Pub Date : 2026-03-14DOI: 10.1007/s11695-026-08583-8
Ravi Teja Pasam, Christopher C Thompson, Pichamol Jirapinyo
{"title":"Impact of Endoscopic Bariatric and Metabolic Therapies on Chronic Kidney Disease in Patients with Impaired Glycemic Control.","authors":"Ravi Teja Pasam, Christopher C Thompson, Pichamol Jirapinyo","doi":"10.1007/s11695-026-08583-8","DOIUrl":"https://doi.org/10.1007/s11695-026-08583-8","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s11695-026-08551-2
Lucas Monteiro Delgado, Gabriel Barone, Giulia Garcia, Giovanna Pilon, Patrícia Viana, Fabio Israel Lima Castelo Branc Marques, Cristina Bellotti Formiga Bueno, Leonardo Del Grande, Cláudia Theis, Sérgio Poli de Figueiredo, Bernardo Fontel Pompeu
Introduction: Metabolic and bariatric surgery (MBS) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are both effective strategies for obesity management, but their comparative efficacy remains uncertain. This systematic review and meta-analysis aimed to compare weight loss outcomes between MBS and GLP-1 RA therapy in adults with obesity.
Methods: A systematic search of PubMed, Scopus, and Cochrane Library was conducted from inception to September 22, 2025. Eligible studies included randomized and observational comparisons between MBS-specifically sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB)-and GLP-1 RA therapy in adults with obesity. Pooled mean differences (MDs) for total weight loss (TWL) and body mass index (BMI) change were calculated using a DerSimonian-Laird random-effects model. Risk of bias was assessed using ROBINS-I V2, and certainty of evidence was graded with GRADE.
Results: Five retrospective observational studies (n = 5,944; 3,489 MBS, 2,455 GLP-1 RA) met the inclusion criteria. Pooled analysis showed significantly greater TWL in the MBS group (MD - 18.15%; 95% CI 16.41 to 19.90; p < 0.0001; I² = 95%) and larger BMI reduction (MD 8.73 kg/m²; 95% CI 5.87 to 11.58; p = 0.0001; I² = 94.6%). Sensitivity analyses confirmed the robustness of these results. Overall risk of bias was moderate, primarily due to non-randomized designs and treatment selection bias. Certainty of evidence was rated as moderate.
Conclusions: MBS achieves significantly greater and more durable weight loss compared with GLP-1 RA therapy, reaffirming its role as the most effective intervention for severe obesity. While GLP-1 RAs represent valuable noninvasive or adjunctive options, surgery remains the benchmark for sustained metabolic and weight outcomes.
{"title":"Metabolic Bariatric Surgery versus GLP-1 Receptor Agonists for Obesity Management: A Systematic Review and Meta-Analysis.","authors":"Lucas Monteiro Delgado, Gabriel Barone, Giulia Garcia, Giovanna Pilon, Patrícia Viana, Fabio Israel Lima Castelo Branc Marques, Cristina Bellotti Formiga Bueno, Leonardo Del Grande, Cláudia Theis, Sérgio Poli de Figueiredo, Bernardo Fontel Pompeu","doi":"10.1007/s11695-026-08551-2","DOIUrl":"https://doi.org/10.1007/s11695-026-08551-2","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic and bariatric surgery (MBS) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are both effective strategies for obesity management, but their comparative efficacy remains uncertain. This systematic review and meta-analysis aimed to compare weight loss outcomes between MBS and GLP-1 RA therapy in adults with obesity.</p><p><strong>Methods: </strong>A systematic search of PubMed, Scopus, and Cochrane Library was conducted from inception to September 22, 2025. Eligible studies included randomized and observational comparisons between MBS-specifically sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB)-and GLP-1 RA therapy in adults with obesity. Pooled mean differences (MDs) for total weight loss (TWL) and body mass index (BMI) change were calculated using a DerSimonian-Laird random-effects model. Risk of bias was assessed using ROBINS-I V2, and certainty of evidence was graded with GRADE.</p><p><strong>Results: </strong>Five retrospective observational studies (n = 5,944; 3,489 MBS, 2,455 GLP-1 RA) met the inclusion criteria. Pooled analysis showed significantly greater TWL in the MBS group (MD - 18.15%; 95% CI 16.41 to 19.90; p < 0.0001; I² = 95%) and larger BMI reduction (MD 8.73 kg/m²; 95% CI 5.87 to 11.58; p = 0.0001; I² = 94.6%). Sensitivity analyses confirmed the robustness of these results. Overall risk of bias was moderate, primarily due to non-randomized designs and treatment selection bias. Certainty of evidence was rated as moderate.</p><p><strong>Conclusions: </strong>MBS achieves significantly greater and more durable weight loss compared with GLP-1 RA therapy, reaffirming its role as the most effective intervention for severe obesity. While GLP-1 RAs represent valuable noninvasive or adjunctive options, surgery remains the benchmark for sustained metabolic and weight outcomes.</p>","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s11695-026-08580-x
Beibei Cui, Jun He, Hongliang Yao
{"title":"Effects of Metabolic Bariatric Surgery on Weight Loss and Diabetes Remission Over 10 Years: A Network Meta-Analysis of Randomized Controlled Trials.","authors":"Beibei Cui, Jun He, Hongliang Yao","doi":"10.1007/s11695-026-08580-x","DOIUrl":"https://doi.org/10.1007/s11695-026-08580-x","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s11695-026-08573-w
Kayleigh Ann Martina van Dam, Maurizio De Luca, Matteo Monami, Evert-Jan Gijsbert Boerma, Giovanni Merola, Antonio Vitiello, Ricardo Cohen, Ashraf Haddad, Khaled Gawdat, Jodok Fink, Mohammad Hayssam El Fawal, Amanda Belluzzi, Jan Willem Greve
{"title":"Correction to: Ring-augmented Metabolic Bariatric Surgery Procedures GRADE-based International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Position Statement.","authors":"Kayleigh Ann Martina van Dam, Maurizio De Luca, Matteo Monami, Evert-Jan Gijsbert Boerma, Giovanni Merola, Antonio Vitiello, Ricardo Cohen, Ashraf Haddad, Khaled Gawdat, Jodok Fink, Mohammad Hayssam El Fawal, Amanda Belluzzi, Jan Willem Greve","doi":"10.1007/s11695-026-08573-w","DOIUrl":"https://doi.org/10.1007/s11695-026-08573-w","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1007/s11695-026-08499-3
Raquel Rodríguez, Daniel Salete-Granado, Lourdes Hernández-Cosido, María Teresa Cabero Morán, Oscar Blanco, Nuria Matesanz, Vanessa Rueda-Cala, Fabiola Campo, María-Ángeles Pérez-Nieto, Carlos Gutiérrez Cerrajero, Edgar Bernardo, Ronald Macías, Guadalupe Sabio, Jorge-Luis Torres, Maura Rojas-Pirela, Miguel Marcos
{"title":"miR-128-3p and miR-223-3p as Potential Biomarkers of Metabolic Dysfunction in Liver Tissue from Patients Undergoing Metabolic Bariatric Surgery.","authors":"Raquel Rodríguez, Daniel Salete-Granado, Lourdes Hernández-Cosido, María Teresa Cabero Morán, Oscar Blanco, Nuria Matesanz, Vanessa Rueda-Cala, Fabiola Campo, María-Ángeles Pérez-Nieto, Carlos Gutiérrez Cerrajero, Edgar Bernardo, Ronald Macías, Guadalupe Sabio, Jorge-Luis Torres, Maura Rojas-Pirela, Miguel Marcos","doi":"10.1007/s11695-026-08499-3","DOIUrl":"https://doi.org/10.1007/s11695-026-08499-3","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1007/s11695-026-08577-6
Izabela Karpińska, Armour Forse, Manish Singh, Piotr Major, Tomasz Rogula
{"title":"30-day Outcomes of Bariatric Surgery in Patients Over 75: Insights from the MBSAQIP Database.","authors":"Izabela Karpińska, Armour Forse, Manish Singh, Piotr Major, Tomasz Rogula","doi":"10.1007/s11695-026-08577-6","DOIUrl":"https://doi.org/10.1007/s11695-026-08577-6","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1007/s11695-026-08570-z
Louise Becroft, Priya Sumithran, Paul Burton, Wendy Brown
{"title":"Is All Weight Loss Equal Following Sleeve Gastrectomy? Defining Body Composition and Anthropometric Thresholds for Hyperglycemia Remission in Women from a Prospective Cohort Study.","authors":"Louise Becroft, Priya Sumithran, Paul Burton, Wendy Brown","doi":"10.1007/s11695-026-08570-z","DOIUrl":"https://doi.org/10.1007/s11695-026-08570-z","url":null,"abstract":"","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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