Rigorous peer-reviews are the basis of high-quality academic publishing [...]
严格的同行评议是高质量学术出版的基础[…]
{"title":"Acknowledgment to Reviewers of Oral in 2021","authors":"","doi":"10.3390/oral2010003","DOIUrl":"https://doi.org/10.3390/oral2010003","url":null,"abstract":"Rigorous peer-reviews are the basis of high-quality academic publishing [...]","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80579227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Del Vecchio, G. Tenore, Daniele Pergolini, F. Rocchetti, G. Palaia, U. Romeo
Medication-Related Osteo-Necrosis of the Jaws (MRONJ) is a severe painful complication of the long-lasting administration of bisphosphonates and anti-resorptive and anti-angiogenetic drugs in neoplastic and dysmetabolic patients, secondary to minor surgical oral interventions or chronic epithelial decubitus ulcers. Its pathogenesis is still largely unknown even if the activity change of the osteoclasts plays a relevant role in bone remodeling. The management of these patients aims to prevent the onset of the pathology or to reduce the pain and remove the necrotic bone, promoting the healing of the pathological area. Photobiomodulation therapy (PBMT), the therapeutic application of low-energy laser or LED lights, was recently introduced in the management of this condition. Thanks to its therapeutic and biomodulating action on the irradiated tissues, PBM can be used alone or in combination with antibiotic and antibacterial therapies as a preventive, antalgic or palliative tool, and in support of surgery in a combined multi-protocol that leads to a positive and better resolution and healing of the pathologic process, with great improvement of the Quality of Life (QoL) of the patients. In this narrative review, a wide analysis of the various applications of PBM in MRONJ patients’ management is analyzed, emphasizing its role as supportive care for this condition.
{"title":"The Role of the Laser Photobiomodulation (PBM) in the Management of Patients at Risk or Affected by MRONJ","authors":"A. Del Vecchio, G. Tenore, Daniele Pergolini, F. Rocchetti, G. Palaia, U. Romeo","doi":"10.3390/oral2010002","DOIUrl":"https://doi.org/10.3390/oral2010002","url":null,"abstract":"Medication-Related Osteo-Necrosis of the Jaws (MRONJ) is a severe painful complication of the long-lasting administration of bisphosphonates and anti-resorptive and anti-angiogenetic drugs in neoplastic and dysmetabolic patients, secondary to minor surgical oral interventions or chronic epithelial decubitus ulcers. Its pathogenesis is still largely unknown even if the activity change of the osteoclasts plays a relevant role in bone remodeling. The management of these patients aims to prevent the onset of the pathology or to reduce the pain and remove the necrotic bone, promoting the healing of the pathological area. Photobiomodulation therapy (PBMT), the therapeutic application of low-energy laser or LED lights, was recently introduced in the management of this condition. Thanks to its therapeutic and biomodulating action on the irradiated tissues, PBM can be used alone or in combination with antibiotic and antibacterial therapies as a preventive, antalgic or palliative tool, and in support of surgery in a combined multi-protocol that leads to a positive and better resolution and healing of the pathologic process, with great improvement of the Quality of Life (QoL) of the patients. In this narrative review, a wide analysis of the various applications of PBM in MRONJ patients’ management is analyzed, emphasizing its role as supportive care for this condition.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85215762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edouard Di Donna, Loïc Mahé Keller, Annika Neri, Alexandre Perez, T. Lombardi
Supernumerary teeth may be encountered as an incidental finding on a radiograph. When impacted, they may be associated with clinical signs related to different problems such as failure of eruption, teeth displacement, root resorption or cystic lesions. They may occur in primary and permanent dentition, in both the maxilla and mandible and can be single or multiple in patients with syndromes. Mesiodens is the most commonly impacted tooth and appears between the central maxillary incisors in pediatric ages. Supernumerary teeth distal to the third molar are rare, usually impacted and referred to as a distomolar. A 46-year-old male consulted with the main complaint of pain on the left side of the maxilla. A panoramic radiograph revealed a right impacted maxillary fourth molar located posterior to the third molar associated with a pericoronal radiolucency. The supernumerary tooth was removed surgically under local anesthesia and the pericoronal lesion enucleated. Histopathological examination was consistent with the diagnosis of a dentigerous cyst associated with an impacted distomolar. Healing was uneventful, and the patients remained asymptomatic. The occurrence of a maxillary distomolar is rare and even rarer the association with a dentigerous cyst.
{"title":"Maxillary Distomolar Associated with Dentigerous Cyst: An Unusual Entity","authors":"Edouard Di Donna, Loïc Mahé Keller, Annika Neri, Alexandre Perez, T. Lombardi","doi":"10.3390/oral2010001","DOIUrl":"https://doi.org/10.3390/oral2010001","url":null,"abstract":"Supernumerary teeth may be encountered as an incidental finding on a radiograph. When impacted, they may be associated with clinical signs related to different problems such as failure of eruption, teeth displacement, root resorption or cystic lesions. They may occur in primary and permanent dentition, in both the maxilla and mandible and can be single or multiple in patients with syndromes. Mesiodens is the most commonly impacted tooth and appears between the central maxillary incisors in pediatric ages. Supernumerary teeth distal to the third molar are rare, usually impacted and referred to as a distomolar. A 46-year-old male consulted with the main complaint of pain on the left side of the maxilla. A panoramic radiograph revealed a right impacted maxillary fourth molar located posterior to the third molar associated with a pericoronal radiolucency. The supernumerary tooth was removed surgically under local anesthesia and the pericoronal lesion enucleated. Histopathological examination was consistent with the diagnosis of a dentigerous cyst associated with an impacted distomolar. Healing was uneventful, and the patients remained asymptomatic. The occurrence of a maxillary distomolar is rare and even rarer the association with a dentigerous cyst.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89927716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Total edentulism is the loss of all teeth for any cause by a multifactorial process that involves biological and patient-related factors. Studies on edentulism and risk factors in Mexico are limited, and the epidemiological surveillance data is scarce and controversial since official governmental reports are not statistically representative of the country. We estimate the distribution for edentulism according to sociodemographic and socioeconomic variables in adults from a low-income state in 2003 and its progress in Mexico. We analyzed data from the National Performance Evaluation Survey in Oaxaca, Mexico, and the annual reports of the Epidemiological Surveillance System of Oral Pathologies in 2009–2019 using X2. Oaxacan patients older than 75 y.o. (17.9%, p < 0.05), those with lower schooling (11.2%), and diabetes (14.5%) presented the highest percentage of edentulism. We do not observe differences in edentulism between sex or residence (p > 0.05). From 2009 to 2019, country data reports the lowest rate of edentulism in adults over 20 y.o. (0.32%; 95% CI 0.18–0.48%) and the most affected population over 79 y.o. (7.29%; 95% CI 5.2–9.30%). As it is a cumulative phenomenon, it is necessary to establish better surveillance, prevention, and treatment programs to improve the oral health of older thus reducing edentulism.
全牙缺牙症是一种多因素的过程，包括生物因素和患者相关因素。在墨西哥，关于蛀牙症和危险因素的研究是有限的，流行病学监测数据是稀缺和有争议的，因为官方政府报告在统计上不能代表该国。根据2003年墨西哥低收入州成年人的社会人口学和社会经济变量，我们估计了无牙症的分布及其进展。我们使用X2分析了墨西哥瓦哈卡州国家绩效评估调查数据以及2009-2019年口腔病理流行病学监测系统年度报告。瓦哈卡州年龄大于75岁的患者(17.9%，p < 0.05)、受教育程度较低的患者(11.2%)和糖尿病患者(14.5%)患全牙症的比例最高。我们没有观察到性别和居住地之间的牙切性差异(p > 0.05)。从2009年到2019年，国家数据显示，20岁以上成年人的蛀牙率最低(0.32%;95% CI 0.18-0.48%)， 79岁以上人群受影响最大(7.29%;95% ci 5.2-9.30%)。由于它是一个累积现象，有必要建立更好的监测，预防和治疗方案，以改善老年人的口腔健康，从而减少蛀牙。
{"title":"Total Edentulism and Its Epidemiological Surveillance in Oaxaca, Mexico from 2009–2019","authors":"E. Martínez-Martínez, C. Medina-Solís, J. Alpuche","doi":"10.3390/oral1040035","DOIUrl":"https://doi.org/10.3390/oral1040035","url":null,"abstract":"Total edentulism is the loss of all teeth for any cause by a multifactorial process that involves biological and patient-related factors. Studies on edentulism and risk factors in Mexico are limited, and the epidemiological surveillance data is scarce and controversial since official governmental reports are not statistically representative of the country. We estimate the distribution for edentulism according to sociodemographic and socioeconomic variables in adults from a low-income state in 2003 and its progress in Mexico. We analyzed data from the National Performance Evaluation Survey in Oaxaca, Mexico, and the annual reports of the Epidemiological Surveillance System of Oral Pathologies in 2009–2019 using X2. Oaxacan patients older than 75 y.o. (17.9%, p < 0.05), those with lower schooling (11.2%), and diabetes (14.5%) presented the highest percentage of edentulism. We do not observe differences in edentulism between sex or residence (p > 0.05). From 2009 to 2019, country data reports the lowest rate of edentulism in adults over 20 y.o. (0.32%; 95% CI 0.18–0.48%) and the most affected population over 79 y.o. (7.29%; 95% CI 5.2–9.30%). As it is a cumulative phenomenon, it is necessary to establish better surveillance, prevention, and treatment programs to improve the oral health of older thus reducing edentulism.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85802146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oskar Bunz, Darja Iwantschenko, S. Tulka, Claudia Barthel-Zimmer, A. Piwowarczyk
Objective: The question of whether classic cast post-and-core (CPC) or fiber-reinforced composite resin posts (FRCP) are the best clinical decision has still not been fully solved. Materials and Methods: One hundred and sixty-two teeth were restored with FRCP, and 162 CPC restored teeth were included in this study with a matched-pair design. In a primary analysis, the survival rates after one year (primary endpoint) were compared. The additional analysis included an evaluation of tooth- and construction-specific variables and an illustration of the survival up to 60 months via Kaplan-Meier curves. Results: FRCP showed lower failure risk considering the definitive prosthetic restoration and tooth type compared to CPC restored teeth. In total, 17 failures were observed in the FRCP group and 35 failures in the CPC group. A 60-month survival rate of 79.3% for FRCP and 64.5% for CPC was observed. Teeth serving as abutments for telescopic dentures were more likely to be affected by failure compared to teeth restored with single crowns. Conclusion: Within the limitations of this study, the FRCP showed a lower failure risk compared to the CPC, considering the definitive prosthetic restoration and tooth type within the observation period.
{"title":"Survival of Fiber-Reinforced Composite Resin Post-Restored vs. Cast Post-and-Core-Restored Teeth: A Retrospective Clinical Study","authors":"Oskar Bunz, Darja Iwantschenko, S. Tulka, Claudia Barthel-Zimmer, A. Piwowarczyk","doi":"10.3390/oral1040034","DOIUrl":"https://doi.org/10.3390/oral1040034","url":null,"abstract":"Objective: The question of whether classic cast post-and-core (CPC) or fiber-reinforced composite resin posts (FRCP) are the best clinical decision has still not been fully solved. Materials and Methods: One hundred and sixty-two teeth were restored with FRCP, and 162 CPC restored teeth were included in this study with a matched-pair design. In a primary analysis, the survival rates after one year (primary endpoint) were compared. The additional analysis included an evaluation of tooth- and construction-specific variables and an illustration of the survival up to 60 months via Kaplan-Meier curves. Results: FRCP showed lower failure risk considering the definitive prosthetic restoration and tooth type compared to CPC restored teeth. In total, 17 failures were observed in the FRCP group and 35 failures in the CPC group. A 60-month survival rate of 79.3% for FRCP and 64.5% for CPC was observed. Teeth serving as abutments for telescopic dentures were more likely to be affected by failure compared to teeth restored with single crowns. Conclusion: Within the limitations of this study, the FRCP showed a lower failure risk compared to the CPC, considering the definitive prosthetic restoration and tooth type within the observation period.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84410652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Todescan, Marcos Masayuki Hayashi, Luiz Roberto Giugni, M. Bottino, João Paulo Mendes Tribst
Proper maxillomandibular relationship registration can be clinically challenging during a digital workflow in full-arch rehabilitations. This dental technique requires the manufacturing and use of a hybrid surgical guide custom scanning device, indicated to be used during implant placement surgery, in addition to being used to simultaneously register the maxillomandibular relationship and transfer the implants’ 3D positioning, ensuring a fully digital workflow in full-arch implant-supported prosthesis rehabilitation. The sequence of steps presented here will allow dentists and dental technicians to conduct rehabilitations from denture to the final implant-supported prosthesis using a full-digital protocol, using a minimal quantity of intraoral devices and digital tools.
{"title":"From Denture to the Final Implant-Supported Prosthesis Using a Full-Digital Protocol: A Dental Technique","authors":"F. Todescan, Marcos Masayuki Hayashi, Luiz Roberto Giugni, M. Bottino, João Paulo Mendes Tribst","doi":"10.3390/oral1040033","DOIUrl":"https://doi.org/10.3390/oral1040033","url":null,"abstract":"Proper maxillomandibular relationship registration can be clinically challenging during a digital workflow in full-arch rehabilitations. This dental technique requires the manufacturing and use of a hybrid surgical guide custom scanning device, indicated to be used during implant placement surgery, in addition to being used to simultaneously register the maxillomandibular relationship and transfer the implants’ 3D positioning, ensuring a fully digital workflow in full-arch implant-supported prosthesis rehabilitation. The sequence of steps presented here will allow dentists and dental technicians to conduct rehabilitations from denture to the final implant-supported prosthesis using a full-digital protocol, using a minimal quantity of intraoral devices and digital tools.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"544 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77157041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Mauceri, C. Toro, V. Panzarella, Martina Iurato Carbone, V. Rodolico, G. Campisi
(1) Background: Medication-related osteonecrosis of the jaw (MRONJ) is a potential adverse drug reaction of antiresorptive and/or antiangiogenic treatment. MRONJ is mostly diagnosed by anamnestic data, clinical examination and radiological findings, with signs and symptoms often unspecific. On the other hand, oral squamous cell carcinoma (OSCC) is characteristic for its pleomorphic appearance (e.g., ulcer, mucous dehiscence, non-healing post-extractive socket). We report three cases where OSCC mimicked MRONJ lesions. (2) Patients: Three patients undergoing amino-bisphosphonate treatment for osteoporosis presented with areas of intraorally exposed jawbone and unspecific radiological signs compatible with MRONJ. Due to the clinical suspicious of malignant lesion, incisional biopsy for histological examination was also performed. (3) Results: Histological examination of the tissue specimen revealed the presence of OSCC. All patients underwent cancer treatment. (4) Conclusions: Several signs and symptoms of OSCC may simulate, in patients with a history of anti-resorptive, MRONJ; for these reasons, it is important to perform histologic analysis when clinicians are facing a suspicious malignant lesion.
{"title":"Oral Squamous Cell Carcinoma Mimicking Medication-Related Osteonecrosis of the Jaws (MRONJ): A Case Series","authors":"R. Mauceri, C. Toro, V. Panzarella, Martina Iurato Carbone, V. Rodolico, G. Campisi","doi":"10.3390/oral1040032","DOIUrl":"https://doi.org/10.3390/oral1040032","url":null,"abstract":"(1) Background: Medication-related osteonecrosis of the jaw (MRONJ) is a potential adverse drug reaction of antiresorptive and/or antiangiogenic treatment. MRONJ is mostly diagnosed by anamnestic data, clinical examination and radiological findings, with signs and symptoms often unspecific. On the other hand, oral squamous cell carcinoma (OSCC) is characteristic for its pleomorphic appearance (e.g., ulcer, mucous dehiscence, non-healing post-extractive socket). We report three cases where OSCC mimicked MRONJ lesions. (2) Patients: Three patients undergoing amino-bisphosphonate treatment for osteoporosis presented with areas of intraorally exposed jawbone and unspecific radiological signs compatible with MRONJ. Due to the clinical suspicious of malignant lesion, incisional biopsy for histological examination was also performed. (3) Results: Histological examination of the tissue specimen revealed the presence of OSCC. All patients underwent cancer treatment. (4) Conclusions: Several signs and symptoms of OSCC may simulate, in patients with a history of anti-resorptive, MRONJ; for these reasons, it is important to perform histologic analysis when clinicians are facing a suspicious malignant lesion.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The influence of area-based and individual indicators of socioeconomic status (SES) on health-related quality of life (HRQOL) and patient concerns following head and neck cancer is complex and under-reported. The aim of this study is to use baseline data collected as part of a randomised controlled trial to provide greater detail on the attribution of SES to University of Washington Quality of Life version 4 (UWQOL v4), Distress Thermometer and European Quality of Life Five-Dimension Five-Level (EQ-5D-5L) outcomes. A total of 288 trial patients attended baseline clinics a median (Interquartile (IQR)) of 103 (71–162) days after the end of treatment. Area-based SES was assessed using the Index of Multiple Deprivation (IMD) 2019. Thirty-eight per cent (110/288) of patients lived in the most deprived IMD rank quintile. Less than good overall quality of life (31% overall) was associated with current working situation (p = 0.008), receipt of financial benefits (p < 0.001), total household income (p = 0.003) and use of tobacco (p = 0.001). Income and employment were significant patient level indicators predictors of HRQOL outcomes after case-mix adjustment. The number of Patient Concerns Inventory items selected varied significantly by overall clinical tumour clinical stage (p < 0.001) and by treatment (p < 0.001) but not by area IMD or patient-level deprivation indicators. In conclusion, interventions to improve employment and finance could make a substantial positive effect on HRQOL outcomes and concerns.
{"title":"Social Determinants of Health-Related Quality of Life Outcomes for Head and Neck Cancer Patients","authors":"S. Rogers, D. Lowe, A. Kanatas","doi":"10.3390/oral1040031","DOIUrl":"https://doi.org/10.3390/oral1040031","url":null,"abstract":"The influence of area-based and individual indicators of socioeconomic status (SES) on health-related quality of life (HRQOL) and patient concerns following head and neck cancer is complex and under-reported. The aim of this study is to use baseline data collected as part of a randomised controlled trial to provide greater detail on the attribution of SES to University of Washington Quality of Life version 4 (UWQOL v4), Distress Thermometer and European Quality of Life Five-Dimension Five-Level (EQ-5D-5L) outcomes. A total of 288 trial patients attended baseline clinics a median (Interquartile (IQR)) of 103 (71–162) days after the end of treatment. Area-based SES was assessed using the Index of Multiple Deprivation (IMD) 2019. Thirty-eight per cent (110/288) of patients lived in the most deprived IMD rank quintile. Less than good overall quality of life (31% overall) was associated with current working situation (p = 0.008), receipt of financial benefits (p < 0.001), total household income (p = 0.003) and use of tobacco (p = 0.001). Income and employment were significant patient level indicators predictors of HRQOL outcomes after case-mix adjustment. The number of Patient Concerns Inventory items selected varied significantly by overall clinical tumour clinical stage (p < 0.001) and by treatment (p < 0.001) but not by area IMD or patient-level deprivation indicators. In conclusion, interventions to improve employment and finance could make a substantial positive effect on HRQOL outcomes and concerns.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78057874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/gutjnl-2021-bsg.2
Umair Kamran, D. King, M. Banks, Sophie Barker, Matthew Caffrey, D. Cheung, James Evans, Mark Fox, M. Glynn, J. Greenaway, Sanjay Gupta, S. Hebbar, Miriam Jones, S. Kadri, David Mitchell, D. Nylander, R. Ransford, Sharan J Shetty, T. Tham, Matthew Williams, N. Trudgill
OTU-12 Figure 1 Cancer Dysphagia Score Abstracts Gut 2021;70(Suppl 4):A1–A220 A1 on Jauary 1, 2022 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-B S G .2 on 7 N ovem er 221. D ow nladed fom Results 1496 patients were studied: median age 62 (IQR 5173), 58% female. Median EDS score was 4 (IQR 2.5-6); with 67% having an EDS 3.5. 64% were triaged to 2WW endoscopy; 18% to urgent (but not 2WW) endoscopy; 2.8% to urgent CT scan; 5.5% to routine OGD; and 4.4% to barium swallow. After excluding patients who declined investigation, results were available for 96%. 91 UGI cancers were diagnosed (prevalence 7.1%); with 3 (3%) UGI cancers diagnosed in patients with EDS<3.5 (one with EDS 3, two with EDS 1.5). EDS 3.5 had sensitivity of 96.7% and negative predictive value of 99% for UGI cancer. The factors associated with UGI cancer and hence selected to develop CDS included: age odds ratio 1.05 (95% CI 1.03-1.06); male 3.95 (2.36-6.58); progressive dysphagia 2.30 (1.39-3.79); unintentional weight loss 3.28 (2.02-5.31); acid reflux symptoms 0.47 (0.25-0.88) and dysphagia localised to the neck (0.26 (0.12-0.57). Dysphagia duration less than 6 months was not statistically significant (1.02 (0.452.22). AUROC was 0.83 for CDS as compared to 0.81 for EDS. Cancer dysphagia score and its receiver operating curve in comparison to Edinburgh dysphagia score is presented in figure 1. Conclusion A national prospective cohort confirms that EDS has high sensitivity and negative predictive value for UGI cancer, however, a modified cancer dysphagia score offers higher diagnostic accuracy. Our results suggest that CDS should be incorporated in the UGI cancer 2WW pathway for risk stratification of patients with dysphagia and further studies in primary care are needed. OTU-13 EUS CHOLEDOCHODUODENOSTOMY IN MALIGNANT DISTAL BILIARY OBSTRUCTION: MULTI-CENTRE COLLABORATION FROM THE UK AND IRELAND Wei On*, Bharat Paranandi, Andrew M Smith, Alistair Young, James Pine, Suresh V Venkatachalapathy, Martin W James, Guruprasad P Aithal, Ioannis Varbobitis, Danny Cheriyan, Ciaran McDonald, John S Leeds, Manu Nayar, Kofi Oppong, Joe Geraghty, John Devlin, Wafaa Ahmed, Ryan Scott, Terence Wong, Matthew T Huggett. Leeds Teaching Hospitals NHS Trust, Leeds, UK; Nottingham Digestive Diseases Centre (NDDC) and NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University and Nottingham University Hospitals NHS Trust, Queen’s Medical Centre, Nottingham, UK; Beaumont Hospital and RCSI, Dublin, Ireland; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK; Manchester University NHS Foundation Trust, Manchester, UK; King’s College Hospital NHS Foundation Trust, London, UK; Belfast Health and Social Care Trust, Belfast, Ireland; Guys’ and St Thomas’ NHS Foundation Trust, London, UK 10.1136/gutjnl-2021-BSG.3 Introduction Endoscopic ultrasound guided choledochoduodenostomy (EUS-CDD) with electrocautery enhanced lumen apposing metal stent
Liya Lu, Jamie Catlow, Raphael Broughton, Peter Rogers, Linda Sharp, Matt Rutter*。纽卡斯尔大学人口健康科学研究所，代表NED-APRIQOT团队;北蒂斯国民保健服务基金会信托;伦敦RCP JAG;Weblogik
{"title":"OTU-12 Validation of Edinburgh dysphagia score in a national evaluation of upper GI cancer 2ww pathway","authors":"Umair Kamran, D. King, M. Banks, Sophie Barker, Matthew Caffrey, D. Cheung, James Evans, Mark Fox, M. Glynn, J. Greenaway, Sanjay Gupta, S. Hebbar, Miriam Jones, S. Kadri, David Mitchell, D. Nylander, R. Ransford, Sharan J Shetty, T. Tham, Matthew Williams, N. Trudgill","doi":"10.1136/gutjnl-2021-bsg.2","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-bsg.2","url":null,"abstract":"OTU-12 Figure 1 Cancer Dysphagia Score Abstracts Gut 2021;70(Suppl 4):A1–A220 A1 on Jauary 1, 2022 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-B S G .2 on 7 N ovem er 221. D ow nladed fom Results 1496 patients were studied: median age 62 (IQR 5173), 58% female. Median EDS score was 4 (IQR 2.5-6); with 67% having an EDS 3.5. 64% were triaged to 2WW endoscopy; 18% to urgent (but not 2WW) endoscopy; 2.8% to urgent CT scan; 5.5% to routine OGD; and 4.4% to barium swallow. After excluding patients who declined investigation, results were available for 96%. 91 UGI cancers were diagnosed (prevalence 7.1%); with 3 (3%) UGI cancers diagnosed in patients with EDS<3.5 (one with EDS 3, two with EDS 1.5). EDS 3.5 had sensitivity of 96.7% and negative predictive value of 99% for UGI cancer. The factors associated with UGI cancer and hence selected to develop CDS included: age odds ratio 1.05 (95% CI 1.03-1.06); male 3.95 (2.36-6.58); progressive dysphagia 2.30 (1.39-3.79); unintentional weight loss 3.28 (2.02-5.31); acid reflux symptoms 0.47 (0.25-0.88) and dysphagia localised to the neck (0.26 (0.12-0.57). Dysphagia duration less than 6 months was not statistically significant (1.02 (0.452.22). AUROC was 0.83 for CDS as compared to 0.81 for EDS. Cancer dysphagia score and its receiver operating curve in comparison to Edinburgh dysphagia score is presented in figure 1. Conclusion A national prospective cohort confirms that EDS has high sensitivity and negative predictive value for UGI cancer, however, a modified cancer dysphagia score offers higher diagnostic accuracy. Our results suggest that CDS should be incorporated in the UGI cancer 2WW pathway for risk stratification of patients with dysphagia and further studies in primary care are needed. OTU-13 EUS CHOLEDOCHODUODENOSTOMY IN MALIGNANT DISTAL BILIARY OBSTRUCTION: MULTI-CENTRE COLLABORATION FROM THE UK AND IRELAND Wei On*, Bharat Paranandi, Andrew M Smith, Alistair Young, James Pine, Suresh V Venkatachalapathy, Martin W James, Guruprasad P Aithal, Ioannis Varbobitis, Danny Cheriyan, Ciaran McDonald, John S Leeds, Manu Nayar, Kofi Oppong, Joe Geraghty, John Devlin, Wafaa Ahmed, Ryan Scott, Terence Wong, Matthew T Huggett. Leeds Teaching Hospitals NHS Trust, Leeds, UK; Nottingham Digestive Diseases Centre (NDDC) and NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University and Nottingham University Hospitals NHS Trust, Queen’s Medical Centre, Nottingham, UK; Beaumont Hospital and RCSI, Dublin, Ireland; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK; Manchester University NHS Foundation Trust, Manchester, UK; King’s College Hospital NHS Foundation Trust, London, UK; Belfast Health and Social Care Trust, Belfast, Ireland; Guys’ and St Thomas’ NHS Foundation Trust, London, UK 10.1136/gutjnl-2021-BSG.3 Introduction Endoscopic ultrasound guided choledochoduodenostomy (EUS-CDD) with electrocautery enhanced lumen apposing metal stent","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87676161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/gutjnl-2021-bsg.6
J. Lindsay, S. Din, C. Hawkey, D. Hind, P. Irving, A. Lobo, Y. Mahida, G. Moran, M. Parkes, J. Satsangi, S. Subramanian, Lizzie Swaby, S. Travis, J. Snowden
James Lindsay*, Shahida Din, Chris Hawkey, Danny Hind, Peter Irving, Alan Lobo, Yash Mahida, Gordon Moran, Miles Parkes, Jack Satsangi, Sree Subramanian, Lizzie Swaby, Simon Travis, John Snowden. Barts Health NHS Trust, London, UK; Western General Hospital, Edinburgh, UK; University of Nottingham, Nottingham, UK; University of Sheffield, Sheffield, UK; Guy’s and St Thomas’ Hospital, London, UK; Cambridge University Hospitals, Cambridge, UK; Oxford University Hospitals, Oxford, UK; Royal Liverpool University Hospital, Liverpool, UK
James Lindsay*、Shahida Din、Chris Hawkey、Danny Hind、Peter Irving、Alan Lobo、Yash Mahida、Gordon Moran、Miles Parkes、Jack Satsangi、Sree Subramanian、Lizzie Swaby、Simon Travis、John Snowden。Barts Health NHS Trust，伦敦，英国;英国爱丁堡西部总医院;诺丁汉大学，英国诺丁汉;谢菲尔德大学，英国谢菲尔德;盖伊和圣托马斯医院，伦敦，英国;英国剑桥大学附属医院;牛津大学医院，英国牛津;皇家利物浦大学医院，英国利物浦
{"title":"OFR-9 An RCT of autologous stem-cell transplantation in treatment refractory Crohn’s disease (low-intensity therapy evaluation): ASTIClite","authors":"J. Lindsay, S. Din, C. Hawkey, D. Hind, P. Irving, A. Lobo, Y. Mahida, G. Moran, M. Parkes, J. Satsangi, S. Subramanian, Lizzie Swaby, S. Travis, J. Snowden","doi":"10.1136/gutjnl-2021-bsg.6","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-bsg.6","url":null,"abstract":"James Lindsay*, Shahida Din, Chris Hawkey, Danny Hind, Peter Irving, Alan Lobo, Yash Mahida, Gordon Moran, Miles Parkes, Jack Satsangi, Sree Subramanian, Lizzie Swaby, Simon Travis, John Snowden. Barts Health NHS Trust, London, UK; Western General Hospital, Edinburgh, UK; University of Nottingham, Nottingham, UK; University of Sheffield, Sheffield, UK; Guy’s and St Thomas’ Hospital, London, UK; Cambridge University Hospitals, Cambridge, UK; Oxford University Hospitals, Oxford, UK; Royal Liverpool University Hospital, Liverpool, UK","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73449440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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