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Hospitalization for Nonlethal Self-Harm and Premature Mortality in the 3 Years Following Adolescent Pregnancy: Population-Based Nationwide Cohort Study 青少年怀孕后三年内因非致命性自我伤害住院和过早死亡:基于人口的全国队列研究
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001015960.60124.c0
K. Goueslard, F. Jollant, J. Cottenet, S. Bechraoui-Quantin, P. Rozenberg, E. Simon, C. Quantin
(BJOG. 2023;130(9):1016–1027) Research proves a rising risk of suicidal ideation and acts in the year before and the year after giving birth. Suicide is 1 of the 2 main causes of mortality for mothers in France. There is not a solid correlation between nonlethal self-harm and suicide following childbirth, so it is difficult to predict and prevent. Adolescents are at higher risk of nonlethal self-harm, and suicide is the second cause of premature deaths in their age category. Adolescent pregnancy is tied to additional mental disorders, psychosocial problems, anxiety, depression, and eating disorders, which are all risk factors for suicidal actions. This retrospective cohort study was designed to primarily provide insights about nonlethal self-harm risks and mortality in adolescent pregnancies. Secondarily, the study aimed to evaluate the causes of deaths when possible.
(BJOG.2023;130(9):1016-1027))研究证明,产前一年和产后一年内出现自杀念头和行为的风险不断上升。自杀是法国母亲死亡的两大主要原因之一。非致命性自残与产后自杀之间并没有确切的关联,因此很难预测和预防。青少年非致命性自残的风险较高,自杀是他们这个年龄段过早死亡的第二大原因。青少年怀孕与其他精神障碍、社会心理问题、焦虑、抑郁和饮食失调有关,这些都是导致自杀行为的危险因素。这项回顾性队列研究的主要目的是了解青少年怀孕期间的非致命性自残风险和死亡率。其次,该研究旨在尽可能评估死亡原因。
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引用次数: 0
Tranexamic Acid to Prevent Obstetrical Hemorrhage After Cesarean Delivery 氨甲环酸预防剖腹产后产科出血
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001015900.50238.ba
L.D. Pacheco, R.G. Clifton, G. Saade, H. Simhan, G.A. Macones
(N Engl J Med 2023;388(15):1365–1375) Postpartum hemorrhage is the second leading cause of pregnancy-related death in the United States, and accounts for up to 27.1% of global maternal deaths. Tranexamic acid has been previously associated with a reduction in overall mortality in several different settings, but majorly in obstetrical contexts. Research has not discovered, however, if the use of tranexamic acid is beneficial when it comes to its prophylactic use to prevent significant blood loss after birth or related other outcomes such as incidence of blood transfusion products or need for additional intervention to control bleeding. This study was a randomized trial to assess the effectiveness of tranexamic acid administered immediately after umbilical cord clamping in reducing the risk of maternal death or blood transfusion compared to placebo.
(N Engl J Med 2023;388(15):1365-1375)在美国,产后出血是导致妊娠相关死亡的第二大原因,占全球孕产妇死亡人数的 27.1%。氨甲环酸曾在多种不同情况下与降低总死亡率有关,但主要是在产科情况下。然而,研究并未发现使用氨甲环酸是否有利于预防产后大量失血或相关的其他结果,如输血产品的发生率或控制出血所需的额外干预。这项研究是一项随机试验,目的是评估与安慰剂相比,脐带钳夹后立即使用氨甲环酸对降低产妇死亡或输血风险的有效性。
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引用次数: 0
Alternative Routes for Tranexamic Acid Treatment in Obstetric Bleeding (WOMAN-PharmacoTXA Trial): A Randomized Trial and Pharmacological Study in Cesarean Section Births 氨甲环酸治疗产科出血的替代途径(WOMAN-PharmacoTXA 试验):剖宫产中的随机试验和药理研究
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001016024.85550.bb
H. Shakur-Still, I. Roberts, S. Grassin-Delyle, R. Chaudhri, A. Geer, M. Arribas, E. Lamy, R. Mansukhani, M.K. Lubeya, K. Javaid, A. Kayani, N. Israr, S.B. Mazhar, S. Urien, N. Bouazza, F. Foissac, D. Prowse, L. Carrington, C. Barrow, J. Onandia, E. Balogun
(BJOG. 2023;130(10):1177–1186) Many maternal deaths due to severe postpartum bleeding (PPH) occur in middle-income or low-income countries. A widely practiced method for reducing postpartum bleeding is administration of tranexamic acid (TXA); methods of administration vary, with the drug being available as an intravenous (IV) infusion, intramuscular (IM) injection, and oral solution. The previous WOMAN-PharmacoTXA trial showed that IV TXA administered within 3 hours of delivery reduced PPH deaths by one-third, but IV administration is a barrier for care in low-income and middle-income countries. Therefore, it is important that such other administration options for such an integral lifesaving medication be evaluated in settings where IV infusion is difficult or impossible. This study was designed to evaluate the population pharmacokinetics (PK) and pharmacodynamics (PD) of TXA administered by IV infusion, IM injection, and oral routes in women having cesarean delivery (CD). This included evaluation of safety, adverse events, the concentration of TXA that crosses the placenta and its clearance, and the effect of administration route on D-dimer concentration.
(BJOG.2023;130(10):1177-1186) 在中等收入或低收入国家,许多产妇死于严重产后出血(PPH)。氨甲环酸(TXA)是减少产后出血的一种广泛使用的方法;给药方法各不相同,有静脉注射、肌肉注射和口服溶液等。之前的 WOMAN-PharmacoTXA 试验表明,分娩后 3 小时内静脉注射氨甲环酸可将 PPH 死亡人数减少三分之一,但静脉注射是中低收入国家护理工作的障碍。因此,在静脉输注困难或不可能的情况下,对这种不可或缺的救命药物的其他给药方案进行评估非常重要。本研究旨在评估剖宫产(CD)产妇通过静脉输注、IM 注射和口服途径给药 TXA 的群体药代动力学(PK)和药效学(PD)。这包括对安全性、不良事件、TXA 穿过胎盘的浓度及其清除率以及给药途径对 D-二聚体浓度的影响进行评估。
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引用次数: 0
The Effect of Prophylactic Steroids on Shivering in Adults Undergoing Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 预防性类固醇对接受手术的成人颤抖的影响:随机对照试验的系统回顾和元分析
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001016000.14492.92
S. Misra, S. Singh, S. Sarkar, B.K. Behera, S.S. Jena
(Anesth Analg. 2023;137(2):332–344) Shivering is a common side effect to numerous things, such as hypothermia and often anesthetic drugs. Shivering is often an involuntary contraction of the skeletal muscles. It is often unwarranted and during surgery or delivery a patient can shiver due to general anesthetic drugs. Up to 65% of patients shiver when given general anesthetics and up to 60% also have it with spinal anesthesia. Certain nonpharmacological interventions have been attempted to decrease shivering for patients. Corticosteroids and anti-inflammatories may be given to help constrict the shivering effect of an anesthetic. To assess patients and decrease the risk of shivering for those undergoing surgery, additional studies have been made in using these types of drugs and research in randomized trials in perioperative shivering.
(Anesth Analg.2023;137(2):332-344)颤抖是许多情况下常见的副作用,如体温过低和麻醉药物。颤抖通常是骨骼肌的不自主收缩。它通常是不必要的,在手术或分娩过程中,病人会因全身麻醉药物而颤抖。多达 65% 的病人在使用全身麻醉药时会出现颤抖,多达 60% 的病人在使用脊髓麻醉药时也会出现颤抖。已经尝试过一些非药物干预措施来减少患者的颤抖。可使用皮质类固醇和消炎药来帮助抑制麻醉剂的颤抖效应。为了对患者进行评估并降低接受手术的患者出现颤抖的风险,在使用这类药物方面进行了更多的研究,并对围术期颤抖进行了随机试验研究。
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引用次数: 0
Postpartum Navigation Decreases Severe Maternal Morbidity Most Among Black Women 产后导航对降低黑人妇女严重孕产妇发病率的作用最大
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001016012.95407.df
Z. Brown, C. Messaoudi, E. Silvia, H. Bleau, A. Meskill, A. Flynn, A.C. Abel-Bey, T.J. Ball
(Am J Obstet Gynecol. 2023;229:160.e1–160.e8) The United States has significant disparities across varying racial and ethnic groups for pregnancy-related deaths. Research shows that Black women and American Indian or Alaskan Native women have a 3 to 4 times higher risk of pregnancy-related death than White women do, regardless of education. Postpartum care can greatly affect how severe maternal morbidity (SMM) and maternal mortality conditions are addressed. The primary aim of this study was to determine if a postpartum navigation program lowered 30-day postpartum hospitalization admissions from all causes and hospitalization admissions from indicators of SMM. This was done using guidelines from the US Centers for Disease Control and Prevention (CDC). This study also analyzed if the effectiveness of this program transcended across patient demographics like ethnicity and race.
(Am J Obstet Gynecol. 2023;229:160.e1-160.e8)在美国,不同种族和族裔群体之间在与妊娠相关的死亡方面存在显著差异。研究表明,黑人妇女和美国印第安人或阿拉斯加原住民妇女与妊娠相关死亡的风险是白人妇女的 3 到 4 倍,与教育程度无关。产后护理会在很大程度上影响严重孕产妇发病率(SMM)和孕产妇死亡情况的处理方式。本研究的主要目的是确定产后指导计划是否能降低产后 30 天因各种原因住院的人数和因 SMM 指标住院的人数。这项研究采用了美国疾病控制和预防中心(CDC)的指导方针。这项研究还分析了该计划的有效性是否跨越了患者的人口统计学特征,如民族和种族。
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引用次数: 0
Identifying Risk of Stillbirth Using Machine Learning 利用机器学习识别死产风险
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001015988.43986.ab
T.E.K. Cersonsky, N.K. Ayala, H. Pinar, D.J. Dudley, G.R. Saade, R.M. Silver, A.K. Lewkowitz
(Am J Obstet Gynecol. 2023;229:327:e1–16) A tool that could help identify women at risk for stillbirth would be a welcome addition to clinical practice. Machine learning models, which can look at relationships between variables in large data sets, was investigated in this article. This study’s aim was to refine a machine learning model to predict stillbirth using data available prior to the gestational age of viability (22 to 24 wk). The researchers performed a secondary analysis of data in the Stillbirth Collaborative Research Network (SCRN), a study database of 982 stillbirths and 3000 representative live births from 2006 to 2009. The study included patients who delivered a live or stillborn fetus at >18 weeks’ gestation from 59 hospitals in 5 states (Georgia, Massachusetts, Rhode Island, Texas, and Utah). The data set included 6000 measures collected from interviews with the mother, postmortem pathological exam, cause of death analysis, and medical record Abstractsion. Subsequently 101 risk factor variables were identified and used in the model. These included maternal and biological father demographics, family history, maternal health history, prenatal lab data, fetal genetics, second-trimester screen, prenatal care history, ultrasound, and social determinants of health.
(Am J Obstet Gynecol. 2023;229:327:e1-16)一种能帮助识别死产风险妇女的工具将是临床实践中一个受欢迎的补充。本文对机器学习模型进行了研究,该模型可以研究大型数据集中变量之间的关系。这项研究的目的是改进机器学习模型,利用可存活胎龄(22 到 24 周)之前的数据预测死产。研究人员对死胎合作研究网络(SCRN)中的数据进行了二次分析,该研究数据库收录了2006年至2009年间的982例死胎和3000例有代表性的活产。研究对象包括 5 个州(佐治亚州、马萨诸塞州、罗德岛州、得克萨斯州和犹他州)59 家医院中妊娠大于 18 周的活产或死胎患者。数据集包括从母亲访谈、死后病理检查、死因分析和病历摘要中收集的 6000 个测量指标。随后,101 个风险因素变量被确定并用于模型中。这些变量包括母亲和生父的人口统计学特征、家族史、母亲健康史、产前实验室数据、胎儿遗传学、二胎筛查、产前护理史、超声波和健康的社会决定因素。
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引用次数: 0
Association Between Hypertensive Disorders of Pregnancy and Cardiovascular Diseases Within 24 Months After Delivery 妊娠期高血压疾病与产后 24 个月内心血管疾病的关系
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001015964.97203.7e
C. Ackerman-Banks, H. Lipkind, K. Palmsten, K. Ahrens
(Am J Obstet Gynecol. 2023;229(1):65.e1–65.e15) Cardiovascular disease (CVD) is the leading cause of death among women in the United States. The association between hypertensive diseases of pregnancy (HDP) and CVD are well known with an increased risk of long-term morbidity. For short-term CVD outcomes after HDP, most existing data are limited to the immediate postpartum period and the data are limited on which specific cardiovascular diagnoses have the greatest risk profiles during the first 24 months after delivery. This study aimed to assess the risk of various cardiovascular diagnoses in the initial 24 months postdelivery among individuals with HDP compared with those without.
(Am J Obstet Gynecol.2023;229(1):65.e1–65.e15)心血管疾病(CVD)是美国妇女死亡的主要原因。众所周知,妊娠高血压疾病(HDP)与心血管疾病之间存在关联,会增加长期发病的风险。对于妊娠高血压疾病后的短期心血管疾病结果,大多数现有数据仅限于产后初期,而且关于产后 24 个月内哪些特定心血管疾病诊断的风险最大的数据也很有限。本研究旨在评估 HDP 患者与非 HDP 患者在产后最初 24 个月内罹患各种心血管疾病的风险。
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引用次数: 3
Anxiety and Depressive Symptoms in Pregnant Women During the COVID-19 Pandemic in the Czech Republic—Broader Sociodemographic Causes, Connections and Implications 捷克共和国 COVID-19 大流行期间孕妇的焦虑和抑郁症状--更广泛的社会人口学原因、联系和影响
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001015972.29684.2b
L. Krámská, S. Slabá, L. Hrešková, A. Kajdy, D. Sys, L. Poon, P. Calda
(Acta Obstet Gynecol Scand. 2023;102:1014–1025) The COVID-19 pandemic has profoundly impacted various aspects of life, posing risks not only to physical health but also to mental well-being. Psychological effects such as stress, anxiety, and depression are prevalent, particularly among pregnant women, with potential repercussions for pregnancy outcomes. This study explored the sociodemographic and psychological factors during the COVID pandemic that affected the mood of pregnant Czech women. Conducted through the MindCOVID study, our survey included 1830 pregnant women, utilizing standardized instruments (GAD-7 and PHQ-9) to assess anxiety and depression. The study focused on culturally specific characteristics and risk factors for mental disorders, providing valuable insights for effective multidisciplinary health care planning.
(Acta Obstet Gynecol Scand. 2023; 102:1014-1025)COVID-19大流行对生活的各个方面产生了深远的影响,不仅给身体健康带来风险,也给心理健康带来风险。压力、焦虑和抑郁等心理影响普遍存在,尤其是在孕妇中,可能会对妊娠结果产生影响。本研究探讨了 COVID 大流行期间影响捷克孕妇情绪的社会人口和心理因素。通过 MindCOVID 研究,我们对 1830 名孕妇进行了调查,利用标准化工具(GAD-7 和 PHQ-9)评估焦虑和抑郁。该研究重点关注精神障碍的特定文化特征和风险因素,为有效的多学科医疗保健规划提供了宝贵的见解。
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引用次数: 0
Women and Partners’ Experience of Major Postpartum Hemorrhage: A Qualitative Study 妇女和伴侣对产后大出血的体验:定性研究
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001016036.85902.38
L. Rosvig, E. Steffensen, L. Brogaard, L. Hvidman, O. Kierkegaard, A.C. Kjeldsen, K. Taastrøm, N. Uldbjerg, S. Lou
(BJOG. 2023;130(9):1087–1095) Major postpartum hemorrhage (PPH) is classified as losing more than or equal to 1 L of blood within 2 hours of vaginal birth. In Denmark, this occurs in 7.2% of vaginal deliveries, compared with an incidence of about 4% in the developed countries. Managing major PPH requires a quick and appropriate response from multiple clinical professionals and providing proper medicine. Women and their partners often have negative experiences of PPH, which may relate to deficiencies in communication.
(BJOG.产后大出血(PPH)是指在阴道分娩后 2 小时内失血超过或等于 1 升。在丹麦,7.2%的阴道分娩会发生这种情况,而发达国家的发生率约为 4%。处理严重的 PPH 需要多名临床专业人员做出快速、适当的反应,并提供适当的药物。妇女及其伴侣往往对 PPH 有负面的体验,这可能与沟通不足有关。
{"title":"Women and Partners’ Experience of Major Postpartum Hemorrhage: A Qualitative Study","authors":"L. Rosvig, E. Steffensen, L. Brogaard, L. Hvidman, O. Kierkegaard, A.C. Kjeldsen, K. Taastrøm, N. Uldbjerg, S. Lou","doi":"10.1097/01.aoa.0001016036.85902.38","DOIUrl":"https://doi.org/10.1097/01.aoa.0001016036.85902.38","url":null,"abstract":"(BJOG. 2023;130(9):1087–1095)\u0000 Major postpartum hemorrhage (PPH) is classified as losing more than or equal to 1 L of blood within 2 hours of vaginal birth. In Denmark, this occurs in 7.2% of vaginal deliveries, compared with an incidence of about 4% in the developed countries. Managing major PPH requires a quick and appropriate response from multiple clinical professionals and providing proper medicine. Women and their partners often have negative experiences of PPH, which may relate to deficiencies in communication.","PeriodicalId":19432,"journal":{"name":"Obstetric Anesthesia Digest","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation and Outcomes of a Uterine Artery Embolization and Tranexamic Acid Protocol for Placenta Accreta Spectrum 子宫动脉栓塞和氨甲环酸治疗胎盘早剥方案的实施和结果
Pub Date : 2024-05-24 DOI: 10.1097/01.aoa.0001016028.15303.42
J.L. Munoz, L.M. Blankenship, P.S. Ramsey, G.A. McCann
(Am J Obstet Gynecol. 2023;229(1):61.e1–61.e7) During pregnancy, complications may arise such as placenta accreta spectrum (PAS) disorders. PAS is a continuum of conditions characterized by abnormal placental invasion, posing intraoperative risks during delivery. Patients with PAS often face postpartum complications, typically necessitating scheduled cesarean deliveries (CD) between 34 and 36 weeks gestation, making the delivery high risk. High blood loss and post-CD complications are common in women with placenta accreta, prompting the implementation of specific observations and protocols in medical facilities.
(Am J Obstet Gynecol.2023;229(1):61.e1-61.e7) 在怀孕期间,可能会出现并发症,如胎盘滞留症(PAS)。PAS 是以异常胎盘侵入为特征的一系列疾病,在分娩过程中会带来术中风险。PAS 患者通常会面临产后并发症,通常需要在妊娠 34 至 36 周之间进行剖宫产(CD),因此分娩风险很高。高失血量和剖宫产后并发症是胎盘早剥产妇的常见病,这促使医疗机构实施特定的观察和规程。
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引用次数: 0
期刊
Obstetric Anesthesia Digest
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