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Could Periodontitis Aggravate Psoriasis?—An Update by Systematic Review 牙周炎会加重牛皮癣吗?-系统评价的更新
Juan José Meneu, C. Márquez-Arrico, F. Silvestre, J. Silvestre-Rangil
(1) Background: Psoriasis is a chronic and inflammatory systemic disease that has been associated with periodontal pathologies, specifically periodontitis. The aim of this research is to answer the following question: Could periodontitis aggravate psoriasis? (2) Methods: We carried out a systematic review following the PRISMA guide using PubMed, Embase, Scopus, and WOS; (3) Results: A total of 111 studies were identified in the databases and 11 were obtained after screening. The selection included nine case–control studies, one cross-sectional study, and one cohort study. Most of the publications report an increase in bleeding on probing and the presence of periodontal pockets in patients with psoriasis, confirming that inflammation caused by periodontitis can contribute to systemic inflammation worsening psoriasis. To summarize, the scientific literature indicates that local periodontal inflammation could aggravate psoriasis.
(1)背景:银屑病是一种慢性炎症性全身性疾病,与牙周病变,特别是牙周炎有关。本研究的目的是回答以下问题:牙周炎会加重牛皮癣吗?(2)方法:根据PRISMA指南,使用PubMed、Embase、Scopus和WOS进行系统评价;(3)结果:在数据库中共识别出111篇研究,经筛选获得11篇。入选研究包括9项病例对照研究、1项横断面研究和1项队列研究。大多数出版物报道了银屑病患者在穿刺时出血和牙周袋的增加,证实了由牙周炎引起的炎症可导致全身炎症恶化银屑病。综上所述,科学文献表明局部牙周炎症可加重银屑病。
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引用次数: 0
Efficacy of Elastodontic Devices vs. Clear Aligners in Lower Intercanine Distance Changes Assessed by Computer-Aided Evaluation 计算机辅助评估弹性矫形器与透明矫形器在下齿间距离变化中的疗效
E. Ortu, D. Pietropaoli, S. Cova, M. Giannoni, A. Monaco
Background: This pilot study aimed to verify the efficacy of two orthodontic appliances in relation to changes in the lower intercanine distance in growing patients. Methods: Twenty patients aged 10–16 years were enrolled in the study and separated into test and control groups. The test group included 10 patients (5 males, 5 females; mean age, 10.4 ± 1.57 years) who were treated with an elastodontic device. The control group included 10 patients (5 males, 5 females; mean age 10.8 ± 1.53 years) who were treated with clear aligners. The two groups exhibited the same orthodontic features. The orthodontic criteria were: skeletal class I relationship, molar class I relationship, and presence of lower crowding. Patients were evaluated as having mild or moderate crowding according to the Daniels and Richmond index. The lower intercanine distance was evaluated at three timepoints via intraoral scans: T0 (before starting therapy), T1 (after six months), and T2 (after 1 year). Data were analyzed using a nonparametric approach via the Wilcoxon signed-rank test. Results: There was no statistically significant difference between the two groups at T0, T1, or T2 (p < 0.05). Conclusions: elastodontic devices and clear aligners can successfully help the orthodontist conduct lower arch expansion treatment. These appliances are comfortable to wear, simple to clean every day, and reduce the number of dentist appointments. Finally, but not of least importance, these devices have allowed dentists to continue orthodontic treatments during the lockdowns of the COVID-19 pandemic.
背景:本初步研究旨在验证两种正畸矫治器对成长期患者下齿间距离变化的影响。方法:选取20例10 ~ 16岁的患者作为研究对象,分为试验组和对照组。试验组患者10例,男5例,女5例;平均年龄(10.4±1.57岁)。对照组10例,男5例,女5例;平均年龄(10.8±1.53岁)。两组表现出相同的正畸特征。正畸标准是:骨骼I级关系,磨牙I级关系,存在较低的拥挤。根据丹尼尔斯和里士满指数,患者被评估为轻度或中度拥挤。通过口内扫描在三个时间点评估犬间距离:T0(开始治疗前),T1(6个月后)和T2(1年后)。数据分析采用非参数方法,通过Wilcoxon符号秩检验。结果:两组在T0、T1、T2时比较,差异均无统计学意义(p < 0.05)。结论:弹性矫治装置和透明矫直器可以成功地帮助正畸医师进行下弓扩张治疗。这些器具佩戴舒适,每天清洁简单,减少了看牙医的次数。最后,但并非最不重要的是,这些设备使牙医能够在COVID-19大流行封锁期间继续进行正畸治疗。
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引用次数: 0
Analysis of Global Search and Research Interests on Dentists Using Infoveillance and Bibliometric Approaches 利用信息监控和文献计量学方法分析牙医的全球搜索和研究兴趣
K. Kanmodi, Oluwafemi Abolade, J. Amzat, L. Nnyanzi
About half of the world’s population requires the services of a dentist. However, the in-depth understanding of the concerns and priorities of the global public and scientific communities concerning dentists is essential for the planning and development of sustainable strategies, interventions, and policies that will cater for the current global oral health needs. Therefore, this study investigated the global search and research interests on dentists using a hybrid research design—a combination of infoveillance and bibliometric research designs. The data analysed in this study were obtained from Google Trends and SCOPUS. The findings show that, over the years, there has been a significant growth in the volume of information search and research outputs on dentists with huge inequalities existing between the Global South and North. It is also notable that the COVID-19 pandemic played a significantly influential role in the global information search and dissemination trends on dentists. The knowledge and funding for dentist-related research flow significantly from the countries of the Global North. The review of the network visualisation of keyword co-occurrence revealed a misplaced priority in the global research interest areas on dentists and oral health. The obtained findings could help to shape the future of dental healthcare and policy.
世界上大约一半的人口需要牙医的服务。然而,深入了解全球公众和科学界对牙医的关注和优先事项,对于规划和制定可持续战略、干预措施和政策至关重要,这些战略、干预措施和政策将满足当前全球口腔健康需求。因此,本研究使用混合研究设计——信息监测和文献计量研究设计的结合——调查了全球对牙医的搜索和研究兴趣。本研究分析的数据来自谷歌Trends和SCOPUS。研究结果表明,多年来,在全球南北之间存在巨大不平等的情况下,关于牙医的信息搜索量和研究产出显著增长。值得注意的是,新冠肺炎疫情对全球牙医信息搜索和传播趋势产生了重大影响。牙医相关研究的知识和资金大量来自全球北方国家。关键词共现的网络可视化的审查揭示了错位的优先级在牙医和口腔健康的全球研究兴趣领域。获得的发现可以帮助塑造牙科保健和政策的未来。
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引用次数: 3
Effectiveness of Passive Ultrasonic Irrigation Protocols in Simulated Complex Root Canal Cavities 被动超声灌洗方案在模拟复杂根管腔中的有效性
F. Plazza, R. Dal-Fabbro, L. Cosme-Silva, P. T. Duarte, C. Loureiro, Vitória Z. Custódio, L. Cintra, M. Duarte, J. E. Gomes‐Filho
This study aimed to evaluate the effectiveness of different Passive Ultrasonic Irrigation (PUI) protocols on debris removal and exposure of dentinal tubules in simulated complex root canal cavities. Twenty single-rooted human mandibular premolars with simulated root canal cavities were filled with the debris and randomly divided into ten groups based on the final irrigation protocol: 1—positive control; 2—negative control; 3—conventional irrigation (CI) with 2.5% sodium hypochlorite (NaOCl); 4—CI with 17% ethylenediaminetetraacetic acid (EDTA) followed by NaOCl; 5—three cycles of PUI for 20 s (NaOCl-NaOCl-NaOCl); 6—three cycles of PUI for 20 s (NaOCl-EDTA-NaOCl); 7—one 60 s PUI cycle (NaOCl); 8—one PUI 180 s cycle (NaOCl); 9—two cycles of PUI for 60 s (EDTA-NaOCl); and 10—two cycles of PUI for 60 s (NaOCl-EDTA). The groups were analyzed by SEM. The Kruskal-Wallis test was used at a 5% level. PUI showed a higher reduction of debris, similar to the positive control group (p > 0.05) and higher than the CI and negative control groups (p < 0.05). Regarding the exposure tubules, the CI groups were similar to the negative control group in all cavities (p > 0.05). The PUI groups were similar to the positive control group (p > 0.05). However, only groups 6, 7, and 10 were statistically different from the CI and negative control (p < 0.05). The protocols using PUI, comprising groups with three cycles of 20 s (NaOCl-EDTA-NaOCl), two cycles of 60 s (EDTA-NaOCl), or one cycle of 60 s (NaOCl), were more effective at removing debris and increasing the exposure of dentinal tubules.
本研究旨在评估不同被动超声灌洗(PUI)方案对模拟复杂根管腔中牙本质小管碎片清除和暴露的有效性。将20颗具有模拟根管腔的单根人下颌前磨牙充填碎片,根据最终的冲洗方案随机分为10组:1组为阳性对照组;2 -控制;3、2.5%次氯酸钠(NaOCl)常规灌溉;4-CI加17%乙二胺四乙酸(EDTA),再加NaOCl;5 - 3次循环PUI 20 s (NaOCl-NaOCl-NaOCl);6 - 3周期PUI 20 s (NaOCl-EDTA-NaOCl);7 - 1个60 s PUI循环(NaOCl);8 - 1 PUI 180 s循环(NaOCl);9 - 2次PUI 60 s (EDTA-NaOCl);60 s的10 - 2周期PUI (NaOCl-EDTA)。用扫描电镜对各组进行分析。Kruskal-Wallis检验采用5%水平。PUI组的碎片减少率较高,与阳性对照组相似(p < 0.05),高于CI组和阴性对照组(p < 0.05)。在暴露小管方面,CI组各空腔与阴性对照组相似(p < 0.05)。PUI组与阳性对照组相似(p < 0.05)。但只有6、7、10组与CI及阴性对照有统计学差异(p < 0.05)。使用PUI的方案,包括3个20秒周期(NaOCl-EDTA-NaOCl)、2个60秒周期(EDTA-NaOCl)或1个60秒周期(NaOCl)组,在去除碎片和增加牙本质小管暴露方面更有效。
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引用次数: 1
Factors Determining the Willingness of Nigerian Clinicians to Recommend Protected Oral Sex: An Online Exploratory Study 决定尼日利亚临床医生推荐保护性口交意愿的因素:一项在线探索性研究
K. Kanmodi, J. Nwafor, U. Eze, B. Amoo, A. Salami, Bello Almu, M. Ogbeide, P. Obute, Timothy Olukunle Aladelusi, O. Adebayo, L. Nnyanzi
Oral sex, a risky sexual behaviour, is now a common sexual behaviour in Nigeria. Nigerian clinicians play crucial roles in the promotion of healthy sexual behaviours among the lay public. This study seeks to identify those factors that determine the willingness of Nigerian clinicians to recommend protected oral sex to patients with history of oral sex practice. This study surveyed 330 clinicians in Nigeria, using an e-questionnaire circulated via WhatsApp. The collected data were analysed using SPSS version 21 software. The majority (89.1%) of the respondents were willing to recommend protected oral sex for patients engaging in oral sex. Amidst all of the factors (sociodemographic factors, sexual history, etc.) investigated, only one factor (which was the uncertainty about the risk level of oral sex) was found to predict the willingness to recommend protective measures to patients on oral sex (OR = 3.06, p = 0.036). In conclusion, only few factors were found to influence Nigerian clinicians in engaging in patient education on safer oral sex practices.
口交,一种危险的性行为,现在在尼日利亚是一种常见的性行为。尼日利亚临床医生在促进非专业公众健康的性行为方面发挥着至关重要的作用。本研究旨在确定那些决定尼日利亚临床医生向有口交史的患者推荐保护性口交的意愿的因素。这项研究使用通过WhatsApp分发的电子问卷调查了尼日利亚的330名临床医生。采用SPSS 21版软件对收集的数据进行分析。绝大多数(89.1%)的受访者愿意建议患者进行有保护的口交。在调查的所有因素(社会人口学因素、性史等)中,只有一个因素(对口交风险水平的不确定性)可以预测患者推荐口交保护措施的意愿(OR = 3.06, p = 0.036)。总之,只有少数因素被发现影响尼日利亚临床医生从事患者安全口交行为教育。
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引用次数: 3
Phenotypes, Genotypes, and Treatment Options of Primary Failure of Eruption: A Narrative Review 表型,基因型,和治疗方案的主要失败的爆发:叙述回顾
L. Testarelli, Francesca Sestito, A. D. De Stefano, Chiara Seracchiani, R. Vernucci, G. Galluccio
Tooth eruption is a complex process, during which a series of factors can cause a failure of it. Among this, primary failure of eruption (PFE) is a non-syndromic condition that leads to an incomplete tooth eruption despite the presence of a clear eruption pathway. The aim of this narrative review is to provide an overall view about clinical considerations, genetics-related aspects, and possible treatments of PFE based on the latest findings. A literature search using the PubMed/Medline and Scopus database was performed. The search terms used were “PFE”, “orthodontics”, “primary failure of eruption”, and “treatment”, and all the articles, according to the inclusion criteria, from 2008 until June 2022 were screened. Among them, 12 articles were considered useful to highlight some of the main genotypical and phenotypical aspects and several treatment options. Indeed, if there is a suspicion of primary failure of eruption, a PTH1R screening should be performed, because a mutation in this gene is responsible for an altered balance between the resorptive and the appositional processes during the eruption. This is important to know before starting an orthodontic treatment because it could lead to ankylosis of the affected tooth, exposing patients to iatrogenic damage. Treatment options depend on the growth phase of the patient and on the clinical situation.
萌牙是一个复杂的过程,在这个过程中,一系列的因素会导致萌牙的失败。其中,原发性出牙失败(PFE)是一种非综合征性疾病,尽管存在明确的出牙途径,但仍会导致牙齿不完全出牙。这篇叙述性综述的目的是根据最新发现提供关于PFE的临床考虑、遗传学相关方面和可能的治疗方法的总体观点。使用PubMed/Medline和Scopus数据库进行文献检索。检索词为“PFE”、“orthodontics”、“primary failure of萌牙”和“treatment”,根据纳入标准对2008年至2022年6月期间的所有文章进行筛选。其中,12篇文章被认为是有用的,强调了一些主要的基因型和表型方面以及几种治疗方案。事实上,如果怀疑是原发性喷发失败,则应进行PTH1R筛查,因为该基因的突变导致喷发期间吸收和释放过程之间的平衡发生改变。在开始正畸治疗之前了解这一点很重要,因为它可能导致受影响的牙齿僵硬,使患者暴露于医源性损伤。治疗方案取决于患者的生长阶段和临床情况。
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引用次数: 0
Self-Reported Mandibular Impairment and Cervical Pain Comorbidity in Undergraduate Dental Students 自我报告的下颌损伤和颈椎疼痛在牙科本科学生中的共病
Luciana Paula Benício Arcas, L. Pinto, Ana Laura Sebben Fornari Moromizato, J. S. Miranda, João Paulo Mendes Tribst, M. Amaral
The aim of this study was to evaluate the frequency of co-existence of self-reported mandibular functional impairment and cervical pain in the same individuals. Participants answered a validated Mandibular Functional Impairment Questionnaire (MFIQ) and also indicated in a schematic map the region of cervical pain when it was reported. The frequency of cervical pain in participants with or without mandibular functional was compared with Chi-squared test. The final evaluated population consisted of 80 participants, 28 men (35%) and 52 women (65%), with ages ranging between 18 and 55 years (median = 20). It was found that 43.75% (n = 35) reported cervical pain, 15% of participants reported some degree of mandibular impairment, and 11.25% presented the comorbidity. In conclusion, participants with mandibular impairment presented significantly more frequent cervical pain than participants without mandibular impairment.
本研究的目的是评估同一个体中自我报告的下颌功能障碍和颈椎疼痛共存的频率。参与者回答了一份有效的下颌功能障碍问卷(MFIQ),并在报告颈椎疼痛时在示意图中指出了颈椎疼痛的区域。用卡方检验比较有或无下颌骨功能的受试者颈椎疼痛的频率。最终评估的人群包括80名参与者,28名男性(35%)和52名女性(65%),年龄在18至55岁之间(中位数= 20)。结果发现,43.75% (n = 35)的参与者报告了颈椎疼痛,15%的参与者报告了一定程度的下颌损伤,11.25%的参与者出现了合并症。总之,有下颌骨损伤的参与者比没有下颌骨损伤的参与者更频繁地出现颈椎疼痛。
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引用次数: 0
Onset of MRONJ in Breast Cancer Patients after Switching from Low to High Dose of Bone Modifying Agents Due to Bone Metastases Development: A Single Center Retrospective Cohort Study 由于骨转移的发展,乳腺癌患者从低剂量骨修饰剂切换到高剂量后MRONJ的发病:一项单中心回顾性队列研究
R. Mauceri, Martina Coppini, G. Campisi
Background: Medication-Related Osteonecrosis of the Jaw (MRONJ) is an adverse drug reaction mainly associated to bone modifying agents (BMAs). Breast cancer (BC) is the most frequent cancer worldwide. Its therapy can cause cancer treatment-induced bone loss (CTIBL), commonly treated with BMAs. The aims of this retrospective study are: to describe characteristics of BC patients under BMAs for CTIBL; to record any switch to high-dose BMAs; to assess MRONJ onset and to identify any factors associated with it. Patients: Authors included patients referred for MRONJ prevention to the Unit of Oral Medicine (University Hospital of Palermo). Results: Fourteen female BC patients under low-dose BMAs for CTIBL were eligible (mean age 66.6 years). Four patients switched to high-dose BMAs for bone metastases. In two of the four, MRONJ developed: one case, in the mandible (risedronate for 48 months then Xgev® for 60 months); the other case, in the maxilla (Prolia® for 20 months then zoledronate for 16 months). Conclusion: It can be theorized that BC patients under BMAs for CTIBL are likely to have MRONJ risk similar to osteo-metabolic patients. These patients need more careful monitoring of oral health since they may switch, for preventing or treating bone metastases, to heavier BMAs therapy, thus increasing their risk of MRONJ.
背景:颌骨药物相关性骨坏死(MRONJ)是一种主要与骨修饰剂(bma)相关的药物不良反应。乳腺癌(BC)是世界上最常见的癌症。它的治疗可以导致癌症治疗性骨质流失(CTIBL),通常用BMAs治疗。本回顾性研究的目的是:描述因CTIBL接受BMAs治疗的BC患者的特征;记录任何转向高剂量bma的情况;评估MRONJ的发病并确定与之相关的任何因素。患者:作者包括转介到口腔医学(巴勒莫大学医院)预防MRONJ的患者。结果:14例接受低剂量bma治疗的女性BC患者(平均年龄66.6岁)符合条件。4名患者改用高剂量bma治疗骨转移。4例患者中有2例出现MRONJ: 1例在下颌骨(利塞膦酸钠治疗48个月,Xgev治疗60个月);另一组在上颌骨(Prolia®治疗20个月,唑来膦酸钠治疗16个月)。结论:从理论上可以推断,接受CTIBL的BMAs治疗的BC患者可能与骨代谢患者有相似的MRONJ风险。这些患者需要更仔细地监测口腔健康,因为为了预防或治疗骨转移,他们可能会改用更重的BMAs治疗,从而增加MRONJ的风险。
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引用次数: 0
Utilization of Machine Learning Methods for Predicting Orthodontic Treatment Length 利用机器学习方法预测正畸治疗时间
M. H. Elnagar, Allen Y. Pan, Aryo Handono, F. Sanchez, Sameh Talaat, C. Bourauel, Ahmed Kaboudan, B. Kusnoto
Treatment duration is one of the most important factors that patients consider when deciding whether to undergo orthodontic treatment or not. This study aimed to build and compare machine learning (ML) models for the prediction of orthodontic treatment length and to identify factors affecting the duration of orthodontic treatment using the ML approach. Records of 518 patients who had successfully finished orthodontic treatment were used in this study. Seventy percent of the patient data were used for training ML models, and thirty percent of the data were used for testing these models. We applied and compared nine machine-learning algorithms: simple linear regression, modified simple linear regression, polynomial linear regression, K nearest neighbor, simple decision tree, bagging regressor, random forest, gradient boosting regression, and adaboost regression. We then calculated the importance of patient data features for the ML models with the highest performance. The best overall performance was obtained through the bagging regressor and adaboost regression ML methods. The most important features in predicting treatment length were age, crowding, artificial intelligence case difficulty score, overjet, and overbite. Without patient information, several ML algorithms showed comparable performance for predicting treatment length. Bagging and adaboost showed the best performance when patient information, including age, malocclusion, and crowding, was provided.
治疗时间是患者决定是否接受正畸治疗的重要因素之一。本研究旨在建立和比较预测正畸治疗时间的机器学习(ML)模型,并利用ML方法确定影响正畸治疗时间的因素。本研究使用518例成功完成正畸治疗的患者的记录。70%的患者数据用于训练ML模型,30%的数据用于测试这些模型。我们应用并比较了九种机器学习算法:简单线性回归、修正简单线性回归、多项式线性回归、K近邻、简单决策树、bagging回归、随机森林、梯度增强回归和adaboost回归。然后,我们计算了具有最高性能的ML模型的患者数据特征的重要性。通过bagging回归和adaboost回归ML方法获得了最佳的综合性能。预测治疗时间的最重要特征是年龄、拥挤程度、人工智能病例困难评分、复盖和复咬。在没有患者信息的情况下,几种ML算法在预测治疗时间方面表现出相当的性能。Bagging和adaboost在提供患者信息(包括年龄、错牙合和拥挤程度)时表现最佳。
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引用次数: 1
A Preliminary Study Investigating the Impact of the COVID-19 Pandemic on Dental Education in the Caribbean: A Student’s Perspective 调查COVID-19大流行对加勒比地区牙科教育影响的初步研究:学生的视角
T. Hoyte, Anil Ali, Adilah Mahabir
Dental education was heavily impacted by the COVID-19 pandemic. The aim of this preliminary study was to begin to assessment of the effect of the pandemic on dental education in the Caribbean. An online self-administered questionnaire was emailed to undergraduate dental students. The survey was conducted at the end of the semester’s online learning period. The survey assessed the experiences and attitudes of the students. Chi-square and Fisher exact test were tabulated to ascertain the relationship between questions asked with the year of study and gender. The response rate was 73% (n = 100). The respondents comprised 53.4% (n = 24) of preclinical and 72.7% (n = 40) of clinical students who stated didactic and clinical training were affected. In total, 86.7% (n = 39) of preclinical students felt that their lab experience was affected and 96.4% (n = 53) of clinical students reported their clinical training was affected. Restorative dentistry was the sub-specialty students felt was mainly affected. Recorded lectures to review later was stated as the most significant advantage of online learning. A lack of hands-on experience as a result of no access to a preclinical lab was the most negative aspect of online learning for preclinical students. Clinical students reported that their clinical experience was affected by clinic closure and the move to online learning. Moreover, 66% (n = 66) of respondents reported poor internet connection. There was no statistically significant correlation between gender and year of study with the questions asked. Students reported a positive attitude to online learning. However, they did not consider it a substitute for face-to-face laboratory and clinical teaching.
牙科教育受到COVID-19大流行的严重影响。这项初步研究的目的是开始评估大流行对加勒比地区牙科教育的影响。通过电子邮件向牙科本科学生发送了一份在线自我管理的问卷。该调查是在学期在线学习结束时进行的。这项调查评估了学生们的经历和态度。卡方检验和Fisher精确检验被制成表格以确定所问问题与研究年份和性别之间的关系。有效率为73% (n = 100)。受访者中有53.4% (n = 24)的临床前学生和72.7% (n = 40)的临床学生表示教学和临床训练受到影响。总共有86.7% (n = 39)的临床预科生认为他们的实验室体验受到了影响,96.4% (n = 53)的临床生表示他们的临床训练受到了影响。口腔修复是学生认为受影响最大的亚专业。在线学习最显著的优点是录下讲座供以后复习。由于无法进入临床前实验室而缺乏实践经验,这是临床前学生在线学习最不利的方面。临床学生报告说,他们的临床经验受到诊所关闭和转向在线学习的影响。此外,66% (n = 66)的受访者表示互联网连接较差。性别和学习年限与所问问题之间没有统计学上的显著相关性。学生们对在线学习持积极态度。然而,他们并不认为它可以代替面对面的实验室和临床教学。
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引用次数: 0
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Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
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