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A case of Poncet’s disease; a mimicker of rheumatoid arthritis 庞塞氏病1例;类风湿关节炎的模仿者
Pub Date : 2021-09-15 DOI: 10.4038/gmj.v26i3.8104
C. Dharmaratne, D. Jayasena, V. Sobana, U. D. Silva, S. Muhunthan
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引用次数: 0
Interaction between lean, fat and bone masses among patients with chronic kidney disease; a cross-sectional comparative study 慢性肾病患者瘦、脂、骨量的相互作用横断面比较研究
Pub Date : 2021-09-15 DOI: 10.4038/gmj.v26i3.8100
E. H. Silva, C. Wickramatilake, S. Lekamwasam, L. Mudduwa, R. Ubayasiri
Introduction: Interactions between three major body compartments; lean, fat and bone masses are essential for the maintenance of optimum bodily functions. This interaction is disturbed by factors such as advancing age, disease and drugs. The aim of the study was to understand the interaction of body compartments in chronic kidney disease (CKD) to optimise disease outcome. Methods: Fifty patients (38 males) with CKD awaiting kidney transplant at Teaching Hospitals, Karapitiya and Kandy and 50 age and gender matched control subjects were compared. Socio-demographic data, social habits and anthropometric measurements with blood pressure was obtained. Both patients and controls underwent DEXA scan to assess body composition. Results: Mean (SD) age of the patients was 48(9.6) years. In both groups; patients with CKD and participants in the control group, total body lean mass (TBLM) showed significant correlations with total body bone mineral density (TBBMD) (patients: r = 0.38, p = 0.008) (controls: r = 0.57, p = <0.001) and total body bone mineral content (TBBMC) (patients: r = 0.62, p = <0.001) (controls: r = 0.78, p = <0.001). No significant correlations were observed between total body fat mass (TBFM) and TBBMD or TBBMC. When regression models were fitted with TBBMD and TBBMC as dependent variables and TBLM as the independent variable, 1kg difference 2 2 in TBLM was associated with 0.007 g/cm ( p = 0.02) and 0.010 g/cm change in TBBMD in patients and controls, respectively. Furthermore, 1kg difference in TBLM was associated with 32 g ( p = 0.02) and 33 g ( p = 0.018) difference in TBBMC in patients with CKD and participants in the control group, respectively. Conclusions: Similar to participants in the control group, TBLM is a better predictor of TBBMC and TBBMD compared to TBFM and TRFM in patients with end stage renal disease (ESRD) and this knowledge can be used in health promotion programs to improve bone health of these patients.
导言:三个主要身体隔室之间的相互作用;瘦肉、脂肪和骨骼是维持最佳身体机能所必需的。这种相互作用受到年龄增长、疾病和药物等因素的干扰。该研究的目的是了解慢性肾脏疾病(CKD)中身体隔室的相互作用,以优化疾病结局。方法:将Karapitiya和Kandy教学医院的50例等待肾移植的CKD患者(男性38例)与50例年龄和性别匹配的对照组进行比较。获得社会人口统计数据、社会习惯和人体测量值与血压。患者和对照组均行DEXA扫描以评估身体成分。结果:患者平均(SD)年龄为48(9.6)岁。在两组中;CKD患者和对照组的参与者,全身瘦质量(TBLM)与全身骨矿物质密度(TBBMD)(患者:r = 0.38, p = 0.008)(对照组:r = 0.57, p = <0.001)和全身骨矿物质含量(TBBMC)(患者:r = 0.62, p = <0.001)(对照组:r = 0.78, p = <0.001)呈显著相关。总体脂量(TBFM)与TBBMD或TBBMC之间无显著相关性。以TBBMD和TBBMC为因变量,TBLM为自变量拟合回归模型时,TBLM的1kg差异2与患者和对照组TBBMD的变化分别相关0.007 g/cm (p = 0.02)和0.010 g/cm。此外,1kg TBLM的差异与CKD患者和对照组中TBBMC的差异分别为32 g (p = 0.02)和33 g (p = 0.018)。结论:与对照组的参与者相似,终末期肾病(ESRD)患者的TBLM比TBFM和TRFM更能预测TBBMC和TBBMD,这一知识可用于健康促进计划,以改善这些患者的骨骼健康。
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引用次数: 0
Characteristics of cases of fatal drowning at a tertiary care hospital in Sri Lanka 斯里兰卡三级保健医院致命溺水病例的特征
Pub Date : 2021-09-15 DOI: 10.4038/gmj.v26i3.8103
H. Ariyarathna, E. A. Jayathilaka
Introduction: Deaths due to drowning largely manifest as preventable accidents or suicides. This study deals with characteristics of cases of fatal drowning presented to a tertiary care hospital in Sri Lanka. Methods: A descriptive study was conducted retrospectively based on postmortem reports of deaths due to drowning available at the Colombo South Teaching Hospital from September 2015 to September 2020. The study reviews characteristics of fatal drowning cases reported to the institution including their epidemiology, features, injury patterns and associated factors. Results: Drowning accounted for 1.35% (n = 65) of total postmortems performed. The male to female ratio was 8:1. Children below 15 years of age contributed to 7.7% of the deaths. Accidental deaths were the commonest followed by suicide and homicide respectively. Evidence of alcohol consumption was noted in 30.8% (n = 20) and the majority of the drownings occurred in the sea. No putrefaction was seen in 58.5% (n = 38) bodies. The characteristic froth was noted in 43.1% (n = 28) of the study sample and there had not been a significant association between the presence of froth with the medium of water. Facial and chest injuries were the commonest associated injuries. Four cases of late death (near drowning) were reported. Twenty-six (40%) deaths could have been prevented. Conclusions: This study helps to emphasize an existing problem in Sri Lanka. The prevention of drowning is mostly an achievable goal in Sri Lanka as long as the risk factors and epidemiology are known along with an adequate emphasis.
溺水死亡主要表现为可预防的事故或自杀。本研究涉及的特点,致命溺水的情况下提出了三级护理医院在斯里兰卡。方法:根据2015年9月至2020年9月在科伦坡南教学医院提供的溺水死亡尸检报告进行回顾性描述性研究。该研究回顾了向该机构报告的致命性溺水病例的特征,包括其流行病学、特征、伤害模式和相关因素。结果:溺亡占死亡总数的1.35% (n = 65)。男女比例为8:1。15岁以下儿童占死亡人数的7.7%。意外死亡是最常见的,其次是自杀和他杀。30.8% (n = 20)的人有饮酒的证据,大多数溺水发生在海里。58.5% (n = 38)的尸体未见腐败。在43.1% (n = 28)的研究样本中发现了特征泡沫,并且泡沫的存在与水的介质之间没有显着关联。面部和胸部损伤是最常见的相关损伤。报告了4例晚期死亡(几乎溺水)。26例(40%)死亡本来是可以避免的。结论:本研究有助于强调斯里兰卡存在的一个问题。在斯里兰卡,只要了解危险因素和流行病学并给予充分重视,预防溺水基本上是一个可以实现的目标。
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引用次数: 0
The relationship between platelet count and the onset of leaking phase in dengue patients 登革热患者血小板计数与渗漏期发生的关系
Pub Date : 2021-09-15 DOI: 10.4038/gmj.v26i3.8102
P. Nishshanka, R. W. Kodikararachchi, A. Karunanayake
Introduction: The complications of dengue are related to reduced intravascular volume following plasma leakage. Thrombocytopenia or platelet dysfunctions are detected in all stages of the illness and are related to the clinical outcome. The main objective of the study was to correlate absolute platelet count to the onset of leaking phase in dengue patients who had entered into leaking phase after the hospital admission. Methods: One hundred and sixteen patients (age range 14-74 years, median age 33 years) who entered the leaking phase after admission were recruited to the study. Dengue infection in patients was confirmed with either the presence of positive NS1 or positive IgM antibodies. Serial ultrasonography was done from admission until the leaking phase is detected. Platelet counts were assessed twice per day just prior to the ultrasonography. Results: There were 47 (40.5%) females and 69 (59.5%) males among the recruited patients. The mean number of days at which leaking was detected following onset of fever was 4.9 ± 0.9 days. The mean platelet count at the onset of leaking phase was 30,051 ± 17,023 /μL. Age and the platelet count at the time of onset of leaking phase was significantly negatively correlated (whole group r = -0.323 p Conclusions: According to this study, the value of platelet count as a predictor of the progression of dengue infection depends on the age of the patients. Young patients are more prone to develop leaking phase with higher platelet counts than the older patients.
简介:登革热的并发症与血浆泄漏后血管内容量减少有关。血小板减少症或血小板功能障碍在疾病的所有阶段都可以检测到,并且与临床结果有关。该研究的主要目的是将住院后进入渗漏期的登革热患者的绝对血小板计数与渗漏期的发生联系起来。方法:入组后进入漏期的116例患者(年龄14 ~ 74岁,中位年龄33岁)。患者的登革热感染被证实为存在阳性NS1或阳性IgM抗体。从入院到检测到漏相,进行了连续超声检查。在超声检查之前,每天评估血小板计数两次。结果:女性47例(40.5%),男性69例(59.5%)。发热后出现渗漏的平均天数为4.9±0.9天。渗漏期开始时平均血小板计数为30,051±17,023 /μL。年龄与漏期开始时血小板计数呈显著负相关(全组r = -0.323 p)。结论:血小板计数作为登革热感染进展的预测值取决于患者的年龄。年轻患者血小板计数高于老年患者,更容易出现漏相。
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引用次数: 0
Immunohistochemical assessment of PTEN expression and itsassociation with tamoxifen resistance in ER positive breast cancers 雌激素受体阳性乳腺癌中PTEN表达及其与他莫昔芬耐药关系的免疫组织化学评估
Pub Date : 2021-09-15 DOI: 10.4038/gmj.v26i3.8101
T. Wijesiri, Harshini Peiris, L. Mudduwa
Introduction: Although Estrogen Receptor (ER) positivity is a good prognostic factor in breast carcinoma (BC), a subset of patients experiences poor disease-free survival (DFS). Mutation in phosphatase and tensin homologue deleted on chromosome ten (PTEN) is identified as a poor prognostic feature in BC. This study was designed to find out the impact of lost or poor PTEN expression on ER positive BC, in terms of the recognized prognostic factors and survival outcome to find out its association with tamoxifen resistance. Methods: This was a cross sectional study with a follow up component. BC tissue blocks submitted to our unit from 2006 to 2012 were selected. From the laboratory data, patients who had ER positive BC, undergone mastectomy, treated with tamoxifen were selected. All clinicopathological parameters, DFS and overall survival (OS) were analysed against lost or poor PTEN expression. Clinicopathological features were compared using Chi-square test. Kaplan-Meier model with log-rank test was used for the survival analysis. Results: A total of 130 BC patients satisfied the inclusion criteria. PTEN expression was lost or poor in 82.3% (n=107) patients. PTEN expression had a positive association with the level of ER expression (p=0.011) and a negative association with Nottingham prognostic index (NPI) (p=0.045) and pathological stage (p Conclusions: This study showed that there is a statistically significant association between lost or poor PTEN expression and low ER expression, high NPI and stage 3 in ER positive BC. Further studies including larger study sample with a longer follow up are recommended to find out the association of PTEN with the survival in ER positive BC treated with tamoxifen.
虽然雌激素受体(ER)阳性是乳腺癌(BC)的一个良好预后因素,但一部分患者的无病生存期(DFS)较差。10号染色体上磷酸酶和紧张素同源物缺失(PTEN)突变被认为是BC预后不良的特征。本研究旨在了解PTEN表达缺失或表达不良对ER阳性BC的影响,从公认的预后因素和生存结局方面探讨其与他莫昔芬耐药的关系。方法:这是一项横断面研究,有随访成分。选取2006 - 2012年提交给我单位的BC组织块。从实验室数据中,选择ER阳性BC,接受乳房切除术,他莫昔芬治疗的患者。所有临床病理参数,DFS和总生存期(OS)分析PTEN表达缺失或不良。采用卡方检验比较临床病理特征。生存分析采用Kaplan-Meier模型和log-rank检验。结果:共有130例BC患者符合纳入标准。82.3% (n=107)患者PTEN表达缺失或表达不良。PTEN表达与ER表达水平呈正相关(p=0.011),与诺丁汉预后指数(NPI)和病理分期呈负相关(p=0.045)。结论:本研究显示,在ER阳性BC中,PTEN表达缺失或表达不良与低ER表达、高NPI和3期有统计学意义。建议进一步研究,包括更大的研究样本和更长时间的随访,以发现PTEN与ER阳性BC治疗他莫昔芬的生存率之间的关系。
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引用次数: 0
Abstracts of oral and poster presentations of the 80th Annual Academic Sessions of Galle Medical Association (GMA) 2021 on 15 & 16 September 2021 2021年9月15日和16日加勒医学协会(GMA) 2021第80届年度学术会议的口头和海报演讲摘要
Pub Date : 2021-09-13 DOI: 10.4038/gmj.v26i0.8097
Editors Gmj
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引用次数: 0
Identifying thyroid follicular proliferations that need lobectomy; value of the Bethesda category 4 鉴别甲状腺滤泡增生是否需要肺叶切除术;Bethesda类别的值
Pub Date : 2021-08-14 DOI: 10.4038/gmj.v26i2.8088
A. Kankanamge, T. Liyanage, L. Mudduwa
Introduction: Thyroid follicular proliferations (TFPs) identified on fine needle aspiration cytology can be either follicular lesions of undetermined significance; Bethesda category 3 or follicular neoplasms and lesions suspicious for a follicular neoplasm; Bethesda category 4. The purpose of categorizing to Bethesda category 4 is to identify a thyroid nodule that might be a follicular carcinoma and triage it for thyroid lobectomy. This study was designed to determine the predictive value of categorizing TFPs to Bethesda category 4 in deciding on lobectomy for cytologically identified TFPs. Methods: This retrospective study included all patients with TFPs identified on cytology, and had a subsequent histological diagnosis, at our unit, over a period of two years. TFPs were categorized into either Bethesda category 3 or 4 on cytology, according to the Bethesda system. Sensitivity, specificity and positive (PPV) and negative predictive values (NPV) for Bethesda category 4 in identifying neoplastic TFPs and implied risk of malignancy for Bethesda category 3 and 4 were calculated taking histopathology as the gold standard. A total of 52 TFPs (Bethesda category 3; n = 39, Bethesda category 4; n = 13) were included. Subsequent histology has confirmed 18 neoplastic and 34 non-neoplastic TFPs. Sensitivity and specificity of Bethesda category 4 in identifying neoplastic TFPs were 66.66% and 97.05% respectively. PPV and NPV of Bethesda category 4 were 92.3% and 84.6% respectively. Implied risk of malignancy for Bethesda category 3 and 4 were 5.12% and 15.38% respectively. Conclusions: Bethesda category 4 predicts the TFPs that need thyroid lobectomy to triage for follicular carcinoma. The Bethesda category 3 and 4 carry an implied risk of malignancy comparable to the expected values given in Bethesda system.
细针穿刺细胞学检查发现的甲状腺滤泡增生(tfp)可能是意义不明的滤泡病变;Bethesda 3类或滤泡性肿瘤及疑似滤泡性肿瘤的病变;贝塞斯达4类。分类为Bethesda第4类的目的是识别可能是滤泡性癌的甲状腺结节,并对其进行甲状腺小叶切除术。本研究旨在确定将tfp分类为Bethesda分类4在决定对细胞学鉴定的tfp进行肺叶切除术时的预测价值。方法:这项回顾性研究包括所有在细胞学上确诊的tfp患者,并进行了随后的组织学诊断,在我单位,为期两年。根据Bethesda系统,tfp在细胞学上被分为Bethesda 3类或4类。以组织病理学为金标准,计算Bethesda 4类鉴别肿瘤tfp的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV),以及Bethesda 3、4类的隐含恶性风险。总共52个tfp (Bethesda类别3;n = 39, Bethesda类别4;N = 13)。随后的组织学证实18例为肿瘤性tfp, 34例为非肿瘤性tfp。Bethesda分类4鉴别肿瘤tfp的敏感性和特异性分别为66.66%和97.05%。Bethesda第4类的PPV和NPV分别为92.3%和84.6%。Bethesda分类3和4的隐含恶性风险分别为5.12%和15.38%。结论:Bethesda分级4可预测滤泡癌患者是否需要甲状腺小叶切除术。Bethesda分类3和4携带与Bethesda系统给出的期望值相当的隐含恶性肿瘤风险。
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引用次数: 0
Kawasaki-like disease and myocarditis in a child with recent COVID-19 Infection 近期感染COVID-19儿童的川崎样病和心肌炎
Pub Date : 2021-08-14 DOI: 10.4038/gmj.v26i2.8090
P. Jayawardana, P. Gamage, I. Ragunathan, I. Vithanage, W. Aslam
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引用次数: 0
Health and social problems following illicit drug use among males experiencing incarceration in prison; a cross sectional study on single centre experience 在监狱服刑的男性使用非法药物后出现的健康和社会问题;单中心经验的横断面研究
Pub Date : 2021-08-14 DOI: 10.4038/gmj.v26i2.8051
I. Darshana, R. Ruben, C. Wijesinghe
Background: Illicit drug use is a growing problem in Sri Lanka. A significant proportion of prison admissions is illicit drug related in many countries including Sri Lanka. Objective: This study was conducted to describe the possible health and social problems following illicit drug use among males experiencing incarceration in Prison, Galle. Methodology: A cross-sectional study was conducted among 254 males with history of illicit drug use behavior. An interviewer assisted, self-administered questionnaire was used to assess the presence of known health and social problems related to drug use which were identified through literature. Associations for presence of health and social problems following illicit drug use were assessed using Chi square test at 0.05 significance level. Results: Health and social problems following illicit drug use were common among individuals experiencing incarceration and their presence was associated with poly drug use, drug dependence and problematic drug use (p<0.05 for all). Conclusion: Past illicit drug use and related health and social problems are common among inmates in Prison, Galle, creating a considerable burden for the prison system of the country. Urgent attention of policy makers is needed to address the prevention of the illicit drug use in the country.
背景:非法药物使用在斯里兰卡是一个日益严重的问题。在包括斯里兰卡在内的许多国家,相当大比例的囚犯与非法毒品有关。目的:本研究旨在描述在加勒监狱服刑的男性在使用非法药物后可能出现的健康和社会问题。方法:对254名有非法药物使用史的男性进行横断面研究。一份由采访者协助的自我填写的问卷用于评估通过文献确定的与吸毒有关的已知健康和社会问题的存在。使用卡方检验评估非法药物使用后健康和社会问题存在的相关性,显著性水平为0.05。结果:非法药物使用后的健康和社会问题在服刑人员中普遍存在,并与多重药物使用、药物依赖和问题药物使用相关(p均<0.05)。结论:在加勒监狱的囚犯中,过去的非法药物使用和相关的健康和社会问题很常见,给该国的监狱系统造成了相当大的负担。需要决策者紧急注意在该国预防非法药物使用的问题。
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引用次数: 0
Profile of stress among a group of female school children in their early adolescence in the Galle educational zone; a descriptive cross sectional study 加勒教育区一组青春期早期女学童的压力概况一项描述性横断面研究
Pub Date : 2021-08-14 DOI: 10.4038/gmj.v26i2.8086
H. Madhushanthi, S. Wimalasekera, C. Goonewardena, A. Amarasekara, J. Lenora
Introduction: Age ranging from 11 to 14 years is regarded as early adolescence. Females are p vulnerable to experience stress with rapid physical, psychological, cognitive and social changes accompanied in adolescence. Stress experienced in adolescence is linked with a range of adverse physical and psychological consequences. The study aimed to determine the level of stress and factors contributing to stress among female adolescents in the Galle educational zone, Sri Lanka. Methods: A school based cross - sectional study was conducted on female adolescents (11 - 14 years, n = 218). A self-administered socio-demographic questionnaire and psychosocial adversity scale were used to assess socioeconomic status and psychosocial adversities respectively. The Body Mass Index (BMI), waist hip ratio (WHR), waist height ratio (WHtR) and fat percentage (FM%) were calculated to assess the nutritional status. Adolescent Stress Questionnaire (ASQ), which measures 9 dimensions of stress, was used to assess stress. Results: Normal nutritional status was observed in 118 (54.1%) while 65 (29.8%) and 35(16.1%) adolescents were underweight and overweight respectively. A majority of adolescents (n = 158, 72.9%) were experiencing stress. An increased stress levels were observed for the domains of school attendance (n = 203, 93.1%), future uncertainty (n = 202, 92.7%), school performance (n = 185, 84.9%), emerging responsibility (n = 186, 85.3%), and conflict of school/leisure time (n = 178, 81.7%). Conclusions: Most adolescents considered future uncertainty and school attendance as the greatest stress inducing factors. Urgent measures to decrease stress levels amongst these adolescents need to be implemented.
11岁到14岁被认为是青春期早期。女性在青春期容易受到压力的影响,伴随着快速的身体、心理、认知和社会变化。青春期所经历的压力与一系列不利的生理和心理后果有关。该研究旨在确定斯里兰卡加勒教育区的女性青少年的压力水平和造成压力的因素。方法:以学校为单位,对11 ~ 14岁的女性青少年进行横断面研究,共218例。采用自我管理的社会人口调查问卷和社会心理逆境量表分别评估社会经济状况和社会心理逆境。计算体重指数(BMI)、腰臀比(WHR)、腰高比(WHtR)和脂肪率(FM%)来评估营养状况。采用青少年压力问卷(ASQ)来评估压力,该问卷测量了9个维度的压力。结果:青少年营养状况正常118例(54.1%),体重过轻65例(29.8%),超重35例(16.1%)。大多数青少年(n = 158, 72.9%)有压力。在出勤率(n = 203, 93.1%)、未来不确定性(n = 202, 92.7%)、学业表现(n = 185, 84.9%)、新出现的责任(n = 186, 85.3%)和学习/休闲时间冲突(n = 178, 81.7%)等领域,压力水平均有所增加。结论:大多数青少年认为未来不确定性和上学是最大的压力诱发因素。需要采取紧急措施,降低这些青少年的压力水平。
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引用次数: 0
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Galle Medical Journal
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