Ophthalmology最新文献

{"title":"This Issue at a Glance","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2024.12.002","DOIUrl":"10.1016/j.ophtha.2024.12.002","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Page 125"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on the Incidence of Acanthamoeba Keratitis","authors":"Francesco Aiello MD, PhD ,&nbsp;Gabriele Gallo Afflitto MD ,&nbsp;Francesca Ceccarelli MD ,&nbsp;Maria Vittoria Turco MD ,&nbsp;Yuyi Han MD ,&nbsp;Guillermo Amescua MD ,&nbsp;John K. Dart MD ,&nbsp;Carlo Nucci MD, PhD","doi":"10.1016/j.ophtha.2024.08.003","DOIUrl":"10.1016/j.ophtha.2024.08.003","url":null,"abstract":"<div><h3>Topic</h3><div>To provide an overview on the incidence of <em>Acanthamoeba</em> keratitis (AK).</div></div><div><h3>Clinical Relevance</h3><div>Although being a sight-threatening cause of infectious keratitis, a comprehensive assessment of the incidence of AK is lacking.</div></div><div><h3>Methods</h3><div>Incidence of AK was computed as the number of eyes with AK per health care center, per year (annualized center incidence [ACI]). Two meta-analytical ratios also were calculated: (1) the ratio of eyes with AK to the count of eyes with nonviral microbial keratitis (MK) and (2) the ratio of eyes with AK to the overall population (i.e., the total number of people in a nation or region, as indicated by the authors in each study). Center was defined as the health care facility where the study took place. Actual and projected estimates of the number of eyes with AK in years were calculated multiplying the ratio of eyes with AK to the total population and the corresponding population estimates, sourced from the United Nations Population Prospects.</div></div><div><h3>Results</h3><div>Overall, 105 articles were included, published between 1987 and 2022. The total number of eyes identified was 91 951, with 5660 eyes affected by AK and 86 291 eyes affected by nonviral MK. The median ACI was 1.9 eyes with AK per health care center per year (95% confidence interval [CI], 1.5–2.6 eyes), with no statistically significant differences among continents. The ratio of eyes with AK to the total number of eyes with MK was 1.52% (95% CI, 1.03%–2.22%), whereas the ratio of eyes with AK in relationship to the entire population was estimated at 2.34 eyes per 1 000 000 people (95% CI, 0.98–5.55 per 1 000 000 people). The projected increase in the numbers of eyes with AK indicated an increase of 18.5% (n = 15 355 eyes with AK) in 2053 and 25.5% (n = 16 253 eyes with AK) in 2073, compared with the baseline of 2023 (n = 12 953 eyes with AK).</div></div><div><h3>Discussion</h3><div><em>Acanthamoeba</em> keratitis emerged as a relatively low-incident disorder, and no significant differences in terms of its incidence were found among different continents.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages 206-218"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrahigh and High-frequency Ultrasound Imaging in Uveal Effusion","authors":"Mathilde Kaspi MD, FEBO ,&nbsp;Jean Luc Perrot MD, PhD ,&nbsp;Thibaud Garcin MD, PhD","doi":"10.1016/j.ophtha.2024.03.016","DOIUrl":"10.1016/j.ophtha.2024.03.016","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Page e36"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Xanthelasma Palpebrarum with Cardiovascular Risk and Dyslipidemia","authors":"Yael Lustig-Barzelay MD ,&nbsp;Noa Kapelushnik MD ,&nbsp;Inbal Goldshtein PhD ,&nbsp;Ari Leshno MD ,&nbsp;Shlomo Segev MD ,&nbsp;Guy J. Ben-Simon MD, MHA ,&nbsp;Daphna Landau-Prat MD","doi":"10.1016/j.ophtha.2024.07.033","DOIUrl":"10.1016/j.ophtha.2024.07.033","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine whether xanthelasma palpebrarum (XP) is associated with dyslipidemia, cardiovascular disease (CVD), and other systemic conditions in a large population.</div></div><div><h3>Design</h3><div>Case-control study conducted at a single tertiary care center.</div></div><div><h3>Participants</h3><div>Individuals who were examined at a medical screening institute from 2001 through 2020.</div></div><div><h3>Methods</h3><div>Medical records were reviewed to extract data on ophthalmic evaluations, blood test results, and systemic diagnoses. Patients identified with XP in at least 1 eye constituted the study group. A control group without XP was established matched by age and sex at a 10:1 ratio to allow robust statistical analysis.</div></div><div><h3>Main Outcome Measures</h3><div>Associations between XP and dyslipidemia and CVD were determined. Lipid profiles and diagnoses of dyslipidemia and CVD were compared between the case and control groups.</div></div><div><h3>Results</h3><div>The database included 35 452 individuals, 24 287 of whom were male (69%), with a mean ± standard deviation age of 52.2 ± 12.2 years. The study population included 203 patients with XP (0.6%) and 2030 matched control participants. The prevalence of dyslipidemia diagnosis was similar between the two groups (42% XP vs. 46% controls, <em>P</em> = 0.29), as were the use rates of statins, fibrates, or other cholesterol-lowering medications (48% XP vs. 47% controls, <em>P</em> = 0.88)<strong>.</strong> Lipid profiles were similar between the groups, including total cholesterol (controls median 187 [IQR, 163-211] vs. XP 192 [166-215], <em>P</em> = 0.093), high-density lipoprotein (controls median 48 [IQR, 41-57] vs. XP 47 [42-57], <em>P</em> = 0.65), low-density lipoprotein (controls median 120 [101-141] vs. XP 125 [104-145], <em>P</em> = 0.17), and triglyceride levels (controls median 111 [81-152] vs. XP 105 [81-139], <em>P</em> = 0.16). The rate of CVD was similar as well (10% control group vs. 8.9% XP group; <em>P</em> = 0.56). The prevalences of related conditions, including hypertension, diabetes mellitus, and history of cerebrovascular accident, were similar between groups (24% control group vs. 23% XP group, 14% control group vs. 10% XP group, and 1.3% control group vs. 1% XP group, respectively; <em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Xanthelasma palpebrarum was not associated with increased rates of dyslipidemia or CVD. This questions the extent to which XP serves as an indicative marker for heightened systemic risk.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages 164-169"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"En Breve","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2024.12.003","DOIUrl":"10.1016/j.ophtha.2024.12.003","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages e1-e2"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"期刊一览","authors":"Sandeep Ravindran PhD","doi":"10.1016/j.ophtha.2024.12.001","DOIUrl":"10.1016/j.ophtha.2024.12.001","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Page e3"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pearl-Appearing “Pseudohypopyon” in a Child: Exclude Malignancy","authors":"Nan Zhou MD, PhD,&nbsp;Dongjun Li MD, PhD,&nbsp;Wenbin Wei MD, PhD","doi":"10.1016/j.ophtha.2024.02.011","DOIUrl":"10.1016/j.ophtha.2024.02.011","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Page e29"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Aberrometry versus Preoperative Biometry for Intraocular Lens Power Calculations","authors":"Seth M. Pantanelli MD, MS ,&nbsp;Kathryn Hatch MD ,&nbsp;Charles C. Lin MD ,&nbsp;W. Allan Steigleman MD ,&nbsp;Zaina Al-Mohtaseb MD ,&nbsp;Jennifer R. Rose-Nussbaumer MD ,&nbsp;Marcony R. Santhiago MD ,&nbsp;Tiarnán D.L. Keenan BM BCh, PhD ,&nbsp;Stephen J. Kim MD ,&nbsp;Deborah S. Jacobs MD, MSc ,&nbsp;Julie M. Schallhorn MD","doi":"10.1016/j.ophtha.2024.08.007","DOIUrl":"10.1016/j.ophtha.2024.08.007","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the published literature to compare intraoperative aberrometry (IA) with preoperative biometry-based formulas with respect to intraocular lens (IOL) power calculation accuracy for various clinical scenarios.</div></div><div><h3>Methods</h3><div>Literature searches in the PubMed database conducted in August 2022, July 2023, and February 2024 identified 157, 18, and 6 citations, respectively. These were reviewed in abstract form, and 61 articles were selected for full-text review. Of these, 29 met the criteria for inclusion in this assessment. The panel methodologists assigned a level of evidence rating to each of the articles; 4 were rated level I, 19 were rated level II, and 6 were rated level III.</div></div><div><h3>Results</h3><div>Intraoperative aberrometry performed better than traditional vergence formulas, including the Haigis, HofferQ, Holladay, and SRK/T, and similarly to the Barrett Universal II and Hill-RBF with respect to minimization of spherical equivalent (SE) refractive error. For toric IOLs, IA outperformed formulas that only considered anterior corneal astigmatism and was similar to formulas like the Barrett Toric Calculator (BTC), which empirically account for the contribution from the posterior cornea. In eyes with a history of corneal refractive surgery, IA performed similarly to the Barrett True-K and slightly better than other tested methods, including the Haigis-L, Shammas, and Wang-Koch-Maloney formulas.</div></div><div><h3>Conclusions</h3><div>Intraoperative aberrometry corresponds well with modern vergence formulas, including the Barrett Universal II, Hill-RBF, BTC, and Barrett True-K. It has greater accuracy than traditional vergence-based IOL power calculation formulas in eyes with and without a history of corneal refractive surgery.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found after the references.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages 238-252"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2025;132:141-153)","authors":"Alessandro Rabiolo MD ,&nbsp;Giovanni Montesano MD, PhD ,&nbsp;Gus Gazzard MD, FRCOphth ,&nbsp;Joseph Caprioli MD ,&nbsp;Stefano De Cillà MD","doi":"10.1016/j.ophtha.2024.10.002","DOIUrl":"10.1016/j.ophtha.2024.10.002","url":null,"abstract":"","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages e20-e22"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facedown Positioning in Macular Hole Surgery","authors":"Raffaele Raimondi MD ,&nbsp;Nikolaos Tzoumas MBChB ,&nbsp;Steven Toh MBBS ,&nbsp;Gurkaran S. Sarohia MD ,&nbsp;Mark R. Phillips PhD ,&nbsp;Varun Chaudhary MD, FRCSC ,&nbsp;David H. Steel MD, FRCOphth","doi":"10.1016/j.ophtha.2024.08.012","DOIUrl":"10.1016/j.ophtha.2024.08.012","url":null,"abstract":"<div><h3>Topic</h3><div>To assess the anatomic and visual effects of facedown positioning (FDP) advice in patients undergoing vitrectomy with gas tamponade for idiopathic full-thickness macular holes (FTMHs) and to explore differential treatment effects by macular hole size and FDP duration.</div></div><div><h3>Clinical Relevance</h3><div>The necessity and duration of FDP for FTMH closure remain contentious, with no consensus guidelines.</div></div><div><h3>Methods</h3><div>Prospectively registered systematic review and individual patient data (IPD) meta-analysis of randomized controlled trials comparing FDP with no FDP (nFDP) across the MEDLINE, Embase, and Cochrane Library databases and clinical trial registries from January 2000 to March 2023 (CRD42023395152). All adults with idiopathic FTMHs undergoing vitrectomy with gas tamponade were included. The main outcomes were primary macular hole closure and postoperative visual acuity at 6 months or nearest time point.</div></div><div><h3>Results</h3><div>Of 8 eligible trials, 5 contributed IPD for 379 eyes and were included in our analysis. The adjusted odds ratio (OR) for primary closure with FDP versus nFDP was 2.41 (95% confidence interval [CI], 0.98–5.93, <em>P</em> = 0.06; low-certainty evidence), translating to a risk ratio (RR) of 1.08 (1.00–1.11) and a number needed to treat (NNT) of 15. The FDP group exhibited a mean improvement in postoperative visual acuity of –0.08 logarithm of the minimum angle of resolution (logMAR) (–0.13 to –0.02, <em>P</em> = 0.006; low-certainty evidence) compared with the nFDP group. Benefits were more certain in participants with larger holes of minimum linear diameter ≥ 400 μm: adjusted OR for closure ranged from 1.13 to 10.12 (<em>P</em> = 0.030) (NNT 12), with a mean visual acuity improvement of –0.18 to –0.01 logMAR (<em>P</em> = 0.022). Each additional day of FDP was associated with improved odds of anatomic success (adjusted OR, 1.02–1.41, RR, 1.00–1.02, <em>P</em> = 0.026) and visual acuity improvement (–0.02 logMAR, –0.03 to –0.01, <em>P</em> = 0.002), possibly plateauing at 3 days.</div></div><div><h3>Conclusions</h3><div>This study provides low-certainty evidence that FDP improves the anatomic and visual outcomes of macular hole surgery modestly and indicates that the effect may be more substantial for macular holes exceeding 400 μm. The findings support recommending FDP for patients with macular holes exceeding 400 μm pending further investigation.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found after the references.</div></div>","PeriodicalId":19533,"journal":{"name":"Ophthalmology","volume":"132 2","pages":"Pages 194-205"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}