 0.50, 2.08], P=.952). However, there was a decreased risk of macrosomia (OR 0.42 [95% CI: 0.19, 0.92], P=.031) and increased need for insulin use (OR 2.23 [95% CI: 1.30, 3.84], P=.004) for early treatment group. After separate analyses on GDM and prediabetics as distinct groups, the risk of macrosomia was not decreased for GDM and prediabetic subgroups after early treatment. CONCLUSION: Treatment in early pregnancy for GDM or prediabetes does not appear to improve the maternal or neonatal outcomes.
本荟萃分析旨在确定早期治疗妊娠期糖尿病(GDM)和糖尿病前期妊娠的高血糖是否能改善围产儿结局。方法:系统检索截至2022年6月30日的PubMed/Medline、EMBASE、ClinicalTrials.gov和Web of Science。早期治疗妊娠期糖尿病(国际糖尿病与妊娠研究组协会[IADPSG]或Carpenter and Coustan [C&C]标准)和妊娠20周前前驱糖尿病(HbA1c 5.7-6.4%)的随机临床试验(rct)被认为符合条件。随机效应模型荟萃分析采用95% CI合并优势比(OR)和/或平均差异(MD)。此外,根据干预适应症(GDM与前驱糖尿病)进行亚组分析。结果:纳入7项随机对照试验,共纳入2757例孕妇,其中647例妊娠20周前筛查阳性。在647个人中,346人被分配到早期治疗,301人被分配到常规治疗。分娩时胎龄(MD = -0.21 [95% CI: - 0.44, 0.02], P= 0.089)、剖宫产率(OR = 0.93 [95% CI: 0.64, 1.34], P= 0.394)、妊娠高血压疾病(OR = 1.19 [95% CI: 0.59, 2.39], P= 0.341)、任何糖尿病药物的使用(OR 1.31 [95% CI: 0.89, 1.93], P= 0.177)和新生儿低血糖(OR 1.02 [95% CI: 0.50, 2.08], P= 0.952)均无显著差异。然而,早期治疗组发生巨大儿的风险降低(OR为0.42 [95% CI: 0.19, 0.92], P= 0.031),胰岛素使用需求增加(OR为2.23 [95% CI: 1.30, 3.84], P= 0.004)。在将GDM和前驱糖尿病作为不同的组进行单独分析后,GDM和前驱糖尿病亚组在早期治疗后发生巨大儿的风险并未降低。结论:妊娠早期治疗GDM或前驱糖尿病并不能改善产妇或新生儿的预后。
{"title":"Early Treatment of Gestational Diabetes Mellitus and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [ID: 1377137]","authors":"K. Hessami, Lorie M. Harper, A. Shamshirsaz, E. Werner","doi":"10.1097/01.aog.0000930124.76180.1e","DOIUrl":"https://doi.org/10.1097/01.aog.0000930124.76180.1e","url":null,"abstract":"INTRODUCTION: This meta-analysis aims to determine whether early treatment of hyperglycemia in gestational diabetes mellitus (GDM) and prediabetic pregnancies improve perinatal outcomes. METHODS: PubMed/Medline, EMBASE, ClinicalTrials.gov and Web of Science were systematically searched up to June 30, 2022. Randomized clinical trials (RCTs) of early treatment for gestational diabetes mellitus (International Association of the Diabetes and Pregnancy Study Groups [IADPSG] or Carpenter and Coustan [C&C] criteria) and prediabetes (HbA1c 5.7–6.4%) before 20 weeks of gestation were considered eligible. Random-effects model meta-analysis was used to pool the odds ratios (OR) and/or mean differences (MD) with 95% CI. Furthermore, subgroup analysis was performed stratifying by indication for intervention (GDM versus prediabetic). RESULTS: Seven RCTs including 2,757 pregnant individuals, of whom 647 had positive screening before 20 weeks of gestation, were included. Of 647 individuals, 346 were allocated to early treatment and 301 to the routine treatment. There was no significant difference in terms of gestational age at delivery (MD –0.21 [95% CI: −0.44, 0.02], P=.089), rate of cesarean delivery (OR 0.93 [95% CI: 0.64, 1.34], P=.394), hypertensive disorder of pregnancy (OR 1.19 [95% CI: 0.59, 2.39], P=.341), any diabetic medication use (OR 1.31 [95% CI: 0.89, 1.93], P=.177), and neonatal hypoglycemia (OR 1.02 [95% CI: 0.50, 2.08], P=.952). However, there was a decreased risk of macrosomia (OR 0.42 [95% CI: 0.19, 0.92], P=.031) and increased need for insulin use (OR 2.23 [95% CI: 1.30, 3.84], P=.004) for early treatment group. After separate analyses on GDM and prediabetics as distinct groups, the risk of macrosomia was not decreased for GDM and prediabetic subgroups after early treatment. CONCLUSION: Treatment in early pregnancy for GDM or prediabetes does not appear to improve the maternal or neonatal outcomes.","PeriodicalId":19405,"journal":{"name":"Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84413357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers to HPV Vaccination in Women at a Federally Qualified Health Center [ID: 1377846] 联邦合格医疗中心妇女接种HPV疫苗的障碍[ID: 1377846]
Pub Date : 2023-05-01 DOI: 10.1097/01.aog.0000931136.85731.b0
Sophie Blakey-Cheung, Kristen Demertzis, Q. Zeeshan
INTRODUCTION: Human papillomavirus (HPV) vaccination significantly decreases the rate of HPV-related diseases; however, vaccine uptake is limited in the United States. New York State set a goal of 80% HPV vaccination by 2023. First-dose rates at our Federally Qualified Health Center (FQHC) in 2021 were 68% in girls aged 13–19 years and 31% in women aged 20–29 years. Little research surrounding barriers to HPV vaccination in adults exists. METHODS: An anonymized survey was distributed to providers at a network of FQHCs using REDCap. Question domains included provider demographics, provider attitudes, and practices. Questions were subdivided by patient age group. Descriptive statistics were analyzed. RESULTS: Our response rate was 15%. Respondent specialties included family practice (49%), women's health (27%), pediatrics (13%), and internal medicine (11%). Frequency of vaccine recommendation decreased as patient age increased. Most common barriers for vaccination included previous vaccination, parental or patient objection, and lack of time for counseling. Additional barriers in the 19–45 age group included concerns about efficacy and cost. Common reasons for patient refusal included objection to vaccination, feeling low risk for infection, lack of knowledge, and side effect concerns. CONCLUSION: The expansion of HPV vaccination eligibility to include women aged 27–45 in 2018 provided an opportunity to protect more patients against HPV-related diseases. Patient and provider knowledge about HPV risk and vaccine efficacy can limit the implementation. Significant barriers for vaccine administration included the lack of provider engagement, knowledge about the vaccine, and time for counseling. This study underscores the need for provider and patient education about the benefits of HPV vaccination, especially in the 19–45 age group.
导读:人乳头瘤病毒(HPV)疫苗接种显著降低HPV相关疾病的发病率;然而,在美国,疫苗的吸收是有限的。纽约州设定了到2023年80%的HPV疫苗接种率的目标。2021年,我们联邦合格卫生中心(FQHC) 13-19岁女孩的首次剂量率为68%,20-29岁女性的首次剂量率为31%。关于成人接种HPV疫苗的障碍的研究很少。方法:使用REDCap向fqhc网络的提供者分发匿名调查。问题域包括提供者人口统计、提供者态度和实践。问题按患者年龄组细分。进行描述性统计分析。结果:有效率为15%。受访者的专业包括家庭执业(49%)、妇女健康(27%)、儿科(13%)和内科(11%)。推荐疫苗的频率随着患者年龄的增加而降低。接种疫苗最常见的障碍包括以前接种过疫苗、父母或患者反对以及缺乏咨询时间。19-45岁年龄组的其他障碍包括对疗效和费用的担忧。患者拒绝接种疫苗的常见原因包括反对接种、感觉感染风险低、缺乏相关知识和担心副作用。结论:2018年将HPV疫苗接种资格扩大到27-45岁的女性,为保护更多患者免受HPV相关疾病的侵害提供了机会。患者和提供者对HPV风险和疫苗效力的了解可能会限制疫苗的实施。疫苗管理的重大障碍包括缺乏提供者参与、疫苗知识和咨询时间。这项研究强调需要对提供者和患者进行HPV疫苗接种益处的教育,特别是在19-45岁年龄组。
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引用次数: 0
Emergency Department Readmission for Early Pregnancy Concerns Among Patients Who Speak Spanish [ID: 1366721] 会说西班牙语的早期妊娠患者的再入院问题[j]
Pub Date : 2023-05-01 DOI: 10.1097/01.AOG.0000929904.21738.96
Gabrielle Taper, M. Álvarez, L. Thaxton, S. Tristan
INTRODUCTION: The purpose of this study was to compare readmission rates for early pregnancy concerns in the emergency department (ED) among patients that speak English versus Spanish as their primary language. METHODS: From January 1, 2020 to June 1, 2021, we conducted a chart review to identify pregnant patients presenting to the ED using ICD-10 codes for pregnancy and first-trimester diagnoses (n=383). Charts were excluded if pregnancy was beyond 13 weeks or an ultrasound-confirmed ectopic pregnancy. Readmission was a separate ED encounter during the first trimester of that same pregnancy. Preventable readmission was one that could have been prevented if the patient had received correct counseling, diagnosis, or management at the index admission. Our primary outcome was frequency of ED readmission among English versus Spanish speakers. This protocol was approved for IRB exemption by the University of Texas. RESULTS: Threatened abortion was the most common diagnosis among both groups. Readmissions were more frequent among Spanish speakers (40% versus 26% [P=.01]). Preventable readmissions were more common among Spanish speakers (31% versus 25%). The majority of preventable readmissions (81%) among Spanish speakers could have been prevented if correct management was offered, compared to 25% in English speakers (P=.03). CONCLUSION: Spanish and English speakers present with similar types of early pregnancy concerns, but Spanish speakers are not offered management of early pregnancy concerns at the same frequency. Standardization of care for early pregnancy concerns in the ED may help reduce language-based disparities in quality and equity of care.
简介:本研究的目的是比较以英语和西班牙语为主要语言的早期妊娠患者在急诊科(ED)的再入院率。方法:从2020年1月1日至2021年6月1日,我们进行了一项图表回顾,以确定使用ICD-10代码进行妊娠和早期妊娠诊断的妊娠患者(n=383)。如果怀孕超过13周或超声确认宫外孕,则排除图表。再入院是一个单独的ED遭遇在同一怀孕的前三个月。可预防的再入院是指如果患者在入院时接受了正确的咨询、诊断或管理,就可以预防的再入院。我们的主要结局是英语和西班牙语患者再入院的频率。该方案已获得德克萨斯大学IRB豁免批准。结果:先兆流产是两组中最常见的诊断。西班牙语患者的再入院率更高(40% vs 26% [P= 0.01])。可预防的再入院在说西班牙语的人群中更为常见(31%对25%)。如果提供正确的管理,西班牙语患者中大多数可预防的再入院(81%)是可以避免的,而英语患者中这一比例为25% (P=.03)。结论:西班牙语和英语患者出现的早孕问题类型相似,但西班牙语患者未获得相同频率的早孕问题管理。在急诊科对早孕问题的标准化护理可能有助于减少基于语言的护理质量和公平性的差异。
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引用次数: 0
期刊
Obstetrics & Gynecology
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